Scopus Publications
- Clinical and Ultrasonographic Characterization of the Transition from Hashimoto Thyroiditis to Graves' Disease: A Long-term Follow-up Study
Alberto Vassallo, Francesca Ferrari, Luigi di Filippo, Francesca Perticone, Laura Castellino, et al.
Endocrine, 2026 - Increased prevalence of morphometric vertebral fractures in patients with hypercalcitoninemia due to medullary thyroid carcinoma
Luigi di Filippo, Vincenzo Franzese, Giuseppina Incampo, Anna Maria Formenti, Lucrezia Albanese, et al.
Bone, 2026 - Vertebral fractures may occur early in the history of Cushing disease associating with male gender and degree of cortisol secretion
Luigi di Filippo, Stefano Frara, Umberto Terenzi, Sara Menotti, Pietro Mortini, et al.
Pituitary, 2026 - Osteometabolic complications in patients with secreting pituitary adenomas: Is there an impact of gender?
Luigi di Filippo, Matteo Acanfora, Simona Bolamperti, Umberto Terenzi, Maristella Bonomo, et al.
Pituitary, 2026 - Consensus on acromegaly complications: an update
Andrea Giustina, Luigi di Filippo, Maria Fleseriu, Rosario Pivonello, Stephan Petersenn, et al.
Pituitary, 2026 - Vitamin D in Gut and Systemic Immune Tolerance and in Infections’ Risk: An International Evidence-Based Consensus Statement
John P. Bilezikian, Luigi di Filippo, Antonio Bianchi, Daniel D. Bikle, Neil Binkley, et al.
Reviews in Endocrine and Metabolic Disorders, 2026 - Consensus statement on vitamin D role in metabolic health
Andrea Giustina, Luigi di Filippo, Aneta Aleksova, Jens Bollerslev, Anna Maria Colao, et al.
Metabolism Clinical and Experimental, 2026 - Vitamin D in the elderly: the phil-rouge in preventing bone, muscle and adipose deterioration?
Archives of Endocrinology and Metabolism, 2026 - Chronic cholecalciferol supplementation and adequate vitamin D status are associated with reduced risk of Long COVID
Luigi di Filippo, Umberto Terenzi, Simona Bolamperti, Camilla Bechini, Simonetta Bossoni, et al.
Journal of Endocrinological Investigation, 2026 - X-Linked Hypophosphatemia: Role of Fibroblast Growth Factor 23 on Human Skeletal Muscle-Derived Cells
I. Falsetti, G. Palmini, S. Donati, C. Aurilia, R. Zonefrati, et al.
Calcified Tissue International, 2025
X-linked hypophosphatemia (XLH) is a rare and progressive disease, due to inactivating mutations in the phosphate-regulating endopeptidase homolog X-linked (PHEX) gene. These pathogenic variants result in elevated circulating levels of fibroblast growth factor 23 (FGF23), responsible for the main clinical manifestations of XLH, such as hypophosphatemia, skeletal deformities, and mineralization defects. However, XLH also involves muscular disorders (muscle weakness, pain, reduced muscle density, peak strength, and power). Although XLH is characterized by muscle disorders, to date there are few studies on the action of FGF23 on muscle. Therefore, this study aims to evaluate the effects of FGF23 in an in vitro model of skeletal muscle satellite cells derived from human biopsies (hSMCs). After isolating and characterizing three lines of hSMCs from three volunteers, we evaluated the effect of FGF23 on the proliferative and myogenic differentiation process. We observed that none of the three concentrations of FGF23 tested (1, 10, 100 ng/mL) affected the proliferative process after 48 h of treatment. On the contrary, after 24 and 48 h of treatment, FGF23 resulted in a significant reduction in the gene expression of the myogenic regulatory factors family (Myf-5, MyoD-1, Myogenin, and MRF4), irisin, myosin heavy chain, myostatin, desmin, FGF23 receptors (FGRF1-4) and KLOTHO coreceptor. We, therefore, hypothesized that FGF23 is directly involved in the muscular disorders that characterize XLH, and clarifying these effects at the molecular and cellular level is essential to elucidate XLH pathogenesis and, consequently, its management. - Bone status in patients with chronic hypoparathyroidism: results from the Italian HypoparaNET database
Francesca Marini, Francesca Giusti, Blandine Weiss, Michel Ovize, Salvatore Benvenga, et al.
