CHUN HOE TAN

Scopus Publications

Computational Elucidation of Hub Genes and Pathways Correlated with the Development of 5-Fluorouracil Resistance in HCT 116 Colorectal Carcinoma Cell Line
Chun Hoe Tan, Siew Huah Lim, Kae Shin Sim
Biochemical Genetics, 2026
Exploring the molecular characteristics of a benzoindoleninyl-pyrazolo[3,4- b ]pyridine
Abdul Qaiyum Ramle, Edward R.T. Tiekink, Shameer Hisham, Chun Hoe Tan, Haresh Sivakumar, Yee Seng Tan, Wan Jefrey Basirun
Zeitschrift Fur Kristallographie Crystalline Materials, 2026
A new benzoindolenine containing a fused pyrazolo[3,4- b ]pyridine moiety was synthesized in 51 % yield and structurally characterized using spectroscopic techniques. The reaction mechanism suggests that the fused bicyclic ring is generated via the formation of C=N and C–C bonds. X-ray crystallographic analysis reveals that the molecule is planar with both moieties adopting an anti -conformation, and its intermolecular noncovalent C–H⋯π, π⋯π, C–H⋯N, and H⋯H interactions were accessed by Hirshfeld surface analysis. The compound displayed a bathochromic fluorescence shift from solution to the solid state, and the nature of the photoluminescence decay was investigated. Furthermore, the compound was subjected to in silico ADMET analyses, which indicated compliance with all Veber’s rules and several criteria of Lipinski’s rule of five. The compound was also tested for antibacterial and antifungal activities, but showed no appreciable potency towards the tested microbial strains.
Sequence analysis, homology modeling, and molecular docking studies of the effects of point mutations on the ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7) in colorectal cancer
Chun Hoe Tan, Hiba Ahmed Hassan
Network Modeling Analysis in Health Informatics and Bioinformatics, 2025
Erratum to: “Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis”(Fitoterapia, (2025), 186, C, (106851), (S0367326X25004770), 10.1016/j.fitote.2025.106851)
Wen Xin Toh, Sin Yee Tang, Kae Shin Sim, Siew Huah Lim, Chun Hoe Tan
Fitoterapia, 2025
Effects of microwave intermittent drying on physicochemical properties, biochemical composition, and sensory profile of three banana cultivars
Zuliana Razali, Ler Xuan Chang, Chandran Somasundram, Joo Jie Ching, Chun Hoe Tan
Applied Food Research, 2025
The consumption of bananas is highly appreciated for their nutritional value and distinctive sensory notes, but it is limited due to their low shelf life. Additionally, literature on the preservation of various banana cultivars is scarce. Thus, after microwave intermittent drying, an evaluation was conducted on three banana cultivars' physicochemical properties, biochemical composition, and sensory profile (Mas, Rastali, and Berangan). The microwave parameters applied for drying were as determined: 300 W and 10 s drying time with 50 s intermittent time for a sample mass of 3.42 ± 0.01 g and thickness of 5 mm. A comparison was carried out between the fresh and dried samples. Overall, dried Mas banana excels in most of the physicochemical properties and biochemical composition analyses, in which it has the highest color change, total soluble solids, ratio of total soluble solids and titratable acidity, total antioxidant content, total phenolic content, and total carotenoid content. However, panelists in our sensory survey indicated that dried Mas banana is the least favored, while dry Berangan and Rastali scored highly in terms of overall sensory preference.
