DEVI M

@apdch.in

Professor department of Oral Pathology
Adhiparasakthi Dental college and hospital

DEVI M


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EDUCATION

2006
MDS
Ragas dental college and hospital

2000
BDS
Mahatma Gandhi Post Graduate Institute of Dental Sciences

RESEARCH INTERESTS

Immunohistochemistry Markers
oral Squamous cell carcinoma
13

Scopus Publications

142

Scholar Citations

1

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Estimation of Salivary Ferritin Levels in Subjects with Chronic Periodontitis with Type 2 Diabetes Mellitus
    Adhithya Baskaran, V Ramya, A Beeula, S Shamala, M Devi, Kokila Sivakumar
    Indian Journal of Dental Research, 2024
    Background: Ferritin is an iron storage protein essential for iron homeostasis regulation and an indicator of iron stores. It is an acute phase reactant and is elevated in inflammation and chronic infection. Periodontitis is a chronic inflammatory disease with periodontopathogens possessing haemolytic activity which leads to increased local iron concentration and iron disorder. Inflammation and excess systemic iron are mediating risk factors of type 2 diabetes mellitus. Aim: To evaluate and compare the salivary ferritin levels in subjects with chronic periodontitis with and without type 2 diabetes mellitus. Methodology: Unstimulated saliva sample was collected by standardized spitting technique from 45 individuals, aged between 30 and 65 years divided into three groups. Group I-Healthy individuals, Group II-Subjects with chronic periodontitis with type 2 diabetes mellitus, Group III-Subjects with chronic periodontitis without type 2 diabetes mellitus. The salivary ferritin levels are analysed using latex-enhanced turbidimetric assay in an autoanalyzer. Results: The salivary ferritin level was elevated in chronic periodontitis with type 2 diabetes mellitus (Group II) and in chronic periodontitis without type 2 diabetes mellitus (Group III).
  • Self-negligence and awareness among oral precancerous and cancer patients - A cross-sectional questionnaire study
    Vezhavendhan Nagaraj, S Priya, Sivaramakrishnan Muthanandam, M Devi, Umamaheswari Giri, M Aravind Babu
    Journal of Oral and Maxillofacial Pathology, 2023
    Background:The National Institute of Health and Family Welfare (NIHFW) reports that India has the highest global prevalence of oral cancers. The incidence is significantly more in developing countries when compared to the developed countries. Early detection is key to increasing the survival rate of the patients. Important causes for this late diagnosis could be self-negligence, lack of patient awareness about the causes and asymptomatic and subtle clinical presentation of the lesions.Aim:To assess the causes of self-neglect and awareness levels among oral cancer and pre-cancerous patients.Settings and Design:A cross-sectional questionnaire study was conducted among pre-cancerous and cancerous patients.Methods and Material:A questionnaire with 16 closed-ended questions was framed relating to the causes of self-neglect and awareness of the patients. A total of 45 patients were selected by convenient sampling technique from the Institutional Tumour Board register of which 62 per cent were male patients and 38 per cent were female patients.Statistical Analysis:Data analysis for demographic data, patients' awareness, and causes of self-neglect about precancer and cancer was done using SPSS Version 10.Results and Conclusions:The present study concluded that the patients had adequate awareness that deleterious habits could lead to cancer but had a low level of awareness about the other causes of cancer, symptoms and management options available to treat cancer. The study result emphasizes that the government should plan for more cancer-screening camps in order to prevent the progression of cancer and to increase the awareness.Reference I.D.:2015-05006 for funding the project.ICMR)
  • A large aneurysmal bone cyst of mandible: A rare case report
    S. Shamala, A Beeula, M Devi, P Hariganesh
    Journal of Oral and Maxillofacial Pathology, 2023
    An aneurysmal bone cyst (ABC) is a rare benign tumor-like lesion, described as an expanding osteolytic lesion consisting of blood-filled spaces of variable sizes separated by connective tissue septa. It is frequently accompanied by multiple cystic lesions due to aggressive hemodynamics with reactive bone formation and a genetic predisposition. This lesion has been classified as an atypical giant cell tumor or benign bone cyst. ABC has an incidence of 0.5% and comprises approximately around 1.5% of all non-odontogenic and non-epithelial cysts of the jaws. About 50% of the ABCs are reported in long bones and the vertebral column and only 2% have been reported to involve jaw bones. This case report gives an overview of a very large size ABC of the mandible in a 14-year-old male patient.
