dos Santos, Catarina

@assis.unesp.br

Biological Sciences
São Paulo State University

https://researchid.co/csantos1965

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Plant Science

Scopus Publications

640

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Effect of microencapsulation on antioxidant activities of Eugenia punicifolia (Kunth) DC hydroethanolic extracts
MANOELA MARTINS, DANIJELA STANISIC, and CATARINA DOS SANTOS
FapUNIFESP (SciELO)
Eugenia punicifolia (Kunth) DC (Myrtaceae) is a folk medicinal plant in the Brazilian Cerrado with antioxidant, anti-inflammatory, antinociceptive, antiulcerogenic activities, etc., usually attributed to its phenolic compounds. Since these compounds are sensitive to heat and light, and to increase their applications, Hydroethanolic Extracts E. punicifolia (HEEP, EtOH:H2O 70% v/v) were encapsulated by freeze-drying in xanthan gum (mesh 80, HEEPX80; mesh 200, HEEPX200) in ratio 1:1(w/w). Flavonoids had the highest encapsulation efficiency in HEEPX80, with a total flavonoid content of 55.56%. The release profile at different pH levels showed that pH = 4.5, a relevant antioxidant activity for HEEPX80 and HEEPX200. Also, in HEEP-modified release, higher antioxidant activity was observed in more acidic media (pH 4.5) than in a more neutral medium (pH 7.4). From these results, we could infer that HEEP encapsulations with Xanthan gum could be a good alternative for preserving antioxidants in these extracts.

Role of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifolia
Larissa Lucena Périco, Raquel de Cássia dos Santos, Vinícius Peixoto Rodrigues, Vânia Vasti Alfieri Nunes, Wagner Vilegas, Lúcia Regina Machado da Rocha, Catarina dos Santos, and Clélia Akiko Hiruma-Lima
Springer Science and Business Media LLC

Optimization of Eugenia punicifolia (Kunth) D. C. leaf extraction using a simplex centroid design focused on extracting phenolics with antioxidant and antiproliferative activities
Catarina dos Santos, Andressa Lie Mizobucchi, Bruna Escaramboni, Bruno Pereira Lopes, Celio Fernando Figueiredo Angolini, Marcos Nogueira Eberlin, Karina Alves de Toledo, and Eutimio Gustavo Fernández Núñez
Springer Science and Business Media LLC
AbstractEugenia punicifolia (Kunth) D. C. (Myrtaceae) has been showing interesting biological activities in the literature which was correlated to its phenolic compounds. In the sense of a better recovering of phenolics with the best antioxidant and antiproliferative activities, an extraction, based on multivariate analytical approach, was developed from E. punicifolia leaves. The different extractor solvents (ethanol, methanol and water) and their binary and ternary combinations were evaluated using a simplex-centroid mixture design and surface response methodology. The optimized crude extracts were investigated for phenol and flavonoid content and compared to their antioxidant (EC50) and antiproliferative properties against HEp-2 (cell line derived from the oropharyngeal carcinoma) and mononuclear viability cells. Ethanolic extracts showed the best phenolic content with the highest antioxidant activity and moderated activity antiproliferative to HEp-2. ESI-QTOF–MS revealed the presence of quercetin and myricetin derivatives, which was correlated to activities tested. Then, simplex-centroid design allowed us to correlate the Eugenia punicifolia biological activities with the extracts obtained from solvent different polarity mixtures.

Can the gastric healing effect of Eugenia punicifolia be the same in male and female rats?
Larissa Lucena Périco, Vinícius Peixoto Rodrigues, Rie Ohara, Vânia Vasti Alfieri Nunes, Lúcia Regina Machado da Rocha, Wagner Vilegas, Catarina dos Santos, and Clélia Akiko Hiruma-Lima
Elsevier BV

Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats
Larissa Lucena Périco, Vinícius Peixoto Rodrigues, Rie Ohara, Gabriela Bueno, Vânia Vasti Alfieri Nunes, Raquel de Cássia dos Santos, Ana Carolina Lima Camargo, Luis Antônio Justulin Júnior, Sérgio Faloni de Andrade, Viviane Miranda Bispo Steimbach,et al.
Baishideng Publishing Group Inc.
AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia (HEEP) leaves on gastric ulcer healing. METHODS In this rat study involving males, intact (cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity. RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males (52.44%), intact females (85.22%), and ovariectomized females (65.47%), confirming that HEEP accelerates the healing of acetic acid-induced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor (intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2 (intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed. CONCLUSION In gastric ulcers, HEEP-induced healing (modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration.

