Dmitry Chugunov

@rsmu.ru

Institute of Neurosciences and Neurotechnologies
Pirogov Russian National Research Medical University

Dmitry Chugunov


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https://researchid.co/dmitry8383

EDUCATION

Pirogov Russian National Research Medical University: Moscow, Moscow region, RU - M.D.

RESEARCH, TEACHING, or OTHER INTERESTS

Psychiatry and Mental health, Immunology and Allergy, Clinical Psychology, Biological Psychiatry
8

Scopus Publications

16

Scholar Citations

2

Scholar h-index

Scopus Publications

  • Effect of aripiprazole on cytokine production by T cells in schizophrenia
    D.A. Chugunov, A.A. Sviridova, A.V. Lopatina, M.V. Melnikov
    Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2026
    Objective. To evaluate the modulatory effect of the antipsychotic agent aripiprazole on ex vivo production of the cytokines interleukin-17 (IL-17) and interferon-γ (IFN-γ) by T-lymphocytes in patients with schizophrenia. Material and methods. The study included 15 patients diagnosed with schizophrenia and 12 healthy donors as the control group. A peripheral blood mononuclear cell (PBMC) model was employed to assess the effects of aripiprazole on cytokine profiles. Cells were stimulated with microparticles coated with antibodies to CD3 and CD28 surface markers. To investigate the roles of D1 and D2 dopamine receptors (D1DR and D2DR) in the mechanism of action of aripiprazole, PBMCs were stimulated in the presence of aripiprazole alone and in combination with specific antagonists: SCH23390 for D1DR and sulpiride for D2DR. Concentrations of IL-17 and IFN-γ in culture supernatants were measured using an enzyme-linked immunosorbent assay. Results. In patients with schizophrenia, the induced production of both IL-17 and IFN-γ by PBMC was significantly lower than in the healthy donor group. Aripiprazole exhibited a dose-dependent suppressive effect on cytokine secretion in both groups. Blockade of D1DR enhanced the inhibitory effect of aripiprazole, whereas blockade of D2DR diminished it. Isolated blockade of D1DR, in the absence of aripiprazole, inhibited cytokine production by stimulated PBMCs in both groups, while isolated blockade of D2DR had no significant effect. Conclusion. Aripiprazole may exert anti-inflammatory effects in schizophrenia by inhibiting the secretion of pro-inflammatory cytokines by T cells. This effect is likely mediated through D2DR activation.
  • The relationship between the aspects of mindfulness and coping strategies in patients with schizophrenic spectrum disorders and anorexia nervosa
    T.V. Moiseeva, E.S. Ryauzova, E.V. Fedorova, D.A. Chugunov, O.V. Mikhalevskaya, E.D. Krasteleva, N.V. Chernov, G.P. Kostyuk
    Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2026
    Objective. To study the relationship between mindfulness and coping strategies in patients with schizophrenia, schizotypal disorder, and anorexia nervosa. Material and methods. Seventy-five patients were examined (25 with anorexia nervosa (F50.0), 25 with schizotypal disorder (F21), and 25 with paranoid schizophrenia (F20.0)), who were treated in outpatient units of Psychiatric Clinical Hospital No. 1, named after N.A. Alekseev, Moscow, as well as a control group of 25 mentally healthy volunteers. The clinical-psychopathological, psychometric, and statistical methods were used. Mindfulness was assessed using the Five Facet Mindfulness Questionnaire (FFMQ). Karpov’s reflexivity questionnaire was also used. Coping strategies were assessed using the Ways of Coping Questionnaire (WCQ), and a short version of the Difficulties in Emotion Regulation Scale 18 (DERS-18) was used. Results. Significant differences in the relationship between mindfulness and coping strategies between groups have been identified. In the control group, non-judgmentality and description were negatively correlated with self-control (p<0.001 and p=0.018), detachment (p=0.023), acceptance of responsibility (p<0.001), and avoidance (p=0.001). In patients with schizotypal disorder, non-judgmentality was negatively correlated with avoidance (p<0.001), detachment (p=0.017), and clarity (p=0.007). In paranoid schizophrenia patients, non-judgmentality and reflexivity were negatively associated with detachment (p=0.018) and acceptance of responsibility (p=0.021). In patients with anorexia nervosa, non-judgmentality was negatively associated with avoidance (p=0.008) and rejection (p<0.001). Conclusion. There was no direct link between mindfulness components and the choice of coping strategies in clinical groups. In patients with paranoid schizophrenia and schizotypal disorder, these findings are presumably due to emotional ambivalence, dampening of emotional response; in anorexia nervosa patients, due to a lack of emotional self-regulation skills.
  • The role of neuroinflammation in schizophrenia: Focus on Th17 cells functions
    Mikhail Melnikov, Anna Lopatina, Anastasiya Sviridova, Dmitriy Chugunov, Theofanis Vavilis, Vasileios-Periklis Stamatellos, Eleni Stamoula, Marco Cosentino
    Asian Journal of Psychiatry, 2025
  • SCHIZOPHRENIA AND NEUROINFLAMMATION: PATHOGENETIC AND THERAPEUTIC ASPECTS
    D. A. Chugunov, A. A. Shmilovich, D. V. Nikolaeva, T. V. Yashina, M. R. Larina, V. S. Rogovsky, A. A. Sviridova
    Extreme Medicine, 2025