Aging Clinical and Experimental Research, 2025 - Postvaccine early-onset (PoVEO) forms of Graves’ disease after anti-SARS-CoV-2 vaccination are characterized by favourable long-term disease outcomes
Luigi di Filippo, Matteo Acanfora, Alberto Vassallo, Fanny Valsecchi, Laura Castellino, et al.
Endocrine, 2025 - Consensus on acromegaly therapeutic outcomes: an update
Shlomo Melmed, Luigi di Filippo, Maria Fleseriu, Moisés Mercado, Niki Karavitaki, et al.
Nature Reviews Endocrinology, 2025 - Non-classical congenital adrenal hyperplasia: current insights into clinical implications, diagnosis and treatment
Paola Loli, Sara Menotti, Luigi di Filippo, Andrea Giustina
Endocrine, 2025 - Pathophysiology and evaluation of bone health in adrenal diseases
M. M. Uygur, L. di Filippo, S. Frara, S. Menotti, A. Giustina
Endocrine, 2025 - Obesity and blunted FGF23 response associate with kidney impairment in patients with hypoparathyroidism
Luigi di Filippo, Agnese Allora, Anna Maria Formenti, Francesca Ferrari, Marta Villanova, et al.
Endocrine, 2025 - Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence
Luigi di Filippo, Mauro Doga, Francesca Mangini, Licia Gifuni, Seynt Jiro Sahagun, et al.
Journal of Endocrinological Investigation, 2025 - Hypophosphatemic rickets in an Italian multicentric cohort of 24 subjects: a clinical and molecular characterisation
R. Chimenz, C. Columbu, F. Pugliese, A. Arena, L. Bonifazi Meffe, et al.
Endocrine, 2025 - Vitamin D Deficiency and Type 2 Diabetes: The Dangerous Link Between Two Modern Pandemics
Luigi di Filippo, Andrea Giustina
Journal of Clinical Endocrinology and Metabolism, 2025 - New onset of Graves' disease after controlled ovarian stimulation: A case report and brief literature review
Alberto Vassallo, Luigi Di Filippo, Stefano Frara, Massimo Bertoli, Mauro Pagani, et al.
International Journal of Gynecology and Obstetrics, 2025 - Response to letter to the editor “Hypopituitarism and COVID-19, what else?”
Giulia Carosi, Giovanna Mantovani, Luigi Di Filippo, Andrea Giustina
Pituitary, 2025 - New-Onset Graves’ Disease and Type 1 Diabetes After COVID-19 and Anti-SARS-CoV-2 Vaccination
Luigi di Filippo, Umberto Terenzi, Sara Menotti, Simona Santoro, Mauro Doga, et al.
Thyroid Diabetes and Osteoporosis the Bermuda Triangle, 2025 - Latest on Anabolic Agents for Osteoporosis Treatment
Luigi di Filippo, Clifford J. Rosen
Endocrinology and Metabolism Clinics of North America, 2024 - Growth hormone and bone: a basic perspective
Simona Bolamperti, Isabella Villa, Luigi di Filippo
Pituitary, 2024 - Long COVID and pituitary dysfunctions: a bidirectional relationship?
Luigi di Filippo, Vincenzo Franzese, Simona Santoro, Mauro Doga, Andrea Giustina
Pituitary, 2024 - Hypophysitis in COVID-19: a systematic review
Sara Menotti, Luigi di Filippo, Umberto Terenzi, Sabrina Chiloiro, Laura De Marinis
Pituitary, 2024 - Correction: Novel protective circulating miRNA are associated with preserved vitamin D levels in patients with mild COVID-19 presentation at hospital admission not progressing into severe disease (Endocrine, (2024), 86, 1, (119-123), 10.1007/s12020-024-03900-6)
Luigi di Filippo, Umberto Terenzi, Giovanni Di Ienno, Silvia Trasciatti, Silvano Bonaretti, et al.
Endocrine, 2024 - Copeptin after pituitary surgery: is it worth measuring?
Pietro Maffei, Luigi di Filippo
Pituitary, 2024 - Novel protective circulating miRNA are associated with preserved vitamin D levels in patients with mild COVID-19 presentation at hospital admission not progressing into severe disease
Luigi di Filippo, Umberto Terenzi, Giovanni Di Ienno, Silvia Trasciatti, Silvano Bonaretti, et al.
Endocrine, 2024 - V600E BRAF-mutated anaplastic thyroid carcinoma after radioactive iodine for Graves’ disease: a case report and a review of the literature
Marta Villanova, Luigi di Filippo, Filippo Maria Bolamperti, Carlo Rodella, Laura Castellino, et al.
