Dinesh Kumar Sharma

@mru.edu.in

Professor & Dean Examination
Department of Sciences, Manav Rachna University, Faridabad



              

https://researchid.co/dksharma.mrce

EDUCATION

M. Sc., Ph. D.

RESEARCH, TEACHING, or OTHER INTERESTS

Atmospheric Science, General Physics and Astronomy, Geophysics, Earth and Planetary Sciences

325

Scopus Publications

272

Scholar Citations

10

Scholar h-index

11

Scholar i10-index

Scopus Publications


  • Evaluation of in vitro Antibacterial Activities of Vitexnegundo, Phyllanthusemblica and Cymbopogoncitratus against Common Bacterial Pathogens Causing Subclinical Mastitis in Cows
    Kanika Mahajan, Pardeep Sharma, Dinesh Kumar Sharma, Monika Bhardwaj, and Rajendra D Patil

    Indian Veterinary Association

  • Modeling the growth, yield and N dynamics of wheat for decoding the tillage and nitrogen nexus in 8-years long-term conservation agriculture based maize-wheat system
    Kamlesh Kumar, C. M. Parihar, D. R. Sena, Samarth Godara, Kiranmoy Patra, Ayan Sarkar, K. Srikanth Reddy, P. C. Ghasal, Sneha Bharadwaj, A. L. Meena,et al.

    Frontiers Media SA
    ContextAgricultural field experiments are costly and time-consuming, and their site-specific nature limits their ability to capture spatial and temporal variability. This hinders the transfer of crop management information across different locations, impeding effective agricultural decision-making. Further, accurate estimates of the benefits and risks of alternative crop and nutrient management options are crucial for effective decision-making in agriculture.ObjectiveThe objective of this study was to utilize the Crop Environment Resource Synthesis CERES-Wheat model to simulate crop growth, yield, and nitrogen dynamics in a long-term conservation agriculture (CA) based wheat system. The study aimed to calibrate the model using data from a field experiment conducted during the 2019-20-2020-21 growing seasons and evaluation it with independent data from the year 2021–22.MethodCrop simulation models, such as the Crop Environment Resource Synthesis CERES-Wheat (DSSAT v 4.8), may provide valuable insights into crop growth and nitrogen dynamics, enabling decision makers to understand and manage production risk more effectively.Therefore, the present study employed the CERES-Wheat (DSSAT v 4.8) model and calibrated it using field data, including plant phenological phases, leaf area index, aboveground biomass, and grain yield from the 2019-20-2020-21 growing seasons. An independent dataset from the year 2021–22 was used for model evaluation. The model was used to investigate the relationship between growing degree days (GDD), temperature, nitrate and ammonical concentration in soil, and nitrogen uptake by the crop. Additionally, the study explored the impact of contrasting tillage practices and fertilizer nitrogen management options on wheat yields. The experimental site is situated at ICAR-Indian Agricultural Research Institute (IARI), New Delhi, representing Indian Trans-Gangetic Plains Zone (28o 40’N latitude, 77o 11’E longitude and an altitude of 228 m above sea level). The treatments consist of four nitrogen management options, viz., N0 (zero nitrogen), N150 (150 kg N ha−1 through urea), GS (Green seeker based urea application) and USG (urea super granules @150 kg N ha−1) in two contrasting tillage systems, i.e., CA-based zero tillage (ZT) and conventional tillage (CT).ResultThe outcomes exhibited favorable agreement between the model’s simulations and the observed data for crop phenology (With less than 2 days variation in 50% onset of flowering), grain and biomass yield (Root mean square error; RMSE 336 kg ha−1 and 649 kg ha−1, respectively), and leaf area index (LAI) (RMSE 0.28 & normalized RMSE; nRMSE 6.69%). The model effectively captured the nitrate-N (NO3−-N) dynamics in the soil profile, exhibiting a remarkable concordance with observed data, as evident from its low RMSE = 12.39 kg ha−1 and nRMSE = 13.69%. Moreover, as it successfully simulated the N balance in the production system, the nitrate leaching and ammonia volatilization pattern as described by the model are highly useful to understand these critical phenomena under both conventional tillage (CT) and CA-based Zero Tillage (ZT) treatments.ConclusionThe study concludes that the DSSAT-CERES-Wheat model has significant potential to assess the impacts of tillage and nitrogen management practices on crop growth, yield, and soil nitrogen dynamics in the western Indo-Gangetic Plains (IGP) region. By providing reliable forecasts within the growing season, this modeling approach can facilitate better planning and more efficient resource management.Future implicationsThe successful implementation of the DSSAT-CERES-Wheat model in this study highlights its applicability in assessing crop performance and soil dynamics. Future research should focus on expanding the model’s capabilities by reducing its sensitivity to initial soil nitrogen levels to refine its predictions further. Moreover, the model’s integration with decision support systems and real-time data can enhance its usefulness in aiding agricultural decision-making and supporting sustainable crop management practices.


