Claudia Kutter

@ki.se

Karolinska Institute, Department of Microbiology, Tumor and Cell Biology, Science for Life Laboratory
Karolinska Institute

Claudia Kutter


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https://researchid.co/ckutter
Principal Researcher, Karolinska Institute, SciLifeLab, Stockholm, Sweden, since 2016
Research Scientist, University of Cambridge, CRUK Cambridge Institute, 2013 - 2016
Postdoctoral Researcher, Cancer Research UK, Cambridge Research Institute, 2007 - 2013
PhD Student, Friedrich Miescher Institute (FMI), Basel, Switzerland, 2003 - 2007

EDUCATION

PhD and Msc (Genetics, summa cum laude), University of Basel, Switzerland, 2003 - 2007
Diplom (Biology), Martin-Luther-University, Halle/Saale, Germany, 1996 - 2001

RESEARCH INTERESTS

comparative and functional genomics, regulatory transcriptomics, metabolomics, interaction of RNA binding proteins and regulatory RNAs (lncRNAs, tRNAs, sRNA) in diseases, Pol III 3D genome organization, tRNA gene evolution and disease association, diet-induced gene expression adaptation and trans
57

Scopus Publications

8875

Scholar Citations

30

Scholar h-index

42

Scholar i10-index

Scopus Publications

  • RAPseq enables large-scale identification of RBP–RNA interactions and reveals essentials of post-transcriptional gene regulation
    Riccardo Mosca, Carlos J Gallardo-Dodd, Qun Li, Christian Sommerauer, Justas Šidiškis, et al.
    Nucleic Acids Research, 2026
    Over the past decade, thousands of putative human RNA-binding proteins (RBPs) have been identified, increasing the need for methods that define their RNA-binding capacities across diverse biological settings. Existing methods rely either on antibody-based in vivo capture (e.g. CLIP-seq), which depends on cross-linking efficiency and antibody availability, or on synthetic oligonucleotide-based assays (e.g. RNAcompete), which use artificial RNA substrates and cannot assess binding across the native transcriptome. To bridge this gap, we developed RNA affinity purification followed by sequencing (RAPseq), an in vitro method that profiles RBP-binding to native cellular RNA, enabling large-scale transcriptome-wide characterization of RNA–protein interactions without antibodies or synthetic probes. Using RAPseq, we characterized the RNA interactomes of 11 canonical RBPs and 26 non-canonical RBPs, and uncovered novel and specialized moonlighting RNA-binding activities. Applying RAPseq to vertebrate HUR proteins revealed recognition of a conserved RNA-binding motif but showed species-specific binding preferences. Profiling of five pathological IGF2BP family variants exhibited distinct gain- and loss-of-function binding patterns, with implications for cancer biology. Our combinatorial RBP-binding assay (co-RAPseq) uncovered cooperative RNA-binding by HUR and PTBP1, including de novo estimation of the optimal binding distance. Lastly, we introduce a modification-sensitive assay (mod-RAPseq) to distinguish between modification-dependent and -independent RNA-binding sites of YTHDF1 and YBX1. Overall, our simple, scalable, and versatile method enables exploration of complex RNA–protein interactions and the regulatory layers that shape post-transcriptional gene regulation.
  • Author Correction: Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis (Molecular Systems Biology, (2024), 20, 4, (374-402), 10.1038/s44320-024-00024-x)
    Christian Sommerauer, Carlos J Gallardo-Dodd, Christina Savva, Linnea Hases, Madeleine Birgersson, et al.
    Molecular Systems Biology, 2025
  • Intestinal estrogen receptor beta modulates the murine colon tumor immune microenvironment
    Madeleine Birgersson, Matilda Holm, Carlos J. Gallardo-Dodd, Baizhen Chen, Lina Stepanauskaitė, et al.
    Cancer Letters, 2025
  • PHYSIOLOGICAL RESPONSE OF THE AQUATIC FERN Salvinia minima UNDER EXPOSURE TO METALS SUCH Pb, Ni, Cu, Zn AND Li
    Gabriela Fuentes, Daniel Leal-Alvarado, Ignacio Fuentes-Franco, Tony Hoffmann, Claudia Kutter, et al.
    Tropical and Subtropical Agroecosystems, 2025