Clinical and Translational Imaging, 2024 - Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows
Andrea Giustina, John P Bilezikian, Robert A Adler, Giuseppe Banfi, Daniel D Bikle, et al.
Endocrine Reviews, 2024 - New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases
Luigi di Filippo, John P. Bilezikian, Ernesto Canalis, Umberto Terenzi, Andrea Giustina
Endocrine, 2024 - High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma
Stefano Frara, Meliha Melin Uygur, Filippo Bolamperti, Luigi di Filippo, Mauro Doga, et al.
Pituitary, 2024 - Transition from Hashimoto thyroiditis to Graves’s Disease: an unpredictable change?
Alberto Vassallo, Francesca Ferrari, Luigi di Filippo, Andrea Giustina, Paola Loli
Endocrine, 2024 - Correction: Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta‑analysis (Reviews in Endocrine and Metabolic Disorders, (2024), 25, 2, (447-448), 10.1007/s11154-023-09837-x)
Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A. Adler, Neil Binkley, et al.
Reviews in Endocrine and Metabolic Disorders, 2024 - Fat-to-blood recirculation of partially dysfunctional PD-1+CD4 Tconv cells is associated with dysglycemia in human obesity
Anna Giovenzana, Eugenia Bezzecchi, Anita Bichisecchi, Sara Cardellini, Francesca Ragogna, et al.
Iscience, 2024 - Use of vitamin D with anti-osteoporotic drugs: are available clinical trials telling us the whole story?
Luigi di Filippo, Fabio Massimo Ulivieri, Ranuccio Nuti, Andrea Giustina
Endocrine, 2024 - Response to the Letter to the Editor From Min et al: Low Vitamin D Levels are Associated With Long COVID Syndrome in COVID-19 Survivors
Luigi di Filippo, Stefano Frara, Andrea Giustina
Journal of Clinical Endocrinology and Metabolism, 2024 - Tissue location of SARS-CoV-2 RNA: A focus on bone and implications for skeletal health
Edoardo Guazzoni, Luigi di Filippo, Alberto Castelli, Andrea Giustina, Federico Grassi
Management Body Systems and Case Studies in Covid 19, 2024 - Cholecalciferol Use Is Associated With a Decreased Risk of Incident Morphometric Vertebral Fractures in Acromegaly
Sabrina Chiloiro, Stefano Frara, Irene Gagliardi, Antonio Bianchi, Antonella Giampietro, et al.
Journal of Clinical Endocrinology and Metabolism, 2024 - Lack of vitamin D predicts impaired long-term immune response to COVID-19 vaccination
Luigi di Filippo, Stefano Frara, Umberto Terenzi, Fabrizio Nannipieri, Massimo Locatelli, et al.
Endocrine, 2023 - Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis
Andrea Giustina, Luigi di Filippo, Antonio Facciorusso, Robert A. Adler, Neil Binkley, et al.
Reviews in Endocrine and Metabolic Disorders, 2023 - Longitudinal Changes in Physical Function and Their Impact on Health Outcomes in COVID-19 Patients
Rebecca De Lorenzo, Luigi Di Filippo, Sabrina Scelfo, Aurora Merolla, Andrea Giustina, et al.
Nutrients, 2023 - Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors
Luigi di Filippo, Stefano Frara, Fabrizio Nannipieri, Alice Cotellessa, Massimo Locatelli, et al.
Journal of Clinical Endocrinology and Metabolism, 2023 - Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization
Luigi di Filippo, Melin Uygur, Massimo Locatelli, Fabrizio Nannipieri, Stefano Frara, et al.
Endocrine, 2023 - Modern approach to resistant acromegaly
Andrea Giustina, Luigi di Filippo, Melin M. Uygur, Stefano Frara
Endocrine, 2023 - New tools for bone health assessment in secreting pituitary adenomas
Meliha Melin Uygur, Stefano Frara, Luigi di Filippo, Andrea Giustina
Trends in Endocrinology and Metabolism, 2023 - High prevalence of adrenal cortical adenomas in patients with cerebral meningiomas
L. di Filippo, S. La Marca, M. Losa, M. S. Lena, R. Mapelli, et al.
Journal of Endocrinological Investigation, 2023 - Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?
Andrea Giustina, Luigi di Filippo, Agnese Allora, Daniel D. Bikle, Giulia Martina Cavestro, et al.