  • Interactive effects of elevated ozone and carbon dioxide on physiological traits of different Indian mustards
    Gayathri Jawahar Jothi, Dinesh Kumar Sharma, Boomiraj Kovilpillai, Arti Bhatia, Sudhir Kumar, and Diogenes L. Antille

    Springer Science and Business Media LLC

  • Residue recycling options and their implications for sustainable nitrogen management in rice–wheat agroecosystems
    Ajay Kumar Bhardwaj, Kapil Malik, Manu Rani, Uttam Kumar Mandal, Nirmalendu Basak, Awtar Singh, Rajender Kumar Yadav, Suresh Kumar Chaudhari, and Dinesh Kumar Sharma

    Springer Science and Business Media LLC
    Abstract Background In the Indo-Gangetic Plain, rice–wheat is the most extensively practiced crop rotation. The escalating issue of crop residue burning, particularly rice straw, and the necessity to lower the exorbitant expenses associated with fertilizer inputs stand out as significant challenges for farmers in the region. A well-suited integrated nutrient management (INM) strategy that focuses on recycling crop residues can serve as a solution to address these issues. Such a strategy not only mitigates air pollution resulting from residue burning but also helps combat water pollution due to nitrate losses from agroecosystems. Field experiments were used to evaluate the suitability of eight INM-modules that included various combinations of inorganic fertilizer rates (50%, 100%, 150% of recommended dose), crop residues (wheat and rice stubble retention at 30 cm standing stubble equivalent to 1/3 the straw yield), rice straw compost (RSC), farmyard manure (FYM), and green manuring (GM), compared to 100% recommended dose of fertilizers (F) and no fertilizer application. Results There was a considerable improvement in nitrogen mineralization, grain yields, and nitrogen use efficiency under GM + RSC-F50 and GM + FYM-F50. These INM modules would permit a 50% reduction in the use of chemical fertilizers. There was a little yield penalty with in situ rice residue incorporation at 100% F; however, this could be overcome with 150% F fertilizer application. In situ retention of wheat straw with a full application of fertilizer resulted in steadily rising crop yields over time. Changes in the redox potential, soil pH, and soil organic carbon best accounted for the observed trajectories in nitrogen use efficiency. Conclusion The most promising INM modules for adoption by farmers in the Indo-Gangetic Plain to judiciously use crop residues and curtail chemical fertilizer inputs are green manuring with Sesbania aculeata + rice straw compost at 5 t ha−1 + only 50% of recommended dose of fertilizers (GM + RSC-F50), and green manuring with Sesbania aculeata + farmyard manure at 5 t ha−1 + only 50% of recommended dose of fertilizers (GM + FYM-F50). Sole incorporation of crop residues without nitrogen augmentation from other sources might not help curtail chemical fertilizer use. Composting rice straw, which otherwise is widely burnt, proved a useful nitrogen source and a vital component of INM. Waste rice straw composting at the community scale and its application as a nutrient source can help achieve sustainable nitrogen management in the agroecosystems of Indo-Gangetic Plain.

  • Effect of row proportions, organic and inorganic nutrient sources on growth and yield of potato (Solanum tubersoum) cultivars
    AJAY KUMAR, V.S. VERMA, DINESH KUMAR SHARMA, and ANIL KUMAR MISHRA

    The Indian Society of Agronomy
    The effects of row proportions and nutrient management was studied in potato (Solanum tubersoum L.) + Indian mustard [Brassica juncea (L.) Czernj.] intercropping system during 2014–15 and 2015–16 at Amar Singh College Farm, Lakhaoti (Bulandshahr), Uttar Pradesh. The field experiment was laid out in a split-split plot design with 3 replications. The main plot treatments consisted of 3 varieties, viz. ‘Kufri Pukhraj’, ‘Kufri Anand’ and ‘Chipsona 3’, and subplots comprised row proportions of 2 : 1 potato : Indian mustard (P : M), 4 : 1 P : M, potato sole and Indian mustard sole and the sub-subplot treatments consisted of 3 nutrient sources 100% organic (FYM), 100% inorganic and 50% organic + 50% inorganic. The maximum fresh weight of tubers (450.33 g), total tuber dry weight (56.99 g), total number of tubers/plant (15.40) as well as total biological yield (49.14) were recorded in ‘Kufri Pukhraj’ both for A - grade and total tuber yield. Row ratio of 2 : 1 (P : M) recorded higher fresh weight of haulms/ plant (191.48), while higher dry weight/plant of potato (119.70) was recorded in the sole crop. Number of tuber/ plant, fresh and dry weight of tubers were significantly higher under sole potato than row ratio of 4 : 1 however, row ratio of 4 : 1 was slightly superior to row ratio of 2 : 1. Sole potato and row ratio of 4 : 1 resulted in significantly higher total biomass than row ratio of 2 : 1. Yield of different grades and total tubers was recorded significantly higher in sole crop than that for row ratio of 4 : 1 and 2 : 1, though variations were observed nominal in case of Cgrade tubers. Significantly higher potato yield (2.85 t/ha) was observed with the application of nutrients through 50% organic + 50% inorganic fertilizer application.

