CHANDRASHEKHAR V M

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Drug Discovery, Toxicology

Scopus Publications

Beverage Combination of Pomegranate Juice and Quinoa Extract Ameliorates Lipid Profile in Rat Study
Kavyashree K N, B. G, Ganiger V M, Chandrashekhar V M, Giridhar Goudar, Lingaraj Amawal, R. D L, Anand G Nanjappanavar and Nagaraju Mergu




Evaluation of hypoglycaemic activity of spine gourd powder (Momordica dioica Roxb.) formulated product (Khakra) in STZ induced diabetic rats
R. Hamsa, G. Bhuvaneshwari, S.L. Jagadeesh, V.M. Chandrashekhar, N. Basavaraj, and N.A. Natikar
Society for the Advancement of Horticulture
Spine gourd is popular as an emerging underutilized crop due to its various health benefits and medicinal properties. Its powder is used to form a dish called Khakra. Khakra is one of the famous dishes made out of mat bean and wheat flour, a popular dish of western India mainly in Gujarat and Rajasthan, which is used as a snack or during breakfast. During the preparation of Khakra along with whole wheat flour and Bengal gram flour, 50 % of spine gourd powder was used and evaluated for hypoglycaemic activity in STZ induced diabetic wistar rats. The oral administration of Khakra of about 5 to 10 g/rat/day was given for diabetic induced and normal rats for about 21 days and observations were recorded at 0th, 7th, 14th and 21st day for serum glucose (mg/dL), serum cholesterol (mg/dL) and serum haemoglobin (mg/dL). The Group 6 (STZ + Laboratory diet + Spine gourd Khakraat 10g/ kg body weight/day) showed significant decrease (P&lt0.01) in serum glucose, serum cholesterol and significant increase (P&lt0.01) in serum haemoglobin which was found to be dose-dependent. In case of normal rats no significant decrease in serum glucose and serum cholesterol was observed.


Neuroprotective effect of Convolvulus pluricaulis Choisy in oxidative stress model of cerebral ischemia reperfusion injury and assessment of MAP2 in rats
Mallappa H. Shalavadi, V.M. Chandrashekhar, and I.S. Muchchandi
Elsevier BV



Physicochemical and phytochemical screening of convolvulus pluricaulis collected from Bagalkot, Karnataka




Anti-osteoporotic activity of ethanol extract of terminalia Arjuna (Roxb.) wight & arn. on ovariectomized rats




Co(II), Ni(II), Cu(II) and Zn(II) complexes of isatinyl-2-aminobenzoylhydrazone: Synthesis, characterization and anticancer activity
Rekha S. Hunoor, Basavaraj R. Patil, Dayananda S. Badiger, Chandrashekhar V. M., I. S. Muchchandi, and Kalagouda B. Gudasi
Wiley
This article describes the synthesis, structural aspects and biological studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of a new hydrazone derived from the condensation of isatin and 2‐aminobenzoylhydrazide. The ligand is well characterized using 1H NMR, 13C NMR, 2D HETCOR, mass and IR spectral studies. The chelating tendency of the ligand towards transition metal ions is established using analytical and spectral studies, which reveal the monobasic tridentate nature of the ligand. Octahedral geometry for Co(II), Cu(II) and Zn(II) and tetrahedral geometry for Ni(II) are tentatively proposed. All the synthesized compounds were screened for in vitro anticancer activity against Ehrlich ascites carcinoma and human cancer cell lines (adenocarcinoma HT29, kidney cancer cell line K293 and breast cancer cell line MDA231) using tryphan blue exclusion method and MTT assay. Copyright © 2014 John Wiley & Sons, Ltd.