    <p><strong>Background: </strong>Metals can be found in nature, but they are also generated by anthropogenic activities associated with technological waste, such as batteries and electronic components. These metals, when released to the environment may contaminate and cause significant health damage. Phytoremediation is a process to de-contaminate water bodies from metals using plants. Obviously, those plants should be able not only to uptake high amounts of metals, but also, they should be able to tolerate those high concentrations in their tissues. <em>Salvinia minima</em> is a fast-growing, floating aquatic fern and its ability to take up metals from the environment has been evaluated. <strong>Objective</strong>: To characterize the physiological and molecular response of <em>Salvinia minima</em> plants exposed to different metals. <strong>Methodology</strong>: A system was designed to expose <em>Salvinia minima</em> plants to different metals such as Pb, Ni, Cu, Zn and Li, for seven days at different concentrations levels and take samples every 24 h. Various parameters were evaluated including metal uptake, metal concentration in the medium, leaf appearance, PSII efficiency (Fv/Fm), photosynthesis, transpiration, stomatal conductance. <strong>Results: </strong><em>S. minima</em> plants were capable to accumulate Pb (28 mg /g DW at 40 uM), Zn (10 mg/g at 80uM) Li (10 mg/g at 20mM), Cu (8 mg/g at 40 uM) and Ni (4 mg/g at 40 uM), at their roots. At short times (0-24 h) and at low concentrations (of certain metals) no significant physiological damage was observed, however, at high concentrations or longer exposure times (48-144 h), physiological damage can be observed in terms of decreased photosynthesis and PSII efficiency, transpiration and stomatal conductance. <strong>Implications</strong>: <em>Salvinia minima</em> plant are capable to take Pb, Ni, Cu, Zn and Li from the medium, which indicates that it is a good candidate to be used in the phytoremediation of water bodies contaminated with these metals. <strong>Conclusions</strong>: <em>Salvinia minima</em> plants take up and accumulate high concentrations of Pb, Ni, Cu, Zn and Li in their tissues, thus reducing the metal content of aqueous media. Even though at high concentrations those metals may affect its physiological performance, this occurs at much higher concentrations than those normally found in natural water bodies, therefore <em>S. minima</em> is certainly a good candidate to be used for the phytoremediation of water bodies contaminated with metals.</p>
  • The regulatory landscape of interacting RNA and protein pools in cellular homeostasis and cancer
    Carlos J. Gallardo-Dodd, Claudia Kutter
    Human Genomics, 2024
    Biological systems encompass intricate networks governed by RNA-protein interactions that play pivotal roles in cellular functions. RNA and proteins constituting 1.1% and 18% of the mammalian cell weight, respectively, orchestrate vital processes from genome organization to translation. To date, disentangling the functional fraction of the human genome has presented a major challenge, particularly for noncoding regions, yet recent discoveries have started to unveil a host of regulatory functions for noncoding RNAs (ncRNAs). While ncRNAs exist at different sizes, structures, degrees of evolutionary conservation and abundances within the cell, they partake in diverse roles either alone or in combination. However, certain ncRNA subtypes, including those that have been described or remain to be discovered, are poorly characterized given their heterogeneous nature. RNA activity is in most cases coordinated through interactions with RNA-binding proteins (RBPs). Extensive efforts are being made to accurately reconstruct RNA-RBP regulatory networks, which have provided unprecedented insight into cellular physiology and human disease. In this review, we provide a comprehensive view of RNAs and RBPs, focusing on how their interactions generate functional signals in living cells, particularly in the context of post-transcriptional regulatory processes and cancer.
  • Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis
    Christian Sommerauer, Carlos J Gallardo-Dodd, Christina Savva, Linnea Hases, Madeleine Birgersson, et al.
    Molecular Systems Biology, 2024
