Dr. Deborah Arimie Adah is a veterinarian, aquatic animal health researcher, and academic affiliated with the Department of Veterinary Medicine at the University of Ilorin, Nigeria. Her research focuses on aquaculture health management, antimicrobial use, and antimicrobial resistance (AMR) in fish farming systems, with particular emphasis on One Health–oriented interventions in low- and middle-income settings. Dr. Adah’s broader scholarly interests include Fish disease diagnosis, AMR, fish parasitology, water quality management, and disease prevention. She has worked on bacterial, parasitic, and environmental diseases of fish, particularly in Clarias gariepinus, and is actively involved in developing veterinary educational materials and training programs for students and practitioners.
She is committed to capacity building, policy-relevant research, and interdisciplinary collaboration aimed at strengthening aquatic veterinary education and mitigating AMR
EDUCATION
Doctor of Veterinary Medicine (DVM), Master's in Veterinary Medicine ( Aquatic Medicine ), Doctorate in Veterinary Medicine, Fellow College of Veterinary Surgeons, Nigeria (FCVSN)
Molecular characterization and antibiotics resistance of Aeromonas species isolated from farmed African catfish Clarias gariepinus Burchell, 1822 Deborah Arimie Adah, Lawal Saidu, Sonnie Joshua Oniye, Adakole Sylvanus Adah, Oluwafemi Babatunde Daoudu, et al. BMC Veterinary Research, 2024 Background Aeromonas species are one of the most important etiologies of diseases in fish farms, leading to clinical manifestation and mortality and are associated with public health risks. This study aimed to investigate the prevalence, phenotypic and molecular characteristics of Aeromonas species isolated from farmed Clarias gariepinus using 16 S rRNA sequencing. Additionally, their antibiogram and multiple antibiotic resistance index were determined using a disc diffusion test. Results A total of 230 Aeromonas strains were isolated from Clarias gariepinus with 40.9% obtained from diseased fish, and 25% isolated from apparently healthy ones. Five different species including Aeromonas caviae, Aeromonas veronii, Aeromonas hydrophila, Aeromonas dhakensis and Aeromonas enteropelogenes were fully identified and genetically characterized. Based on the available literature, this is the first report of Aeromonas enteropelogenes from the study area. The phylogenetic analysis showed genetic heterogeneity and distance within the species and the reference strains. The multiple resistant Aeromonas species were susceptible to ciprofloxacin, gentamycin, and florfenicol. The Aeromonas species’ multiple antibiotic resistance index values varied between 0.20 and 0.80 and were isolated from the farms where antibiotics were intensively used. Conclusions The diversity of multidrug-resistant Aeromonas species isolated from fish farms is a major threat to fish production giving us more understanding of epidemiology and the multidrug Aeromonas species with a MAR index of greater than 0.2 were isolated from farms where antibiotic use was widespread. As a result, a considerably increased danger of multiple antibiotic resistance spreading to the fish culture environment may impact aquaculture production. Hence there is a need for appropriate and monitored drug usage.
An in vivo and in silico predictive study on the toxicological and modulatory effects of abused substances on sperm quality and testicular function in Wistar rats Charles Obiora Nwonuma, Adeola Oluwaseun Adedoyin, Melody Onyemaka, Emenike Irokanulo, Omokolade Oluwaseyi Alejolowo, et al. Revista Colombiana De Ciencias Quimico Farmaceuticas Colombia, 2024 Introduction: Some compounds like Opioids that are commonly used may affect the biological system in addition to having a high potential for addiction. Objective: This study assessed the effects of commonly misused substances on sperm quality and testicular function in Wistar rats. Material and Methods: Twenty-five Wistar rats weighing an average of 120 ± 0.1 g were randomly assigned to five treatment groups and were orally administered with water for the control, carbonated sugar drink, 150, 300, and 300 mg/kg body weight doses of menthol, monosodium glutamate, and tramadol respectively. The rats were euthanized 24 hours after the last day of the thirty-day treatment. Biochemical assays were on carried out the plasma and testicular homogenate. Results: There was a significant increase (p<0.05) in testosterone, FSH, LH, HDL, TG, phospholipids, glycogen, reduced glutathione concentration, sperm total count; %testicular weight change, and; there was also a significant decrease in the %tail defect, and %non-motile sperm across the treatment groups compared to the control. Contrary, there was a significant increase (p<0.05) in the testicular ACP and Na-K ATPases activities but MDA levels decreased significantly across treatment groups. The ouabain-α-ATPase complex’s binding energy is comparable to that of the α-ATPase complexes with tramadol, glucose, menthol, and MSG, respectively. Conclusion: The improved sperm quality and testicular function show that these compounds were not harmful to the reproductive functions of Wistar rats. The docking analysis corroborated the effects of ATPase activity modulation on sperm motility.
Molecular docking and experimental validation of the effect of ergothioneine on heat shock protein-70 following endurance exercise by Arabian stallions Adakole Sylvanus Adah, Joseph Olusegun Ayo, Deborah Arimie Adah, Charles Obiora Nwonuma, Teslim Alabi Lawal BMC Veterinary Research, 2023 Background Exercise-induced oxidative stress is a challenge in equine sports. This study aims at determining the effects of ergothioneine on heat shock protein-70 (HSP-70) following the stress of an endurance exercise of 30 km by Arabian stallions. Molecular docking was also done to investigate the interaction between the ligand ergothioneine and heat shock protein-70 using sulfogalactosylceramide and sulfogalactoglycerolipid as standards. The study involved a total of 18 clinically healthy stallions, with an average age of 6.7 ± 2.4 years and an average weight of 411.54 ± 12.46 kg. Only clinically healthy stallions were selected as subjects. The stallions were divided into two groups of nine stallions each. Group I (ERGX) was administered ergothioneine at a dose of 0.02 mg/kg once daily orally for four weeks while group II (ERGN) was not administered ergothioneine. The activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were determined in the two groups before and post-exercise. The concentrations of malondialdehyde and HSP-70 were also determined. Results The results obtained showed that the activities of the antioxidant enzymes and concentration of HSP-70 were higher ( P < 0.05) in the ERGX group compared to the ERGN group. The concentration of malondialdehyde was however lower in the ERGX group. Following molecular docking, ergothioneine and the selected standards have common amino acids at the site of interaction with the target protein (HSP-70) suggesting that ergothioneine may have a modulatory effect on the synthesis of HSP-70. Conclusion The results obtained indicated that ergothioneine modulated the synthesis of HSP-70 and the biomarkers of oxidative stress. It was therefore concluded that ergothioneine may be beneficial to horses subjected to endurance exercise.
Prevalence and Risk Factors Associated with Aeromonas hydrophila infection in Clarias gariepinus and Pond Water from Fish Farms in Kaduna State, Nigeria. Jordan Journal of Biological Sciences, 2021