Rassoul Dinarvand
@tums.ac.ir
Faculty of Pharmacy
Tehran University of Medical Sciences
Rassoul Dinarvand, received his Pharm.D. from University of Tehran in 1988. He then successfully completed his M.Sc. in 1990 and his Ph.D. in 1993 in the field of Controlled Drug Delivery Systems at the University of Manchester, UK. He then joined Faculty of Pharmacy, Tehran University of Medical Sciences in 1994 as a faculty member. He was promoted to full professorship in Pharmaceutics in 2005. He then became the Dean of the Faculty of Pharmacy at Tehran University of Medical Sciences in 2009 for 4 years.
Prof. Dinarvand has been active in the pharmaceutical administration in both industry and government at the highest level: seven years as CEO of several Pharmaceutical companies and twice as Deputy Minister of Health and Head of Iran Food and Drug Administration (8 years). He has also been involved in pharmacoeconomy and national drug policy research. However his main research interest is in the area of polymeric drug delivery systems and has published over 350 international papers
EDUCATION
Pharm. D. from Tehran university 1982-1988
M.Sc. from Manchester University 1989-1990
Ph.D. from Manchester University 1991-1994
RESEARCH INTERESTS
Controlled drug delivery
Polymeric drug delivery
Targeted drug delivery
Microparticles
Nanoparticles
Nanomedicine
Anticancer
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Hanieh Mahdiani, Faegheh Yazdani, Mahsa Khoramipour, Vahideh Valizadeh, Haleh Bakhshandeh, and Rassoul Dinarvand
Springer Science and Business Media LLC
AbstractRemarkable resistance of bacterial biofilms to high doses of antimicrobials and antibiotics is one of their main challenges. Encapsulation of proteolytic enzymes is one of the suggested strategies to tackle this problem. In this regard, the antibacterial and anti-biofilm activity of biocompatible hyaluronic acid- Lysine nanogels containing serratiopeptidase (SRP-loaded HA-Lys nanogel) was assessed against P. aeruginosa and S. aureus strains. SRP-loaded HA-Lys nanogel was prepared using dropping method and optimized by Box-Behnken experimental design. These formulations were studied for physical characterization, release profile, stability, bioactivity, and anti-biofilm effects. The particle size, polydispersity index (PDI), and surface charge were measured by Zetasizer Nano ZS. The average particle size and zeta potential of the optimum sample were 156 nm and -14.1 mV, respectively. SRP release showed an initial burst followed by sustained release and the highest release was around 77%. Enzyme biological activity data revealed the higher efficiency of free SRP compared to SRP-loaded HA-Lys nanogel. The time-kill assay showed that both forms of SRP-loaded HA-Lys nanogel and blank HA-Lys nanogel showed significant antimicrobial activity against examined bacteria in comparison to the free enzyme. The obtained results demonstrated improved anti-biofilm efficacy and down regulation of tested biofilm genes for both SRP-loaded HA-Lys nanogel 100% and blank HA-Lys nanogel 100% compared to SRP 100%.
Anna Fathi, Marziye Gholami, Hamidreza Motasadizadeh, Atefeh Malek-Khatabi, Roya Sedghi, and Rassoul Dinarvand
Elsevier BV
Saeed Shahbaz, Mahta Esmaeili, Mohammad Hosein Fathian Nasab, Zhila Imani, Reza Bafkary, Mohsen Amini, Fatemeh Atyabi, and Rassoul Dinarvand
Elsevier BV
Samane Maghsoudian, Hamidreza Motasadizadeh, Hassan Farhadnejad, Yousef Fatahi, Mohammad Hosein Fathian Nasab, Athar Mahdieh, Zeinab Nouri, Alyeh Abdollahi, Mohsen Amini, Fatemeh Atyabi,et al.
Elsevier BV
Marjan Bagheri-Meyabad, Hamidreza Motasadizadeh, Parisa Norouzi, Yousef Fatahi, Hamed Asadi, Reyhaneh Varshochian, Mahmoud Ghazi-Khansari, and Rassoul Dinarvand
Springer Science and Business Media LLC
Alaleh Yourdkhani, Mehdi Esfandyari-Manesh, Paniz Ranjbaran, and Rassoul Dinarvand
Elsevier BV
Ayda Moradi, Armina Shirangi, Mehdi Asadi, Mehdi Farokhi, Mehdi Gholami, Hossein Aminianfar, Fatemeh Atyabi, Fatemeh Mottaghitalab, and Rassoul Dinarvand
Elsevier BV
Nazgol Karimi Dastgerdi, Nurcan Gumus, Hulya Bayraktutan, Darryl Jackson, Krunal Polra, Paul F. McKay, Fatemeh Atyabi, Rassoul Dinarvand, Robin J. Shattock, Luisa Martinez-Pomares,et al.
Royal Society of Chemistry (RSC)
Therapeutic self-amplifying RNA (saRNA) is a promising approach for disease treatment, as it can be administered in lower doses than messenger RNA (mRNA) to achieve comparable protein production levels.
Farkhondeh Chaharband, Reyhaneh Varshochian, Rassoul Dinarvand, Hamideh Sabbaghi, Mozhgan Rezaei Kanavi, Narsis Daftarian, and Ramin Nourinia
Knowledge E DMCC
Purpose: Recent studies have reported the promising effect of intravitreal propranolol on retinal neovascularization. However, rapid clearance and short half-life of the drug in the vitreous are the main drawbacks of this therapeutic approach. This study investigates the extension of the residence time of propranolol in the vitreous by polymeric nanoparticles (NPs) with the prospect of improving choroidal neovascularization treatment.