  • Conservation agriculture impacts on soil carbon sequestration under a cotton (Gossypium hirsutum)-wheat (Triticum aestivum) system in the Indo-Gangetic plains
    ANN MARIA JOSEPH, RANJAN BHATTACHARYYA, T K DAS, D K SHARMA, PLABANI ROY, and S L JAT

    Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
    Despite many studies reporting conservation agriculture (CA) impacts on soil organic carbon (SOC) sequestration, the impacts of long-term permanent bed planting under CA on SOC sequestration are rarely reported. Hence, this study assessed the permanent bed planted CA impacts on SOC sequestration rates in 0–30 and 30–60 cm soil depths under a cotton (Gossypium hirsutum L.)-wheat (Triticum aestivum L.) system in the Indo-Gangetic Plains (IGP). The treatments comprised diverse combinations of tillage and residue retention (R), viz. conventional tillage (CT), narrow bed, narrow bed + R, broad bed, broad bed + R, flat bed + R and flat bed. Results indicated that the total SOC stock was ~32, 31 and 29% higher in CA plots than in CT plots (farmers' practice), in 0–30 cm soil depth. The SOC sequestration rate (over CT plots) in the CA plots was ~0.76 Mg C/ha/yr. The broad bed + R, narrow bed + R and flat bed + R plots had appreciably high total SOC sequestration (~0.24 Mg C/ha/yr) compared to CT plots in deep soil layer (30–60 cm). The yield data (2-year mean basis) was recorded highest in the broad bed + R (3.48 tonnes/ha and 8.11 tonnes/ha for cotton and wheat, respectively) and flat bed + R (3.38 tonnes/ha and 8.46 tonnes/ha for cotton and wheat, respectively) treatments showing a positive impact of the adoption of long-term CA in the IGP. Thus, adopting raised beds with residue retention has great potential for higher carbon sequestration and improving yields and can be recommended for sustainable intensification of arable lands in the region.

  • New distribution record of the Greater False Vampire Bat (Megaderma lyra, Geoffroy 1810) from North-Western Himalaya
    Devandra singh, , Dinesh Sharma, and

    Galaxy Science
    India has been stated to have 10% of the world's total bat's diversity. The present survey was aimed to study the bat species diversity, distribution and activity patterns in north-western Himalayan region of India. Field surveys were conducted and echolocation calls were recorded using bat detector, Echometer touch 2 in Shiwalik ranges of Himalaya. The Greater False Vampire Bat (Megaderma lyra) has a broad distribution range that stretches from south to south east Asia. In India the distribution of the species was mostly recorded from southern subtropical coastal regions and north-eastern subtropical moist evergreen forests. In the present study The Greater False Vampire Bat (Megaderma lyra) has been recorded for the first time from Garhwal region of north-western Himalayas. Greater False Vampire Bat (Megaderma lyra) having long forearm (>6.63 ± 0.03cm) and lengthy ear (>3.66 ± 0.08cm), which is a distinguishable feature of the family Megadermatidae. The peak frequency (FMaxE) of echolocation was recorded as 50.295 ± 9.18 kHz. This frequency was initiated at 108.20 ± 2.51 kHz and terminated at 30.76 ± 1.37 kHz. The call structure recorded was very distinguishable and specific to this family.

  • NUTRITIONAL EVALUATION OF GREEN MORINGA (MORINGA OLEIFERA) FOLIAGE IN BARBARI GOATS
    Ravindra Kumar, A.K. Dixit, A. Kumar, and D.K. Sharma

    Diva Enterprises Private Limited

  • Integrated Nutrient Management Modules for Utilization of Crop Residues to Enhance the Productivity of Rice-Wheat Systems in the North-Western Indo-Gangetic Plain
    Ajay Kumar Bhardwaj, Kapil Malik, Sukirtee Chejara, Nirmalendu Basak, Bhaskar Narjary, Priyanka Chandra, Uttam Kumar Mandal, Dinesh Kumar Sharma, and Suresh Kumar Chaudhari

    Diva Enterprises Private Limited

  • Conservation Tillage and Waste Crop Residue Based Zinc Fortification in Rice and Wheat under Reclaimed Sodic Soils: Progress toward Nutrient Circularity and Sustainability
    Sunil Kumar Jha, Vinay Kumar Mishra, Thukkaram Damodaran, Atul Kumar Singh, Parbodh Chander Sharma, Dinesh Kumar Sharma, Deepak Ojha, and Yash Pal Singh

    American Chemical Society (ACS)
    Nearly 50% of the population across the globe is at risk of malnutrition with respect to zinc (Zn) in areas where a cereal based dietary system dominates. The present study estimated daily Zn intake in humans through field experiments in reclaimed sodic soil, utilizing waste crop residue (CR) in conservation tillage where CR played a vital role in enhancing Zn uptake in rice and wheat grains. Zn dynamics, its bioavailability, interaction with soil properties, and plausible contribution in dietary intake were studied extensively to supplement the research. A higher mobility factor (2.70%) and plant available Zn resulted in its higher uptake in rice (58.2 mg kg-1) and wheat (67.2 mg kg-1) under zero tillage in rice followed by zero tillage in wheat where CR was retained on the surface (ZTR-ZTW+CR). Daily Zn intake was found to be maximum (0.651 mg kg-1 day-1) under ZTR-ZTW+CR, demonstrating zinc sufficiency. Thus, this study may help in formulating actionable policies for combating both nutritional security and environmental hazards due to CR burning.