Neuroprotective activity of gossypin from Hibiscus vitifolius against global cerebral ischemia model in rats
VM Chandrashekhar, S Ganapaty, A Ramkishan, and MLaxmi Narsu
Medknow
Objectives: The objective of this study is to evaluate the neuroprotective effect of gossypin (isolated from Hibiscus vitifolius) against global cerebral ischemia/reperfusion (I/R) injury-induced oxidative stress in rats. Materials and Methods: Sprague Dawlet rats of wither gender were used in the study. Evaluation of cerbroprotective activity of bioflavonoid gossypin (in 5, 10 and 20 mg/kg oral doses) isolated from H. vitifolius was carried out by using the global cerebral I/R model by bilateral carotid artery occlusion for 30 min, followed by 24 h reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated along with histopathological studies. Result: Gossypin showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (P < 0.001) and increase in the superoxide dismutase, catalase, glutathione and total thiol levels in gossypin treated groups when compared to control group. Cerebral infarction area was markedly reduced in gossypin treated groups when compared to control group. Conclusion: Gossypin showed potent neuroprotective activity against global cerebral I/R injury-induced oxidative stress in rats.


Neuroprotective activity of Stereospermum suaveolens against global cerebral ischemia rat model
M. H. Shalavadi, V. M. Chandrashekhar, A. Ramkishan, R. B. Nidavani, and B. S. Biradar
Informa UK Limited
Abstract Context: Stereospermum suaveolens DC. (Bignoniaceae) is a medicinal tree species native to India. Traditionally, the whole plant is used for various diseases including neuronal disorders. Objective: The present study evaluated the neuroprotective activity of Stereospermum suaveolens against global cerebral ischemia in a rat model. Materials and methods: Neuroprotective activity was carried out by global cerebral ischemia on Sprague-Dawley rats and divided into five groups of eight rats each; sham and control groups received normal saline (10 ml/kg) and treated groups received methanol extract of Stereospermum suaveolens (MES) orally (125, 250, and 500 mg/kg) for 10 days prior to the experiment. Global cerebral ischemia was induced by bilateral carotid artery (BCA) occlusion for 30 min followed by 4-h reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated by UV spectroscopic method along with cerebral infarction area; histopathological studies were carried out. Results: LD50 of MES was found to be 5000 mg/kg of body weight. The entire test was performed at dose levels 125, 250, and 500 mg/kg of body weight. The results of the study indicate that the Stereospermum suaveolens methanol extract showed neuroprotective activity by a significant decrease in lipid peroxidation (p < 0.001) and an increase in superoxide dismutase (p < 0.01), catalase (p < 0.01), glutathione (p < 0.001), and total thiol (p < 0.001) levels in extract-treated groups as compared to control group. Measurement of cerebral infarction area and histopathological studies further supported the protective effect of the extract. Discussion and conclusion: These findings suggest a potential protective role of Stereospermum suaveolens against global cerebral ischemia/reperfusion-induced brain injury.


A rat model against chemotherapy plus radiation-induced oral mucositis
Alkesh Patel, S. Rajesh, V.M. Chandrashekhar, Shivprakash Rathnam, Karishma Shah, C. Mallikarjuna Rao, and K. Nandakumar
Elsevier BV



Synthesis, p38 kinase inhibitory and anti-inflammatory activity of new substituted benzimidazole derivatives
Ravindra G. Kulkarni, Stefan A. Laufer, Chandrashekhar V. M, and Achaiah Garlapati
Bentham Science Publishers Ltd.
P38 mitogen activated protein kinases have been found to involve in the production and release of unwarranted levels of pro-inflammatory cytokines including TNFα and IL-1β in numerous inflammatory diseases. A new series of molecules, 5-substituted benzoylamino-2-substituted phenylbezimidazoles has been synthesized from 4-nitro-1, 2- diaminobenzene. The synthesized compounds were characterized by FTIR, 1HNMR and Mass. The final compounds were screened for in vitro p38 kinase inhibitory and in vivo anti-inflammatory activity. Three compounds from the series demonstrated nearly 50% inhibition of p38 kinase in the in vitro screening method at 10 μM concentration and two molecules exhibited greater than 75% inhibition of paw oedema volume during the first hour. The docking study of synthesized molecule revealed a new binding pose in ATP binding pocket.


Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson's disease model
VM Chandrashekhar, SP Avinash, C Sowmya, A Ramkishan, and MH Shalavadi
Medknow
Objectives: To evaluate the neuroprotective effect of Stereospermum suaveolens DC on 6-hydroxy dopamine induced Parkinson's disease model. Materials and Methods: The study was conducted on Sprague-Dawley rats where parkinson's disease was induced by producing the striatal 6-hydroxy dopamine lesions. The test animals received methanolic extract of Stereospermum suaveolens at dose of 125, 250 and 500 mg/kg for 42 days. Behavioral assessment, spontaneous locomotor activity and muscular coordination were studied. Antioxidant levels, striatal infraction area were assessed and histopathological studies were carried out. Results: The Stereospermum suaveolens DC methanolic extract showed significant dose dependent increase in behavioral activity, improved muscular coordination. Significant reduction of lipid peroxidation (LPO), increased antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT) and non-enzymatic activity of glutathione (GSH) and total thiol levels in extract treated groups was observed in test groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group. Conclusion: The methanolic extract of Stereospermum suaveolens DC showed neuroprotective activity against 6-hydroxy dopamine induced Parkinson's disease in rats.


Transition metal complexes of 1,2-dihydroquinazolinone derivative, an emerging class of analgesic and anti-inflammatory agents
Dayananda S. Badiger, Ramesh B. Nidavani, Rekha S. Hunoor, Basavaraj R. Patil, Ramesh S. Vadavi, V. M. Chandrashekhar, Iranna S. Muchchandi, and Kalagouda B. Gudasi
Wiley
A new 1,2‐dihydroquinazolinone, 2‐(2‐hydroxy‐phenyl)‐3‐[1‐(2‐oxo‐2H‐chromen‐3‐yl)‐ethylideneamino]‐2,3‐dihydro‐1H‐quinazolin‐4‐one (L) and its Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes have been prepared. These were characterized by elemental, spectral [UV–visible, IR, NMR (1H, 13C and 2D heteronuclear correlation) and mass], conductance, magnetic susceptibility and thermal studies. The physicochemical data indicate that the ligand behaves as tridentate with ONO donor sequence towards the metal ions, and trigonal bipyramidal geometry was assigned for complexes. The ligand and its metal complexes were evaluated for their in vivo anti‐inflammatory and analgesic activity. The tested compounds have shown excellent activity, which are almost equipotent to the standard used in the study. Copyright © 2011 John Wiley &amp; Sons, Ltd.


Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model
V.M. Chandrashekhar, K.S. Halagali, R.B. Nidavani, M.H. Shalavadi, B.S. Biradar, D. Biswas, and I.S. Muchchandi
Elsevier BV



Influence of esomeprazole on hypoglycemic activity of oral antidiabetic agents in rats and rabbits
Prashant D. Phadatare and V. M. Chandrashekhar
Springer Science and Business Media LLC



Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats
V.L. Ranpariya, S.K. Parmar, N.R. Sheth, and V.M. Chandrashekhar
Informa UK Limited
Context: Oxidative stress plays a key role in pathophysiology of many neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and so on. Although Matricaria recutita L. (Asteraceae), German chamomile, is traditionally used for central nervous system (CNS)-related diseases, its antistress properties have received little attention. Objective: The present study evaluated the neuroprotective effect of German chamomile against aluminium fluoride (AlF4−)-induced oxidative stress in rats. Materials and methods: The Sprague-Dawley rats of either sex (200–250 g) were selected and grouped as: group I received normal saline; group II received AlF4− (negative control); groups III, IV, and V received 100, 200, and 300 mg/kg, orally, German chamomile methanol extract (GCME) along with AlF4−; and group VI received quercetin (25 mg/kg, i.p.) + AlF4−, respectively. After 10 days treatment with GCME, oxidative stress was induced by administering AlF4− through drinking water for 7 days. Then, the protective antioxidant enzyme levels were measured and the histopathological studies were carried out. Results: The GCME showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and total thiol levels in extract-treated animals as compared with negative control group (P < 0.001). The histopathological studies also revealed the potent neuroprotective action of German chamomile against oxidative brain damage. Conclusion: The present study for the first time shows potent neuroprotective activity of the methanol extract of German chamomile against AlF4−-induced oxidative stress in rats.


