Doctora en Ciencias por la UNAM y miembro del SNI Nivel 2. Lidero la línea de investigación en detección de daño en ADN por exposición a xenobióticos. He ocupado cargos académicos en la UAdeO, incluyendo el de Vicerrectora Académica, espacio desde donde coordiné la reestructuración de planes y programas de estudio. He sido gestora y directora de la Unidad de Investigación en Ambiente y Salud. Actualmente, soy profesora investigadora en el Departamento de Ciencias Naturales y Exactas de la UAdeO, con reconocimiento PRODEP-SEP. He publicado 61 artículos científicos en revistas indexadas, otros más en revistas arbitradas, de divulgación, libro infantil y capítulos de libro, Imparto cursos y he dirigido más de 40 tesis de nivel licenciatura, maestría y doctorado en UAdeO, UNAM, UAM y UAIM. Colaborado en proyectos con la Universidad Paris-Est Créteil, realicé estancias en las Universidades Autónoma de Barcelona y en UCI, logrando convenios con ambas instituciones internacionales. Soy Res
EDUCATION
Doctora en genotoxicología UNAM
RESEARCH, TEACHING, or OTHER INTERESTS
Medicine, Multidisciplinary, Biochemistry, Genetics and Molecular Biology, Cancer Research
32
Scopus Publications
1822
Scholar Citations
23
Scholar h-index
37
Scholar i10-index
Scopus Publications
Adipocytokine profiles in maternal obesity: The impact of lipoinflammation on serum, breastmilk, and infant metabolic development Mario Daniel Caba-Flores, Cesar Huerta-Canseco, Carmen Martínez-Valenzuela, Aurora de Jesús Garza-Juárez, Ana María Rivas-Estilla, Alberto Camacho-Morales Clinical Pediatric Endocrinology, 2025 Adipocytokines are proteins with systemic metabolic effects, and additional adipocytokines have been identified. Adipocytokines are present in the serum, and obesity-mediated inflammation can alter their expression. Breast milk also contains adipocytokines that may influence infant metabolism and growth. Nonetheless, the relationship between circulating and milk adipocytokines during maternal inflammation and their effects on infant development remain unclear. We conducted a comprehensive literature review of studies published between 2000 and 2024 in PubMed to analyze the associations between obesity-mediated inflammation and adipocytokines in maternal serum and breast milk and to explore their potential effects on infant growth and metabolic health. We focused on updated evidence for the legacy adipocytokines leptin, adiponectin, TNF-α, and IL-6 and the emerging adipocytokines chemerin, neuregulin-4, and betatrophin. The results indicated that although obesity-mediated inflammation affected circulating adipocytokines, their levels were not consistently reflected in breast milk. Leptin, chemerin, and betatrophin were more influenced by lipoinflammation than adiponectin, IL-6, and TNF-α. Neuregulin-4 was present in milk, and its serum levels decreased during gestational diabetes. Some adipocytokines were correlated with infant growth; however, the evidence remains inconclusive. Importantly, no adverse metabolic or growth outcomes were linked to changes in milk adipocytokine profiles. These findings support the promotion of breastfeeding as part of infant health strategies, even in the context of maternal lipoinflammation.
Inoculation With Azotobacter vinelandii Enhanced Chlorpyrifos Degradation and Reduced Cytotoxic and Genotoxic Effects in Soil V. Conde Avila, C. Martínez Valenzuela, Y. E. Navarro Noya, P. J. Bastidas Bastidas Spanish Journal of Soil Science, 2025 Using microbial cells for bioremediation requires evaluating suitable inoculation techniques and their effects. This study applied liquid and encapsulated in alginate beads inocula of A. vinelandii in agricultural soil to evaluate chlorpyrifos (CP) degradation and its impact on cytotoxic and genotoxic effects. Allium sativum cells and Eisenia foetida organisms were used as biomarkers for toxicological evaluations. Changes in the mitotic index and nuclear abnormalities in A. sativum cells were used for toxicity determinations. The percentage survival of E. foetida was calculated. Ultra-high-performance liquid chromatography was used to detect CP. The initial CP concentration (250 mg/kg) decreased by 92% when inoculated with liquid A. vinelandii and by 82% with A. vinelandii encapsulated after 14 d. A 60% decrease in cytotoxic and genotoxic damage to A. sativum cells was detected in treatments inoculated with A. vinelandii. The survival rate of E. foetida was improved by 33% when inoculated with free A. vinelandii compared to contaminated soil. Encapsulation as an inoculation strategy extended the viability of A. vinelandii compared to free inoculation. Both free and encapsulated inocula of A. vinelandii effectively degrade CP in soil and decrease its toxic effects. This study contributed by identifying sustainable agricultural alternatives for the inoculation and bioremediation of agricultural soils.