  • Molecular dynamics simulation-based trinucleotide and tetranucleotide level structural and energy characterization of the functional units of genomic DNA
    Dinesh Sharma, Kopal Sharma, Akhilesh Mishra, Priyanka Siwach, Aditya Mittal, and B. Jayaram

    Royal Society of Chemistry (RSC)
    Our work focuses on the structural and energetic analysis of promoters and exon–intron boundaries within DNA using Molecular Dynamics simulation-based parameters mapped over trinucleotides and tetranucleotides.

  • Diagnostic Analysis of mZN Microscopy and PCR for Detection of Cryptosporidiosis in Goat Kids - A Molecular Epidemiological Study


  • Pyrazole; A Privileged Scaffold of Medicinal Chemistry: A Comprehensive Review
    Ram Kumar, Raksha Sharma, and Dinesh Kumar Sharma

    Bentham Science Publishers Ltd.
    Abstract: Pyrazole is considered an important active scaffold that possesses various types of pharmacological activities. The overwhelming literature reported earlier reflects the immense biological potential of pyrazole derivatives. The presence of this moiety in various FDA-approved drugs, including celecoxib (anti-inflammatory), apixaban (anticoagulant), rimonabant (anti-obesity), difenamizole (analgesic), and sildenafil (for erectile dysfunction), has proved its pharmacological potential. Owing to its diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the literature supporting the research of the past 10 years related to the structures of pyrazole derivatives with their corresponding biological activities. The findings of this review may open new avenues for an upcoming scientific breakthrough.

  • Effect of Conservation Agriculture Practices on Carbon Pools in a Sandy Loam Soil of Indo-Gangetic Plains
    Govindaraj Kamalam Dinesh, Dinesh Kumar Sharma, Shankar Lal Jat, Kalikinkar Bandyopadhyay, Cherukumalli Srinivasa Rao, Veluswamy Venkatramanan, Praveen Vasant Kadam, Murugaiyan Sinduja, Velusamy Sathya, Sethupathi Nedumaran,et al.

    Informa UK Limited
    ABSTRACT Conservation agriculture practices have been globally recognized for improving soil quality by enhancing soil organic carbon, mitigating climate change, and boosting resilience, thereby supporting food security. However, declining soil organic carbon (SOC) is reported as a significant issue in Indian soil, particularly in Indo-Gangetic Plain (IGP). In this investigation, the experiment was conducted to assess the impacts of crop residue retention under conservation agriculture practices with green seeker (GS)-based nitrogen (N) application. The finding of this study revealed that passive carbon pools were 25% and 22% higher in Zero Tillage with Residue Retention (ZTWR) than in Zero Tillage without Residue Retention (ZTWoR) during 2018 and 2019, respectively. Active carbon pools were found to increase, 5.47 g kg−1 in ZTWR plots and 4.34 g kg−1 in ZTWoR plots, while passive carbon pools were recorded at 7.46 g kg−1 in ZTWoR plots and 9.23 g kg−1 in ZTWR plots. The passive carbon pool was recorded as highest in ZTWR 50% N+GS treatment (8.61 g kg−1) and lowest in ZTWoR 70%N+GS treatment (8.15 g kg−1). 50%N+GS subplot treatment performed well in precision nitrogen management treatment under conservation agriculture, and it also improved various carbon pools; Overall, ZTWR performed better than ZTWoR plots, and 50%N+GS improved SOC pools in the subplot, it is followed by RDN, 33%N+GS and RDN subplot treatment. The soil organic pools are positively correlated with crop yields. Hence, the present study recommends that residue retention in conservation agriculture and optimized precision nitrogen management improve the soil organic carbon pools, ultimately improving soil fertility and sustainability. GRAPHICAL ABSTRACT This figure shows the salient findings of the current study. By adopting the conservation agriculture techniques (residue retention and zero tillage) the study finds an increase in the passive pools by 24% and active pools by 26%, which improves the soil organic carbon.