    Sex-based differences in obesity-related hepatic malignancies suggest the protective roles of estrogen. Using a preclinical model, we dissected estrogen receptor (ER) isoform-driven molecular responses in high-fat diet (HFD)-induced liver diseases of male and female mice treated with or without an estrogen agonist by integrating liver multi-omics data. We found that selective ER activation recovers HFD-induced molecular and physiological liver phenotypes. HFD and systemic ER activation altered core liver pathways, beyond lipid metabolism, that are consistent between mice and primates. By including patient cohort data, we uncovered that ER-regulated enhancers govern central regulatory and metabolic genes with clinical significance in metabolic dysfunction-associated steatotic liver disease (MASLD) patients, including the transcription factor TEAD1. TEAD1 expression increased in MASLD patients, and its downregulation by short interfering RNA reduced intracellular lipid content. Subsequent TEAD small molecule inhibition improved steatosis in primary human hepatocyte spheroids by suppressing lipogenic pathways. Thus, TEAD1 emerged as a new therapeutic candidate whose inhibition ameliorates hepatic steatosis.
  • Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles
    Keyi Geng, Lara G Merino, Raül G Veiga, Christian Sommerauer, Janine Epperlein, et al.
    Life Science Alliance, 2024
    The CRISPR-Cas9 system is a powerful tool for studying gene functions and holds potential for disease treatment. However, precise genome editing requires thorough assessments to minimize unintended on- and off-target effects. Here, we report an unexpected 283-kb deletion on Chromosome 10 (10q23.31) in chronic myelogenous leukemia-derived HAP1 cells, which are frequently used in CRISPR screens. The deleted region encodes regulatory genes, includingPAPSS2,ATAD1,KLLN, andPTEN. We found that this deletion was not a direct consequence of CRISPR-Cas9 off-targeting but rather occurred frequently during the generation of CRISPR-Cas9–modified cells. The deletion was associated with global changes in histone acetylation and gene expression, affecting fundamental cellular processes such as cell cycle and DNA replication. We detected this deletion in cancer patient genomes. As in HAP1 cells, the deletion contributed to similar gene expression patterns among cancer patients despite interindividual differences. Our findings suggest that the unintended deletion of 10q23.31 can confound CRISPR-Cas9 studies and underscore the importance to assess unintended genomic changes in CRISPR-Cas9–modified cells, which could impact cancer research.
  • Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription
    Donald P. Cameron, Jan Grosser, Swetlana Ladigan, Vladislav Kuzin, Evanthia Iliopoulou, et al.
    Science Advances, 2023
    Pancreatic carcinoma lacks effective therapeutic strategies resulting in poor prognosis. Transcriptional dysregulation due to alterations in KRAS and MYC affects initiation, development, and survival of this tumor type. Using patient-derived xenografts of KRAS- and MYC-driven pancreatic carcinoma, we show that coinhibition of topoisomerase 1 (TOP1) and bromodomain-containing protein 4 (BRD4) synergistically induces tumor regression by targeting promoter pause release. Comparing the nascent transcriptome with the recruitment of elongation and termination factors, we found that coinhibition of TOP1 and BRD4 disrupts recruitment of transcription termination factors. Thus, RNA polymerases transcribe downstream of genes for hundreds of kilobases leading to readthrough transcription. This occurs during replication, perturbing replisome progression and inducing DNA damage. The synergistic effect of TOP1 + BRD4 inhibition is specific to cancer cells leaving normal cells unaffected, highlighting the tumor’s vulnerability to transcriptional defects. This preclinical study provides a mechanistic understanding of the benefit of combining TOP1 and BRD4 inhibitors to treat pancreatic carcinomas addicted to oncogenic drivers of transcription and replication.
  • Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells
    Carlos J. Gallardo-Dodd, Christian Oertlin, Julien Record, Rômulo G. Galvani, Christian Sommerauer, et al.
    Science Advances, 2023
    The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14, and 21 during DI, and 7 days after DI. RNA sequencing of CD3 + T cells revealed transcriptional alterations across all time points, with most changes occurring 14 days after DI exposure. At day 21, T cells showed evidence of adaptation with a transcriptional profile resembling that of 7 days before DI. At 7 days after DI, T cells again changed their transcriptional profile. These data suggest that T cells adapt by rewiring their transcriptomes in response to simulated weightlessness and that remodeling cues persist when reexposed to normal gravity.