Antimicrobial properties of pyrazolyl substituted indolenines and pyridine
Zainab Funmi Adebayo, Edward R.T. Tiekink, Amira Suriaty Yaakop, Chun Hoe Tan, Suhana Arshad, Wan Jefrey Basirun, Melati Khairuddean, Abdul Qaiyum Ramle
Journal of Molecular Structure, 2025
Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis
Wen Xin Toh, Sin Yee Tang, Kae Shin Sim, Siew Huah Lim, Chun Hoe Tan
Fitoterapia, 2025
Effects of different ripening stages on the physiological, biochemical, and sensory properties of microwave-dried berangan banana (Musa acuminata)
Xin Cheng Chee, Zuliana Razali, Chandran Somasundram, Joo Jie Ching, Erlina Abdullah, Chun Hoe Tan
Journal of Food Measurement and Characterization, 2025
Bananas are a climacteric fruit, which means that they continue to ripen after harvest. To increase the length of time that bananas may be stored, a variety of dried banana products are made utilizing the microwave drying method. However, it is unknown at what stage of banana ripening is most suited for microwave drying. The purpose of this study is to examine how various ripening stages affect the quality of microwave-dried bananas. Musa acuminata Colla cv. Berangan bananas in three different ripening stages (3, 5, and 7) were selected, and banana discs with a thickness of 5.0 ± 0.1 mm were microwave-dried using the settings optimized in this study (i.e., 300 W, 10 s drying time with 50 s intermittent time). Physiological (colour, total soluble solids, titratable acidity, moisture content), biochemical (total carotenoid content, total polyphenol content, and total antioxidant content), and sensory acceptance were among the criteria used to evaluate the samples. Our results showed that the optimized drying parameters reduced the moisture content for all ripening stages of dried bananas within the safety moisture content level for dried food (5%). The dried bananas of the ripening stage 7 had the highest color change of 44.68, total soluble solid content to titratable acidity of 16.93, total antioxidant level of 2183.98 µg/g DW, total polyphenol content of 5.92 mg GAE/g DW, and sensory acceptance level of 4.3. In summary, the best bananas for microwave-dried banana chips are those at a stage 7 ripening stage.
2-hydroxylbenzoyl-pyrazolo[1,5-a]pyrimidines as inhibitors against bacterial pathogens and MCF7 human breast cancer cells
Hiba Ahmed Hassan, Abdul Qaiyum Ramle, Chun Hoe Tan, Yee Seng Tan, M. Al-Amin, Salizawati Muhammad Salhimi, Erlina Abdullah, Edward R.T. Tiekink, Wan Jefrey Basirun
Journal of Molecular Structure, 2025
Integrative Network Pharmacology and Molecular Docking Analyses on the Mechanisms of San-Zhong-Kui-Jian-Tang in Treating Oral Squamous Cell Carcinoma
Chun Hoe Tan, Haresh Sivakumar, Da-gui Luo, Yu-xin Cen
Current Medical Science, 2025
In Vitro and Computational Studies of Indoleninyl-Pyrimido[1,2-b]Indazoles as DNA Binding Agents
Li Xuan Yap, Abdul Qaiyum Ramle, Kae Shin Sim, Chun Hoe Tan
National Academy Science Letters, 2025
Computational analysis of antimicrobial phytochemicals from Bambusa vulgaris Schrad. ex J.C.Wendl.: Pharmacokinetics, toxicity, and molecular docking
Asita Elengoe, Chun Hoe Tan, Sandeep Poddar
Advances in Bamboo Science, 2025
Biological Investigation of Spent Coffee Ground for Potential Cosmeceutical Applications
Amanda Harshana Senarath Mudalige Don, Hazwani Mat Saad, Erlina Abdullah, A. Elengoe, Siew Huah Lim, Chun-Hoe Tan
National Academy Science Letters, 2025
Investigation of cytotoxic indoleninyl-thiobarbiturate zwitterions as DNA targeting agents
Adebayo Zainab Funmi, Ching Yi Lim, Min Phin Ng, Wen Xin Toh, Yee Seng Tan, Kae Shin Sim, Siew Huah Lim, Chun Hoe Tan, Abdul Qaiyum Ramle
Journal of Molecular Structure, 2025
Sialic acid detection and theranostic activity of phenylboronic acid-based fluorescent probe in human colorectal adenocarcinoma HT-29 cells
Min Phin Ng, Wei Chuen Chan, Min Li Tan, Chun Hoe Tan, Sheena Yin Xin Tiong, Kae Shin Sim, Kong Wai Tan
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2025
Investigation of Phytochemical Composition, Radical Scavenging Potential, Anti-Obesogenic Effects, and Anti-Diabetic Activities of Kaempferia parviflora Rhizomes
Sangeetha Prabakaran, Hazwani Mat Saad, Chun Hoe Tan, Syarifah Nur Syed Abdul Rahman, Kae Shin Sim
Chemistry and Biodiversity, 2025
Revalidation of Reliability and Validity of the Post-Traumatic Stress Disorder Checklist-civilian Version among High-risk Pregnancy Women
Journal of Natural Science Biology and Medicine, 2024
Structural insights and cytotoxicity evaluation of benz[e]indole pyrazolyl-substituted amides
Abdul Qaiyum Ramle, Nadia Nabihah Mohd Yusof Chan, Min Phin Ng, Chun Hoe Tan, Kae Shin Sim, Edward R. T. Tiekink, Chee Chin Fei
Molecular Diversity, 2024
Discovery of indoleninyl-pyrazolo[3,4-b]pyridines as potent chemotherapeutic agents against colorectal cancer cells
Nur Husnaini Basir, Abdul Qaiyum Ramle, Min Phin Ng, Chun Hoe Tan, Edward R.T. Tiekink, Kae Shin Sim, Wan Jefrey Basirun, Melati Khairuddean
Bioorganic Chemistry, 2024
Quinoline, Indole, and Isogranatanine Alkaloids from Malayan Leuconotis eugeniifolia
Yi-Sheng Tan, Min-Phin Ng, Chun-Hoe Tan, Wai-Kit Tang, Kae-Shin Sim, et al.
