Food Additives and Evolved Methods of Detection: A Review Aiswarya P. S., Ditto Abraham Thadathil, Louis George, Anitha Varghese Critical Reviews in Analytical Chemistry, 2025 Food additives are essential constituents of food products in the modern world. The necessity of food processing went up rapidly as to meet requirements including, imparting desirable properties like preservation, enhancement and regulation of color and taste. The methods of identification and analysis of such substances are crucial. With the advancement of technology, a variety of techniques are emerging for this purpose which have many advantages over the existing conventional ways. This review is on different kinds of additives used in the food industry and few prominent methods for their determination ranging from conventional chromatographic techniques to the recently evolved nano-sensor techniques.
Electrochemical Hydrogenation of Organic Compounds: A Sustainable Approach Krishnapriya Jayan, Ditto Abraham Thadathil, Anitha Varghese Asian Journal of Organic Chemistry, 2023 Conventional methods for hydrogenation of organic compounds generally use corrosive catalysts and reagents, along with extreme conditions like high temperatures and pressures. Quenching of corrosive materials does not deter its negative impact on the environment, nor is one safe when it comes to working with high temperature and pressure. Electrochemical hydrogenation (ECH) has proven to be safe and green since most of the efficient reactions are conducted at ambient pressure and temperature, minimizing, and sometimes even negating the use of toxic catalysts and corrosive reagents as compared to conventional methods. This review therefore provides different strategies used for ECH in the past, modification of different electrodes, half reactions taken up for efficient energy usage and catalysts used for different hydrogenation reactions. It presents the advances in electrochemical hydrogenation reactions of organic compounds, starting from simple aliphatic compounds to complex polyaromatics and heterocyclic aromatic compounds.
Co-Electrodeposited Pi-MnO2-rGO as an Efficient Electrode for the Selective Oxidation of Piperonyl Alcohol Roopa Margaret Rodrigues, Ditto Abraham Thadathil, G. Shanker, Uraiwan Sirimahachai, Anitha Varghese, et al. Journal of the Electrochemical Society, 2023 Pi-MnO2-rGO-CFP electrode was developed through a concurrent deposition of Pi-MnO2 and reduced graphene oxide (rGO) on carbon fiber paper (CFP). Cyclic voltammetry (CV) and electrochemical impedance studies (EIS) were applied for the electrochemical characterization of the electrode. The electro catalytic activity of the modified electrode was improved by the increased synergistic characteristics of the CFP and electrochemically deposited rGO-Pi-MnO2 composite. The performance of the modified electrode was remarkable due to its lowest charge transfer resistance (R ct), and highest surface area offering more active sites and quicker electron transport kinetics. X-ray diffraction spectroscopy (XRD), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and optical profilometry (OP) were employed to study the physicochemical properties. Furthermore, the modified electrode was availed to oxidize piperonyl alcohol mediated by 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxyl (4-acetamido TEMPO or 4-ACT). The product obtained was purified and characterized by 1HNMR. The turnover frequency of 4-ACT was studied at different concentrations of the reactant, and the reaction parameters were also optimized using statistical tool design of experiment. This methodology is demonstrated to be economical, environmentally benign, and highly efficient in obtaining piperonal as it is carried out under milder reaction conditions.
New Horizons in the Synthesis, Properties, and Applications of MXene Quantum Dots Sariga, Ann Mariella Babu, Shashi Kumar, Rijo Rajeev, Ditto Abraham Thadathil, et al. Advanced Materials Interfaces, 2023 The progress of MXenes, a 2D layered structural material since its discovery in 2011 recently arouses a great deal of attention due to their plethora of applications in a diverse range of fields. Their excellent properties in terms of surface chemistry, optical activity, electrical conductivity, presence of abundant active catalytic sites, tunable band gap structure, ease of surface functionalization, and good biocompatibility make them an ideal candidate. The authors aim to guide the readers through various aspects such as their unique properties, synthesis techniques, and the recent advancements associated with MXene quantum dots (QDs). Herein, this review serves as a one‐stop point for prospective researchers to gain a better understanding of the application of MXene QDs in various fields including electrochemical detection, biomedical applications, and energy conversion and storage applications.