Synthesis, characterization, anti-inflammatory and analgesic activity of transition metal complexes of 3-[1-(2-hydroxyphenyl) ethylideamino]-2-phenyl-3, 4-dihydroquinazolin-4(3H)-one
Rekha S. Hunoor, Basavaraj R. Patil, Dayananda S. Badiger, Ramesh S. Vadavi, Kalagouda B. Gudasi, V. M. Chandrashekhar, and I. S. Muchchandi
Wiley
AbstractA new quinazolinone derivative, 3‐[1‐(2‐hydroxyphenyl)ethylideamino]‐2‐phenyl‐3,4‐dihydroquinazolin‐4(3H)‐one (LH) was synthesized by the condensation of 2‐hydroxyacetophenone‐2‐aminobenzoylhydrazone and benzaldehyde. The cyclization to form 1,2‐dihydroquinazolinone was confirmed by IR, 1D and 2D HETCOR studies. Coordination compounds of Co(II), Ni(II), Cu(II) and Zn(II) of LH were synthesized and characterized using various physico‐chemical studies like stoichiometric, conductivity, magnetic moment measurements and spectral techniques such as IR, NMR, UV‐vis and EPR spectroscopy. The elemental analysis and thermal studies suggested a general stoichiometry [M(HEPDQ)Cl] for all the complexes. A four‐coordinate geometry was assigned to all the complexes. The complexes along with the parent ligand were screened for their anti‐inflammatory activity, using carrageenan‐induced rat paw edema, and for their analgesic activity by Eddy's hot plate method. The activity of the ligand was enhanced on complexation with metal ions. This enhanced activity was attributed to the increased lipophilic nature of the complexes. Notable anti‐inflammatory activity was observed for Ni(II), Cu(II) and Zn(II) complexes. The analgesic activity of the ligand was greater than the standard at 60 min. and at a 10 mg kg−1 dose, whereas the activity of Ni(II) and Cu(II) complexes at 10 mg kg−1 dose was comparable with the standard used. Copyright © 2011 John Wiley &amp; Sons, Ltd.


Antiulcer and gastroprotective potential of Stereospermum suaveolens in wistar rats
Ashok A. Muchandi and V. M. Chandrashekhar
SAGE Publications
Sir, Peptic ulcer is one of the most frequent disorders of the alimentary tract and, in various countries, its prevalence is estimated at 5–10% of the adult population, still remaining one of the most important problems.[1] The etiology of peptic ulcer is not clearly known. It results probably due to an imbalance between the aggressive and the defensive factors. Reactive oxygen metabolites, free radicals, nitric oxide and genetic and environmental factors are also thought to play a role in the pathogenesis of ulcers. Although a number of antiulcer drugs, such as H2 receptor antagonists, proton pump inhibitors and cytoprotectants, are available, all these drugs have side-effects and limitations.[2] Indian medicinal plants and their derivatives have been an invaluable source of therapeutic agents with fewer side-effects to treat various disorders including peptic ulcer disease (PUD).


Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats
H.S. Yogesh, V.M. Chandrashekhar, H.R. Katti, S. Ganapaty, H.L. Raghavendra, Girish K. Gowda, and B. Goplakhrishna
Elsevier BV



Evaluation of hepatoprotective and antioxidant activity of stereospermum suaveolens against aluminium fluoride induced hepatotoxicity




Spectroscopic, magnetic and thermal studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 3-acetylcoumarin-isonicotinoylhydrazone and their antimicrobial and anti-tubercular activity evaluation
Rekha S. Hunoor, Basavaraj R. Patil, Dayananda S. Badiger, Ramesh S. Vadavi, Kalagouda B. Gudasi, V.M. Chandrashekhar, and I.S. Muchchandi
Elsevier BV