  • Silymarin: A Phytoconstituent with Significant Therapeutic Potential-A Narrative Review
    Pravin Kumar, Sahil Sharma, Mahendra Singh Ashawat, Vinay Pandit, Chandrapal Singh Verma, and Dinesh Kumar Sharma

    Bentham Science Publishers Ltd.
    Abstract:Silymarin, is a phytoactive constituent isolated from the fruits and seeds of Silybum marianum L Gaetn.), also called milk thistle belonging to the family of Asteracease. The phytoactive has been used to treat several physiological disorders. The objective of this manuscript was to review the therapeutic prospective of silymarin due to its ability to treat several physiological disorders. The databases such as Pubmed, Elsevier, and Google Scholar were reviewed for the investigations or reviews published related to the title. The discussion is focused on the immunomodulatory, chemopreventive, and anti-inflammatory mechanisms of silymarin in various metabolic and dermatological disorders. In addition, the review discusses the different therapeutic potentials of silymarin such as the management of the liver disorder, skin carcinogenesis, cardiovascular disorders, diabetes mellitus, neurodegenerative disorders, and several dermatological disorders such as melasma, anti-aging, acne, rosacea, atopic dermatitis, and psoriasis. Silymarin is safe even with a dose higher than the therapeutic dose. Silymarin had good potential for the safe and effective treatment of numerous metabolic and dermatological disorders.

  • Deciphering trait associated morpho-physiological responses in pearlmillet hybrids and inbred lines under salt stress
    Ashwani Kumar, Parvender Sheoran, Anita Mann, Devvart Yadav, Arvind Kumar, Sunita Devi, Naresh Kumar, Pooja Dhansu, and Dinesh K. Sharma

    Frontiers Media SA
    Pearl millet is a staple food for more than 90 million people residing in highly vulnerable hot arid and semi–arid regions of Africa and Asia. These regions are more prone to detrimental effects of soil salinity on crop performance in terms of reduced biomass and crop yields. We investigated the physiological mechanisms of salt tolerance to irrigation induced salinity stress (ECiw ~3, 6 & 9 dSm–1) and their confounding effects on plant growth and yield in pearl millet inbred lines and hybrids. On average, nearly 30% reduction in above ground plant biomass was observed at ECiw ~6 dSm-1 which stretched to 56% at ECiw ~9 dSm-1 in comparison to best available water. With increasing salinity stress, the crop performance of test hybrids was better in comparison to inbred lines; exhibiting relatively higher stomatal conductance (gS; 16%), accumulated lower proline (Pro; –12%) and shoot Na+/K+(–31%), synthesized more protein (SP; 2%) and sugars (TSS; 32%) compensating in lower biomass (AGB; –22%) and grain yield (GY: –14%) reductions at highest salinity stress of ECiw ~9 dSm–1. Physiological traits modeling underpinning plant salt tolerance and adaptation mechanism illustrated the key role of 7 traits (AGB, Pro, SS, gS, SPAD, Pn, and SP) in hybrids and 8 traits (AGB, Pro, PH, Na+, K+, Na+/K+, SPAD, and gS) in inbred lines towards anticipated grain yield variations in salinity stressed pearl millet. Most importantly, the AGB alone, explained >91% of yield variation among evaluated hybrids and inbreed lines at ECiw ~9 dSm–1. Cumulatively, the better morpho–physiological adaptation and lesser yield reduction with increasing salinity stress in pearl millet hybrids (HHB 146, HHB 272, and HHB 234) and inbred lines (H77/833–2–202, ICMA 94555 and ICMA 843–22) substantially complemented in increased plant salt tolerance and yield stability over a broad range of salinity stress. The information generated herein will help address in deciphering the trait associated physiological alterations to irrigation induced salt stress, and developing potential hybrids in pearl millet using these parents with special characteristics.

  • Molecular characterization of Hyalomma dromedarii and evaluation of acaricidal potential of herbal methanolic extracts against H. dromedarii larvae in comparison to synthetic acaricides
    Aman D. Moudgil, Prashant S. Daundkar, Anil K. Nehra, Sukhdeep Vohra, Snehil Gupta, and Dinesh Sharma

    Springer Science and Business Media LLC

  • Development of duplex real-time PCR for quick detection of cryptosporidiosis in goats
    Atul Kumar Sharma, K. Gururaj, Rama Sharma, Anjana Goel, Souvik Paul, and Dinesh Kumar Sharma

    Wiley
    AbstractCryptosporidium spp. is the most important foodborne and waterborne pathogens and a leading cause of mortality from foodborne and waterborne gastrointestinal diseases. In neonates of domestic animals, it is associated with consistent diarrhea and dehydration. Cryptosporidium infection begins with the ingestion of sporulated oocytes disseminated by carrier animals that consistently contaminate the environment. Many diagnostic tests are available including microscopy and antigen trap‐ELISA, but none of the diagnostic tests available currently cannot differentiate between active and passive infection in the host. In the current study, to address this challenge an mRNA‐based duplex TaqMan® probe PCR was developed to target the Cryptosporidium oocyst wall protein gene and 18SSU rRNA gene in a single tube that can detect metabolically active cryptosporidial oocysts. The mRNA transcripts are the direct indicator of any actively replicating cell and they will help decipher the active stages of its lifecycle in a host. This diagnostic assay was standardized by computing transcript copy number‐based limit of detection (LOD). For COWP and 18SSU rRNA genes, the LOD was 7.08 × 1004 and 5.95 × 1005, respectively. During active infections, the oocyst wall protein will be active and so its COWP gene transcripts will act as a marker for active infection. While transcripts for 18SSU rRNA are constitutively expressed in cryptosporidial life cycle. This current diagnostic assay will be a quantitative marker that will help assess the active stages of Cryptosporidium infection in neonates. The disease dynamics will help better understand to formulate the control strategies and contain infection among healthy animals.