Journal of Natural Products, 2024
Computational and In vitro Elucidation of Indolenine-barbituric Acid Zwitterions as Potential Chemotherapeutical Agents
Kang Kit Ong, Abdul Qaiyum Ramle, Min Phin Ng, Siew Huah Lim, Kae Shin Sim, Chun Hoe Tan
Letters in Drug Design and Discovery, 2024
Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from Tabernaemontana polyneura
Sin-Yee Tang, Min-Phin Ng, Chun-Hoe Tan, Kae-Shin Sim, Kuan-Hon Lim, Kien-Thai Yong, Yun-Yee Low, Siew-Huah Lim
Tetrahedron, 2023
Medicinal plants for SARS-CoV-2 infections
Medicinal Plants and Covid 19, 2023
The pathogenesis of coronavirus through the host
Medicinal Plants and Covid 19, 2023
Clinical symptoms and diagnoses of COVID-19
Medicinal Plants and Covid 19, 2023
Polyneurines A−H, iboga alkaloids from Tabernaemontana polyneura
Sin-Yee Tang, Chun-Hoe Tan, Kae-Shin Sim, Kien-Thai Yong, Kuan-Hon Lim, Yun-Yee Low, Siew-Huah Lim
Phytochemistry, 2023
A new cinnamaldehyde-rhodamine based dual chemosensor for Cu2+ and Fe3+ and its applicability in live cell imaging
Nur Amira Solehah Pungut, Chun Hoe Tan, Hazwani Mat Saad, Kae Shin Sim, Sheena Yin Xin Tiong, Chee Wei Ang, Chun Hau Gan, Kien Voon Kong, Kong Wai Tan
Journal of Photochemistry and Photobiology A Chemistry, 2023
A new lipophilic cationic rhodamine-based chemosensor for detection of Al(III)/Cu(II) and intracellular pH change and its application as a smartphone-assisted sensor in water sample analysis
Wei Chuen Chan, Min Phin Ng, Chun Hoe Tan, Chee Wei Ang, Kae Shin Sim, Sheena Yin Xin Tiong, Nur Amira Solehah Pungut, Chew Hee Ng, Kong Wai Tan
Journal of Photochemistry and Photobiology A Chemistry, 2023
Artocarpus heterophyllus Lam. Stem bark inhibits melanogenesis through regulation of ROS, cAMP, and MAPK pathways
Hazwani Mat Saad, Chun Hoe Tan, Sugumaran Manickam, Siew Huah Lim, Kae Shin Sim
Sains Malaysiana, 2023
Antiproliferative and Microtubule-stabilizing Activities of Two Iboga-vobasine Bisindoles Alkaloids from Tabernaemontana corymbosa in Colorectal Adenocarcinoma HT-29 Cells
Chun Hoe Tan, Dawn Su Yin Sim, Siew Huah Lim, Taznim Begam Mohd Mohidin, Gokula Mohan, Yun Yee Low, Toh Seok Kam, Kae Shin Sim
Planta Medica, 2022
Synthesis, characterisation and biological activity of diorganotin compounds of (E)-N'-(5-nitro-2-hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide
See Mun Lee, Kong Mun Lo, Li Yuan Liew, Jactty Chew, Chun Hoe Tan, Kae Shin Sim, Edward R.T. Tiekink
Polyhedron, 2022
Group 6 photo-activable carbon monoxide-releasing molecules (PhotoCORMs) with 1’10-phenanthroline based ligand as potential anti-proliferative and anti-microbial agents
Shiaw Xian Lee, Chun Hoe Tan, Wee Li Mah, Richard Chee Seng Wong, Ninie Suhana Abdul Manan, Yuen Lin Cheow, Kae Shin Sim, Kong Wai Tan
Inorganica Chimica Acta, 2022
Synthesis, anticancer and antimalarial activities of organosulfur and organoselenium derivatives of cyclopentadienyliron dicarbonyl as photoCORMs
Chun Hau Gan, Kong Wai Tan, Mei Lee Ooi, Jonathan Wee Kent Liew, Yee Ling Ng, Yee Ling Lau, Yin Zhuang Ng, Chew Hee Ng, Chun Hoe Tan, Richard C.S. Wong
Inorganica Chimica Acta, 2022
Synthesis of phenanthroline-based ligand and its UV activable tetracarbonyl photoCORMs based on chromium, molybdenum, and tungsten as cytotoxic and antimicrobial agents
Shiaw Xian Lee, Chun Hoe Tan, Wee Li Mah, Richard Chee Seng Wong, Kae Shin Sim, Yuen Lin Cheow, Chew-Hee Ng, Kong Wai Tan
Journal of Organometallic Chemistry, 2021
Nickel(II) Complexes with Polyhydroxybenzaldehyde and O,N,S tridentate Thiosemicarbazone ligands: Synthesis, Cytotoxicity, Antimalarial Activity, and Molecular Docking Studies.