Hepatoprotective activity of Stereospermum suaveolens against CCl4-induced liver damage in albino rats
V. M. Chandrashekhar, Ashok A. Muchandi, Sarasvathi. V. Sudi, and Seru. Ganapty
Informa UK Limited
The present study aims to evaluate the hepatoprotective activity of Stereospermum suaveolens DC (Bignoniaceae). Hepatoprotective activity is studied by carbon tetrachloride (CCl4)-induced liver damage in albino rats. The degree of protection in this activity has been measured by using biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin, LDL-cholesterol and SOD, CAT, GSH, total thiols, NO, and lipid peroxidation in liver tissue homogenate. The results suggest that the methanol stem bark extract of Stereospermum suaveolens at the doses 125, 250, and 500 mg/kg and reference standard Liv-52 treated group produced significant (p <0.001) hepatoprotection against CCl4-induced liver damage by decreasing the activities of serum enzymes, bilirubin and lipid peroxidation. The extract significantly (p <0.001) increased levels of SOD, CAT, GSH and total thiols, as compared to control group. Histopathological studies further substantiate the protective effect of the extract. It was concluded that methanol stem bark extract of Stereospermum suaveolens showed effective hepatoprotective activity.


Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model




Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats
V.M. Chandrashekhar, V.L. Ranpariya, S. Ganapaty, A. Parashar, and A.A. Muchandi
Elsevier BV



Antiallergic activity of aristolochia bracteolata lank in animal model




Free radical scavenging activity of Stereospermum suaveolens DC: An in-vitro evaluation

RECENT SCHOLAR PUBLICATIONS

Beverage Combination of Pomegranate Juice and Quinoa Extract Ameliorates Lipid Profile in Rat Study
K KN, G VM, C VM, G Goudar, L Amawal, R DL, A G. Nanjappanavar, ...
Plant Foods for Human Nutrition 80 (1), 14 2025



Molecular dynamics directed neuroprotective activity of alcoholic extract of Garuga pinnata Roxb. in experimental rats
S Jagannath, W Vinayak, M Amol, P Sandhya, C VM, S Vaibhav, ...
Journal of Ayurveda and Integrative Medicine 16 (1), 101032 2025



Insights into the Emerging Therapeutic Targets of Triple-negative Breast Cancer.
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Current Cancer Drug Targets 25 (1), 3-25 2025



Anti-Inflammatory Activities of Pyrazole Benzamides: Integrating In Vivo, Molecular Docking, and Dynamics Studies
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Neuroprotective Activity of Polyherbal Formulation on Colchicine Induced Alzheimer’s Disease in Rat Model
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Asian Journal of Pharmacy and Technology 14 (3) 2024



Nephroprotective effect of Cansjera rheedii on Gentamicin induced Renal toxicity in Wistar albino rats
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Research Journal of Pharmacy and Technology 17 (8), 3863-3868 2024



Neuroprotective activity of Hibiscus abelmoschus Linn. against 6-OHDA induced Parkinson’s disease in rats
K Akki, M Shalavadi, VM Chandrashekhar, S Teli, L Anawal, B Khombare
Pharmacological Research-Natural Products 3, 100027 2024



Synthesis, In Silico Analysis, Antibacterial, Radical Scavenging and Antidiabetic Activities of Certain Bis-Azetidinones and Bis-Thiazolidinones
SR Deshpande, MT Mandalamari, PV Malagi, C VM
Pharmaceutical Chemistry Journal 58 (1), 62-73 2024



Anti-epileptic activity of against PTZ induced epilepsy in Swiss Mentha cordifolia Albino mice
M Shalavadi, A Hosoor, MM Devraj, R Kinnal, S Patil, VM Chandrashekar, ...
Asian Journal of Pharmacy and Pharmacology 10 (2), 59-63 2024



Neuroprotective activity of phonixsylvestris against colchicine induced neuroinflammation and cognitive deficts in rats
PB Parvati Suryvanshi, Chandrashekhar V M, Basavaraj Lalasangi, Mallappa ...
Journal of Chemical Health Risks 14 (1), 405-424 2024



NEUROPROTECTIVE ACTIVITY OF MICHELIA CHAMPACA AGAINST ALZHEIMER’S DISEASE IN RAT MODEL
L Anawal Jr, M Shalavadi
Alzheimer's & Dementia 19, e073074 2023