Reviews in Endocrine and Metabolic Disorders, 2023 - Distinct Clinical Features of Post-COVID-19 Vaccination Early-onset Graves' Disease
Luigi di Filippo, Laura Castellino, Agnese Allora, Stefano Frara, Roberto Lanzi, et al.
Journal of Clinical Endocrinology and Metabolism, 2023 - The osteo-metabolic phenotype of COVID-19: an update
Luigi di Filippo, Stefano Frara, Mauro Doga, Andrea Giustina
Endocrine, 2022 - Ultrasound and FibroScan® Controlled Attenuation Parameter in patients with MAFLD: head to head comparison in assessing liver steatosis
Andrea Salmi, Luigi di Filippo, Clarissa Ferrari, Stefano Frara, Andrea Giustina
Endocrine, 2022 - Novel approaches to bone comorbidity in Cushing’s disease: an update
Stefano Frara, Luigi di Filippo, Mauro Doga, Paola Loli, Felipe F. Casanueva, et al.
Pituitary, 2022 - Vertebral fractures at hospitalization predict impaired respiratory function during follow-up of COVID-19 survivors
Luigi di Filippo, Nicola Compagnone, Stefano Frara, Agnese Allora, Mauro Doga, et al.
Endocrine, 2022 - A novel evidence-based algorithm to predict thromboembolism in patients with COVID-19: preliminary data from a single-center cohort
Giuseppe A. RAMIREZ, Stefania L. CALVISI, Rebecca DE LORENZO, Valentina DA PRAT, Giorgia BORIO, et al.
Minerva Medica, 2022 - High Prevalence of Vertebral Fractures Associated With Preoperative GH Levels in Patients With Recent Diagnosis of Acromegaly
Stefano Frara, Meliha Melin Uygur, Luigi di Filippo, Mauro Doga, Marco Losa, et al.
Journal of Clinical Endocrinology and Metabolism, 2022 - Role of chromogranin A-derived fragments after resection of nonfunctioning pancreatic neuroendocrine tumors
V. Andreasi, S. Partelli, M. F. Manzoni, F. Muffatti, L. Di Filippo, et al.
Journal of Endocrinological Investigation, 2022 - Biobanking for COVID-19 research
Patrizia ROVERE-QUERINI, Cristina TRESOLDI, Caterina CONTE, Annalisa RUGGERI, Silvia GHEZZI, et al.
Panminerva Medica, 2022 - Vitamin D in Osteosarcopenic Obesity
Luigi Di Filippo, Rebecca De Lorenzo, Andrea Giustina, Patrizia Rovere-Querini, Caterina Conte
Nutrients, 2022 - Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications
Luigi di Filippo, Mauro Doga, Stefano Frara, Andrea Giustina
Reviews in Endocrine and Metabolic Disorders, 2022 - COVID-19 and hypopituitarism
Stefano Frara, Paola Loli, Agnese Allora, Chiara Santini, Luigi di Filippo, et al.
Reviews in Endocrine and Metabolic Disorders, 2022 - Adrenal schwannoma: why should endocrinologists be aware of this uncommon tumour?
Giuseppina Incampo, Luigi Di Filippo, Erika Maria Grossrubatscher, Paolo Dalino Ciaramella, Stefano Frara, et al.
Endocrine, 2022 - Occurrence and response to treatment of Graves’ disease after COVID vaccination in two male patients
Luigi di Filippo, Laura Castellino, Andrea Giustina
Endocrine, 2022 - Vitamin D Levels Are Associated with Blood Glucose and BMI in COVID-19 Patients, Predicting Disease Severity
Luigi di Filippo, Agnese Allora, Mauro Doga, Anna Maria Formenti, Massimo Locatelli, et al.
Journal of Clinical Endocrinology and Metabolism, 2022 - Hypocalcemia in COVID-19 is associated with low vitamin D levels and impaired compensatory PTH response
Luigi di Filippo, Agnese Allora, Massimo Locatelli, Patrizia Rovere Querini, Stefano Frara, et al.
Endocrine, 2021 - Adiponectin to leptin ratio reflects inflammatory burden and survival in COVID-19: Adiponectin and leptin in COVID-19
Luigi Di Filippo, Rebecca De Lorenzo, Clara Sciorati, Annalisa Capobianco, Nicola I. Lorè, et al.
Diabetes and Metabolism, 2021 - Weight trajectories and abdominal adiposity in COVID-19 survivors with overweight/obesity
Luigi Di Filippo, Rebecca De Lorenzo, Elena Cinel, Elisabetta Falbo, Marica Ferrante, et al.
