Dr. Santosh Kumar SIngh
@arkajainuniversity.ac.in
Assistant Professor, Biotechnology
Arka Jain University, Jharkhand
RESEARCH INTERESTS
Molecular Microbiology, Antibiotics resistant gram negative bacteria
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Anurag Kumar Singh, Saumitra Sen Singh, Aaina Singh Rathore, Surya Pratap Singh, Gaurav Mishra, Rajendra Awasthi, Sunil Kumar Mishra, Vibhav Gautam, and Santosh Kumar Singh
American Chemical Society (ACS)
Divya Mishra, Ashish Mishra, Sachchida nand Rai, Santosh kumar Singh, Emanuel Vamanu, and Mohan P. Singh
IMR Press
Harshita Tiwari, Nilesh Rai, Swati Singh, Priyamvada Gupta, Ashish Verma, Akhilesh Kumar Singh, Kajal, Prafull Salvi, Santosh Kumar Singh, and Vibhav Gautam
MDPI AG
Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis and treatment. Nanomaterials are extensively employed in the field of oncology because of their minute size and ultra-specificity. A wide range of nanocarriers, such as dendrimers, micelles, PEGylated liposomes, and polymeric nanoparticles are used to facilitate the efficient transport of anti-cancer drugs at the target tumor site. Real-time labeling and monitoring of cancer cells using quantum dots is essential for determining the level of therapy needed for treatment. The drug is targeted to the tumor site either by passive or active means. Passive targeting makes use of the tumor microenvironment and enhanced permeability and retention effect, while active targeting involves the use of ligand-coated nanoparticles. Nanotechnology is being used to diagnose the early stage of cancer by detecting cancer-specific biomarkers using tumor imaging. The implication of nanotechnology in cancer therapy employs photoinduced nanosensitizers, reverse multidrug resistance, and enabling efficient delivery of CRISPR/Cas9 and RNA molecules for therapeutic applications. However, despite recent advancements in nano-oncology, there is a need to delve deeper into the domain of designing and applying nanoparticles for improved cancer diagnostics.
Nilesh Rai, Priyamvada Gupta, Ashish Verma, Santosh Kumar Singh, and Vibhav Gautam
Wiley
Endophytic fungi are a well-established reservoir of bioactive compounds that are pharmaceutically valuable and therefore, contribute significantly to the biomedical field. The present study aims to identify the bioactive anticancer compound from ethyl acetate extract of fungal endophyte, Colletotrichum gloeosporioides associated with the leaf of the medicinal plant Oroxylum indicum. The fatty acid amide compound N-(2-Hydroxyethyl)hexadecanamide (Palmitoylethanolamide; PEA) was identified using antioxidant activity-guided fractionation assisted with tandem liquid chromatography coupled with quadrupole time of flight mass spectrometry, Fourier transform-infrared spectroscopy, time-of-flight mass spectrometry, and nuclear magnetic resonance. In-Silico molecular docking analysis showed that PEA potentially docked to the active sites of apoptosis-inducing proteins including BAX, BCL-2, P21, and P53. Further validation was done using in vitro study that showed PEA inhibitsthe proliferation, alters nuclear morphology and attenuates the wound closure ability of MDA-MB-231 and MCF-7 cells. PEA induces apoptosis via upregulating cell-cycle arrest (P21), tumor suppression (P53), pro-apoptotic (BAX, CASPASE-8, and FADD) genes, and downregulating anti-apoptotic gene BCL-2. The upregulation of the active form of Caspase-3 was also reported. This is the first-ever report for the isolation of PEA from C. gloeosporioides with anticancer activity against human breast cancer cells and therefore holds great potential for future therapeutics.