Preterm Delivery in Obese Mothers Predicts Tumor Necrosis Factor-α Levels in Breast Milk Mario Daniel Caba-Flores, Marcela Cardenas-Tueme, Rubí Viveros-Contreras, Carmen Martínez-Valenzuela, Jorge Iván Zurutuza-Lorméndez, Roció Ortiz-López, Gabriela Cruz-Carrillo, Juan Gerardo Neme Kuri, David Huerta Morales, Samantha Ponce Ramos, Edith Nava Bustos, Alberto Camacho-Morales Breastfeeding Medicine, 2023 Background: Breast milk (BM) is a nutritive fluid that is rich in bioactive components such as hormones and cytokines that can shape the newborn's feeding habits and program the newborn's immature immune system. BM components can change under different scenarios that include maternal body mass index (BMI) and premature birth. This study aimed to study the interaction of premature status or maternal obesity on the hormonal and cytokine profile in BM according to the sex of the offspring. Materials and Methods: We recruited 31 women with preterm births from the Centro de Alta Especialidad Dr. Rafael Lucio in Mexico. Luminex multiplexing assay was used for quantifying cytokine profile of monocyte chemoattractant protein-1, tumor necrosis factor (TNF)-α, interferon-γ, interleukin (IL)1-β, IL-2, IL-4, IL-6, IL-7, and hormones insulin, ghrelin, leptin, and glucagon in mature BM samples. Biological modeling was performed to predict the interaction between cytokines and hormones, maternal BMI status, infant birth sex, parity, and gestational age. Results: BM multiplex analysis showed positive correlations for TNF-α and increasing prematurity and for higher maternal BMI and IL-2, IL-4, and IL-6 cytokines. Multiple regression models identified an interaction between maternal BMI and gestational weeks in male infants that is associated to TNF-α accumulation in BM. Biological modeling predicts that preterm delivery in mothers with obesity modulates TNF- α levels in mature BM of women with male offspring. Conclusion: Prematurity and obesity modify BM's immune profile. TNF- α expression increases as prematurity increases, and maternal BMI correlates positively with increases in IL-2, IL-6, and IL-4. Our multiple regression model also shows that maternal BMI and gestational weeks in male infants predict TNF-α.
Genotoxic Biomonitoring in Children Living near the El Fraile Mine Tailings in Northern Guerrero State, Mexico María Elena Calderon-Segura, Alejandro Ramírez-Guzmán, Oscar Talavera-Mendoza, Yolanda Carbajal-López, María del Carmen Martínez-Valenzuela, Martha Elena Mora-Herrera, Liliana Salinas-Alcántara, Patricia Hurtado-Brito Toxics, 2022 A genotoxic study was conducted with 101 elementary school children (56 girls and 45 boys) in the 6–7, 8–9, and 10–12 age ranges from El Fraile rural community, which is located beside the El Fraile mine tailings in Taxco of Alarcon City, in northern Guerrero State, Mexico. For this, we used the alkaline comet assay in exfoliated buccal mucosa cells, scoring three genotoxic parameters: tail intensity, tail moment, and tail length. Additionally, we detected oxidative DNA damage through urinary 8-OHdG levels by enzyme-linked immunosorbent assay. We also evaluated a control group consisting of 101 children in the same age ranges from Chilpancingo City, Guerrero, who had never lived near mining zones. Genotoxic results showed that there was a significant increase in three genotoxic parameters and urinary 8-OHdG levels in the exposed children group compared with the control group. Analysis of MANOVA revealed that boys aged 8 and 9 years had higher DNA damage than girls from the same exposure group, and Spearman’s analysis identified a positive correlation between DNA damage and sex and age. This study provides the first valuable genotoxic data in children living in areas with environmental pollution.
