Dr. Devendra S. Shirode
@dyppharmaakurdi.ac.in
Associate Professor, Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune
Dr. Devendra S. Shirode
RESEARCH INTERESTS
hepatoprotective, antiulcer, antiobesity, analgesic, nephroprotective, antidiabetic, dermal toxicity etc.
Scopus Publications
Scopus Publications
Devika Jadhav, Nikita Saraswat, Neeraj Vyawahare, and Devendra Shirode
Springer Science and Business Media LLC
Abstract Introduction Alzheimer’s disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of life. Clinically, it is distinguished by a transition from episodic memory to a gradual reduction in cognitive ability leading to cognitive dysfunction. Neurofibrillary tangles and amyloid plaques are unique structures that are thought to have a role in the pathogenesis of Alzheimer's disease. In this review, we focus our attention on the risk factors, pathophysiology, etiology, epidemiology, stages, diagnosis, treatment, mechanisms, pathways, ongoing clinical trials data and risks potentially associated with the development of Alzheimer's disease. Short summary This review aims to extrapolate the information about Alzheimer's disease. Preliminary research was done by selecting reviews on PubMed, Elsevier, and Google open-access publications using the keywords like “Alzheimer, dementia, neurodegenerative, memory, amyloid β, mechanism of action, pathways”. Conclusion Here we show the discussion and interpretation of several signaling pathways in the pathogenesis of Alzheimer's disease such as amyloid β plaque cleavage, Metal ion hypothesis, amyloid β degradation, initiation of amyloidogenic and non-amyloidogenic pathway, oxidative stress hypothesis, Metabolic syndrome, insulin resistance and tau phosphorylation associated apolipoprotein- cholesterol, neurofibrillary tangles accumulation, and insulin resistance which are significant for better understanding of the disease initiation and progression. On studying the ongoing clinical trials, it was found that current drugs being tested are crenezumab, gantenerumab and sodium oligonucleotide. Graphical Abstract
Devendra S. Shirode, Priyatama Powar, Brijendra B. Jain, and Amit Agarwal
A and V Publications
Devendra S. Shirode, Brijendra B. Jain, and C.B. Mahendra Kumar
Oriental Scientific Publishing Company
The present investigation was aimed to study the effect of ethanol extract of Sphaeranthus indicus against rifampicin induced hepatotoxicity in rats. The 70 % ethanol extract of aerial part of Sphaeranthus indicus (SIEE) at the doses of 200 and 400 mg/kg and silymarin 100 mg/kg were administered to the rifampicin challenged rats. The effect of SIEE and silymarin on physical (wet liver weight, liver volume) and biochemical parameters (SGOT, SGPT, ALP, direct and total Bilirubin) were measured in rifampicin induced hepatotoxicity in rats. Similarly, hepatic tissues were subjected to histopathological observations and in-vivo antioxidant activity (tissue glutathione and lipid peroxidation levels). Treatment with SIEE (200mg/ kg and 400mg/kg) reduced the elevated levels of above mentioned physical parameters and biochemical markers of hepatotoxicity. Histopathological findings and in vivo antioxidants studies also confirmed that SIEE possess hepatoprotective effects. The hepatoprotective and in vivo antioxidant properties may be attributed to the polyphenolic compounds like flavonoids, saponins and tannins that are present in the SIEE.