Savina Savir, Jonathan Wee Kent Liew, Indra Vythilingam, Yvonne Ai Lian Lim, Chun Hoe Tan, Kae Shin Sim, Vannajan Sanghiran Lee, Mohd. Jamil Maah, Kong Wai Tan
Journal of Molecular Structure, 2021
Synthesis of group 6 (chromium, molybdenum, and tungsten) photoCORMs as potential antimicrobial and anticancer agents
Shiaw Xian Lee, Chun Hoe Tan, Wee Li Mah, Richard Chee Seng Wong, Yuen Lin Cheow, Kae Shin Sim, Kong Wai Tan
Inorganica Chimica Acta, 2021
Evaluation of antioxidant activity and phytochemical composition of Baeckea frutescens and Leptospermum javanicum essential oils
Hazwani Mat Saad, Syarifah Nur Syed Abdul Rahman, Suerialoasan Navanesan, Chun Hoe Tan, Sugumaran Manickam, Sri Nurestri Abd Malek, Kae Shin Sim
South African Journal of Botany, 2021
The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization
Chun-Hoe Tan, Joanne Soon-Yee Yeap, Siew-Huah Lim, Yun-Yee Low, Kae-Shin Sim, Toh-Seok Kam
Journal of Natural Products, 2021
Evaluation of anti-melanogenesis and free radical scavenging activities of five Artocarpus species for cosmeceutical applications
Hazwani Mat Saad, Chun Hoe Tan, Siew Huah Lim, Sugumaran Manickam, Kae Shin Sim
Industrial Crops and Products, 2021
Arbolodinines A−C, biologically-active aspidofractinine-aspidofractinine, aspidofractinine-strychnan, and kopsine-strychnan bisindole alkaloids from Kopsia arborea
Soon-Kit Wong, Joanne Soon-Yee Yeap, Chun-Hoe Tan, Kae-Shin Sim, Siew-Huah Lim, Yun-Yee Low, Toh-Seok Kam
Tetrahedron, 2021
Evaluation of DNA Binding and Topoisomerase I Inhibitory Activities of 16′-Decarbomethoxydihydrovoacamine from Tabernaemontana corymbosa
Chun Hoe Tan, Dawn Su Yin Sim, Mok Piew Heng, Siew Huah Lim, Yun Yee Low, Toh Seok Kam, Kae Shin Sim
Chemistryselect, 2020
Macroline, talpinine, and sarpagine alkaloids from Alstonia penangiana. An NMR-based method for differentiating between A. penangiana and A. macrophylla
Joanne Soon-Yee Yeap, Chun-Hoe Tan, Kien-Thai Yong, Kuan-Hon Lim, Siew-Huah Lim, Yun-Yee Low, Toh-Seok Kam
Phytochemistry, 2020
Mitochondria-dependent apoptosis inducer: Testosterone-N4-ethylthiosemicarbazonate and its metal complexes with selective cytotoxicity towards human colorectal carcinoma cell line (HCT 116)
Mok Piew Heng, Chun Hoe Tan, Hazwani Mat Saad, Kae Shin Sim, Kong Wai Tan
Inorganica Chimica Acta, 2020
Macroline-Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana
Joanne Soon-Yee Yeap, Hazwani Mat Saad, Chun-Hoe Tan, Kae-Shin Sim, Siew-Huah Lim, Yun-Yee Low, Toh-Seok Kam
Journal of Natural Products, 2019

CHUN HOE TAN

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Scopus Publications