Riya Thapa, A. Goyal, Gaurav Gupta, A. Bhat, Santoshkumar Singh, V. Subramaniyan, Sunil Sharma, P. Prasher, V. Jakhmola, Sachin Kumar Singh and K. Dua
, a significant metabolite of BBE for activating autophagy and, by extension, playing a neuroprotective function. Their results showed that neuronal morphological damage was mitigated in AβPP/PS1 animals treated with BBE, and autophagy-related
Anjali Rai, Santosh K. Singh, Sumit K. Singh, Poornima Sharma, Arvind K. Ahlawat, Sung Soo Han, and Anju Mahendru-Singh
Cambridge University Press (CUP)
Abstract The study of polymorphism of glutenin makes it possible to identify and isolate desirable genotypes with higher grain quality. In the last few years, only a part of the genetic diversity among the modern and popular wheat germplasm and varieties based on the polymorphism of glutenin subunits are captured. To address this 107 wheat varieties released across different agricultural zones in India, were used to investigate HMW-GS and LMW-GS allele polymorphism, gene diversity and genetic variation in the Glu-1 and Glu-3 loci. Among the different HMW-GS, the highest genetic variation was observed at the Glu-D1 locus with both Glu-D1a and Glu-D1d possessing genetic variation of 0.490, 0.484 respectively. The highest genetic variation at the Glu-A3 locus was observed at the Glu-A3c and GluA3b possessing a genetic variation of 0.463, 0.411 respectively. This was followed by the Glu-B3j having a genetic variation of 0.386 at the Glu-B3 locus. Over 20 years a remarkable increase in the Glu-D1d allele is observed in the newly released varieties in India. Among all the zones, Glu-A1-null is the least frequent allele at the Glu-1 locus, however, it is present as the predominant allele in the NHZ of India. This study elucidates the relationships of these HMW and LMW allelic frequencies and genetic variation with their geographical distribution over the two different periods. This study provides reference data that can be used to assist the breeding, quality evaluation and development of good-quality wheat varieties.
Sachchidanand Pathak, Anurag Mishra, Ganesh Sonawane, Kajal Sonawane, Sarita Rawat, Abhay Raizaday, Santosh Kumar Singh, and Gaurav Gupta
Elsevier
Juvin Ann Thomas, Athira Gireesh Gireesh Moly, Hima Xavier, Priya Suboj, Amit Ladha, Gaurav Gupta, Santosh Kumar Singh, Partha Palit, and Suboj Babykutty
Frontiers Media SA
Breast cancer ranks second among the causes of cancer-related deaths in women. In spite of the recent advances achieved in the diagnosis and treatment of breast cancer, further study is required to overcome the risk of cancer resistance to treatment and thereby improve the prognosis of individuals with advanced-stage breast cancer. The existence of a hypoxic microenvironment is a well-known event in the development of mutagenesis and rapid proliferation of cancer cells. Tumor cells, purposefully cause local hypoxia in order to induce angiogenesis and growth factors that promote tumor growth and metastatic characteristics, while healthy tissue surrounding the tumor suffers damage or mutate. It has been found that these settings with low oxygen levels cause immunosuppression and a lack of immune surveillance by reducing the activation and recruitment of tumor infiltrating leukocytes (TILs). The immune system is further suppressed by hypoxic tumor endothelium through a variety of ways, which creates an immunosuppressive milieu in the tumor microenvironment. Non responsiveness of tumor endothelium to inflammatory signals or endothelial anergy exclude effector T cells from the tumor milieu. Expression of endothelial specific antigens and immunoinhibitory molecules like Programmed death ligand 1,2 (PDL–1, 2) and T cell immunoglobulin and mucin-domain containing-3 (TIM-3) by tumor endothelium adds fuel to the fire by inhibiting T lymphocytes while promoting regulatory T cells. The hypoxic microenvironment in turn recruits Myeloid Derived Suppressor Cells (MDSCs), Tumor Associated Macrophages (TAMs) and T regulatory cells (Treg). The structure and function of newly generated blood vessels within tumors, on the other hand, are aberrant, lacking the specific organization of normal tissue vasculature. Vascular normalisation may work for a variety of tumour types and show to be an advantageous complement to immunotherapy for improving tumour access. By enhancing immune response in the hypoxic tumor microenvironment, via immune-herbal therapeutic and immune-nutraceuticals based approaches that leverage immunological evasion of tumor, will be briefly reviewed in this article. Whether these tactics may be the game changer for emerging immunological switch point to attenuate the breast cancer growth and prevent metastatic cell division, is the key concern of the current study.