  • Technical Applications of Hydrotropes: Sustainable and Green Carriers
    Devika Tripathi, S. Raman, Jagannath Sahoo, D. Sharma, Awani and K. Rai

    AMG Transcend Association
    Hydrotropes are amazingly water-solvent natural materials that focus on improving drugs’ dissolvability with poor aqueous solvency at elevated concentrations, just as in a water medium. Advances in the disintegration of ineffectively dissolvable mixes in fluid media expect a significant function in detailing medications, cleaning specialists, and individual consideration items. Besides, they are likewise of urgent importance identified with mechanical cycles, for example, crystallization and refinement. The end of dangerous solvents in compound cycles and their substitution by eco-accommodating solvents, i.e., hydrotropes, is a significant objective of current engineered science. The fluid arrangement of hydrotropes can be viewed as an ecologically favorable response medium and is safe, nonflammable, less expensive, and is inexhaustible. Attempts have been made to explore different domains of the hydrotropes, their believable functions, and exciting constitutes in expanded innovations to fill in as a superior substitution for toxic organic solvents like methanol, (CH3)2CO, DCM, ethers, including many other processes utilized in cutting edge research applications. Hydrotropes are dynamically engaged with various areas to upgrade and improve the dissolvability of inadequately water-solvent medications, explicitly BCS class II medications. Advances in their utility lead to their participation in extracting bioactive materials substance union of natural compounds. Hydrotropic agents had a compelling function as transporters for dynamic drug fixings. It also helps handle different items from drug to curative, agrochemical, and medication modifiers.

  • Enhanced Solubility of Meloxicam with Sodium Benzoate Hydrotrope: Ecofriendly Approach for Improved Topical Drug Delivery
    Devika Tripathi, Dinesh Kumar Sharma, Jagannath Sahoo, and Sunil Kumar Raman

    EManuscript Technologies
    Background: Hydrotropic solid dispersion has been reported as a potential process to improve the poor solubility of drugs using conventional hydrotropes. The presented investigation has described a water-soluble hydrotropic solid dispersion system for Meloxicam (MX) using sodium benzoate hydrotrope to enhance the poor solubility of Meloxicam and to improve topical delivery. Thus, solid dispersion was prepared, characterized, and converted into HSD-Meloxicam gel. The prepared gel was further characterized for in vitro performance. Material and Methods: Solid dispersion was prepared by a solvent evaporation method using sodium benzoate in 1:4 ratios. The prepared systems were characterized for in-vitro release and drug content. Accordingly, rate-controlling polymer and drug penetration enhancers were selected and formulated into hydrogel bases. The prepared gel was evaluated for performance parameters like drug content, pH, viscosity, spreadability, drug release kinetics, diffusion study, accelerated stability studies, and viscosity parameters. Results: HSD-Meloxicam gel containing carbopol-934 (20%w/w) has appeared a 99% release of the drug over 60 min of time duration. The prepared gel has clarity and is homogeneous in appearance. Similarly, in-vitro dissolution studies showed the prepared HSD Meloxicam gel’s better release and rheological properties. The drug content of gel was found as 96% with improved topical

  • Experimental co-production of knowledge to adapt to environmental change in northern India
    Ranjay K. Singh, Anshuman Singh, Satyendra Kumar, Parvender Sheoran, HS Jat, PC Sharma, DK Sharma, BN Hazarika, SN Bhowmik, Amish K. Sureja,et al.

    Elsevier BV

  • Effect of feeding maize silage containing Moringa (Moringa oleifera) leaves on growth, blood metabolites, serum antioxidant and coccidial egg count in Barbari goats under stall-fed condition
    RAVINDRA KUMAR, D K SHARMA, K SWAROOP, and MOHD. ARIF

    Indian Council of Agricultural Research, Directorate of Knowledge Management in Agriculture
    Feeding cum growth trial was conducted on male Barbari goats to study the growth, blood metabolites, antioxidant and coccidial egg count on feeding of Maize silage having Moringa leaves. Eighteen male Barbari goats (Aged about 3 months and Avg B.Wt. 9.53±0.42 kg) were divided in completely randomized design into (CRD) three groups of six each. Control group (Gr C) was fed with concentrate pellet, green and gram straw ad lib. Treatment groups (Gr M) were fed with concentrate pellet + maize silage ad lib.; Gr MM was fed with concentrate pellet + Maize –Moringa silage ad lib. Average daily gain (g/day) was highest in Gr MM (71.42) followed by Gr M (60.87) and Gr C (55.31). There was no significant difference in hematological and serum metabolites (Glucose, total protein, albumin, globulin, AG ratio) among groups. Serum cholesterol (mg/dl) was significantly lower in Gr MM as compared to Gr M and Gr C. There was improvement in the serum antioxidant activity of the goats fed with MM silage. Present study concluded that incorporation of Moringa olifera in the maize silage improved the body weight gain with reduction in serum cholesterol in growing Barbari goats under stall feeding system.