Microencapsulation of an anthocyanin-rich blackberry (Rubus spp.) by-product extract by freeze-drying
Camila Yamashita, Monique Mi Song Chung, Catarina dos Santos, Cassia Roberta Malacrida Mayer, Izabel Cristina Freitas Moraes, and Ivanise Guilherme Branco
Elsevier BV

Influence of pasteurization on antioxidant and in vitro anti-proliferative effects of jambolan (Syzygium cumini (L.) Skeels) fruit pulp
Ivanise Guilherme Branco, Izabel Cristina Freitas Moraes, Eliana Janet Sanjinez Argandoña, Grasiele Scaramal Madrona, Catarina dos Santos, Ana Lúcia Tasca Góis Ruiz, João Ernesto de Carvalho, and Charles Windson Isidoro Haminiuk
Elsevier BV

Eugenia aurata and Eugenia punicifolia HBK inhibit inflammatory response by reducing neutrophil adhesion, degranulation and NET release
Mírian Feliciano Costa, Tais Iara Jesus, Bruno Rafael Pereira Lopes, Célio Fernando Figueiredo Angolini, Abner Montagnolli, Lorraine de Paula Gomes, Gabriela Sterle Pereira, Ana Lucia Tasca Gois Ruiz, João Ernesto Carvalho, Marcos Nogueira Eberlin,et al.
Springer Science and Business Media LLC

Profiles of phenolic compounds by FT-ICR MS and antioxidative and antiproliferative activities of: Stryphnodendron obovatum Benth leaf extracts
M. F. da Costa, R. S. Galaverna, Marcos A. Pudenzi, A. L. T. G. Ruiz, J. E. de Carvalho, M. N. Eberlin, and C. dos Santos
Royal Society of Chemistry (RSC)
The main phenolic constituents of S. obovatum leaf extracts, analyzed by FT-ICR MS, were correlated with their antioxidant and in vitro antiproliferative activities.

Novel sustained-release of stryphnodendron obovatum leaves extract using natural rubber latex as carrier

Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents
Rosanna T. Basting, Catarine M. Nishijima, Juliana A. Lopes, Raquel C. Santos, Larissa Lucena Périco, Stefan Laufer, Silke Bauer, Miriam F. Costa, Lourdes C. Santos, Lúcia R.M. Rocha,et al.
Elsevier BV

Chemical inhibition of the contaminant Lactobacillus fermentum from distilleries producing fuel bioethanol
Pedro de Oliva Neto, Fabíola Aliaga de Lima, Ketrin Cristina da Silva, Douglas Fernandes da Silva, Ana Flavia Azevedo Carvalho, and Catarina dos Santos
FapUNIFESP (SciELO)
The purpose of this study was to determine the Mini mum Inhibitory Concentration (MIC) of pure or mixed chemicals for Saccharomyces cerevisiae and Lactobacillus fermentum in the samples isolated from distilleries with serious bacterial contamination problems. The bioci des, which showed the best results were: 3,4,4’ trichlorocarbanilide (TCC), tested at pH 4.0 (MIC = 3.12 mg/l), TCC with benzethonium chloride (CBe) a t pH 6.0 (MIC = 3.12 mg/l) and TCC mixed with benzalkonium c hloride (CBa) at pH 6.0 (MIC = 1.53 mg /l). If CBa was used in sugar cane milling in 1:1 ratio with TCC, a 8 times reduction of CBa was possible. This formul ation also should be tested in fermentation steps since it was more difficult for the bacterium to develop resist ance to biocide. There was no inhibition of S. cerevisiae and there were only antibiotics as an option to ba cterial control of fuel ethanol fermentation by S. cerevisiae.

Phytotoxicity of organic extracts of Turnera ulmifolia L. and Turnera diffusa Willd. ex Schult. in cucumber seeds
Daniel Moreto Silvestre, Rosana Marta Kolb, Fernando Frei, and Catarina dos Santos
FapUNIFESP (SciELO)
We evaluated the phytotoxic effects that the hexane, ethyl acetate and methanol extracts from leaves and branches of the species Turnera ulmifolia L. and Turnera diffusa Willd. ex Schult. (Turneraceae), at concentrations of 1.25, 2.50, 3.75 and 5.00 mg ml-1, have on seed germination and seedling development in cucumber (Cucumis sativus L.). None of the extracts tested prevented germination, although the ethyl acetate extracts of T. diffusa, at 3.75 and 5.00 mg ml-1, reduced the mean germination speed and time to germination. Hexane extracts of both species reduced the main root length, number of secondary roots and hypocotyl length. In the ethyl acetate and methanol extracts, the number of secondary roots and hypocotyl length varied by species and concentration. Ethyl acetate extracts of T. ulmifolia at 2.50 mg ml-1. Comparatively, T. diffusa extracts inhibited development to a greater degree, thus presenting greater allelopathic potential, than did T. ulmifolia extracts.

Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): Control of inflammation and pain screening
Ricardo Jose Dunder, Anderson Luiz-Ferreira, Ana Cristina Alves de Almeida, Felipe Meira de-Faria, Christiane Takayama, Eduardo Augusto Rabelo Socca, Marcos Jose Salvador, Glaucia Coelho Mello, Catarina dos Santos, Pedro de Oliva-Neto,et al.
FapUNIFESP (SciELO)
The present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties.

Synthesis of an oidiolactone analogue from abietic acid
Paulo M. Imamura and Catarina dos Santos
Informa UK Limited
Abstract A synthesis of a new analogue of homosesquiterpene oidiolactone is described, starting from abietic acid.

Chemical Transformation of Abietic Acid to New Chiral Derivatives
Catarina dos Santos, Julio Zukerman-Schpector, and Paulo M. Imamura
FapUNIFESP (SciELO)
Chemical transformations of the C-ring abietic acid (1a) for the preparation of some new chiral synthons are described. From the intermediate keto-aldehyde 9, readily available from 1b through the ozonide 2, the new tetracyclic diterpene 4 was synthesized. Additionally, from 13 and 17, previously prepared from 2, the bicyclic compounds 14, 15 and 16 and the derivatives containing the abeo-abietane[6,6,5] framework 19 and 20 were also synthesized.

Synthesis of new chiral synthons through regioselective ozonolysis of methyl abietate
Catarina dos Santos, César R.S. de Rosso, and Paulo M. Imamura
Informa UK Limited
Abstract The regioselective ozonolysis of methyl abietate to a stable epoxy-ozonide is described.

RECENT SCHOLAR PUBLICATIONS

Effect of microencapsulation on antioxidant activities of Eugenia punicifolia (Kunth) DC hydroethanolic extracts
M Martins, D Stanisic, CDOS SANTOS
Anais da Academia Brasileira de Cincias 96 (4), e20240184 2024

Os impactos dos efeitos imunomodulatrios das beta-glucanas fngicas na sade humana
RSA Junior, CA da Silva, C dos Santos, VMG do Nascimento, ...
Brazilian Journal of Health Review 7 (3), e69891-e69891 2024

Some new insights into the biological activities of carboxymethylated polysaccharides from Lasiodiplodia theobromae
MC Pires, N de Gois Andriolo, BRP Lopes, ALTG Ruiz, ...
BMC Complementary Medicine and Therapies 23 (1), 356 2023

Antiproliferative activity from five Myrtaceae essential oils
C dos Santos, NC de Melo, ALTG Ruiz, MA Floglio
Research, Society and Development 12 (3), e14612340536-e14612340536 2023

New Insights into the Biological Activities of Carboxymethylated
MC Pires, A NdG, BRP Lopes, C Delarmelina, MCT Duarte, A Ruiz, ...
2022

Role of the antioxidant pathway in the healing of peptic ulcers induced by ischemia–reperfusion in male and female rats treated with Eugenia punicifolia
L Lucena Prico, R de Cssia dos Santos, V Peixoto Rodrigues, ...
Inflammopharmacology 30 (4), 1383-1394 2022

Optimization of Eugenia punicifolia (Kunth) D. C. leaf extraction using a simplex centroid design focused on extracting phenolics with antioxidant and
C Dos Santos, AL Mizobucchi, B Escaramboni, BP Lopes, CFF Angolini, ...
BMC chemistry 14, 1-13 2020

Can the gastric healing effect of Eugenia punicifolia be the same in male and female rats?
LL Perico, VP Rodrigues, R Ohara, VVA Nunes, LRM da Rocha, ...
Journal of ethnopharmacology 235, 268-278 2019

Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats
LL Prico, VP Rodrigues, R Ohara, G Bueno, VVA Nunes, RC Dos Santos, ...
World Journal of Gastroenterology 24 (38), 4369 2018

Antioxidative, Antiproliferative and Antimicrobial Activities of Phenolic Compounds from Three Myrcia Species
C Dos Santos, RS Galaverna, CFF Angolini, VVA Nunes, LFR De Almeida, ...
Molecules 23 (5), 986 2018

Microencapsulation of an anthocyanin-rich blackberry (Rubus spp.) by-product extract by freeze-drying
C Yamashita, MMS Chung, C dos Santos, CRM Mayer, ICF Moraes, ...
Lwt 84, 256-262 2017

Eugenia aurata and Eugenia punicifolia HBK inhibit inflammatory response by reducing neutrophil adhesion, degranulation and NET release
MF Costa, TI Jesus, BRP Lopes, CFF Angolini, A Montagnolli, LP Gomes, ...
BMC complementary and alternative medicine 16, 1-10 2016