    Introduction. Schizophrenia is a complex mental disorder with heterogeneous symptoms, including psychotic, negative, cognitive, affective, and psychomotor symptoms. Although the pathogenesis of schizophrenia is mainly associated with neurotransmitter imbalance, recent studies have suggested the importance of neuroinflammation in the pathogenesis of this disease.Objective. To study the involvement of neuroinflammation in the pathogenesis of schizophrenia and a prognostic assessment of the potential anti-inflammatory effect of antipsychotic medications.Discussion. Current data indicate a significant role of neuroinflammation in the development and course of schizophrenia. At the initial stages of its development, the number of lymphocytes and the level of some proinflammatory cytokines (IL-1, IL-6, TNF-α, IL-1β) increase, which can be decreased by antipsychotic therapy. Studies involving experimental models of maternal immune activation (MIA) and data obtained by immunohistochemical and PET studies confirm an abnormal activation of microglia, indicating the involvement of innate immune cells. Adaptive immune response cells can also play a significant role in the development of neuroinflammation in schizophrenia. Thus, an increased level of Th17 cells and an increase in the production of proinflammatory cytokines, correlating with the disease severity, were revealed. The role of neurotransmitters in modulating the immune-inflammatory response is discussed. Available data suggest that the participation of dopamine in the schizophrenia pathogenesis can be mediated by its immunomodulatory effect. The role of neuroinflammation in schizophrenia is also indicated by the clinical effectiveness of anti-inflammatory treatment in this disease. On the other hand, the immunomodulatory effect of antipsychotics has been established, which, at least in part, may mediate their clinical effectiveness in schizophrenia.Conclusions. Given the importance of neuroinflammation in the schizophrenia pathogenesis, further studies into both the anti-inflammatory properties of antipsychotics and the effects of anti-inflammatory drugs in schizophrenia are promising in order to further optimize the treatment of this disease.
  • Clinical and Psychometric Features of Cognitive and Negative Disorders in Schizophrenia
    D. A. Chugunov, A. A. Shmilovich, M. R. Larina, S. N. Goncharenko, T. V. Moiseeva, E. S. Ryauzova, E. V. Fedorova, A. A. Bukinich
    Neuroscience and Behavioral Physiology, 2024
  • Clinical and psychometric characteristics of cognitive and negative disorders in schizophrenia
    D.A. Chugunov, A.A. Shmilovich, M.R. Larina, S.N. Goncharenko, T.V. Moiseeva, E.S. Ryauzova, E.V. Fedorova, A.A. Bukinich
    Zhurnal Nevrologii I Psihiatrii Imeni S S Korsakova, 2024
    Objective. To establish the characteristics of clinical manifestations and cognitive tests in patients with schizophrenia, with a predominance of cognitive and negative disorders. Material and methods. We examined 76 patients, 66 in the main group, 10 in the comparison group, who were treated in Psychiatric Hospital No. 1 and Psychiatric Hospital No. 4 (Moscow). Clinical-psychopathological, psychometric and statistical methods were used. Features of cognitive functioning were studied using the Frontal Assessment Battery (FAB) and the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis (ALS) Screen (ECAS). Emotional intelligence scores were assessed using the Ekman Face Emotion Recognition (EFER) test. Results. Patients with schizophrenia showed dominance of one of 3 types of deficit symptoms: cognitive, emotional, and volitional. Cognitive functions were significantly reduced in patients with schizophrenia when compared with the comparison group (mean FAB score (M±SD) 13.44±2.97 in patients with schizophrenia vs. 16.10±1.70 in the comparison group; t=4.10; p<0.001). Cognitive functions were particularly reduced in patients with volitional deficit (mean EFER total score 42.40±9.0 in patients with volitional deficit vs. 47.21±633 in patients with cognitive deficit; t=2.12; p=0.039; mean FAB score 12.83±3.29 in patients with volitional deficit vs. 16.10±1.70 in the comparison group; t=4.24; p<0.001; mean ECAS score specific to ALS 78.80±9.07 in patients with volitional deficit vs. 84.50±6.71 in the comparison group; t=2.18; p=0.034). Conclusion. The greatest contribution to the development of cognitive disorders in schizophrenia is made by dysfunction of frontal (especially) and temporal cortex. Executive functions, speech skills and verbal fluency are most severely damaged.
  • Primary and secondary negative disorders in schizophrenia as an actual problem of modern clinical psychiatry
    D.A. Chugunov, A.A. Shmilovich
    Zhurnal Nevrologii I Psihiatrii Imeni S S Korsakova, 2022
    Negative symptoms of schizophrenia represent, at the present stage of their study, a certain group of mental pathology. They include motivation disorders or volitional disorders (anhedonia, abulia, asociality) and disorders of reduced expression or emotional disorders (alogia/poverty of speech and emotional decline/flattening). Negative symptoms are key disorders in schizophrenia, often appear at the pre-manifest stage of the disease, and significantly affect the prognosis and response to therapy. From a scientific and practical point of view, it is important to distinguish between primary and secondary negative symptoms, where the primary symptoms are nuclear, inherent in schizophrenia, and the secondary ones are the result of the influence of positive symptoms (delusions, hallucinations), depression, side-effects of medications, social isolation and hospitalism. Changes in the concept of primary and secondary negative disorders as well as a pathophysiological basis of negative symptoms are considered.
  • Psychopathology of anxiety-phobic disorders that led to hospitalization in a psychiatric hospital
    D. A. Chugunov, A. A. Schmilovitch
    Zhurnal Nevrologii I Psihiatrii Imeni S S Korsakova, 2017
    AIM: To study the psychopathology of anxiety-phobic disorders and motives of hospitalization of patients in a psychiatric hospital. MATERIAL AND METHODS: One hundred and thirty-two patients were examined, 72 patients of the main group were admitted to general psychiatric departments, 60 patients of the control group in the sanatorium psychiatric departments. Clinical-psychopathological, follow-up, psychometric and statistical methods were used. RESULTS AND CONCLUSION: Patients with hospital anxiety-phobic disorders had agoraphobia with panic disorder, social phobias, hypochondriacal phobias, specific phobias and multiple phobias. The main reasons for hospitalization were: the intensity of anxiety-phobic disorders, contrast content of phobias, multiplicity of anxiety-phobic disorders, ambulance calls, personality accentuations and rental aims.

