Kuppam Chandrasekhar
Verified @gmail.com
Research Professor
Yonsei University
EDUCATION
M.Tech and Ph.D
RESEARCH INTERESTS
Renewable energy, Biofuels, Biorefineries, Bioremediation, Environmental Engineering
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Rajasri Yadavalli, C. Nagendranatha Reddy, Bishwambhar Mishra, K. Chandrasekhar, Y Vineetha, and A. Shalini
CRC Press
Tirath Raj, Sandhya Sompura, K. Chandrasekhar, Sushil Kumar Singh, Srinath Pandey, Lalit Kumar Singh, Manish Singh Rajput, Deepak Kumar, Shashi Kant Bhatia, Anil Kumar Patel,et al.
Elsevier BV
Thomas Kiran Marella, Meenakshi Singh, K. Chandrasekhar, Pankaj Kumar Singh, Rashi Tyagi, and Makoto M. Watanabe
CRC Press
S.V. Ramanaiah, K. Chandrasekhar, Cristina M. Cordas, and Irina Potoroko
Elsevier BV
Tirath Raj, Raj Morya, K Chandrasekhar, Deepak Kumar, Shveta Soam, Ravindra Kumar, Anil Kumar Patel, and Sang-Hyoun Kim
Elsevier BV
Subhasree Ray, Chandrasekhar Kuppam, Soumya Pandit, and Prasun Kumar
Springer Science and Business Media LLC
Sahil Kapoor, Meenakshi Singh, Sanchita Paul, Surojit Kar, Trisha Bagchi, Murthy Chavali, and K. Chandrasekhar
CRC Press
Tirath Raj, K Chandrasekhar, Raj Morya, and Sang-Hyoun Kim
CRC Press
Tirath Raj, K. Chandrasekhar, Jungsu Park, Sunita Varjani, Pooja Sharma, Deepak Kumar, Jeong-Jun Yoon, Ashok Pandey, and Sang-Hyoun Kim
Elsevier BV
Veeramuthu Ashokkumar, G. Flora, Radhakrishnan Venkatkarthick, K. SenthilKannan, Chandrasekhar Kuppam, G. Mary Stephy, Hesam Kamyab, Wei-Hsin Chen, Jibu Thomas, and Chawalit Ngamcharussrivichai
Elsevier BV
Tirath Raj, K Chandrasekhar, Raj Morya, Ashutosh Kumar Pandey, Ju-Hyeong Jung, Deepak Kumar, Reeta Rani Singhania, and Sang-Hyoun Kim
Elsevier BV
Ikram Mehrez, K. Chandrasekhar, Woojoong Kim, Sang-Hyoun Kim, and Gopalakrishnan Kumar
Elsevier BV
Ganesh Dattatraya Saratale, J. Rajesh Banu, Rosa Anna Nastro, Abudukeremu Kadier, Veeramuthu Ashokkumar, Chyi-How Lay, Ju-Hyeong Jung, Han Seung Shin, Rijuta Ganesh Saratale, and K. Chandrasekhar
Elsevier BV
Sahil Kapoor, Meenakshi Singh, Atul Srivastava, Murthy Chavali, K. Chandrasekhar, and Pradeep Verma
Wiley
Microalgae are regarded as a rich trove of diverse secondary metabolites that exert remarkable biological activities. In particular, microalgae-derived bioactive phenolic compounds (MBPCs) are a boon to biopharmaceutical and nutraceutical industries due to their diverse bioactivities, including antimicrobial, anticancer, antiviral, and immunomodulatory activities. The state-of-the-art green technologies for extraction and purification of MBPCs, along with the modern progress in the identification and characterization of MBPCs, have accelerated the discovery of novel active pharmaceutical compounds. However, several factors regulate the production of these bioactive phenolic compounds in microalgae. Furthermore, some microalgae species produce toxic phenolic compounds that negatively impact the aquatic ecosystem, animal, and human life. Therefore, the focus of this review paper is to bring into light the current innovations in bioprospection, extraction, purification, and characterization of MBPCs. This review is also aimed at a better understanding of the physicochemical factors regulating the production of MBPCs at an industrial scale. Finally, the present review covers the recent advances in toxicological evaluation, diverse applications, and future prospects of MBPCs in biopharmaceutical industries.