Profiles of phenolic compounds by FT-ICR MS and antioxidative and antiproliferative activities of Stryphnodendron obovatum Benth leaf extracts
MF Da Costa, RS Galaverna, MA Pudenzi, A Ruiz, JE De Carvalho, ...
Analytical Methods 8 (31), 6056-6063 2016

Influence of pasteurization on antioxidant and in vitro anti-proliferative effects of jambolan (Syzygium cumini (L.) Skeels) fruit pulp
IG BRANCO, ICF MORAES, EJS ARGANDOA, GS MADRONA, ...
Industrial Crops and Products 89, 225 2016

Novel sustained-release of Stryphnodendron obovatum leaves extract using natural rubber latex as carrier
FA Borges, PR Siguematsu, RD Herculano, C Santos
Revista de Cincias Farmacuticas Bsica e Aplicada 36 (3) 2015

Effects of leaf extracts of Myrcia guianensis (Aubl.) DC.: on growth and gene expression during root development of Sorghum bicolor (L.) Moench
DM Franco, LL Saldanha, EM Silva, FTS Nogueira, AL Dokkedal, ...
Allelopathy Journal 35 (2), 237-248 2015

Planta do bem: o nosso sistema imune agradece
TI de Jesus, M Costa, BRP Lopes, A Montagnolli, L de Paula Gomes, ...
Aprendendo Cincia (ISSN 2237-8766) 4 (1), 84-87 2014

Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents.
RT Basting, CM Nishijima, JA Lopes, RC Santos, LL Prico, S Laufer, ...
Journal of Ethnopharmacology. 157, 257-267 2014

Chemical inhibition of the contaminant Lactobacillus fermentum from distilleries producing fuel bioethanol
P Oliva-Neto, FA Lima, KC Silva, AFA Carvalho, DF Silva, C SANTOS
Brazilian Archives of Biology and Technology (Impresso) 57, 441-447 2014

Assessment of potential cytotoxic, molluscicidal and allelopathic of Stryphnodendron obovatum Benth hydroethanolic leaves extracts.
PC Salgado, MF Costa, AM Massocatto, A Laverde Jnior, F Frei, ...
2013

MOST CITED SCHOLAR PUBLICATIONS

Microencapsulation of an anthocyanin-rich blackberry (Rubus spp.) by-product extract by freeze-drying
C Yamashita, MMS Chung, C dos Santos, CRM Mayer, ICF Moraes, ...
Lwt 84, 256-262 2017
Citations: 229

Applications of Hexanic Fraction of Agave sisalana Perrine ex Engelm., (Asparagaceae): control of Inflamation and Pain Screening.
R Dunder, AL FERREIRA, FM FARIA, C TAKAYAMA, EAR Socca, ...
Memrias do Instituto Oswaldo Cruz (Online) 4, 263-271 2013
Citations: 22

Avaliao do potencial aleloptico, atividade antimicrobiana e antioxidante dos extratos orgnicos das folhas de Pyrostegia venusta (Ker Gawl.) Miers (Bignoniaceae)
PB Silva, ACM Medeiros, MCT Duarte, A Ruiz, RM Kolb, F Frei, C Santos
Revista Brasileira de Plantas Medicinais 13, 447-455 2011
Citations: 21

Chemical transformation of abietic acid to new chiral derivatives
C Santos, J Zukerman-Schpector, PM Imamura
Journal of the Brazilian Chemical Society 14, 998-1004 2003
Citations: 18

Synthesis of an oidiolactone analogue from abietic acid
PM Imamura, C dos Santos
Synthetic communications 35 (15), 2057-2065 2005
Citations: 14

Synthesis of new chiral synthons through regioselective ozonolysis of methyl abietate
C Santos, CRS de Rosso, PM Imamura
Synthetic communications 29 (11), 1903-1910 1999
Citations: 13

Phytotoxicity of organic extracts of Turnera ulmifolia L. and Turnera diffusa Willd. ex Schult. in cucumber seeds
DM Silvestre, RM Kolb, F Frei, C Santos
Acta Botanica Brasilica 27, 476-482 2013
Citations: 9

Antiproliferative activity from five Myrtaceae essential oils
C dos Santos, NC de Melo, ALTG Ruiz, MA Floglio
Research, Society and Development 12 (3), e14612340536-e14612340536 2023
Citations: 4

Evaluation of allelopathic potential, antimicrobial and antioxidant activities of Pyrostegia venusta (Ker Gawl.) Miers (Bignoniaceae) leaf organic extracts
PB Silva, ACM Medeiros, MCT Duarte, A Ruiz, RM Kolb, F Frei, C Santos
Revista Brasileira de Plantas Medicinais 13, 447-455 2011
Citations: 3