manzoor ahmad parry
@skims.ac.in
senior resident, department of nephrology
Sher i kashmir institute of medical sciences
EDUCATION
DM (Nephrology) from Gauhati Medical College and Hospital: Guwahati, Assam (2016-08-05 to present 2019-08-04 )
MD (internal medicine from Sher-i-Kashmir Institute of Medical Sciences: Srinagar, Jammu and Kashmir (2012-05-29 to 2015-04-28)
MBBS from Government Medical College Srinagar: Srinagar, Jammu and Kashmir, (2005-08-01 to 2011-11-30)
RESEARCH INTERESTS
Nephrology
transplantation
Dialysis
Scopus Publications
Scopus Publications
Aadil Wasil, Manzoor Parry, Abdul Reshi, Roohi Rasool, Imtiyaz Rashid, and Imtiyaz Wani
Medknow
The significance of vascular endothelial growth factor (VEGF) and its polymorphisms in renal allograft rejection has recently become the subject of extensive research. Recently, some studies have shown some role of VEGF in rejection episodes and graft survival. VEGF +936 C>T polymorphism is significant in the transcription regulation of VEGF. Herein, we report the results of a prospective, single-center study seeking an association of VEGF +936 C/T gene polymorphism and allograft rejection. One hundred and forty-seven kidney transplant recipients with age-and sex-matched controls were included in this study. VEGF 936 C/T genes were studied using restriction fragment length polymorphism analysis of the blood specimen of these patients. All patients were studied for allograft rejection, response to treatment, and overall graft survival. We found that CT genotype and T allele carrier state were associated with good graft outcomes (P = 0.008 and 0.002, respectively). There was a lower number of rejection episodes with T allele, although it was not a significant finding (P = 0.880). Our findings suggest that good graft outcome in kidney transplant recipients is associated with an increased frequency of the VEGF 936 CT genotype and T allele, and that determination of the T allele might be helpful for the identification of recipients with overall good graft survival.
P. Mahanta, S. Alam, M. Parry, Manjuri Sharma, P. Doley, G. Pegu, Mastakim Ahmad Mazumder, H. Jeelani and Gayatari Pegu
Full-house pattern on immunofluorescence (IF) on kidney biopsy in a patient without systemic lupus erythematosus is termed as nonlupus full-house nephropathy (FHN). In this study, we retrospectively compiled patients with nonlupus FHN and compared them with lupus FHN for clinicopathological presentation. We included patients with full-house IF patterns in renal biopsies collected from March 2007 to August 2018, clinical and histopathological data at the time of presentation were studied retrospectively. Treatment received and outcome at the end of follow-up was studied. Patients with nonlupus FHN who did not show any systemic disease (idiopathic group) were compared with a group of lupus nephritis patients. Of 178 patients, 34 had nonlupus FHN with 21 having idiopathic nonlupus FHN and 13 patients having secondary nonlupus FHN (membranous nephropathy, IgA nephropathy, postinfection glomerulonephritis). Males were more often in idiopathic nonlupus FHN patients than lupus FHN patients (P = 0.005). Kidney biopsies more often showed a mesangial (P = 0.0006) and less proliferative pattern of injury (P = 0.0002) and less intense C1q staining (P = 0.0001) in idiopathic nonlupus than lupus FHN. Clinically, idiopathic nonlupus FHN presented with more proteinuria (P = 0.0059) and less complement consumption (P = 0.001) than lupus FHN patients. Compared to lupus FHN, nonlupus has mainly nephrotic syndrome as clinical presentation. There was no difference in the clinical outcome between lupus FHN and idiopathic nonlupus FHN. Nonlupus FHN is not a very common condition and has less female involvement than in lupus FHN. Idiopathic nonlupus FHN has certain histopathological features with less C1q staining by IF, less frequent proliferative lesions and higher mesangial or membranous lesions by light microscopy compared to lupus FHN. Regarding outcomes, there is no significant difference between lupus FHN and idiopathic nonlupus FHN.
Hitesh Khatri, Pankaj Adhicari, M. Parry and Manjuri Sharma
Background Cutaneous manifestations in chronic kidney disease (CKD) can affect quality of life and can vary across regions, races, and nutritional status of patients. Objective To study the prevalence of mucocutaneous manifestations in patients with CKD and compare between dialysis and nondialysis patients. Patients and methods This was a cross-sectional study from North-East India. A total of 210 patients with CKD were included, with 61 patients in dialysis group and 149 in the nondialysis group. A comprehensive history, detailed examination, and all the relevant investigations were done. Results There was a male predominance in this study, and the mean age was 49.85±12.5 years. Diabetes mellitus (42.9%) was the most common cause of CKD. Cutaneous involvement was seen in 142 (67.61%) patients, with predominance in dialysis patients (60/61) (98.36%) as compared with nondialysis patients (80/149) (55.03%). Xerosis (58.09%) was the most common skin change seen in 122 patients, being more in the dialysis group as compared with the nondialysis group (73.8 vs. 51.7%; P=0.0034). This was followed by pallor (36.19%) of the skin and mucosa. Pruritus (35.23%) was seen in 74 patients, being more in dialysis patients. Cutaneous infections were seen in 57 patients. Absent lunula (14.26%) and half-and-half nail (12.85%) were the most common nail changes. Mucosal changes were seen in 28 (13.33%) patients. Hair changes were seen in 16.67% of patients, with predominant affection in dialysis patients. Conclusion Xerosis, pruritus, skin pallor, absent lunula, xerostomia, macroglossia, and infections were the most common mucocutaneous manifestations in this study. Xerosis, pruritus, absent lunula, and hair changes were more common in dialysis patients.