Expression Analysis of miRNAs and Their Potential Role as Biomarkers for Prostate Cancer Detection Fernando Bergez-Hernández, Eliakym Arámbula-Meraz, Marco Alvarez-Arrazola, Martín Irigoyen-Arredondo, Fred Luque-Ortega, Alejandra Martínez-Camberos, Dora Cedano-Prieto, José Contreras-Gutiérrez, Carmen Martínez-Valenzuela, Noemí García-Magallanes American Journal of Men S Health, 2022 Prostate cancer (PCa) is the second most frequent cancer diagnosed in men worldwide. The detection methods for PCa are either unreliable, like prostate-specific antigen (PSA), or extremely invasive, such as in the case of biopsies. Therefore, there is an urgent necessity for reliable and less invasive detection procedures that can differentiate between patients with benign diseases and those with cancer. In this matter, microRNAs (miRNAs) are suggested as potential biomarkers for cancer. MiRNAs have been found to be dysregulated in several different cancers, and these genetic alterations may present specific signatures for a given malignancy. Here, we examined the expression of miR141-3p, miR145-5p, miR146a-5p, and miR148b-3p in human tissue samples of PCa ( n = 41) and benign prostatic diseases (BPD) ( n = 30) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We combined the expression results with patient clinicopathological characteristics in logistic regression models to create accurate PCa predictive models. A model including information of miR148b-3p and patient age showed relevant prediction results (area under the curve [AUC] = 0.818, precision = 0.763, specificity = 0.762, and accuracy = 0.762). A model including all four miRNAs and patient age presented outstanding prediction results (AUC = 0.918, precision = 0.861, specificity = 0.861, and accuracy = 0.857). Our results represent a potential novel procedure based on logistic regression models that utilize miRNA expressions and patient age to assist with PCa diagnosis.
Breast Milk and the Importance of Chrononutrition Mario Daniel Caba-Flores, Angel Ramos-Ligonio, Alberto Camacho-Morales, Carmen Martínez-Valenzuela, Rubí Viveros-Contreras, Mario Caba Frontiers in Nutrition, 2022 During pregnancy the human fetus receives timed cues from the circadian rhythms of temperature, metabolites, and hormones from the mother. This influence is interrupted after parturition, the infant does not secrete melatonin and their circadian rhythms are still immature. However, evolution provided the solution to this problem. The newborn can continue receiving the mother's timed cues through breastmilk. Colostrum, transitional, and mature human milk are extraordinary complex biofluids that besides nutrients, contain an array of other non-nutritive components. Upon birth the first milk, colostrum, is rich in bioactive, immunological factors, and in complex oligosaccharides which help the proper establishment of the microbiome in the gut, which is crucial for the infants' health. Hormones, such as glucocorticoids and melatonin, transfer from the mother's plasma to milk, and then the infant is exposed to circadian cues from their mother. Also, milk components of fat, proteins, amino acids, and endogenous cannabinoids, among others, have a markedly different concentration between day and night. In the present review, we give an overview of nutritive and non-nutritive components and their daily rhythms in human milk and explore their physiological importance for the infant. Finally, we highlight some interventions with a circadian approach that emphasize the importance of circadian rhythms in the newborn for their survival, proper growth, and development. It is estimated that ~600,000 deaths/year are due to suboptimal breastfeeding. It is advisable to increase the rate of exclusive breastfeeding, during the day and night, as was established by the evolution of our species.