  • Awareness of probiotics among dental practitioners of Puducherry - A cross-sectional questionnaire study
    Vidyalakshmi Santhanam, M Devi, R Aravindan, Rajaram Suganya, Santhadevy Aroumugam, M Aravind Babu
    Journal of Oral and Maxillofacial Pathology, 2022
    Background: The efficiency of probiotics in prevention and also treatment of oral infections including dental caries, periodontitis, halitosis is found to be appealing in the recent literature. Their antagonistic role in oral infections is mainly through formation of biofilm which needs documentation. Though the emergence and practice of oral probiotics is visualized for the past two decades, the consumption and knowledge level is found to be less among the community. Stronger source to spread scientific evidence to the community would be health professionals. Aim: The current study is aimed at assessing the level of awareness of probiotics among dental practitioners of Puducherry thereby aid and assist in the beneficial practice of the same in the community. Methods: The knowledge level was assessed through a cross sectional survey using closed ended questionnaire. Involves practicing dentists of Puducherry (n-173). A prevalidated questionnaire with 17 closed ended and one open ended question was employed as the research tool. Results: The results revealed an acceptable knowledge in 77.4% and a greater level of knowledge in 20.8% of dentists. More number of studies are expected to fulfill the lacunae in the field of safety of usage and long term effects of probiotics. Conclusion: Responses of the current study which was focused on dental practitioners revealed that the knowledge level is well above the acceptable level. There is no profound difference in the awareness level noticed among BDS and MDS practitioners..
  • Novel approach to the clinical management of completely edentulous Hepatitis B carrier patient
    J. Dhivya Priya, A. Angeline Daisy, M. Karthika Devi, C. Raahini
    Journal of Pharmacy and Bioallied Sciences, 2021
    Incidence of infections is more common in the dental practice. In this article, we describe a novel approach to the clinical management of a completely edentulous patient who is in hepatitis B carrier state including infection control protocol for all clinical and laboratory steps. Furthermore, a novel method of incorporating patient's medical history in the form of a QR code in the processed denture is also described.
  • Immunohistochemical detection of 8-hydroxydeoxyguanosine: A biomarker of oxidative DNA damage in oral submucous fibrosis
    Chandramohan Kulasekaran, M Devi, K Dhivya, D Vijayalakshmi, M Sathishkumar, A Madhanmohan
    Journal of Oral and Maxillofacial Pathology, 2020
    Background: Oral submucous fibrosis (OSMF) is one of the common potentially malignant disorders prevailing in India. The primary etiological factors include tobacco and arecanut, which contain numerous reactive oxygen species (ROS). ROS attack guanine bases in DNA and form 8-hydroxydeoxyguanosine (8-OHdG), which can be detected in patients who have diseases associated with oxidative stress. The oxidative DNA damage produced by oxidative stress may induce malignant transformation. Aim: The aim of the present study is to detect the expression of 8-OHdG in OSMF patients and compare the expression within different grades of OSMF and also normal buccal mucosa. Materials and Methods: A total of 30 samples were examined for the immunohistochemical expression of 8-OHdG. The control group included 10 formalin-fixed paraffin-embedded tissue blocks of the normal buccal mucosa. The study group includes 20 cases of formalin-fixed paraffin-embedded tissue blocks of OSMF (5 cases in each grade of very early, early, moderately advanced and advanced cases of OSMF). Three-micron thick tissue sections were made from each sample and stained with 8-OHdG antibody. The results were statistically analyzed using Kruskal–Wallis and Mann–Whitney U test Results: Statistically significant difference exists in the intensity of 8-OHdG expression between the study groups. The P-value obtained was <0.001, which was highly statistically significant. Conclusion: The present study is the first attempt to evaluate the expression of 8-OHdG in tissue samples of OSMF that revealed the role of free radicals and oxidative DNA damage in these patients. Further research with larger sample size, clinicopathologic correlation and long-term follow-up will shed more light on the pathogenesis of OSMF. It will also be useful for the development of new therapeutic strategies targeting treatment modalities for OSMF.
  • Memory T cells (CD45RO) role and evaluation in pathogenesis of lichen planus and lichenoid mucositis
    Mani Devi
