Degree in Dentistry from ISCSN. PhD from the University of Barcelona (UB) . Regent of the Curricular Unit of the Surgical and Periodontal Clinic I of the Integrated Master's Degree in Dentistry at IUCS. Specialist in Periodontology by the Portuguese Dental Association (OMD)
6
Scopus Publications
824
Scholar Citations
5
Scholar h-index
3
Scholar i10-index
Scopus Publications
Gummy Smile: Comparison Between Botulinum Toxin, Lip Repositioning Surgery and Combined Techniques in Cases of Lip Hypermobility—A Systematic Review Marie Siano, Rosana Costa, Marta Relvas, Ana Sofia Vinhas, Cátia Reis, et al. Oral Health Diseases Therapies and Technologies, 2026 Background: Excessive gingival display is frequently associated with upper lip hypermobility and represents a common aesthetic concern. Several therapeutic approaches have been proposed, including botulinum toxin type A injections, lip repositioning surgery (LRS), and combined techniques; however, no clear consensus exists regarding the most effective and stable treatment option. Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) guidelines. A comprehensive search of multiple electronic databases was performed, leading to the inclusion of 17 human studies that met predefined PICOS criteria. The review protocol was registered in PROSPERO (CRD420261281920). Results: Most included studies reported favorable outcomes in terms of reduction in gingival display, improvement in smile aesthetics, and patient satisfaction. No major adverse effects were reported, suggesting acceptable safety profiles for all therapeutic modalities. Outcomes varied depending on the type of intervention, surgical technique, botulinum toxin dosage and injection protocol, and the initial severity of upper lip hypermobility. Conclusions: Both botulinum toxin injections and LRS demonstrated effectiveness in reducing excessive gingival display. Botulinum toxin provided a rapid but temporary improvement, whereas modified LRS showed greater stability over time. Combined approaches appeared to offer the most consistent long-term results by limiting postoperative relapse. Further standardized protocols and long-term clinical studies are needed to confirm these findings and support evidence-based clinical decision-making.
The Effectiveness and Safety of Stem Cell-Based Tissue Engineering in the Regeneration of Periodontal Bone Lesions: A Systematic Review Marouan Fanid, Ana Sofia Vinhas, Cátia Reis, Marta Relvas, Rosana Costa, et al. Clinics and Practice, 2025 Background/Objectives: Periodontal diseases are highly prevalent worldwide, causing progressive destruction of the alveolar bone and eventual tooth loss when not treated. Despite advances in conventional periodontal therapies, complete tissue regeneration remains limited. This review aims to evaluate the efficacy, safety, and clinical relevance of stem cell-based tissue engineering approaches for regeneration of periodontal bone lesions. Methods: Following PRISMA guidelines, a systematic search was conducted across multiple databases, resulting in the inclusion of 17 studies in humans that met predefined PICO criteria. The study protocol was registered on PROSPERO (CRD420251229271). These studies assessed various stem cell sources, including dental and bone marrow-derived cells among others, both on their own and in combination with scaffolds or growth factors. Results: Most studies reported favorable outcomes in terms of clinical attachment gain, radiographic bone fill, probing depth reduction, and implant stability. No major adverse effects were noted, indicating good safety. However, results varied based on cell type, culture protocols, and defect characteristics. Conclusions: Stem cell therapy shows strong potential for periodontal regeneration, with outcomes that may potentially surpass those of conventional methods in selected cases. Further standardization, cost reduction, and long-term clinical trials are essential to confirm these findings and support their integration into daily dental practice.
The Prevalence of Gingival Recession According to the Cairo Classification in a Population from the North of Portugal Beatriz Moura, Filomena Salazar, Rosana Costa, Cristina Cabral, Cátia Reis Dentistry Journal, 2024 Background/Objectives: Gingival recession (GR) has a multifactorial etiology, resulting from the interaction of various factors. It affects aesthetics and comfort, and has negative consequences for quality of life. The main objective of this study is to investigate the prevalence of gingival recession in a sample of the population in northern Portugal, according to the classification system proposed by Cairo. The secondary objective is to investigate possible risk factors for the prevalence of gingival recession. Methods: This observational study analyzed 50 patients who met all our inclusion criteria. Participants underwent a clinical periodontal examination and completed a questionnaire. Results: On the lingual/palatine side, recession type 2 (RT2) was the most prevalent (39.1%), and on the buccal side, recession type 3 (RT3) was the most prevalent (37.7%). Statistically significant differences were found in the occurrence of RT3 on both sides, buccal and lingual/palatine, which was higher in patients over 65. Buccal side RT2 and buccal and lingual/palatine side RT3 were more prevalent in males. Buccal side RT2 was more prevalent in ex-smokers compared to nonsmokers. RT3 was more prevalent in ex-smokers compared to smokers and nonsmokers. Most patients have gingival recession with loss of interproximal attachment. Conclusions: Older age, male gender, high plaque levels, and smoking habits are considered risk factors.
Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases Elsa Maria Cardoso, Cátia Reis, Maria Cristina Manzanares-Céspedes Postgraduate Medicine, 2018 Periodontal diseases, such as chronic periodontitis, share common inflammatory risk factors with other systemic and chronic inflammatory disorders. Mucosal tissues, such as oral epithelia, are exposed to environmental stressors, such as tobacco and oral bacteria, that might be involved in promoting a systemic inflammatory state. Conversely, chronic disorders can also affect oral health. This review will summarize recent evidence for the interrelationship between chronic periodontitis and other prevalent chronic diseases such as cardiovascular diseases, diabetes, cancer and chronic respiratory diseases. The association with pregnancy is also included due to possible obstetric complications. We will focus on inflammatory cytokines such as TNF-alpha, IL-1, and IL-6, because they have been shown to be increased in patients with chronic periodontitis, in patients with chronic systemic diseases, and in patients with both chronic periodontitis and other chronic diseases. Therefore, an imbalance towards a proinflammatory immune response could underline a bidirectional link between chronic periodontitis and other chronic diseases. Finally, we highlight that a close coordination between dental and other health professionals could promote oral health and prevent or ameliorate other chronic diseases.
Full-mouth periodontal examination prior to and after nonsurgical treatment in chronic periodontitis patients Biomedical Research India, 2016
Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6 Cátia Reis, A. V. DA COSTA, J. Guimarães, Diana Tuna, A. Braga, et al. Experimental and Therapeutic Medicine, 2014 Although a number of inflammatory cytokines have been shown to be associated with periodontal pathogenesis, it is important to investigate further whether these biomarkers are associated with the degree of success in nonsurgical treatment of chronic periodontitis. The aim of the present study was to quantify the total levels of interleukin (IL)-1α, -1β, -6, -10 and tumour necrosis factor (TNF)-α in gingival crevicular fluid (GCF) of chronic periodontitis patients prior to and following nonsurgical periodontal therapy. In total, 52 GCF samples from disease sites of patients with chronic periodontitis, prior to and following periodontal therapy, and ten non-disease sites from non-periodontitis subjects, were collected and cytokine concentrations were determined using a multiplex method. Periodontal parameters, including bleeding on probing, probing pocket depth and the clinical attachment level, in all the sites were recorded. Untreated disease sites exhibited higher cytokine levels in the GCF when compared with the non-disease sites. Nonsurgical periodontal therapy resulted in a statistically significant decrease in the total levels of IL-1α, -1β and -6 in the GCF, but not in IL-10 or TNF-α. The results support the hypothesis that proinflammatory cytokines, including IL-1α, IL-1β and IL-6, are likely to be involved in the pathogenesis of periodontitis and are good markers to evaluate the success of nonsurgical therapy in disease sites of patients with periodontitis.