Growth, respiratory activity and chlorpyrifos biodegradation in cultures of Azotobacter vinelandii ATCC 12837 Victoria Conde-Avila, Carlos Peña, Beatriz Pérez-Armendáriz, Octavio Loera, Carmen Martínez Valenzuela, José Belisario Leyva Morales, Pedro de Jesús Bastidas Bastidas, Holjes Salgado-Lugo, Luis Daniel Ortega Martínez AMB Express, 2021 This study aimed to evaluate the growth, respiratory activity, and biodegradation of chlorpyrifos in cultures of Azotobacter vinelandii ATCC 12837. A strategy based on the modification of culture media and aeration conditions was carried out to increase the cell concentration of A. vinelandii, in order to favor and determine its tolerance to chlorpyrifos and its degradation ability. The culture in shaken flasks, using sucrose as a carbon source, significantly improved the growth compared to media with mannitol. When the strain was cultivated under oxygen-limited (5.5, 11.25 mmol L−1 h−1) and no-oxygen-limited conditions (22 mmol L−1 h−1), the growth parameters were not affected. In cultures in a liquid medium with chlorpyrifos, the bacteria tolerated a high pesticide concentration (500 ppm) and the growth parameters were improved even under conditions with a reduced carbon source (sucrose 2 g L−1). The strain degraded 99.6% of chlorpyrifos at 60 h of cultivation, in co-metabolism with sucrose; notably, A. vinelandii ATCC 12837 reduced by 50% the initial pesticide concentration in only 6 h (DT50). Graphical Abstract
Phenolic content and antioxidant properties of seeds of the Arbuscular mycorrhiza colonized common bean variety Azufrasin from Northern Mexico Phaseolus Vulgaris Cultivars Production and Uses, 2018
Genotoxic risk occupational exposure to pesticides in latin America Revista Internacional De Contaminacion Ambiental, 2013
Assessing the genotoxic risk for Mexican children who are in residential proximity to agricultural areas with intense aerial pesticide applications Revista Internacional De Contaminacion Ambiental, 2013
Impacto del extracto acuoso de Bromelia pinguin en los mecanismos de muerte celular en la línea MDA-MB-231 derivada de cáncer de mama N Montes-Castro, E Méndez-Nevárez, MS Criollo-Mendoza, ... Revista Bioc Scientia 1 (2) , 2025 2025
Inoculation With Azotobacter vinelandii Enhanced Chlorpyrifos Degradation and Reduced Cytotoxic and Genotoxic Effects in Soil V Conde Avila, C Martínez Valenzuela, YE Navarro Noya, ... Spanish Journal of Soil Science 15, 14033 , 2025 2025 Citations: 1
Inoculation with Azotobacter vinelandii enhanced Chlorpyrifos degradation and reduced cytotoxic and genotoxic effects in soil VC Avila, MCM Valenzuela, YEN Noya, PJB Bastidas Spanish Journal of Soil Science: SJSS 15 (1), 12 , 2025 2025 Citations: 3
Adipocytokine profiles in maternal obesity: The impact of lipoinflammation on serum, breastmilk, and infant metabolic development MD Caba-Flores, C Huerta-Canseco, C Martínez-Valenzuela, ... Clinical Pediatric Endocrinology 34 (4), 204-212 , 2025 2025 Citations: 1
Factores de habitabilidad y salud, monitoreados en vivienda vertical de clima cálido seco PMG Fierro, GB Morales, MCM Valenzuela Ciencia Latina: Revista Multidisciplinar 9 (2), 270-289 , 2025 2025
Bromelia pinguin Extract Mitigates Glyphosate-Induced Toxicity in Human Cells LO Masías-Ambriz, MD Caba-Flores, N Montes-Castro, I García-Aguiar, ... Cureus 16 (11) , 2024 2024 Citations: 1
Preterm delivery in obese mothers predicts tumor necrosis factor-α levels in breast milk MD Caba-Flores, M Cardenas-Tueme, R Viveros-Contreras, ... Breastfeeding medicine 18 (12), 934-942 , 2023 2023 Citations: 8
Micro problems with macro consequences: accumulation of persistent organic pollutants and microplastics in human breast milk and in human milk substitutes MD Caba-Flores, C Martínez-Valenzuela, M Cardenas-Tueme, ... Environmental Science and Pollution Research 30 (42), 95139-95154 , 2023 2023 Citations: 42