    Journal of Clinical and Diagnostic Research, 2017
    INTRODUCTION Memory T cells have the ability to survive in a quiescent state for longer periods and are responsible for the rapid responses on subsequent exposure to antigen. Analyzing memory T cells in Oral Lichen planus (OLP) and Lichenoid Mucositis (LM) suggest that these cells may play a role in the immunopathogenic mechanisms. AIM To identify and evaluate Memory T cells in Lichen Planus (LP), Lichenoid Mucositis (LM) and Normal Mucosa (NM) using CD45RO monoclonal antibody immunohistochemically. MATERIALS AND METHODS A total of 30 cases (15 cases of OLP and 15 cases of LM) clinically and histopathologically diagnosed, and 10 cases of NM were stained for CD45RO monoclonal antibody, immunohistochemically using Biotin Streptavidin method. Staining intensity of CD45RO expression was statistically analysed using Chi-square Test. RESULTS The present study demonstrated a higher expression of CD45RO in connective tissue layer of OLP (53.3% intense staining) when compared to LM (20% intense staining) and no intense staining in NM. The difference in staining intensity pattern between the study groups was statistically significant (p=0.014). CONCLUSION This study demonstrates a statistically significant rise in memory T cells in LP than in LM, indicating the possible different immunopathogenic mechanisms.
  • Oral pigmentation: A review
    C Sreeja, K Ramakrishnan, D Vijayalakshmi, M Devi, I Aesha, B Vijayabanu
    Journal of Pharmacy and Bioallied Sciences, 2015
    Pigmentations are commonly found in the mouth. They represent in various clinical patterns that can range from just physiologic changes to oral manifestations of systemic diseases and malignancies. Color changes in the oral mucosa can be attributed to the deposition of either endogenous or exogenous pigments as a result of various mucosal diseases. The various pigmentations can be in the form of blue/purple vascular lesions, brown melanotic lesions, brown heme-associated lesions, gray/black pigmentations.
  • Odontogenic myxoma of maxilla: A rare presentation in an elderly female
    C Sreeja, N Bharath, I Aesha, VSadesh Kannan, M Devi, B Vijayabanu
    Journal of Pharmacy and Bioallied Sciences, 2015
    Odontogenic myxomas are rare benign neoplasm of mesenchymal origin, comprising 3–6% of all odontogenic tumors. They are slow growing, non-metastasizing, often asymptomatic with local aggressiveness due to its infiltrative nature and hence high recurrence rate, with a high incidence of occurrence in the mandible. Most frequently occurs in second to third decade of life, seldom occurs beyond these age groups. Hereby, we present a case of odontogenic myxoma occurring in the maxilla in a 65-year-old female managed by partial maxillectomy.
  • Multiple myeloma involving mandible: In an elderly female
    C Sreeja, B Vijayabanu, D Vijayalakshmi, M Devi, K Ramakrishnan, K Dhivya
    Journal of Pharmacy and Bioallied Sciences, 2015
    Multiple myeloma (MM) is a malignancy of plasma cell origin. It often has a multicentric origin within the bone. It makes about 1% of all malignancies and 15% of all hematologic malignancies. There is a monoclonal proliferation of abnormal plasma cells in this disease that arise from a single malignant precursor that has undergone uncontrolled mitotic division. These cells in turn produce one type of immunoglobulin light chain, either kappa or lambda. Unifocal, monoclonal proliferation of plasma cells is called plasmacytoma. Hereby, we present a case of a 65-year-old female patient who presented with a swelling of the mandible. The uniform sheets of plasma cells in the histopathology punched out radiolucencies in skull radiograph and the blood picture of anemia and hypercalcemia, confirmed the case as MM.
  • Langerhans cells in lichen planus and lichenoid mucositis an immunohistochemical study
    M Devi, TR Saraswathi, K Ranganathan, D Vijayalakshmi, C Sreeja, SShabana Fathima
    Journal of Pharmacy and Bioallied Sciences, 2014
  • Recurrent peripheral odontogenic fibroma associated with basal cell budding
    C Sreeja, N Vezhavendan, F Shabana, D Vijayalakshmi, M Devi, N Arunakiry
    Journal of Pharmacy and Bioallied Sciences, 2014
  • Malignant fibrous histiocytoma of the gingiva
    D. Vijayalakshmi, S. Fathima, K. Ramakrishnan, M. Devi
    BMJ Case Reports, 2012

RECENT SCHOLAR PUBLICATIONS

  • Oral pigmentation: a review
    C Sreeja, K Ramakrishnan, D Vijayalakshmi, M Devi, I Aesha, ...
    Journal of Pharmacy and Bioallied Sciences 7 (Suppl 2), S403-S408 , 2015
    2015
    Citations: 142

MOST CITED SCHOLAR PUBLICATIONS

  • Oral pigmentation: a review
    C Sreeja, K Ramakrishnan, D Vijayalakshmi, M Devi, I Aesha, ...
    Journal of Pharmacy and Bioallied Sciences 7 (Suppl 2), S403-S408 , 2015
    2015
    Citations: 142