RECENT SCHOLAR PUBLICATIONS

  • The role of neuroinflammation in schizophrenia: Focus on Th17 cells functions
    M Melnikov, A Lopatina, A Sviridova, D Chugunov, T Vavilis, ...
    Asian Journal of Psychiatry , 2025
    2025
    Citations: 2
  • ВЛИЯНИЕ АРИПИПРАЗОЛА НА ФУНКЦИИ TH17- И TH1-КЛЕТОК ПРИ ШИЗОФРЕНИИ
    ММВ Яшина Т.В., Свиридова А.А., Лопатина А.В., Чугунов Д.А.
    LiFT II Школа молодых ученых «Медицинские нейротехнологии». тезисы … , 2025
    2025
  • Шизофрения и нейровоспаление: патогенетические и терапевтические аспекты
    ДА Чугунов, АА Шмилович, ДВ Николаева, ТВ Яшина, МР Ларина, ...
    Медицина экстремальных ситуаций 27 (1), 56-63 , 2025
    2025
  • Первичные и вторичные негативные расстройства при шизофрении-актуальная проблема современной клинической психиатрии
    ДА Чугунов, АА ШМИЛОВИЧ
    Журнал неврологии и психиатрии им. CC Корсакова 122 (8), 41-47 , 2022
    2022
    Citations: 2
  • Клинико-динамическая характеристика фобий у больных психиатрического стационара
    ДА Чугунов
    М.: Национальный медицинский исследовательский центр психиатрии и наркологии … , 2018
    2018
    Citations: 4
  • Особенности социального функционирования больных с тревожно-фобическими расстройствами, госпитализированных в психиатрический стационар
    ДА Чугунов, АА Шмилович
    Независимый психиатрический журнал, 18-23 , 2018
    2018
  • ПСИХОПАТОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ТРЕВОЖНО-ФОБИЧЕСКИХ РАССТРОЙСТВ, ПОСЛУЖИВШИХ ПОВОДОМ ДЛЯ ГОСПИТАЛИЗАЦИИ В ПСИХИАТРИЧЕСКИЙ СТАЦИОНАР
    ШАА Чугунов Д.А.
    ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. С.С. КОРСАКОВА 117 (11), 18-23 , 2017
    2017
    Citations: 1
  • Трудности диагностики и особенности терапии тревожно-фобических расстройств в условиях психиатрического стационара
    ДА Чугунов, АА Шмилович
    Современная терапия в психиатрии и неврологии, 4-12 , 2017
    2017
    Citations: 1
  • Comorbidity of panic disorder with agoraphobia and alcohol-related disorders.
    A Chugunov, D., & Pavlichenko
    European Psychiatry , 2014
    2014
  • Паническое расстройство с агорафобией: вопросы диагностики и коморбидность
    АВ Павличенко, ДА Чугунов
    Независимый психиатрический журнал, 16 , 2012
    2012
    Citations: 6
  • КЛИНИЧЕСКИЕ ОСОБЕННОСТИ И ПСИХОТРАВМИРУЮЩИЕ СИТУАЦИИ ПРИ ДИСТИМИИ
    ЧД А.
    Вестник РГМУ, 97 , 2006
    2006