Priyamvada Gupta, Nilesh Rai, Ashish Verma, Dimple Saikia, Surya Pratap Singh, Rajiv Kumar, Santosh Kumar Singh, Deepak Kumar, and Vibhav Gautam
American Chemical Society (ACS)
A green-based approach for the synthesis of silver nanoparticles has gained tremendous attention in biomedical applications. Fungal endophytes have been recognized as a remarkable biological source for the synthesis of potential nanodrugs. The present study focuses on the fabrication of silver nanoparticles using the fungal endophyte Penicillium oxalicum (POAgNPs) associated with the leaf of the Amoora rohituka plant. Sharp UV–visible spectra at 420 nm appeared due to the surface plasmon resonance of POAgNPs and the reduction of silver salt. FT-IR analysis revealed the presence of functional groups of bioactive compounds of P. oxalicum responsible for the reduction of silver salt and validated the synthesis of POAgNPs. A high degree of crystallinity was revealed through XRD analysis, and microscopy-based characterizations such as AFM, TEM, and FESEM showed uniformly distributed, and spherically shaped nanoparticles. Furthermore, POAgNPs showed a potential inhibitory effect against bacterial and fungal strains of pathogenic nature. POAgNPs also exhibited potential antioxidant activity against the synthetically generated free radicals such as DPPH, superoxide, hydroxyl, and nitric oxide with EC50 values of 9.034 ± 0.449, 56.378 ± 1.137, 34.094 ± 1.944, and 61.219 ± 0.69 μg/mL, respectively. Moreover, POAgNPs exhibited cytotoxic potential against the breast cancer cell lines, MDA-MB-231 and MCF-7 with IC50 values of 20.080 ± 0.761 and 40.038 ± 1.022 μg/mL, respectively. POAgNPs showed anticancer potential through inhibition of wound closure and by altering the nuclear morphology of MDA-MB-231 and MCF-7 cells. Further anticancer activity revealed that POAgNPs induced apoptosis in MDA-MB-231 and MCF-7 cells by differential expression of genes related to apoptosis, tumor suppression, and cell cycle arrest and increased the level of Caspase-3. The novel study showed that P. oxalicum-mediated silver nanoparticles exhibit potential biological activity, which can be exploited as nanodrugs in clinical applications.
Asif Ahmad Bhat, Gaurav Gupta, Santosh Kumar Singh, Hemant KS Yadav, Mahendra Saini, Roshan Salfi, Sachin Kumar Singh, and Kamal Dua
Future Medicine Ltd
Sreekala. V, K. N. Dwivedi, and Santosh Kumar Singh
A and V Publications
Background: Cocos nucifera Linn. belongs to the Arecaceae family and is the only accepted species from the genus Cocos. Coconut shell is a usually discarded material from the plant source Cocos nucifera Linn. However, scientifically validated data regarding the chemical and conforming therapeutic profile of Coconut shell is not available till date. It is important to develop analytical standards of Coconut shell using pharmacognostic, phytochemical and chromatographic techniques. Materials and Methods: The present analytical study was designed to determine the organic compounds present in the active fraction of dried ripe Coconut shell and to develop drug standards using powder microscopy, quantitative and qualitative phytochemical analysis and TLC techniques. Results: Powder microscopy and preliminary phytochemical analysis of Cocos nucifera Linn. endocarp indicated the presence of high fibre content in the drug. Further studies revealed the test drug as a rich source of alkaloids, steroids, phenols, flavonoids and tannins. Bioactive chemical profile and analytical standards of the test drug were derived by Thin Layer Chromatographic studies as well. Conclusion: The findings of the current research work ensued in establishing the botanical and analytical standards for Coconut (Cocos nucifera Linn.) shell.
Sumesh Kumar Dash, Lipika Jena, Rajashree Panigrahy, Suneeta Sahu, and Santosh Singh
Journal of Pure and Applied Microbiology
Brucellosis is a rising veterinary and human health problem in India. It may manifest with a varied multisystem clinical presentation. In our case patient was of 72 years male with a complaint of abdominal pain for 2 months following COVID-19 infection. He was a known case of CAD (coronary artery disease) post PTCA status, on regular follow up & treatment. Patient had post COVID pulmonary fibrosis. When the patient admitted in our hospital with above mentioned complaints, necessary investigations along with blood culture by automated method was sent and patient was started on empirical doxycycline along with other symptomatic treatment. As the patient was not very sick and was reluctant to stay in hospital during the COVID-19 situation, he was discharged on request with a treatment and follow up plan. Blood culture was found to be positive for Brucella melitensis. When we got the blood culture report the patient was contacted telephonically and started Rifampicin along with Doxycycline for 6 weeks.