Food additives and evolved methods of detection: A review A PS, DA Thadathil, L George, A Varghese Critical Reviews in Analytical Chemistry 55 (8), 1561-1580 , 2025 2025 Citations: 14
Harnessing immobilized copper salophen complex for the electrochemical synthesis of phenazine DA Thadathil, A Varghese Electrochimica Acta 527, 146265 , 2025 2025 Citations: 1
Electrochemical recognition of MMA-A biomarker for vitamin B 12 deficiency based on β-cyclodextrin self-assembled on polyaminothiazole AR Cherian, DA Thadathil, A Varghese RSC advances 15 (31), 25608-25619 , 2025 2025 Citations: 1
Immobilized proline-based electro-organocatalyst for the synthesis of bis-β-diketone via Knoevenagel condensation reaction DA Thadathil, A Varghese Electrochimica Acta 505, 144999 , 2024 2024 Citations: 2
Electrochemical determination of Vitamin B6 using coral-like MnO2-Pi on Ti3C2Tx MXene R Rajeev, AR Cherian, DA Thadathil, A Varghese Materials Research Bulletin 169, 112523 , 2024 2024 Citations: 20
Electrochemical hydrogenation of organic compounds: a sustainable approach K Jayan, DA Thadathil, A Varghese Asian Journal of Organic Chemistry 12 (10), e202300309 , 2023 2023 Citations: 13
New horizons in surface topography modulation of MXenes for electrochemical sensing toward potential biomarkers of chronic disorders R Rajeev, DA Thadathil, A Varghese Critical Reviews in Solid State and Materials Sciences 48 (5), 580-622 , 2023 2023 Citations: 13
Enzyme immobilized conducting polymer-based biosensor for the electrochemical determination of the eco-toxic pollutant p-nonylphenol S Jose, DA Thadathil, M Ghosh, A Varghese Electrochimica Acta 460, 142591 , 2023 2023 Citations: 28
A comprehensive review on the electrochemical sensing of flavonoids SA George, R Rajeev, DA Thadathil, A Varghese Critical Reviews in Analytical Chemistry 53 (6), 1133-1173 , 2023 2023 Citations: 44
Pi-MnO2 decorated poly-3-thienylacetic acid on carbon fiber paper for electrochemical synthesis of 2-formyl-thiophene RM Rodrigues, DA Thadathil, A Varghese Molecular Catalysis 545, 113242 , 2023 2023 Citations: 15
Co-Electrodeposited Pi-MnO 2 -rGO as an Efficient Electrode for the Selective Oxidation of Piperonyl Alcohol RM Rodrigues, DA Thadathil, G Shanker, U Sirimahachai, A Varghese, ... Journal of the Electrochemical Society 170 (3), 036501 , 2023 2023 Citations: 12
New Horizons in the Synthesis, Properties, and Applications of MXene Quantum Dots AM Babu, S Kumar, R Rajeev, DA Thadathil, A Varghese Advanced Materials Interfaces 10 (5), 2202139 , 2023 2023 Citations: 77
Anchored ferrocene based heterogeneous electrocatalyst for the synthesis of benzimidazoles DA Thadathil, M Bharath, A Varghese, M Ghosh Electrochimica Acta 435, 141399 , 2022 2022 Citations: 14
Conducting polymers: a versatile material for biomedical applications L Benny Mattam, A Bijoy, D Abraham Thadathil, L George, A Varghese ChemistrySelect 7 (42), e202201765 , 2022 2022 Citations: 50
A road map on nanostructured surface tuning strategies of carbon fiber paper electrode: Enhanced electrocatalytic applications S Jose, R Rajeev, DA Thadathil, A Varghese, G Hegde Journal of Science: Advanced Materials and Devices 7 (3), 100460 , 2022 2022 Citations: 41
Enzyme based bioelectrocatalysis over laccase immobilized poly-thiophene supported carbon fiber paper for the oxidation of D-ribofuranose to D-ribonolactone DA Thadathil, A Varghese, CVS Ahamed, KA Krishnakumar, SS Varma, ... Molecular Catalysis 524, 112314 , 2022 2022 Citations: 19
Detection of picric acid in industrial effluents using multifunctional green fluorescent B/N-carbon quantum dots P Keerthana, AR Cherian, U Sirimahachai, DA Thadathil, A Varghese, ... Journal of Environmental Chemical Engineering 10 (2), 107209 , 2022 2022 Citations: 74
Recent advances in electrochemical synthesis of nitriles: a sustainable approach RM Rodrigues, DA Thadathil, K Ponmudi, A George, A Varghese ChemistrySelect 7 (12), e202200081 , 2022 2022 Citations: 40
The Renaissance of Electro‐Organic Synthesis for the Difunctionalization of Alkenes and Alkynes: A Sustainable Approach DA Thadathil, A Varghese, KV Radhakrishnan Asian Journal of Organic Chemistry 10 (11), 2820-2847 , 2021 2021 Citations: 41
ELECTROCHEMICAL SYNTHESIS OF RIBONOLACTONE-A PRECURSOR FOR ANTI-COVID DRUG REMDESIVIR DA Thadathil, A Varghese IN Patent App. 202141035480 A , 2021 2021
MOST CITED SCHOLAR PUBLICATIONS