Meenakshi Singh, Krupa Unadkat, Punita Parikh, and K. Chandrasekhar
Springer International Publishing
Tirath Raj, Kuppam Chandrasekhar, Amradi Naresh Kumar, Pooja Sharma, Ashok Pandey, Min Jang, Byong-Hun Jeon, Sunita Varjani, and Sang-Hyoun Kim
Elsevier BV
Navonil Mal, Kanishka Srivastava, Yagya Sharma, Meenakshi Singh, Kummara Madhusudana Rao, Manoj Kumar Enamala, K. Chandrasekhar, and Murthy Chavali
Springer Science and Business Media LLC
Diatoms are the reservoir of bioactive compounds which have immense application in nutrition, industrial commodities and ecological studies. In the oceans, diatoms form a large bloom of silica under favourable conditions, whereas, in lentic and lotic systems, they colonize according to seasonal disturbances. Notably, the survival of diatoms in a stressed environment is because of their uniqueness; therefore, diatoms serve as an ideal candidate to understand the evolutionary paradigm and successional dynamics. This review outlines the biological uniqueness of diatoms, their role in biogeochemical cycles and the recolonization pattern of diatoms in anthropic disturbed habitats. Furthermore, a detailed discussion on different technologies for extracting valuable biomolecules with an emphasis on lipid extraction has been carried out. Moreover, the diatom-based photosynthetic biorefinery approach for a better understanding of the renewable usage of biomass is done. Graphical abstract
Abudukeremu Kadier, Junying Wang, K. Chandrasekhar, Peyman Abdeshahian, M. Amirul Islam, Farshid Ghanbari, Mukul Bajpai, Surjit Singh Katoch, Prashant Basavaraj Bhagawati, Hui Li,et al.
Elsevier BV
Tirath Raj, K. Chandrasekhar, A. Naresh Kumar, and Sang-Hyoun Kim
Elsevier BV
Meenakshi Singh, Navonil Mal, Reecha Mohapatra, Trisha Bagchi, Sreestha Dinesh Parambath, Murthy Chavali, Kummara Madhusudana Rao, S.V. Ramanaiah, Abudukeremu Kadier, Gopalakrishnan Kumar,et al.
Elsevier BV
Rajasri Yadavalli, Hariprasad Ratnapuram, John Reddy Peasari, C. Nagendranatha Reddy, Veeramuthu Ashokkumar, and Chandrasekhar Kuppam
Springer Science and Business Media LLC
The current study aimed to investigate the concurrent production of astaxanthin and lipids using Chlorella sorokiniana under mixotrophic conditions in an external loop airlift photobioreactor (ELAPB). Supplementation of Fe 2+ into the media in the red phase (stress phase) induced the astaxanthin production. The maximum yield of 154.36 mg L −1 was obtained by the end of the red phase, which is equivalent to 3.4% of the dry biomass weight. The role of reactive oxygen species in the formation of astaxanthin, which protects the microalgal cells from different oxidative stress, has been elucidated. Apart from astaxanthin, unsaturated fatty acids (81.34%) were also produced with excellent biodiesel properties. Unsaturated fatty acids viz., palmitoleic acid (16:1), have resulted in high yields (22.85%), followed by linoleic acid (18:2), 28.27%; oleic acid (C18:1), 14.38%; and eicosapentaenoic acid (20:5), 4.49%. Hence, the simultaneous production of high value-added products, viz., astaxanthin, and lipids makes the whole process economically viable and environmentally sustainable and elevates the commercial potential during scale-up. The astaxanthin radical scavenging activity was also assessed by H 2 O 2 assay, and the maximum scavenging activity was determined as 91%. The study confers the potential advantages of algal cultivation for high-value commercial product synthesis towards additional revenue generation and development of an efficient microalgae-based biorefinery process. Graphical abstract
Rajasri Yadavalli, Hariprasad Ratnapuram, Snehasri Motamarry, C. Nagendranatha Reddy, Veeramuthu Ashokkumar, and Chandrasekhar Kuppam
Springer Science and Business Media LLC
Flavonoids are the secondary metabolites synthesized by microalgae and have diverse applications in various fields. The present study compares among two microalgal strains, Chlorella vulgaris (CV) and Chlorella pyrenoidosa (CP), for the production of flavonoids and lipids, which were cultivated in mixotrophic as well as autotrophic modes. This study also focuses on the role of l-phenylalanine as a supplement to enhance flavonoids. The current work establishes the relation between nitrates, external carbon, and l-phenylalanine for enhanced production of flavonoids and lipids. The extracted flavonoids were found to be maximum in CP-autotrophic mode followed by CV-mixotrophic mode with 138 μg/ml and 118 μg/ml, respectively. The common flavonoids observed with both the microalgal strains were quercetin, catechin, and p-coumaric acid. In comparison, the production of the maximum lipid of 23.7% was reported with mixotrophic operation in CV, followed by CP (19.4%). The scavenging activity of the extracted flavonoids was determined using a hydrogen peroxide assay and was found to be in the range of 63–73% at all experimental conditions. CP was found to produce more flavonoids in autotrophic mode, whereas mixotrophic mode showed maximum production of lipids and flavonoids in the CV. The simultaneous production of high value-added products, viz., flavonoids and lipids, not only paves a pathway for the biorefinery approach but also elevates the commercial potential during scale-up. Graphical abstract
K. Chandrasekhar, Tirath Raj, S.V. Ramanaiah, Gopalakrishnan Kumar, J. Rajesh Banu, Sunita Varjani, Pooja Sharma, Ashok Pandey, Sunil Kumar, and Sang-Hyoun Kim
Elsevier BV
K. Chandrasekhar, Tirath Raj, S.V. Ramanaiah, Gopalakrishnan Kumar, Byong-Hun Jeon, Min Jang, and Sang-Hyoun Kim
Elsevier BV