HABITABILIDAD Y SALUD EN ESPACIOS INTERIORES DE VIVIENDAS DE INTERÉS SOCIAL, MEDIANTE LA PERCEPCIÓN DE SUS HABITANTES. P María Guevara-Fierro, M del Carmen Martínez-Valenzuela, ... Ra Ximhai 19 , 2023 2023 Citations: 2
ESTUDIO DE LA PERCEPCIÓN SOCIAL SOBRE LA EXPOSICIÓN A PLAGUICIDAS EN SINALOA Y EL USO DE PLANTAS MEDICINALES COMO ALTERNATIVA TRADICIONAL PARA SU TRATAMIENTO. L Masias-Ambriz, J Damián Cordero-Ramírez, C Martínez-Valenzuela Ra Ximhai 19 , 2023 2023 Citations: 1
Expression Analysis of miRNAs and their potential role as biomarkers for prostate cancer detection F Bergez-Hernández, E Arámbula-Meraz, M Alvarez-Arrazola, ... American Journal of Men's Health 16 (5), 15579883221120989 , 2022 2022 Citations: 6
Applying the Global Monitoring Plan and analysis of POPs results in atmospheric air in Mexico (2017–2018) CM Valenzuela, AG García, VC Avila, DB Alemán, MA Avalos, JGL Valdez, ... Chemosphere 303, 135154 , 2022 2022 Citations: 5
Breast milk and the importance of chrononutrition MD Caba-Flores, A Ramos-Ligonio, A Camacho-Morales, ... Frontiers in nutrition 9, 867507 , 2022 2022 Citations: 87
Encapsulation of Azotobacter vinelandii ATCC 12837 in Alginate-Na Beads as a Tomato Seedling Inoculant V Conde-Avila, LD Ortega-Martínez, O Loera, B Pérez-Armendáriz, ... Current microbiology 79 (4), 112 , 2022 2022 Citations: 11
Usos e importancia biocultural de la miel en comunidades yoreme-mayo del norte de Sinaloa MDA Avalos, JRR Apodaca, CM Valenzuela, ENR Sauceda Revista Ra Ximhai 18 (1), 235-257 , 2022 2022
Growth, respiratory activity and chlorpyrifos biodegradation in cultures of Azotobacter vinelandii ATCC 12837 V Conde-Avila, C Peña, B Pérez-Armendáriz, O Loera, ... AMB Express 11 (1), 177 , 2021 2021 Citations: 10
Growth, respiratory activity and chlorpyrifos biodegradation in cultures of Azotobacter vinelandii ATCC 12837 VC Avila, C Peña, BP Armendáriz, O Loera, CM Valenzuela, B Leyva, ... 2021
Pesticides degradation by immobilised microorganisms V Conde-Avila, LD Ortega-Martínez, O Loera, EG El Kassis, JG Dávila, ... International Journal of Environmental Analytical Chemistry 101 (15), 2975-3005 , 2021 2021 Citations: 48
Breastfeeding contributes to physiological immune programming in the newborn A Camacho-Morales, M Caba, M García-Juárez, MD Caba-Flores, ... Frontiers in pediatrics 9, 744104 , 2021 2021 Citations: 197
Nuclear abnormalities in umbilical cord blood lymphocytes of newborns from the Ahome and Guasave municipalities in Sinaloa, Mexico C Martínez‐Valenzuela, J Huichapan, LD Ortega, AB Irineo, E Zenteno, ... Journal of Obstetrics and Gynaecology Research 47 (3), 968-977 , 2021 2021 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Riesgo genotóxico por exposición a plaguicidas en trabajadores agrícolas C Martínez-Valenzuela, S Gómez-Arroyo Revista internacional de contaminación ambiental 23 (4), 185-200 , 2007 2007 Citations: 202
Breastfeeding contributes to physiological immune programming in the newborn A Camacho-Morales, M Caba, M García-Juárez, MD Caba-Flores, ... Frontiers in pediatrics 9, 744104 , 2021 2021 Citations: 197
Genotoxic biomonitoring of agricultural workers exposed to pesticides in the north of Sinaloa State, Mexico C Martínez-Valenzuela, S Gómez-Arroyo, R Villalobos-Pietrini, ... Environment International 35 (8), 1155-1159 , 2009 2009 Citations: 162
Evaluation of Genotoxic and Cytotoxic Effects in Human Peripheral Blood Lymphocytes Exposed In Vitro to Neonicotinoid Insecticides News ME Calderón-Segura, S Gomez-Arroyo, R Villalobos-Pietrini, ... Journal of toxicology 2012 (1), 612647 , 2012 2012 Citations: 140