  • Co-implementation of precision nutrient management in long-term conservation agriculture-based systems: A step towards sustainable energy-water-food nexus
    C.M. Parihar, B.R. Meena, Hari Sankar Nayak, K. Patra, D.R. Sena, Raj Singh, S.L. Jat, D.K. Sharma, D.M. Mahala, S. Patra,et al.

    Elsevier BV

RECENT SCHOLAR PUBLICATIONS

  • Variation of Surface Latent Heat Flux (SLHF) observed during high-magnitude earthquakes
    Pooja Sharma, Ananna Bardhan, Raj kumari, D. K. Sharma, Ashok Kr. Sharma
    Journal of Indian Geophysical Union 28 (2), 131-142 2024

  • Role of Meteorological Parameters on Atmospheric Aerosols Concentration and Its Control Through Modern Biomass Application
    DK Sharma, A Bardhan, VV Pathak
    Algal Biofuel, 209-235 2022

  • Low latitude, topside ionosphere composition and its variation with changeable solar activity
    A Bardhan, DK Sharma, B Mangla
    Indian Journal of Radio & Space Physics (IJRSP) 50 (4), 190-197 2022

  • Study of PM2. 5 Distribu-tion, its Relation with Metrological Parameters and Mitigation Over Delhi Region
    A Bardhan, A Sahai, VV Pathak, DK Sharma, M Kapahi
    Stech: Arch of Earth and Env Sci 2, 103 2022

  • Ionospheric and surface thermal parameters during three high magnitude earthquakes
    A Bardhan, P Sharma, A Sahai, DK Sharma
    J. Ind. Geophys. Union 26 (6), 448-461 2022

  • Low latitude ionospheric variations during geomagnetic storms measured using ROCSAT-1 satellite observations
    G Rana, A Bardhan, DK Sharma, MK Yadav
    Indian Journal of Radio & Space Physics (IJRSP) 49 (4), 171-179 2021

  • Perspective of land application of treated effluent in pulp & paper industry.
    N Endlay, DK Sharma, YV Singh, S Kumar, KG Rosin, J Rajput, N Dwivedi, ...
    2021

  • Low latitude, topside ionosphere composition and its variation with changeable solar activity
    B Mangla, NK Dwivedi, DK Sharma, A Bardhan, A Rajput, S Singh
    NIScPR-CSIR, India 2021

  • Variations of ion density and temperature as measured by ROCSAT-1satellite over the Indian region and comparison with IRI-2016 model
    G Rana, A Bardhan, DK Sharma, MK Yadav, M Aggarwal, J Dudeja
    Ann. Geophys 62 (11) 2019

  • Equinoctial asymmetry in ionosphere over Indian region during 2006–2013 using COSMIC measurements
    M Aggarwal, A Bardhan, DK Sharma
    Advances in space Research 60 (5), 999-1014 2017

  • Variability of ionospheric parameters during solar minimum and maximum activity and assessment of IRI model
    DK Sharma, M Aggarwal, A Bardhan
    Advances in Space Research 60 (2), 435-443 2017

  • Seasonal characteristics of COSMIC measurements over Indian sub-continent during different phases of solar activity
    M Aggarwal, DK Sharma
    Advances in Space Research 59 (9), 2279-2294 2017

  • Variability of ion density due to solar flares as measured by SROSS-C2 satellite
    A Bardhan, D Sharma, S Kumar
    Indian Journal of Radio & Space Physics (IJRSP) 44 (2), 88-95 2017

  • Ion density variation at upper ionosphere during thunderstorm
    B Mangla, DK Sharma, A Rajput
    Advances in Space Research 59 (5), 1189-1199 2017

  • Ion density and temperature variations at altitude of 500 km during moderate seismic activity
    A Bardhan, MS Khurana, BM Bahal, M Aggarwal, DK Sharma
    Advances in Space Research 59 (4), 1023-1032 2017

  • Preliminary studies of ionospheric behavior during a seismic event of Mw~ 6.9 at Qinghai station (geog. 33.19 N, 96.75 E)
    M Aggarwal, DK Sharma, A Bardhan
    J. Ind. Geophys. Union 2, 127-132 2016

  • Electron–ion–neutral temperatures and their ratio comparisons over low latitude ionosphere
    A Bardhan, DK Sharma, MS Khurana, M Aggarwal, S Kumar
    Advances in Space Research 56 (10), 2117-2129 2015

  • Study of Ionic Behavior of Ionosphere F2 Region Using Satellite Data
    A Rajput, DK Sharma
    Faridabad 2015

  • Ionospheric disturbances during a strong earthquake (M= 5.5) event
    M Aggarwal, A Bardhan, DK Sharma
    AGU Fall Meeting Abstracts 2014, NH31C-3879 2014

  • Diurnal and seasonal variation of topside ionospheric ion density over Indian region at solar minimum and solar maximum
    B Mangla, DK Sharma, A Rajput
    Advances in Space Research 54 (9), 1813-1817 2014