  • Molecular programming modulates hepatic lipid metabolism and adult metabolic risk in the offspring of obese mothers in a sex-specific manner
    Christina Savva, Luisa A. Helguero, Marcela González-Granillo, Tânia Melo, Daniela Couto, et al.
    Communications Biology, 2022
    Male and female offspring of obese mothers are known to differ extensively in their metabolic adaptation and later development of complications. We investigate the sex-dependent responses in obese offspring mice with maternal obesity, focusing on changes in liver glucose and lipid metabolism. Here we show that maternal obesity prior to and during gestation leads to hepatic steatosis and inflammation in male offspring, while female offspring are protected. Females from obese mothers display important changes in hepatic transcriptional activity and triglycerides profile which may prevent the damaging effects of maternal obesity compared to males. These differences are sustained later in life, resulting in a better metabolic balance in female offspring. In conclusion, sex and maternal obesity drive differently transcriptional and posttranscriptional regulation of major metabolic processes in offspring liver, explaining the sexual dimorphism in obesity-associated metabolic risk.
  • Noncoding RNAs and RNA-binding proteins: emerging governors of liver physiology and metabolic diseases
    Christian Sommerauer, Claudia Kutter
    American Journal of Physiology Cell Physiology, 2022
  • Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells
    Keyi Geng, Lara G. Merino, Linda Wedemann, Aniek Martens, Małgorzata Sobota, et al.
    Genome Research, 2022
  • Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation
    Keying Zhu, Yang Wang, Heela Sarlus, Keyi Geng, Erik Nutma, et al.
    EMBO Reports, 2022
  • FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development
    Thuy T. Luu, Jonas Nørskov Søndergaard, Lucía Peña-Pérez, Shabnam Kharazi, Aleksandra Krstic, et al.
    Frontiers in Immunology, 2022
  • Inhibition of Respiratory Syncytial Virus Infection by Small Non-Coding RNA Fragments
    Sandra Axberg Pålsson, Vaishnovi Sekar, Claudia Kutter, Marc R. Friedländer, Anna-Lena Spetz
    International Journal of Molecular Sciences, 2022
  • ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
    Sandhya Malla, Devi Prasad Bhattarai, Paula Groza, Dario Melguizo‐Sanchis, Ionut Atanasoai, et al.
    EMBO Reports, 2022
  • Cell type-specific analysis by single-cell profiling identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons
    William Gao, Carlos J. Gallardo-Dodd, Claudia Kutter
    Genome Research, 2022
  • Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells
    Amena Archer, Claudia Kutter, Cecilia Williams
    Methods in Molecular Biology, 2022
  • CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism
    Jonas Nørskov Søndergaard, Christian Sommerauer, Ionut Atanasoai, Laura C Hinte, Keyi Geng, et al.
    Gut, 2022
  • Obese mother offspring have hepatic lipidic modulation that contributes to sex-dependent metabolic adaptation later in life
    Christina Savva, Luisa A. Helguero, Marcela González-Granillo, Daniela Couto, Tânia Melo, et al.
    Communications Biology, 2021
  • Genome Size Reduction and Transposon Activity Impact tRNA Gene Diversity While Ensuring Translational Stability in Birds
    Jente Ottenburghs, Keyi Geng, Alexander Suh, Claudia Kutter
    Genome Biology and Evolution, 2021
  • Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes
    Helene Johansson, Jonas Nørskov Søndergaard, Carl Jorns, Claudia Kutter, Ewa C. S. Ellis
    Frontiers in Endocrinology, 2021
  • Author Correction: Liver macrophages regulate systemic metabolism through non-inflammatory factors (Nature Metabolism, (2019), 1, 4, (445-459), 10.1038/s42255-019-0044-9)
    Cecilia Morgantini, Jennifer Jager, Xidan Li, Laura Levi, Valerio Azzimato, et al.
    Nature Metabolism, 2021
  • 5´XP sRNA-seq: efficient identification of transcripts with and without 5´ phosphorylation reveals evolutionary conserved small RNA
    Unn Kugelberg, Daniel Nätt, Signe Skog, Claudia Kutter, Anita Öst
    RNA Biology, 2021
  • High expression of linc01268 is positively associated with hepatocellular carcinoma progression via regulating map3k7
    Xiuli Jin, Weixin Fu, Dan Li, Ningning Wang, Jiayu Chen, et al.
    Oncotargets and Therapy, 2021