RECENT SCHOLAR PUBLICATIONS
Gummy Smile: Comparison Between Botulinum Toxin, Lip Repositioning Surgery and Combined Techniques in Cases of Lip Hypermobility—A Systematic Review M Siano, R Costa, M Relvas, AS Vinhas, C Reis, C Cabral Oral 6 (2), 49 , 2026 2026
The Effectiveness and Safety of Stem Cell-Based Tissue Engineering in the Regeneration of Periodontal Bone Lesions: A Systematic Review M Fanid, AS Vinhas, C Reis, M Relvas, R Costa, C Cabral Clinics and Practice 15 (12), 222 , 2025 2025
The prevalence of gingival recession according to the Cairo classification in a population from the north of Portugal B Moura, F Salazar, R Costa, C Cabral, C Reis Dentistry Journal 12 (12), 376 , 2024 2024 Citations: 7
The influence of non-surgical periodontal treatment with adjuvant methods on reducing HbA1c in type II diabetic patients C Chiche, C Reis EDITORIAL COUNCIL, 65 , 2023 2023
How to optimize the role of Bio-Oss® in bone regeneration? O Bondaz, C Reis EDITORIAL COUNCIL, 60 , 2023 2023
The graftless technique in the maxillary sinus lift elevation with simultaneous implant placement I Benani-Othmani, C Reis EDITORIAL COUNCIL, 52 , 2023 2023
Relationship between gingival biotype and orthodontic treatment C Almeida, C Reis EDITORIAL COUNCIL, 47 , 2023 2023
In vitro comparative evaluation of piezoelectric and magnetostrictive ultrasonic instrumentation in the furcation area G Gronelli, L Bevilacqua, C Reis, M Relvas, C Cabral JOURNAL OF CLINICAL PERIODONTOLOGY 49 (S23), 170-171 , 2022 2022
Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases EM Cardoso, C Reis, MC Manzanares-Céspedes Postgraduate medicine 130 (1), 98-104 , 2018 2018 Citations: 651
Manzanares-C 佴 spedes MC. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases EM Cardoso, C Reis Postgrad Med 130 (1), 98-104 , 2018 2018 Citations: 26
Cytokines in patients with chronic periodontitis CAAC Reis Universitat de Barcelona , 2018 2018
Full-mouth periodontal examination prior to and after nonsurgical treatment in chronic periodontitis patients. C Reis, JJ Pacheco, F Salazar, MC Manzanares-Céspedes, EM Cardoso Biomedical Research , 2016 2016 Citations: 6
Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6 C Reis, AV Da Costa, JT Guimarães, D Tuna, AC Braga, JJ Pacheco, ... Experimental and therapeutic medicine 8 (1), 323-327 , 2014 2014 Citations: 134
Estudo" in vitro" sobre a sensibilidade de varias amostras bacterianas a quatro agentes anti-septicos C Reis, MAV Rodrigues, A Silva, AL Braga 1980
MOST CITED SCHOLAR PUBLICATIONS
Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases EM Cardoso, C Reis, MC Manzanares-Céspedes Postgraduate medicine 130 (1), 98-104 , 2018 2018 Citations: 651
Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6 C Reis, AV Da Costa, JT Guimarães, D Tuna, AC Braga, JJ Pacheco, ... Experimental and therapeutic medicine 8 (1), 323-327 , 2014 2014 Citations: 134
Manzanares-C 佴 spedes MC. Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases EM Cardoso, C Reis Postgrad Med 130 (1), 98-104 , 2018 2018 Citations: 26
The prevalence of gingival recession according to the Cairo classification in a population from the north of Portugal B Moura, F Salazar, R Costa, C Cabral, C Reis Dentistry Journal 12 (12), 376 , 2024 2024 Citations: 7
Full-mouth periodontal examination prior to and after nonsurgical treatment in chronic periodontitis patients. C Reis, JJ Pacheco, F Salazar, MC Manzanares-Céspedes, EM Cardoso Biomedical Research , 2016 2016 Citations: 6
Gummy Smile: Comparison Between Botulinum Toxin, Lip Repositioning Surgery and Combined Techniques in Cases of Lip Hypermobility—A Systematic Review M Siano, R Costa, M Relvas, AS Vinhas, C Reis, C Cabral Oral 6 (2), 49 , 2026 2026
The Effectiveness and Safety of Stem Cell-Based Tissue Engineering in the Regeneration of Periodontal Bone Lesions: A Systematic Review M Fanid, AS Vinhas, C Reis, M Relvas, R Costa, C Cabral Clinics and Practice 15 (12), 222 , 2025 2025
The influence of non-surgical periodontal treatment with adjuvant methods on reducing HbA1c in type II diabetic patients C Chiche, C Reis EDITORIAL COUNCIL, 65 , 2023 2023
How to optimize the role of Bio-Oss® in bone regeneration? O Bondaz, C Reis EDITORIAL COUNCIL, 60 , 2023 2023
The graftless technique in the maxillary sinus lift elevation with simultaneous implant placement I Benani-Othmani, C Reis EDITORIAL COUNCIL, 52 , 2023 2023
Relationship between gingival biotype and orthodontic treatment C Almeida, C Reis EDITORIAL COUNCIL, 47 , 2023 2023
In vitro comparative evaluation of piezoelectric and magnetostrictive ultrasonic instrumentation in the furcation area G Gronelli, L Bevilacqua, C Reis, M Relvas, C Cabral JOURNAL OF CLINICAL PERIODONTOLOGY 49 (S23), 170-171 , 2022 2022
Cytokines in patients with chronic periodontitis CAAC Reis Universitat de Barcelona , 2018 2018
Estudo" in vitro" sobre a sensibilidade de varias amostras bacterianas a quatro agentes anti-septicos C Reis, MAV Rodrigues, A Silva, AL Braga 1980