MOST CITED SCHOLAR PUBLICATIONS

  • Diurnal, seasonal and latitudinal variations of ionospheric temperatures of the topside F region over the Indian region during solar minimum (1995–1996)
    DK Sharma, J Rai, M Israil, P Subrahmanyam
    Journal of atmospheric and solar-terrestrial physics 67 (3), 269-274 2005
    Citations: 27

  • Summer variations of the atmospheric aerosol number concentration over Roorkee, India
    DK Sharma, J Rai, M Israil, P Singh
    Journal of atmospheric and solar-terrestrial physics 65 (9), 1007-1019 2003
    Citations: 23

  • Effect of solar activity on ionospheric temperatures in F2 region
    DK Sharma, PK Sharma, J Rai, SC Garg
    CSIR 2008
    Citations: 21

  • Enhancement in ionospheric temperatures during thunderstorms
    DK Sharma, J Rai, M Israil, P Subrahmanyam, P Chopra, SC Garg
    Journal of atmospheric and solar-terrestrial physics 66 (1), 51-56 2004
    Citations: 21

  • Effect of seismic activities on ion temperature in the F2 region of the ionosphere
    DK Sharma, J Rai, R Chand, M Israil
    Atmsfera 19 (1), 1-7 2006
    Citations: 20

  • Signature of seismic activities in the F2 region ionospheric electron temperature
    DK Sharma, M Israil, R Chand, J Rai, P Subrahmanyam, SC Garg
    Journal of atmospheric and solar-terrestrial physics 68 (6), 691-696 2006
    Citations: 19

  • Enhancement in electron and ion temperatures due to solar flares as measured by SROSS-C2 satellite
    DK Sharma, J Rai, M Israil, P Subrahmanyam, P Chopra, SC Garg
    Annales Geophysicae 22 (6), 2047-2052 2004
    Citations: 19

  • Variation of ionospheric electron and ion temperatures during periods of minimum to maximum solar activity by the SROSS-C2 satellite over Indian low and equatorial latitudes
    PK Sharma, PP Pathak, DK Sharma, J Rai
    Advances in space research 45 (2), 294-302 2010
    Citations: 14

  • Sunrise effect on ionospheric temperature as measured by SROSS-C2 satellite
    DK Sharma, J Rai, M Israil, S Priti, P Subrahmanyam, P Chopra, SC Garg
    J. Ind. Geophysical Union 7, 117-123 2003
    Citations: 13

  • Lightning induced heating of the ionosphere
    DK Sharma, M Israil, J Rai, SC Garg
    Atmsfera 17 (1), 31-38 2004
    Citations: 11

  • Variability of ionospheric parameters during solar minimum and maximum activity and assessment of IRI model
    DK Sharma, M Aggarwal, A Bardhan
    Advances in Space Research 60 (2), 435-443 2017
    Citations: 10

  • Equinoctial asymmetry in ionosphere over Indian region during 2006–2013 using COSMIC measurements
    M Aggarwal, A Bardhan, DK Sharma
    Advances in space Research 60 (5), 999-1014 2017
    Citations: 9

  • Equinoctial asymmetry in low latitude ionosphere as observed by SROSS-C2 satellite
    A Bardhan, M Aggarwal, DK Sharma, J Rai
    Journal of Atmospheric and Solar-Terrestrial Physics 117, 101-109 2014
    Citations: 8

  • Ionospheric electron and ion temperatures response to seismic activity
    DK Sharma, A Bardhan, J Rai
    NISCAIR-CSIR, India 2013
    Citations: 8

  • Preliminary studies of ionospheric behavior during a seismic event of Mw~ 6.9 at Qinghai station (geog. 33.19 N, 96.75 E)
    M Aggarwal, DK Sharma, A Bardhan
    J. Ind. Geophys. Union 2, 127-132 2016
    Citations: 7

  • Electron–ion–neutral temperatures and their ratio comparisons over low latitude ionosphere
    A Bardhan, DK Sharma, MS Khurana, M Aggarwal, S Kumar
    Advances in Space Research 56 (10), 2117-2129 2015
    Citations: 5

  • Diurnal and seasonal variation of topside ionospheric ion density over Indian region at solar minimum and solar maximum
    B Mangla, DK Sharma, A Rajput
    Advances in Space Research 54 (9), 1813-1817 2014
    Citations: 5

  • Variation of the 0+ ion density during low and high solar activity as measured by the SR0SS-C2 satellite
    A Bardhan, DK Sharma, S Kumar, J Rai
    Atmsfera 27 (3), 227-237 2014
    Citations: 5

  • Ion density variation at upper ionosphere during thunderstorm
    B Mangla, DK Sharma, A Rajput
    Advances in Space Research 59 (5), 1189-1199 2017
    Citations: 4

  • Ion density and temperature variations at altitude of 500 km during moderate seismic activity
    A Bardhan, MS Khurana, BM Bahal, M Aggarwal, DK Sharma
    Advances in Space Research 59 (4), 1023-1032 2017
    Citations: 3