New Horizons in the Synthesis, Properties, and Applications of MXene Quantum Dots AM Babu, S Kumar, R Rajeev, DA Thadathil, A Varghese Advanced Materials Interfaces 10 (5), 2202139 , 2023 2023 Citations: 77
Detection of picric acid in industrial effluents using multifunctional green fluorescent B/N-carbon quantum dots P Keerthana, AR Cherian, U Sirimahachai, DA Thadathil, A Varghese, ... Journal of Environmental Chemical Engineering 10 (2), 107209 , 2022 2022 Citations: 74
Surface modulation and structural engineering of graphitic carbon nitride for electrochemical sensing applications AM Babu, R Rajeev, DA Thadathil, A Varghese, G Hegde Journal of Nanostructure in Chemistry 12, 765 , 2021 2021 Citations: 71
Conducting polymers: a versatile material for biomedical applications L Benny Mattam, A Bijoy, D Abraham Thadathil, L George, A Varghese ChemistrySelect 7 (42), e202201765 , 2022 2022 Citations: 50
An Insight into Photophysical Investigation of ( E )-2-Fluoro-N’-(1-(4-Nitrophenyl)Ethylidene)Benzohydrazide through Solvatochromism Approaches and … DA Thadathil, S Varghese, KB Akshaya, R Thomas, A Varghese Journal of fluorescence 29 (4), 1013-1027 , 2019 2019 Citations: 48
A comprehensive review on the electrochemical sensing of flavonoids SA George, R Rajeev, DA Thadathil, A Varghese Critical Reviews in Analytical Chemistry 53 (6), 1133-1173 , 2023 2023 Citations: 44
A road map on nanostructured surface tuning strategies of carbon fiber paper electrode: Enhanced electrocatalytic applications S Jose, R Rajeev, DA Thadathil, A Varghese, G Hegde Journal of Science: Advanced Materials and Devices 7 (3), 100460 , 2022 2022 Citations: 41
The Renaissance of Electro‐Organic Synthesis for the Difunctionalization of Alkenes and Alkynes: A Sustainable Approach DA Thadathil, A Varghese, KV Radhakrishnan Asian Journal of Organic Chemistry 10 (11), 2820-2847 , 2021 2021 Citations: 41
Recent advances in electrochemical synthesis of nitriles: a sustainable approach RM Rodrigues, DA Thadathil, K Ponmudi, A George, A Varghese ChemistrySelect 7 (12), e202200081 , 2022 2022 Citations: 40
Enzyme immobilized conducting polymer-based biosensor for the electrochemical determination of the eco-toxic pollutant p-nonylphenol S Jose, DA Thadathil, M Ghosh, A Varghese Electrochimica Acta 460, 142591 , 2023 2023 Citations: 28
Electrochemical determination of Vitamin B6 using coral-like MnO2-Pi on Ti3C2Tx MXene R Rajeev, AR Cherian, DA Thadathil, A Varghese Materials Research Bulletin 169, 112523 , 2024 2024 Citations: 20
Enzyme based bioelectrocatalysis over laccase immobilized poly-thiophene supported carbon fiber paper for the oxidation of D-ribofuranose to D-ribonolactone DA Thadathil, A Varghese, CVS Ahamed, KA Krishnakumar, SS Varma, ... Molecular Catalysis 524, 112314 , 2022 2022 Citations: 19
Pi-MnO2 decorated poly-3-thienylacetic acid on carbon fiber paper for electrochemical synthesis of 2-formyl-thiophene RM Rodrigues, DA Thadathil, A Varghese Molecular Catalysis 545, 113242 , 2023 2023 Citations: 15
A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4 H -chromenes and ortho -benzylphenols C Sreenivasulu, DA Thadathil, S Pal, S Gedu Synthetic Communications 50 (1), 112-122 , 2020 2020 Citations: 15
Food additives and evolved methods of detection: A review A PS, DA Thadathil, L George, A Varghese Critical Reviews in Analytical Chemistry 55 (8), 1561-1580 , 2025 2025 Citations: 14
Anchored ferrocene based heterogeneous electrocatalyst for the synthesis of benzimidazoles DA Thadathil, M Bharath, A Varghese, M Ghosh Electrochimica Acta 435, 141399 , 2022 2022 Citations: 14
Electrochemical hydrogenation of organic compounds: a sustainable approach K Jayan, DA Thadathil, A Varghese Asian Journal of Organic Chemistry 12 (10), e202300309 , 2023 2023 Citations: 13
New horizons in surface topography modulation of MXenes for electrochemical sensing toward potential biomarkers of chronic disorders R Rajeev, DA Thadathil, A Varghese Critical Reviews in Solid State and Materials Sciences 48 (5), 580-622 , 2023 2023 Citations: 13
Co-Electrodeposited Pi-MnO 2 -rGO as an Efficient Electrode for the Selective Oxidation of Piperonyl Alcohol RM Rodrigues, DA Thadathil, G Shanker, U Sirimahachai, A Varghese, ... Journal of the Electrochemical Society 170 (3), 036501 , 2023 2023 Citations: 12
Electrochemical Strategies for Selective Fluorination of Organic Compounds DA Thadathil, A Varghese, KV Radhakrishnan Journal of The Electrochemical Society 168 (7), 075503 , 2021 2021 Citations: 9