Gaurav Mishra, Rajendra Awasthi, Anurag Kumar Singh, Snigdha Singh, Sunil Kumar Mishra, Santosh Kumar Singh, and Manmath K. Nandi
American Chemical Society (ACS)
Selective permeability of the blood–brain barrier restricts the treatment efficacy of neurologic diseases. Berberine (BBR) and curcumin (CUR)-loaded transferosomes (TRANS) were prepared for the effective management of Alzheimer’s disease (AD). The study involved the syntheses of BBR-TRANS, CUR-TRANS, and BBR-CUR-TRANS by the film hydration method. Vesicles were characterized to ensure the formation of drug-loaded vesicles and their in vivo performance. The particle sizes of BBR-TRANS, CUR-TRANS, and BBR-CUR-TRANS were 139.2 ± 7, 143.4 ± 8, and 165.3 ± 6.5 nm, respectively. The presence of diffused rings in the SED image indicates the crystalline nature of the payload. Low surface roughness in an AFM image could be associated with the presence of a surface lipid. BBR-CUR-TRANS showed 41.03 ± 1.22 and 47.79 ± 3.67% release of BBR and 19.22 ± 1.47 and 24.67 ± 1.94% release of CUR, respectively, in phosphate buffer saline (pH 7.4) and acetate buffer (pH 4.0). Formulations showed sustained release of both loaded drugs. BBR-TRANS, CUR-TRANS, and BBR-CUR-TRANS exhibited a lower percentage of hemolysis than pure BBR and CUR, indicating the safety of the payload from delivery vesicles. Lower percentages of binding were recorded from BBR-CUR-TRANS than BBR-TRANS and CUR-TRANS. Acetylcholinesterase inhibition activity of the prepared transferosomes was greater than that of pure drugs, which are thought to have good cellular penetration. The spatial memory was improved in treated mice models. The level of malondialdehyde decreased in AD animals treated with BBR-TRANS, CUR-TRANS, and BBR-CUR-TRANS, respectively, as compared to the scopolamine-induced AD animals. BBR-CUR-TRANS-treated animals showed the highest decrease in the NO level. The catalase level was significantly restored in scopolamine-intoxicated animals treated with BBR-TRANS, CUR-TRANS, and BBR-CUR-TRANS. The immunohistochemistry result suggested that the BBR-TRANS, CUR-TRANS, and BBR-CUR-TRANS have significantly decreased the regulation of expression of BACE-1 through antioxidant activity. In conclusion, the study highlights the utility of formulated transferosomes as promising carriers for the co-delivery of drugs to the brain.
Nilesh Rai, Priyamvada Gupta, Priyanka Kumari Keshri, Ashish Verma, Pradeep Mishra, Deepak Kumar, Ajay Kumar, Santosh Kumar Singh, and Vibhav Gautam
Springer Science and Business Media LLC
Riya Jalan, Biswaranjan Pradhan, Santosh Kumar Singh, Anuradha Das, Rajib Lochan Barik, Jyotisikha Meher, Rashmi Ranjan Mishra, Debasmita Dubey, and Bikash Chandra Behera
A and V Publications
Nine actinobacteria were isolated from the mangrove soil of Bhitarkanika and screened for their bioactive metabolites and antimicrobial property. Out of the nine actinobacterial isolates, the bacterial isolateBAB-7 showed positive activity towards most of the enzymesscreened,i.e., Cellulase, phosphate solubilization, L-asparaginase, protease, and amylase. The actinobacterial isolate BAB-7 also exhibited antimicrobial activity against K. pneumoniae, V. alginolyticus, V. parahaemolyticus, P. aeruginosa,E. coli, S. typhimurium, and S. salivarius. Based on biochemical characterization, the actinobacterial isolate BAB-7 was identified asSteptomcessp.The secondary metabolites produced by the bacterial strain were analyzed through GC-mass spectroscopy and found to besimilar to the peaks of2-cyclohex-3-en-1-yl-2-oxoacetic acid derivative (ketomycin).
Nilesh Rai, Priyanka Kumari Keshri, Priyamvada Gupta, Ashish Verma, Swapnil C. Kamble, Santosh Kumar Singh, and Vibhav Gautam
Public Library of Science (PLoS)
Oroxylum indicum(L.) Kurz, a medicinal plant, shows numerous pharmacological properties which may be attributed to the bioactive compounds produced byO.indicumor due to associated endophytes. In the present study, leaf ofO.indicumwas evaluated for the presence of associated fungal endophytes, and antioxidant and cytotoxic activities of bioactive compounds produced from them. Using culture-dependent approach, eight fungal endophytes belonging to five different genera were identified. Two endophytesDaldinia eschscholtziiandEctophoma multirostratahave been reported for the first time from the leaf ofO.indicumplant. High-performance thin-layer chromatography (HPTLC) of ethyl acetate (EA) extract of isolated fungal endophytes showed a distinct fingerprinting profile in EA extract ofColletotrichum gloeosporioides. Among identified endophytes, EA extract ofC.gloeosporioidesshowed significant antioxidant activity against DPPH free radical, superoxide anion radical, nitric oxide radical and hydroxyl radical with EC50values of 22.24±1.302 μg/mL, 67.46±0.576 μg/mL, 80.10±0.706 μg/mL and 61.55±1.360 μg/mL, respectively. EA extract ofC.gloeosporioidesexhibited potential cytotoxicity against HCT116, HeLa and HepG2 cancer cell lines with IC50values of 76.59 μg/mL, 176.20 μg/mL and 1750.70 μg/mL, respectively. A comparative HPTLC fingerprinting and the antioxidant activity ofC.gloeosporioidesassociated with two different hosts (leaf ofO.indicumand dead twigs of other plant) showed thatC.gloeosporioidesproduces bioactive compounds in a host-dependent manner.