MastakimAhmed Mazumder, Manjuri Sharma, PranabJyoti Mahanta, ProdipKumar Doley, Gaytri Pegu, Shahzad Alam, ManzoorAhmad Parry, and Hamad Jeelani
Medknow
This study was conducted to retrospectively investigate the indications for renal biopsy in the native kidneys of children and to analyze the pathological findings in a single tertiary care hospital in North-East India for the past 12 years. All children (≤18 years) who underwent renal biopsy at our hospital from March 2007 to April 2018 were included. Renal tissue specimens were studied under light and immunofluorescence microscopy. The study group included 254 patients (female 57%). The median age was 15 years (range 6–18 years). The most frequent indications for renal biopsy were nephrotic syndrome (NS) (53.9%), urinary abnormality in systemic disease (22.1%), nephritic syndrome (15.4%), asymptomatic hematuria (4.7%), significant proteinuria (3.1%), and unexplained renal failure (0.8%). On histopathological examination, primary glomerular diseases were the most frequent (68.9%) followed by secondary glomerular diseases (30.3%) and tubulointerstitial diseases (0.8%). The most common primary glomerular diseases were minimal change disease (26.8%), focal segmental glomerular sclerosis (12.2%), diffuse proliferative glomerulonephritis (9.1%), membranous nephropathy (8.7%), IgA nephropathy (8.3%), membranoproliferative glomerulonephritis (2%), and mesangioproliferative glomerulonephritis (2%). Lupus nephritis (LN) (29.5%) was the most common secondary glomerular disease. NS was the most common indication of renal biopsy, and LN was the most common histopathological diagnosis in children ≤18 years.
ManzoorAhmad Parry, Manjuri Sharma, Hamad Jeelani, PranabJyoti Mahanta, ProdipKumar Doley, and Gayatri Pegu
Medknow
Diabetes mellitus is the most common cause of chronic kidney disease worldwide. The prevalence of nondiabetic renal disease (NDRD) among patients with type 2 diabetes mellitus (T2DM) varies widely. This study aimed to evaluate the renal biopsies performed on type 2 diabetic patients for suspicion of NDRD and to correlate clinicopathological findings. All T2DM patients aged > 18 years were included in this study, who had renal biopsy performed for the following reasons: recent-onset nephrotic syndrome, unexplained rapid deterioration of renal function, proteinuria not accompanied by retinopathy, and unexplained hematuria. Renal biopsy was analyzed by light microscopy and immunofluorescence. Based on biopsy findings, the patients were grouped into three: (i) isolated NDRD, (ii) NDRD ± diabetic nephropathy (DN), and (iii) isolated DN. A total of 140 patients were enrolled in this study. Recent-onset nephrotic syndrome was the most common indication for biopsy, followed by the presence of active urine sediment. Forty-two percent of the patients had isolated DN, while NDRD was seen in 34% and DN ± NDRD in 24%. Focal segmental glomerulosclerosis (FSGS) and IgA nephropathy were the most common causes of isolated NDRD, while chronic tubulointerstitial nephritis (CTIN) was common in NDRD plus DN. Short duration of diabetes, absence of diabetic retinopathy, and lower glycated hemoglobin were predictive of NDRD. NDRD was seen in 58% of the patients with atypical presentations. FSGS and CTIN were common in NDRD diseases. Judicious use of biopsy in diabetic patients with atypical presentation may help in the diagnosis of NDRD.
Mohammad Ashraf Bhat, Manzoor Ahmad Parry, Saniya Nissar, Aga Syed Sameer, Imtiyaz A. Bhat, Zafar A. Shah, and Roohi Rasool
Springer Science and Business Media LLC
Khalid Hamid Changal, Muzamil Latief, Manzoor Parry, and Farhat Abbas
BMJ
Irshad Ahmad Parray, Manzoor Ahmad Parry, and Muzamil latief
Elsevier BV
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
PUBLICATIONS
1. Bhat MA, Parry MA, Nissar S, et al. Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley. BMC Nephrology. 2017;18:111. doi:10.1186/s12882-017-0526-5
2. Irshad Ahmad Parray, Manzoor Ahmad Parry, Muzamil latief “Prevalence of dyslipidemia in school children of Kashmir valley” Diabetes & Metabolic Syndrome: Clinical Research & Review
3. Latief M, Abbas F, Minhas A, Dar W, Parry M, Gupta PD. Vitamin D Defciency in Rheumatoid Arthritisand Vitamin D Levels that vary with Rheumatoid Arthritis Severity:An Indian Study. J Postgrad Med Edu Res 2017;51(4):162-165.