RECENT SCHOLAR PUBLICATIONS

  • RAPseq enables large-scale identification of RBP–RNA interactions and reveals essentials of post-transcriptional gene regulation
    R Mosca, CJ Gallardo-Dodd, Q Li, C Sommerauer, J Šidiškis, ...
    Nucleic Acids Research 54 (5), gkag090 , 2026
    2026
  • Author Correction: Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis
    C Sommerauer, CJ Gallardo-Dodd, C Savva, L Hases, M Birgersson, ...
    Molecular Systems Biology 21 (9), 1282-1283 , 2025
    2025
  • Intestinal estrogen receptor beta modulates the murine colon tumor immune microenvironment
    M Birgersson, M Holm, CJ Gallardo-Dodd, B Chen, L Stepanauskaitė, ...
    Cancer Letters 622, 217661 , 2025
    2025
    Citations: 6
  • FISIOLOGÍA DEL HELECHO ACUATICO SALVINIA MINIMA AL SER EXPUESTO A METALES COMO PB, NI, CU, ZN Y LI
    G Fuentes, D Leal-Alvarado, I Fuentes-Franco, T Hoffmann, C Kutter, ...
    TROPICAL AND SUBTROPICAL AGROECOSYSTEMS 28 (1) , 2025
    2025
  • PHYSIOLOGICAL RESPONSE OF THE AQUATIC FERN Salvinia minima UNDER EXPOSURE TO METALS SUCH Pb, Ni, Cu, Zn AND Li
    G Fuentes, D Leal-Alvarado, I Fuentes-Franco, T Hoffmann, C Kutter, ...
    Tropical and Subtropical Agroecosystems 28 (1) , 2025
    2025
  • The regulatory landscape of interacting RNA and protein pools in cellular homeostasis and cancer
    CJ Gallardo-Dodd, C Kutter
    Human Genomics 18 (1), 109 , 2024
    2024
    Citations: 8
  • Comprehensive analysis of the RBP regulome reveals functional modules and drug candidates in liver cancer
    M Garbulowski, R Mosca, CJ Gallardo-Dodd, C Kutter, ELL Sonnhammer
    bioRxiv, 2024.09. 04.611258 , 2024
    2024
    Citations: 1
  • Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis
    C Sommerauer, CJ Gallardo-Dodd, C Savva, L Hases, M Birgersson, ...
    Molecular Systems Biology 20 (4), 374 , 2024
    2024
    Citations: 24
  • Intrinsic deletion at 10q23. 31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles
    K Geng, LG Merino, RG Veiga, C Sommerauer, J Epperlein, EK Brinkman, ...
    Life Science Alliance 7 (2) , 2024
    2024
    Citations: 2
  • Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription
    DP Cameron, J Grosser, S Ladigan, V Kuzin, E Iliopoulou, A Wiegard, ...
    Science Advances 9 (41), eadg5109 , 2023
    2023
    Citations: 16
  • Estrogen receptor activation remodels TEAD1 gene expression to alleviate nonalcoholic fatty liver disease
    C Sommerauer, CJ Gallardo-Dodd, C Savva, L Hases, M Birgersson, ...
    bioRxiv, 2023.09. 07.556687 , 2023
    2023
  • Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells
    CJ Gallardo-Dodd, C Oertlin, J Record, RG Galvani, C Sommerauer, ...
    Science advances 9 (34), eadg1610 , 2023
    2023
    Citations: 6
  • Revealing the mechanism of the lipid storage disorder Niemann-Pick C by combining multi-omics and biophysical imaging
    P Carravilla, U Ceplaite, C Sommerauer, RG Veiga, E Sezgin, C Kutter
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 52 (SUPPL 1), S122-S122 , 2023
    2023
  • CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the PTEN gene locus mimicking cancer profiles
    K Geng, LG Merino, RG Veiga, C Sommerauer, J Epperlein, EK Brinkman, ...
    bioRxiv, 2023.04. 05.535680 , 2023
    2023
  • The long non-coding RNA H19 is a target of pro-inflammatory cytokines in human beta cells and modulates apoptosis and insulin secretion.
    C Frørup, T Fløyel, AH Mirza, CAS Svane, ML Colli, J Johannesen, ...
    2023
  • Intestinal estrogen receptor beta modulates the tumor immune microenvironment in a mouse model of colitis-associated cancer
    M Birgersson, M Holm, L Stepanauskaite, C Gallardo-Dodd, L Hases, ...
    2023
  • Molecular programming modulates hepatic lipid metabolism and adult metabolic risk in the offspring of obese mothers in a sex-specific manner
    C Savva, LA Helguero, M González-Granillo, T Melo, D Couto, B Angelin, ...
    Communications Biology 5 (1), 1057 , 2022
    2022
    Citations: 14
  • Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells
    K Geng, LG Merino, L Wedemann, A Martens, M Sobota, YP Sanchez, ...
    Genome research 32 (10), 1876 , 2022
    2022
    Citations: 23
  • Noncoding RNAs and RNA-binding proteins: emerging governors of liver physiology and metabolic diseases
    C Sommerauer, C Kutter
    American Journal of Physiology-Cell Physiology 323 (4), C1003-C1017 , 2022
    2022
    Citations: 26
  • CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism
    JN Søndergaard, C Sommerauer, I Atanasoai, LC Hinte, K Geng, ...
    Gut 71 (10), 2081-2092 , 2022
    2022
    Citations: 62