Protocol for Development of Neuro-beverage by Brahmi (Bacopa monnieri) and Kokum (Garcinia indica) for Sensorial Attributes and Bio-chemical Parameters
CVMAN Gouthami Y., Bhuvaneshwari G., Jameel Jhalegar, Vasant M. Ganiger ...
Biological Forum – An International Journal 15 (11), 174-180 2023



Physical, reconstitution and phenolic properties of instant drink mix prepared with Moringa oleifera leaf, raw banana and whey protein concentrate
SH Budnimath, G Bhuvaneshwari, VM Ganiger, SL Jagadeesh, G Goudar, ...
Measurement: Food 11, 100108 2023



Neuroprotective activity of Acanthus maderaspatensis L. against colchicine induced Alzheimer’s disease rat model
L Anawal, M Shalavadi, C VM
Alzheimer's & Dementia 19, e060408 2023



Neuroprotective Activity of Blepharis maderaspatensis Against Colchicine Induced Alzheimer’s Disease Rat Model
VMC Shalavadi Mallappa,Teli Shubham, Anawal Lingaraj
The Natural Products Journal 13 (3), 1-15 2023



Evaluation of Biochemical and Sensory Parameters of Pomegranate Beverage by the Incorporation of Quinoa Extract
G Bhuvaneshwari, KN Kavyashree, VM Ganiger, VM Hiremath, ...
Indian Journal of Ecology 50 (5), 1806-1811 2023



Tongue and teeth hyperpigmentation in etoposide, prednisolone, vincristine, and cyclophosphamide regimen in the treatment of cutaneous lymphoma
CVM Soumya Shivalingappa Morabad, Zahed Ullah Khan, Richa Gad, Nikitha ...
Indian J Pharmacology 55, 405-7 2023



Novel antitubercular agents: Design, synthesis, molecular dynamic and biological studies of pyrazole - 1,2,4-triazole conjugates
GVP Ajin K A, ArunKumar S, Manisha Singh, Akshatha Shankaranarayana Handattu ...
Chem. Biodiversity, e202300971 2023



A Prospective Study on Tracking and Reporting of Adverse Medication Responses in Patients Referred to a Teaching Hospital for Tertiary Care
AL Khatawakar, JR Gudi, S Kora, M Patil, S Morabad, C VM
Indian Journal of Pharmacy Practice 16 (4) 2023



Synthesis, characterization, spectroscopic properties and antihypertensive activity of 4-chlorobenzaldehyde hydralazine hydrazone and its metal complexes
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Journal of the Iranian Chemical Society 20 (1), 147-154 2023

MOST CITED SCHOLAR PUBLICATIONS

Anti-diabetic activity of Terminalia catappa Linn. leaf extracts in alloxan-induced diabetic rats
SM Ahmed, V Swamy, P Gopkumar, R Dhanapal, VM Chandrashekara
Razi Institute for Drug Research (RIDR) of Iran University of Medical 2005
Citations: 186



Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model
VM Chandrashekhar, KS Halagali, RB Nidavani, MH Shalavadi, ...
Journal of ethnopharmacology 137 (1), 336-340 2011
Citations: 142



Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats
VM Chandrashekhar, VL Ranpariya, S Ganapaty, A Parashar, ...
Journal of ethnopharmacology 127 (3), 645-651 2010
Citations: 128



Mixed ligand complex via zinc (II)-mediated in situ oxidative heterocyclization of hydrochloride salt of 2-chlorobenzaldehyde hydralazine hydrazone as potential of
RP Bakale, GN Naik, CV Mangannavar, IS Muchchandi, IN Shcherbakov, ...
European Journal of Medicinal Chemistry 73, 38-45 2014
Citations: 83



Free radical scavenging activity of gossypin and nevadensin: An: in-vitro: evaluation
S Ganapaty, VM Chandrashekhar, HR Chitme, ML Narsu
Indian journal of Pharmacology 39 (6), 281-283 2007
Citations: 83



Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats
VL Ranpariya, SK Parmar, NR Sheth, VM Chandrashekhar
Pharmaceutical Biology 49 (7), 696-701 2011
Citations: 80



Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats
HS Yogesh, VM Chandrashekhar, HR Katti, S Ganapaty, ...
Journal of ethnopharmacology 134 (2), 334-338 2011
Citations: 78



Spectroscopic, magnetic and thermal studies of Co (II), Ni (II), Cu (II) and Zn (II) complexes of 3-acetylcoumarin–isonicotinoylhydrazone and their antimicrobial and anti
RS Hunoor, BR Patil, DS Badiger, RS Vadavi, KB Gudasi, ...
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 77 (4 2010
Citations: 67



Anti-Diarrhoeal Activity of Abutilon indicum Linn Leaf Extract
VM Chandrashekhar, AN Nagappa, TS Channesh, PV Habbu, KP Rao
Journal of natural remedies, 12-16 2004
Citations: 60



Mononuclear late first row transition metal complexes of ONO donor hydrazone ligand: Synthesis, characterization, crystallographic insight, in vivo and in vitro anti
U Kendur, GH Chimmalagi, SM Patil, KB Gudasi, CS Frampton, ...
Journal of Molecular Structure 1153, 299-310 2018
Citations: 53



Antiallergic activity of Aristolochia bracteolata Lank in animal model
HR Chitme, M Malipatil, VM Chandrashekhar, PM Prashant
CSIR 2010
Citations: 45



Synthesis, spectroscopic properties and biological evaluation of transition metal complexes of salicylhydrazone of anthranilhydrazide: X-ray crystal structure of copper complex
DS Badiger, RS Hunoor, BR Patil, RS Vadavi, CV Mangannavar, ...
Inorganica chimica acta 384, 197-203 2012
Citations: 40



Co (II), Ni (II), Cu (II) and Zn (II) complexes of isatinyl‐2‐aminobenzoylhydrazone: synthesis, characterization and anticancer activity
RS Hunoor, BR Patil, DS Badiger, C VM, IS Muchchandi, KB Gudasi
Applied Organometallic Chemistry 29 (2), 101-108 2015
Citations: 38



Neuroprotective activity of gossypin from Hibiscus vitifolius against global cerebral ischemia model in rats
VM Chandrashekhar, S Ganapaty, A Ramkishan, ML Narsu
Indian journal of pharmacology 45 (6), 575-580 2013
Citations: 35



Hepatoprotective activity of Wrightia tinctoria (Roxb) in rats
VM Chandrashekhar, TS Abdul Haseeb, PV Habbu, AN Nagappa
INDIAN DRUGS-BOMBAY- 41, 366-370 2004
Citations: 35



Synthesis, characterization, anti‐inflammatory and analgesic activity of transition metal complexes of 3‐[1‐(2‐hydroxyphenyl) ethylideamino]‐2‐phenyl‐3, 4‐dihydroquinazolin‐4
RS Hunoor, BR Patil, DS Badiger, RS Vadavi, KB Gudasi, ...
Applied Organometallic Chemistry 25 (6), 476-483 2011
Citations: 30



Hepatoprotective activity of Stereospermum suaveolens against CCl4-induced liver damage in albino rats
VM Chandrashekhar, AA Muchandi, SV Sudi, S Ganapty
Pharmaceutical Biology 48 (5), 524-528 2010
Citations: 30



Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson's disease model
MH Shalavadi, VM Chandrashekhar, SP Avinash, C Sowmya, ...
Indian journal of pharmacology 44 (6), 737-743 2012
Citations: 29



Structural characterization and antimicrobial activities of transition metal complexes of a hydrazone ligand
RP Bakale, GN Naik, SS Machakanur, CV Mangannavar, IS Muchchandi, ...
Journal of Molecular Structure 1154, 92-99 2018
Citations: 27



Synthesis and characterization of transition metal complexes of hydrochloride salt of 3‐chlorobenzaldehyde hydralazine hydrazone: a new class of possible anti‐cariogenic agents
RP Bakale, AH Pathan, GN Naik, SS Machakanur, CV Mangannavar, ...
Applied Organometallic Chemistry 28 (9), 720-724 2014
Citations: 26