International Journal of Obesity, 2021 - The emerging osteo-metabolic phenotype of COVID-19: clinical and pathophysiological aspects
Luigi di Filippo, Stefano Frara, Andrea Giustina
Nature Reviews Endocrinology, 2021 - Epicardial adipose tissue characteristics, obesity and clinical outcomes in COVID-19: A post-hoc analysis of a prospective cohort study
Caterina Conte, Antonio Esposito, Rebecca De Lorenzo, Luigi Di Filippo, Anna Palmisano, et al.
Nutrition Metabolism and Cardiovascular Diseases, 2021 - COVID-19 and the pituitary
Stefano Frara, Agnese Allora, Laura Castellino, Luigi di Filippo, Paola Loli, et al.
Pituitary, 2021 - COVID-19 is associated with clinically significant weight loss and risk of malnutrition, independent of hospitalisation: A post-hoc analysis of a prospective cohort study
Luigi Di Filippo, Rebecca De Lorenzo, Marta D'Amico, Valentina Sofia, Luisa Roveri, et al.
Clinical Nutrition, 2021 - Effects of Medical Treatment of Prostate Cancer on Bone Health
Anna Maria Formenti, Alberto Dalla Volta, Luigi di Filippo, Alfredo Berruti, Andrea Giustina
Trends in Endocrinology and Metabolism, 2021 - Osteopathy in mild adrenal Cushing's syndrome and Cushing disease
Stefano Frara, Agnese Allora, Luigi di Filippo, Anna Maria Formenti, Paola Loli, et al.
Best Practice and Research Clinical Endocrinology and Metabolism, 2021 - Radiological Thoracic Vertebral Fractures are Highly Prevalent in COVID-19 and Predict Disease Outcomes
Luigi di Filippo, Anna Maria Formenti, Mauro Doga, Erika Pedone, Patrizia Rovere-Querini, et al.
Journal of Clinical Endocrinology and Metabolism, 2021 - Hypocalcemia is a distinctive biochemical feature of hospitalized COVID-19 patients
Luigi di Filippo, Anna Maria Formenti, Mauro Doga, Stefano Frara, Patrizia Rovere-Querini, et al.
Endocrine, 2021 - Hypocalcemia: the quest for the cause of a major biochemical feature of COVID-19
Luigi di Filippo, Anna Maria Formenti, Andrea Giustina
Endocrine, 2020 - Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study
Vito Lampasona, Massimiliano Secchi, Marina Scavini, Elena Bazzigaluppi, Cristina Brigatti, et al.
Diabetologia, 2020 - Are women with osteoporosis treated with denosumab at risk of severe COVID-19?
Anna Maria Formenti, Erika Pedone, Luigi di Filippo, Fabio Massimo Ulivieri, Andrea Giustina
Endocrine, 2020 - COVID-19: Pharmacology and kinetics of viral clearance
Nicola Farina, Giuseppe A. Ramirez, Rebecca De Lorenzo, Luigi Di Filippo, Caterina Conte, et al.
Pharmacological Research, 2020 - Total thyroidectomy versus lobectomy: Surgical approach to T1-T2 papillary thyroid cancer
Luigi Di Filippo, Gioacchino Giugliano, Marta Tagliabue, Sara Gandini, Federica Sileo, et al.
Acta Otorhinolaryngologica Italica, 2020 - Hyperprolactinemia and bone
Luigi di Filippo, Mauro Doga, Eugenia Resmini, Andrea Giustina
Pituitary, 2020 - Hypocalcemia is highly prevalent and predicts hospitalization in patients with COVID-19
Luigi Di Filippo, Anna Maria Formenti, Patrizia Rovere-Querini, Michele Carlucci, Caterina Conte, et al.
Endocrine, 2020 - A complete flaccid quadriparesis as early presentation of Graves’ disease
L. Di Filippo, E. Bosi, S. Martinenghi
Journal of Endocrinological Investigation, 2020 - Cervix neuroendocrine carcinoma presenting with severe hypokalemia and Cushing’s syndrome
Luigi Di Filippo, Giordano Vitali, Gianluca Taccagni, Federica Pedica, Giulia Guaschino, et al.
Endocrine, 2020 - Vasostatin-1: A novel circulating biomarker for ileal and pancreatic neuroendocrine neoplasms
Andrea Corsello, Luigi Di Filippo, Sara Massironi, Federica Sileo, Anna Dolcetta Capuzzo, et al.
Plos One, 2018