Ashish Verma, Priyamvada Gupta, Nilesh Rai, Rajan Kumar Tiwari, Ajay Kumar, Prafull Salvi, Swapnil C. Kamble, Santosh Kumar Singh, and Vibhav Gautam
MDPI AG
Fungal endophytes have remarkable potential to produce bioactive compounds with numerous pharmacological significance that are used in various disease management and human welfare. In the current study, a total of eight fungal endophytes were isolated from the leaf tissue of Amoora rohituka, and out of which ethyl acetate (EA) extract of Penicillium oxalicum was found to exhibit potential antioxidant activity against DPPH, nitric oxide, superoxide anion and hydroxyl free radicals with EC50 values of 178.30 ± 1.446, 75.79 ± 0.692, 169.28 ± 0.402 and 126.12 ± 0.636 µg/mL, respectively. The significant antioxidant activity of EA extract of P. oxalicum is validated through highest phenolic and flavonoid content, and the presence of unique bioactive components observed through high-performance thin layer chromatography (HPTLC) fingerprinting. Moreover, EA extract of P. oxalicum also displayed substantial anti-proliferative activity with IC50 values of 56.81 ± 0.617, 37.24 ± 1.26 and 260.627 ± 5.415 µg/mL against three cancer cells HuT-78, MDA-MB-231 and MCF-7, respectively. Furthermore, comparative HPTLC fingerprint analysis and antioxidant activity of P. oxalicum revealed that fungal endophyte P. oxalicum produces bioactive compounds in a host-dependent manner. Therefore, the present study signifies that fungal endophyte P. oxalicum associated with the leaf of A. rohituka could be a potential source of bioactive compounds with antioxidant and anticancer activity.
Riya Thapa, G. Gupta, Piyush N. Dave, Santoshkumar Singh, Abhay Raizaday, W. Almalki, G. Vyas, Sachin Kumar Singh, K. Dua and Y. Singh
1 School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura 302017, Jaipur, India 2 Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India 3 Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India 4 Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia 5 Inva-Health Inc, Cranbury, NJ 08512, USA 6 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India 7 Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia 8 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia 9 Department of Pharmacology, Maharishi Arvind College of Pharmacy, Ambabari Circle, Ambabari, Jaipur, 302023, India
Sachchidanand Pathak, Anurag Mishra, Gaurav Gupta, Abhay Raizaday, Santosh Kumar Singh, Pramod Kumar, Sachin Kumar Singh, Neeraj Kumar Jha, Dinesh Kumar Chellappan, and Kamal Dua
Springer Nature Singapore
Suhas Suresh Awati, Santosh Kumar Singh, Abhay Raizaday, Pramod Kumar, Yogendra Singh, Mohammad Arshad Javed Shaikh, and Gaurav Gupta
Springer Nature Singapore
Nilesh Rai, Priyamvada Gupta, Ashish Verma, Rajan Kumar Tiwari, Prasoon Madhukar, Swapnil C. Kamble, Ajay Kumar, Rajiv Kumar, Santosh Kumar Singh, and Vibhav Gautam
American Chemical Society (ACS)
Fungal endophytes are known to be a paragon for producing bioactive compounds with a variety of pharmacological importance. The current study aims to elucidate the molecular alterations induced by the bioactive compounds produced by the fungal endophyte Colletotrichum gloeosporioides in the tumor microenvironment of human breast cancer cells. GC/MS analysis of the ethyl acetate (EA) extract of C. gloeosporioides revealed the presence of bioactive compounds with anticancer activity. The EA extract of C. gloeosporioides exerted potential plasmid DNA protective activity against hydroxyl radicals of Fenton’s reagent. The cytotoxic activity further revealed that MDA-MB-231 cells exhibit more sensitivity toward the EA extract of C. gloeosporioides as compared to MCF-7 cells, whereas non-toxic to non-cancerous HEK293T cells. Furthermore, the anticancer activity demonstrated by the EA extract of C. gloeosporioides was studied by assessing nuclear morphometric analysis and induction of apoptosis in MDA-MB-231 and MCF-7 cells. The EA extract of C. gloeosporioides causes the alteration in cellular and nuclear