 Methods: The poly (lactic-co-glycolic) acid (PLGA) NPs were fabricated by a modified double emulsion solvent evaporation method and the obtained NPs were characterized for their size, poly dispersity index (PDI), and surface image. The in vitro release, cell cytotoxicity, and uptake of NPs were also evaluated. To investigate the effect of the vitreous pharmacokinetic drug loaded NPs versus that of the free propranolol, they were intravitreally injected into the rabbits’ eyes and the drug vitreous concentrations in defined intervals were analyzed by high performance liquid chromatography (HPLC).
 Results: The spherical NPs with about 230 nm size, and almost 10% drug loading were obtained. Based on the 3-(4, 5-Dimethylthiazol-2-Yl)-2, 5-Diphenyltetrazolium Bromide (MTT) outcomes, 30 µg/ml of propranolol was considered as the guide dosage in the intravitreal injection. Confocal microscopy images verified the presence of labeled NPs in the posterior segment after five days of receiving the injection. In vivo assay revealed that the vanishing rate of propranolol in rabbits treated with propranolol NPs was reduced at twice the rate as compared to that of the vanishing rate experienced with only the free drug.
 Conclusion: PLGA NPs can prolong the existence of propranolol in both vitreous and posterior ocular tissues, and thus, may provide an effective approach in treatment of posterior segment neovascularization.
Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Nafiseh Baheiraei, Moein Safarkhani, Abdullah Aldhaher, and Rassoul Dinarvand
Springer Science and Business Media LLC
Seyed Reza Heydari, Mohammad Hossein Ghahremani, Fatemeh Atyabi, Reza Bafkary, Mahmoud Reza Jaafari, and Rassoul Dinarvand
Elsevier BV
Melika Kiani, Fatemeh Moraffah, Fatemeh Khonsari, Bahar Kharazian, Rassoul Dinarvand, Mohammad-Ali Shokrgozar, and Fatemeh Atyabi
Elsevier BV
Malihe Sadat Razavi, Pedram Ebrahimnejad, Hamid Akbari Javar, Thomas A. Weppelmann, Jafar Akbari, Fahimeh Asadi Amoli, Fatemeh Atyabi, and Rassoul Dinarvand
Elsevier BV
Mahta Esmaeili, Saeed Shahbaz, Mojtaba Kamankesh, Mohadeseh Shahin, Farnaz Sadat Mirzazadeh Tekie, Pedram Fadavi, Manijeh Beigi, Seyed Alireza Mortazavi, and Rassoul Dinarvand
Elsevier BV
Athar Mahdieh, Hamid Yeganeh, Hamidreza Motasadizadeh, Effat Nekoueifard, Samane Maghsoudian, Mohammad Hossein Ghahremani, Bo Nyström, and Rassoul Dinarvand
Elsevier BV
Niloofar Noroozi Heris, Leila Baghani, Fatemeh Khonsari, Reyhaneh Varshochian, Rassoul Dinarvand, and Fatemeh Atyabi
Elsevier BV
Malihe Sadat Razavi, Alyeh Abdollahi, Atefeh Malek-Khatabi, Negin Mousavi Ejarestaghi, Ali Atashi, Nazanin Yousefi, Pedram Ebrahimnejad, Mohamed A. Elsawy, and Rassoul Dinarvand
Elsevier BV
Nazanin Shabani Ravari, Maryam Ghareh Sheikhlou, Navid Goodarzi, Bahar Kharazian, Mohsen Amini, Fatemeh Atyabi, Saman A. Nasrollahi, and Rassoul Dinarvand
Springer Science and Business Media LLC
Effat Nekoueiyfard, Fatemeh Radmanesh, Hossein Baharvand, Athar Mahdieh, Hamid Sadeghi-Abandansari, and Rassoul Dinarvand
Elsevier BV
Seyed Mohammad Amini, Seyed Mahdi Rezayat, Rassoul Dinarvand, Sharmin Kharrazi, and Mahmoud Reza Jaafari
Springer Science and Business Media LLC
Maryam Monajati, Ali Mohammad Tamaddon, Samira Sadat Abolmaali, Gholamhossein Yousefi, Sanaz Javanmardi, Sedigheh Borandeh, Reza Heidari, Negar Azarpira, and Rassoul Dinarvand
Elsevier BV
Tina Rabizadeh, Reyhaneh Varshochian, Athar Mahdieh, Mahsa Rezaei, Negin Pazouki, Mahsa Zardkanlou, Shiva Irani, and Rassoul Dinarvand
Springer Science and Business Media LLC
Seyed Reza Heydari, Mahnoush Samadi, Armina Shirangi, Mehdi Farokhi, Ayda Moradi, Reza Bafkary, Fatemeh Atyabi, Fatemeh Mottaghitalab, and Rassoul Dinarvand
Elsevier BV
Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Abdullah Aldhaher, Pooyan Makvandi, Rassoul Dinarvand, Maryam Jouyandeh, Mohammad Reza Saeb, Masoud Mozafari,et al.
American Chemical Society (ACS)
Farhad Alvandifar, Baharnaz Ghaffari, Navid Goodarzi, Nazanin Shabani Ravari, Fahimeh Karami, Mohsen Amini, Effat Souri, Mohammad Reza Khoshayand, Mehdi Esfandyari-Manesh, Razieh Mohammad Jafari,et al.
Elsevier BV