MOST CITED SCHOLAR PUBLICATIONS

  • Паническое расстройство с агорафобией: вопросы диагностики и коморбидность
    АВ Павличенко, ДА Чугунов
    Независимый психиатрический журнал, 16 , 2012
    2012
    Citations: 6
  • Клинико-динамическая характеристика фобий у больных психиатрического стационара
    ДА Чугунов
    М.: Национальный медицинский исследовательский центр психиатрии и наркологии … , 2018
    2018
    Citations: 4
  • The role of neuroinflammation in schizophrenia: Focus on Th17 cells functions
    M Melnikov, A Lopatina, A Sviridova, D Chugunov, T Vavilis, ...
    Asian Journal of Psychiatry , 2025
    2025
    Citations: 2
  • Первичные и вторичные негативные расстройства при шизофрении-актуальная проблема современной клинической психиатрии
    ДА Чугунов, АА ШМИЛОВИЧ
    Журнал неврологии и психиатрии им. CC Корсакова 122 (8), 41-47 , 2022
    2022
    Citations: 2
  • ПСИХОПАТОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ТРЕВОЖНО-ФОБИЧЕСКИХ РАССТРОЙСТВ, ПОСЛУЖИВШИХ ПОВОДОМ ДЛЯ ГОСПИТАЛИЗАЦИИ В ПСИХИАТРИЧЕСКИЙ СТАЦИОНАР
    ШАА Чугунов Д.А.
    ЖУРНАЛ НЕВРОЛОГИИ И ПСИХИАТРИИ ИМ. С.С. КОРСАКОВА 117 (11), 18-23 , 2017
    2017
    Citations: 1
  • Трудности диагностики и особенности терапии тревожно-фобических расстройств в условиях психиатрического стационара
    ДА Чугунов, АА Шмилович
    Современная терапия в психиатрии и неврологии, 4-12 , 2017
    2017
    Citations: 1
  • ВЛИЯНИЕ АРИПИПРАЗОЛА НА ФУНКЦИИ TH17- И TH1-КЛЕТОК ПРИ ШИЗОФРЕНИИ
    ММВ Яшина Т.В., Свиридова А.А., Лопатина А.В., Чугунов Д.А.
    LiFT II Школа молодых ученых «Медицинские нейротехнологии». тезисы … , 2025
    2025
  • Шизофрения и нейровоспаление: патогенетические и терапевтические аспекты
    ДА Чугунов, АА Шмилович, ДВ Николаева, ТВ Яшина, МР Ларина, ...
    Медицина экстремальных ситуаций 27 (1), 56-63 , 2025
    2025
  • Особенности социального функционирования больных с тревожно-фобическими расстройствами, госпитализированных в психиатрический стационар
    ДА Чугунов, АА Шмилович
    Независимый психиатрический журнал, 18-23 , 2018
    2018
  • Comorbidity of panic disorder with agoraphobia and alcohol-related disorders.
    A Chugunov, D., & Pavlichenko
    European Psychiatry , 2014
    2014
  • КЛИНИЧЕСКИЕ ОСОБЕННОСТИ И ПСИХОТРАВМИРУЮЩИЕ СИТУАЦИИ ПРИ ДИСТИМИИ
    ЧД А.
    Вестник РГМУ, 97 , 2006
    2006

GRANT DETAILS

The role of D2-like dopaminergic receptor in the modulation of Th17-immune response in schizophrenia 24-25-00409