morphologies, chromatin condensation, long-term colony inhibition, and inhibition of cell migration and proliferation ability of MDA-MB-231 and MCF-7 cells. The study also revealed that the EA extract of C. gloeosporioides treated cells undergoes apoptosis by increased production of reactive oxygen species and significant deficit in mitochondrial membrane potential. Our study also showed that the EA extract of C. gloeosporioides causes upregulation of pro-apoptotic (BAX, PARP, CASPASE-8, and FADD), cell cycle arrest (P21), and tumor suppressor (P53) related genes. Additionally, the downregulation of antiapoptotic genes (BCL-2 and SURVIVIN) and increased Caspase-3 activity suggest the induction of apoptosis in the EA extract of C. gloeosporioides treated MDA-MB-231 and MCF-7 cells. Overall, our findings suggest that the bioactive compounds present in the EA extract of C. gloeosporioides promotes apoptosis by altering the genes related to the extrinsic as well as the intrinsic pathway. Further in vivo study in breast cancer models is required to validate the in vitro observations.
Bhawana Singh, Awnish Kumar, Rahul Tiwari, Shashi Bhushan Chauhan, Om Prakash Singh, Santosh K Singh, Vibhav Gautam, Shyam Sundar, and Rajiv Kumar
Elsevier
Sakshi Priya, Anchal Tyagi, Mahaveer Singh, Sushama Rawat, Abhay Raizaday, Santosh Kumar Singh, and Gaurav Gupta
Elsevier
Sachchida Nand Rai, Neeraj Tiwari, Payal Singh, Anurag Kumar Singh, Divya Mishra, Mohd. Imran, Snigdha Singh, Etrat Hooshmandi, Emanuel Vamanu, Santosh K. Singh,et al.
Hindawi Limited
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a human coronavirus (HCoV) that has created a pandemic situation worldwide as COVID-19. This virus can invade human cells via angiotensin-converting enzyme 2 (ACE2) receptor-based mechanisms, affecting the human respiratory tract. However, several reports of neurological symptoms suggest a neuroinvasive development of coronavirus. SARS-CoV-2 can damage the brain via several routes, along with direct neural cell infection with the coronavirus. The chronic inflammatory reactions surge the brain with proinflammatory elements, damaging the neural cells, causing brain ischemia associated with other health issues. SARS-CoV-2 exhibited neuropsychiatric and neurological manifestations, including cognitive impairment, depression, dizziness, delirium, and disturbed sleep. These symptoms show nervous tissue damage that enhances the occurrence of neurodegenerative disorders and aids dementia. SARS-CoV-2 has been seen in brain necropsy and isolated from the cerebrospinal fluid of COVID-19 patients. The associated inflammatory reaction in some COVID-19 patients has increased proinflammatory cytokines, which have been investigated as a prognostic factor. Therefore, the immunogenic changes observed in Parkinson’s and Alzheimer’s patients include their pathogenetic role. Inflammatory events have been an important pathophysiological feature of neurodegenerative diseases (NDs) such as Parkinson’s and Alzheimer’s. The neuroinflammation observed in AD has exacerbated the Aβ burden and tau hyperphosphorylation. The resident microglia and other immune cells are responsible for the enhanced burden of Aβ and subsequently mediate tau phosphorylation and ultimately disease progression. Similarly, neuroinflammation also plays a key role in the progression of PD. Several studies have demonstrated an interplay between neuroinflammation and pathogenic mechanisms of PD. The dynamic proinflammation stage guides the accumulation of α-synuclein and neurodegenerative progression. Besides, few viruses may have a role as stimulators and generate a cross-autoimmune response for α-synuclein. Hence, neurological complications in patients suffering from COVID-19 cannot be ruled out. In this review article, our primary focus is on discussing the neuroinvasive effect of the SARS-CoV-2 virus, its impact on the blood-brain barrier, and ultimately its impact on the people affected with neurodegenerative disorders such as Parkinson’s and Alzheimer’s.