MOST CITED SCHOLAR PUBLICATIONS

  • The evolutionary landscape of alternative splicing in vertebrate species
    NL Barbosa-Morais, M Irimia, Q Pan, HY Xiong, S Gueroussov, LJ Lee, ...
    Science 338 (6114), 1587-1593 , 2012
    2012
    Citations: 1315
  • Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding
    D Schmidt, MD Wilson, B Ballester, PC Schwalie, GD Brown, A Marshall, ...
    Science 328 (5981), 1036-1040 , 2010
    2010
    Citations: 896
  • Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression
    A Git, H Dvinge, M Salmon-Divon, M Osborne, C Kutter, J Hadfield, ...
    Rna 16 (5), 991-1006 , 2010
    2010
    Citations: 866
  • Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
    D Schmidt, PC Schwalie, MD Wilson, B Ballester, Â Gonçalves, C Kutter, ...
    Cell 148 (1), 335-348 , 2012
    2012
    Citations: 729
  • Aberrant methylation of tRNAs links cellular stress to neuro‐developmental disorders
    S Blanco, S Dietmann, JV Flores, S Hussain, C Kutter, P Humphreys, ...
    The EMBO journal 33 (18), 2020-2039 , 2014
    2014
    Citations: 691
  • The wound response in tomato–role of jasmonic acid
    C Wasternack, I Stenzel, B Hause, G Hause, C Kutter, H Maucher, ...
    Journal of plant physiology 163 (3), 297-306 , 2006
    2006
    Citations: 422
  • Rapid turnover of long noncoding RNAs and the evolution of gene expression
    C Kutter, S Watt, K Stefflova, MD Wilson, A Goncalves, CP Ponting, ...
    PLoS genetics 8 (7), e1002841 , 2012
    2012
    Citations: 373
  • Molecular characterization of geminivirus-derived small RNAs in different plant species
    R Akbergenov, A Si-Ammour, T Blevins, I Amin, C Kutter, ...
    Nucleic acids research 34 (2), 462-471 , 2006
    2006
    Citations: 359
  • miR393 and Secondary siRNAs Regulate Expression of the TIR1 / AFB2 Auxin Receptor Clade and Auxin-Related Development of Arabidopsis Leaves
    A Si-Ammour, D Windels, E Arn-Bouldoires, C Kutter, J Ailhas, F Meins Jr, ...
    Plant physiology 157 (2), 683-691 , 2011
    2011
    Citations: 271
  • Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
    HK Long, D Sims, A Heger, NP Blackledge, C Kutter, ML Wright, ...
    elife 2, e00348 , 2013
    2013
    Citations: 260
  • JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
    J Stebbing, G Sánchez Nievas, M Falcone, S Youhanna, P Richardson, ...
    Science advances 7 (1), eabe4724 , 2021
    2021
    Citations: 230
  • MicroRNA-Mediated Regulation of Stomatal Development in Arabidopsis
    C Kutter, H Schöb, M Stadler, F Meins Jr, A Si-Ammour
    The Plant Cell 19 (8), 2417-2429 , 2007
    2007
    Citations: 225
  • The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
    C Ernst, DT Odom, C Kutter
    Nature communications 8 (1), 1411 , 2017
    2017
    Citations: 212
  • Enzymes of jasmonate biosynthesis occur in tomato sieve elements
    B Hause, G Hause, C Kutter, O Miersch, C Wasternack
    Plant and Cell Physiology 44 (6), 643-648 , 2003
    2003
    Citations: 190
  • Liver macrophages regulate systemic metabolism through non-inflammatory factors
    C Morgantini, J Jager, X Li, L Levi, V Azzimato, A Sulen, E Barreby, C Xu, ...
    Nature metabolism 1 (4), 445-459 , 2019
    2019
    Citations: 129
  • Role of cis-12-oxo-phytodienoic acid in tomato embryo development
    S Goetz, A Hellwege, I Stenzel, C Kutter, V Hauptmann, S Forner, ...
    Plant Physiology 158 (4), 1715-1727 , 2012
    2012
    Citations: 128
  • Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes
    C Kutter, GD Brown, Â Gonçalves, MD Wilson, S Watt, A Brazma, ...
    Nature genetics 43 (10), 948-955 , 2011
    2011
    Citations: 128
  • Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways
    B Ballester, A Medina-Rivera, D Schmidt, M Gonzalez-Porta, M Carlucci, ...
    Elife 3, e02626 , 2014
    2014
    Citations: 127
  • miRNA, siRNA, piRNA: Knowns of the unknown
    C Kutter, P Svoboda
    RNA biology 5 (4), 181-188 , 2008
    2008
    Citations: 127
  • High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface
    BM Schmitt, KLM Rudolph, P Karagianni, NA Fonseca, RJ White, ...
    Genome research 24 (11), 1797 , 2014
    2014
    Citations: 119