Organic Chemistry, General Chemistry, Fuel Technology, Materials Chemistry
7
Scopus Publications
Scopus Publications
Brønsted Acid Catalyzed Domino Synthesis of Functionalized 4H-Chromens and Their ADMET, Molecular Docking and Antibacterial Studies Rajpratap Kshatriya, Dayanand Kambale, Suraj Mali, Valmik P. Jejurkar, Pradeep Lokhande, Hemchandra K. Chaudhari, Satyajit Saha Chemistryselect, 2019 Highly efficient catalytic one‐pot construction of 3‐acetyl‐4H‐chromene derivatives via a tandem conjugate addition and cyclocondensation using p ‐TSA catalyst was achieved within 3–12 hours. The synthesized compounds were submitted to an in silico ADMET screening, to analyze their overall drug score and toxicity risks as well as ligand‐based virtual screening approaches using Swiss Similarity, databases like ZINC, ASINEX, and chEMBL. Molecular docking studies were also performed to understand the possible ligand‐receptor intermolecular interactions as well as their in vitro antibacterial activities were also studied.
Iodine-mediated direct synthesis of 3-iodoflavones Avinash M. Patil, Dayanand A. Kamble, Pradeep D. Lokhande Synthetic Communications, 2018 Molecular iodine has been used for the regioselective, one pot, direct synthesis of 3-iodoflavones from 2′-allyloxy chalcones, 2′-hydroxy chalcones and flavones. Allyl deprotection, cyclization dehydrogenation and α-iodination of 2′-allyloxychalcones has been achieved in a single step to offer 3-iodoflavones.
A Metal-Free Iodination of Aryl Ethers and Phenols Using I2 Avinash M. Patil, Dayanand A. Kamble, Pradeep D. Lokhande Chemistryselect, 2017 I 2 /DMSO mediated method for deprotection and selective iodination of allyl aryl ethers and phenols has been developed. A wide range of allyl aryl ethers and phenols have been efficiently iodinated to the respective iodophenols in one pot.