4. NajeebUllah Sofi, Waseem Raja , Imtiyaz Ahmad Dar, Basharat Kasana, MuzamilLatief, Faheem Arshad, Moomin Hussain, Hakim Irfan, Manzoor Parray, Khurshid Iqbal “Role of thiamine supplementation in patients with heart failure – An Indian perspective” 1561-8811/# 2015 Indian College of Cardiology
5. Khalid Hamid Changal, Hameed Raina, Manzoor Ahmed Parray. Fayaz Ahmad Sofi ‘’Carcinoma of the breast presenting as deep vein thrombosis of the axillary vein’’ Caspian J Intern Med. 2013 Autumn; 4(4): 790–792.
6. Khalid Hamid Changal , Ab. Hameed Raina , Manzoor Ahmad Parray , Mohammed Sultan Allai ‘’Attempted Suicidal hanging leading to Hypoxic Ischemic Encephalopathy’’Int J Med Health Sci. July 2013,Vol-2;Issue-3
7. Yasir Bashir , Nusrat Bashir , SajadGeelani , Asif Ahmed, Manzoor Parry , Shabeer Ahmad , JavidRasool ‘’Hyperphagia- A Rare Clinical Presentation of Acute Lymphoblastic Leukemia Relapse’’ American Journal of Medical Case Reports, 2014, Vol. 2, No. 11, 247-249
8. Muzamil Latief, waseem Raja, Manzoor Parry, Ravi Rao “Scleral and Body Hyperpigmentation in Disseminated Tuberculosis with Adrenal Insufficiency (Addison’s Disease)” J Gen Practice 2016, 4:2
9. Farhat Abbas, Waseem Raja Dar,Muzamil Latief, Summyia Farooq, Manzoor Ahmad Parry, Peerzada Ziaul haq and Imtiyaz Dar “Gastrointestinal Stromal Tumors: A Review” J MolImag Dynamic 6: 124. doi:10.4172/2155-9937.1000124
10. Dar WR, Latief M, Sofi N, Dar I, Parray M, et al. (2015) A Rare Presentation of Primary Sjogrens Syndrome. J Gen Practice 3: 210. doi: 10.4172/2329-9126.1000210
11. Khuja Z, Parry M, Rasool R, Reshi AR. Association of Forkhead Box P3 Gene Polymorphisms With Allograft Rejection Episodes in Kidney Transplant Patients: a Study From Kashmir, North India. Iran J Kidney Dis. 2018 Oct;12(5):305-311
12. Sharma, M., Parry, M., Jeelani, H., & Mahanta, P. J. (2019). RETROSPECTIVE STUDY OF HISTOLOGICAL ANALYSIS AND ITS CORRELATION WITH CLINICAL PRESENTATION AND OUTCOME OF IGA NEPHROPATHY FROM A TERTIARY CENTRE OF GUWAHATI ASSAM. International Journal of Medical and Biomedical Studies, 3(2).
13. Jeelani, H., Parry, M., Dange, S. (2019). PREVALENCE OF DEPRESSION AND ITS ASSOCIATED FACTORS AMONG PATIENTS OF CHRONIC KIDNEY DISEASE IN A TERTIARY CARE HOSPITAL FROM ASSAM: A CROSS-SECTIONAL STUDY. International Journal of Medical and Biomedical Studies, 3,(11) 95-102
14. Mastakim A Mazumder, Manzoor A Parry, Hamad Jeelani, Shahzad Alam. A Comparative Study of Newer and Conventional Risk Factors of Coronary Artery Disease in Young Patients: A Case-Control Study from a Centre in Uttar Pradesh, India. Int J Med Res Prof. 2018 Nov; 4(6):109-13. DOI:10.21276/
15. Sharma M, Parry MA, Mahanta PJ, Doley P, Pegu G, Jeelani H. Drug-induced Acute Kidney Injury/ Acute Tubulointerstitial Nephritis: A Clinico-etiological Study from a Single Center in North-east India. Journal of Postgraduate Medicine, Education and Research, Jan-Mar 2019;53(1):00-00.
16. Jeelani, H., Sharma, M., Parry, M. A., Doley, P., & Pegu, G. (2019). PULMONARY HYPERTENSION IN END STAGE KIDNEY DISEASE (ESKD) PATIENTS ON MAINTENANCE HEMODIALYSIS (MHD) VIA SURGICALLY CREATED ARTERIOVENOUS FISTULA. International Journal of Medical and Biomedical Studies, 3(11).