Aferrarse o soltar privilegios de género: sobre masculinidades hegemónicas y disidentes GB Wigdor Península 11 (2), 101-122 , 2016 2016 Citations: 117
Breast milk and the importance of chrononutrition MD Caba-Flores, A Ramos-Ligonio, A Camacho-Morales, ... Frontiers in nutrition 9, 867507 , 2022 2022 Citations: 87
Organochlorine pesticide residue levels in blood serum of inhabitants from Veracruz, Mexico SM Waliszewski, M Caba, M Herrero-Mercado, H Saldariaga-Noreña, ... Environmental monitoring and assessment 184 (9), 5613-5621 , 2012 2012 Citations: 68
Riesgo genotóxico por la exposición ocupacional a plaguicidas en América Latina S GÓMEZ-ARROYO, C MARTÍNEZ-VALENZUELA, Y CARBAJAL-LÓPEZ, ... Revista internacional de contaminación ambiental 29, 159-180 , 2013 2013 Citations: 64
Organochlorine pesticide gradient levels among maternal adipose tissue, maternal blood serum and umbilical blood serum M Herrero-Mercado, SM Waliszewski, M Caba, C Martínez-Valenzuela, ... Bulletin of Environmental Contamination and Toxicology 86 (3), 289-293 , 2011 2011 Citations: 52
Pesticides degradation by immobilised microorganisms V Conde-Avila, LD Ortega-Martínez, O Loera, EG El Kassis, JG Dávila, ... International Journal of Environmental Analytical Chemistry 101 (15), 2975-3005 , 2021 2021 Citations: 48
Aerial pesticide application causes DNA damage in pilots from Sinaloa, Mexico C Martínez-Valenzuela, SM Waliszewski, O Amador-Muñoz, E Meza, ... Environmental Science and Pollution Research 24 (3), 2412-2420 , 2017 2017 Citations: 45
Assessing the genotoxic risk for mexican children who are in residential proximity to agricultural areas with intense aerial pesticide applications S Gomez-Arroyo, C Martinez-Valenzuela, S Calvo-Gonzalez, ... Revista internacional de contaminación ambiental 29 (3), 217-225 , 2013 2013 Citations: 43
Micro problems with macro consequences: accumulation of persistent organic pollutants and microplastics in human breast milk and in human milk substitutes MD Caba-Flores, C Martínez-Valenzuela, M Cardenas-Tueme, ... Environmental Science and Pollution Research 30 (42), 95139-95154 , 2023 2023 Citations: 42
Caracterización y funcionalidad de invernaderos en Chignahuapan Puebla, México LD Ortega-Martínez, J Ocampo-Mendoza, E Sandoval-Castro, ... Revista Bio Ciencias 2 (4), 261-270 , 2014 2014 Citations: 41
First report of powdery mildew (Podosphaera pannosa) of roses in Sinaloa, Mexico R Félix-Gastélum, G Herrera-Rodríguez, C Martínez-Valenzuela, ... Plant Disease 98 (10), 1442-1442 , 2014 2014 Citations: 33
Efecto de las giberelinas sobre el crecimiento y calidad de plántulas de tomate LD Ortega-Martínez, JO Mendoza, CM Valenzuela, AP Serrano, JS Olarte Biotecnia 15 (3), 56-60 , 2013 2013 Citations: 29
Evaluation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct levels and DNA strand breaks in human peripheral blood lymphocytes exposed in vitro to polycyclic … RRM Isabel, GA Sandra, VP Rafael, MV Carmen, CE Josefina, ... Toxicology mechanisms and methods 22 (3), 170-183 , 2012 2012 Citations: 28
Cytogenetic biomonitoring of occupationally exposed workers to ashes from burning of sugar cane in Ahome, Sinaloa, México C Martínez-Valenzuela, AR Rodríguez-Quintana, E Meza, ... Environmental Toxicology and Pharmacology 40 (2), 397-401 , 2015 2015 Citations: 27
Monitoring of organochlorine pesticide residue levels in adipose tissue of Veracruz, Mexico inhabitants SM Waliszewski, M Caba, M Herrero-Mercado, H Saldariaga-Noreña, ... Bulletin of environmental contamination and toxicology 87 (5), 539-544 , 2011 2011 Citations: 25
Organochlorine pesticide levels in umbilical cord blood of newborn in Veracruz, Mexico M Herrero-Mercado, SM Waliszewski, M Caba, C Martínez-Valenzuela, ... Bulletin of environmental contamination and toxicology 85 (4), 367-371 , 2010 2010 Citations: 25
