Asaad Khalid Mohamedali

@jazanu.edu.sa

Jazan University



                 

https://researchid.co/drasaad
130

Scopus Publications

3197

Scholar Citations

23

Scholar h-index

62

Scholar i10-index

Scopus Publications

  • The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications
    Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani,et al.
    Elsevier BV

  • Unveiling the Biological Activities, Pharmacological Potential, and Health Benefits of Sorbifolin: A Comprehensive Review
    Omar Belmehdi, Ibrahim Mssillou, Asaad Khalid, Ashraf N. Abdalla, Manal Almalki, Roaya S. Alqurashi, Saad Bakrim, Gokhan Zengin, Bey Hing Goh, and Abdelhakim Bouyahya
    Wiley
    AbstractBioactive phytochemicals act as important factors with preventive and therapeutic potential in the pathogenesis of several disorders, often related to oxidative stress. Many dietary plant secondary metabolites could lower these conditions. Sorbifolin is one of these metabolites. This work is the first review of sorbifolin, a flavone detected in various plant matrices as a major compound. The present study discussed the natural sources, extraction, purification, quantification, and assessment of the biological activities of sorbifolin. Several databases including Google Scholar, Web of Sciences, and Science‐Direct were consulted for relevant English articles related to sorbifolin, the phytochemical profiles of several medicinal plants containing this compound, and its biological activities, such as antioxidant, anticancer, antimicrobial, anti‐inflammatory, and antidiabetic. The positive in vitro and in silico outcomes reported in the literature should be followed by additional in vivo and clinical investigations to further research the mechanisms of action, pharmacokinetic/pharmacodynamic activities, toxicological effects, pharmacological properties, and therapeutic potential of sorbifolin.

  • Recent advances in the use of essential oils and their nanoformulations for wound treatment
    Ibrahim Mssillou, Fatima Ez-Zahra Amrati, Hamza Saghrouchni, Youness El Abdali, Youssra Lefrioui, Gaber El-Saber Batiha, John P. Giesy, Mourad A.M. Aboul-Soud, Rym Hassani, Asaad Khalid,et al.
    Elsevier BV

  • Development and Characterization of Potato Starch–Pectin-Based Active Films Enriched With Juniper Berry Essential Oil for Food Packaging Applications
    Saurabh Bhatia, Muhammad Jawad, Sampath Chinnam, Ahmed Al‐Harrasi, Yasir Abbas Shah, Talha Shireen Khan, Mohammed Said Al‐Azri, Esra Koca, Levent Yurdaer Aydemir, Sevgin Dıblan,et al.
    Wiley
    ABSTRACTThe increasing demand for sustainable food packaging has driven the development of films based on biopolymers. However, enhancing their functional properties remains a challenge. In the current study, potato starch–pectin (PSP) composite films were fabricated and enriched with juniper berry essential oil (JBEO) to improve their physicochemical properties. The effects of incorporating different concentrations of JBEO (0.1%–1% v/v) on various properties of PSP‐based films were evaluated, including surface color, transparency, barrier properties, scanning electron microscopy (SEM), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermal analysis (TGA and DTA), antioxidant activity, and antimicrobial effectiveness. Increasing the level of JBEO led to a significant decrease in the moisture content, film transparency, and mechanical attributes, while an increase in thickness, water permeability, and film elongation was observed. SEM analysis also revealed morphological properties such as some spherical, bubble‐like configuration and cracks on the surface due to an increase in JBEO concentration. TGA and DTA revealed lower weight loss in the initial cycles due to the addition of JBEO, and the thermal stability of the films improved. The antioxidant assays revealed a concentration‐dependent increase in the radical scavenging capacity of the films from 11.31% to 17.28% for DPPH and from 3.06% to 25.53% for ABTS. Moreover, significant antibacterial and antifungal activity of the bioactive films was observed against P. aeruginosa, S. aureus, and C. albicans. These findings suggest that JBEO enhances the functional properties of PSP films, making them suitable for active food packaging applications.

  • Identification of potential natural product inhibitors against the M<sup>pro</sup> enzyme of Covid-19: a computational study
    Amir Zeb, Bader S. Alotaibi, Muhammad Haroon, Muhammad Sameer, Mubarak A. Alamri, Asaad Khalid, and Abdul Wadood
    Springer Science and Business Media LLC

  • Contribution of mushroom farming to mitigating food scarcity: Current status, challenges and potential future prospects in Pakistan
    Asif Khan, Waheed Murad, Salahuddin, Sajid Ali, Syed Sikandar Shah, Sobia Ahsan Halim, Asaad Khalid, Hamdy Kashtoh, Ajmal Khan, and Ahmed Al-Harrasi
    Elsevier BV

  • Elucidating the interactions of advanced glycation end products with RAGE, employing molecular docking and MD simulation approaches: Implications of potent therapeutic for diabetes and its related complications
    Chandni Hayat, Muhammad Yaseen, Sajjad Ahmad, Khadija Khalid, Mubarak A. Alamri, Asaad Khalid, Syed Qasim Shah, Ovinuchi Ejiohuo, Abdul Wadood, Abdulkadir Yusif Maigoro,et al.
    Elsevier BV

  • Shifting paradigms: The promise of allosteric inhibitors against dengue virus protease
    Mamona Mushtaq, Ali Raza Siddiqui, Sehrish Shafeeq, Asaad Khalid, and Zaheer Ul-Haq
    Elsevier BV

  • Subtractive genomics integrated with deep learning, molecular docking, and MD simulation decipher therapeutic drug targets and their potential inhibitors against Nocardia farcinica strain IFM 10152
    Fawaz M. Almufarriji, Amar Ajmal, Bader S. Alotaibi, Mubarak A. Alamri, Asaad Khalid, and Abdul Wadood
    Springer Science and Business Media LLC

  • NMR metabolic profiling and biological activities of different extracts from a Turkish herbal tea-Clinopodium nepeta subsp. glandulosum
    Francesca Guzzo, Carlo Raucci, Gokhan Zengin, Gizem Emre, Asaad Khalid, Mohamad Fawzi Mahomoodally, and Brigida D'Abrosca
    Elsevier BV

  • Therapeutic potential of Buddleja Polystachya Fresen (stem and leaves) extracts: antimicrobial and cytotoxic properties for ocular disease management
    Ali Hendi Alghamdi, Asaad Khalid, Aimun A. E. Ahmed, Haidar Abdalgadir, Mahadi Bashir, Ashraf N. Abdalla, Sami S. Ashgar, Hamdi M. Alsaid, and Magbool E. Oraiby
    Springer Science and Business Media LLC
    AbstractThis study on Buddleja polystachya highlights its phytochemical composition, antimicrobial activity, and cytotoxic impacts. The study emphasizes the plant’s potential to treat ocular diseases by identifying important compounds involved in the bioactivity through GC-MS analysis. This study explores the antimicrobial and cytotoxic potential of Buddleja polystachya (stem and leaves) extracts, with a focus on their application in treating bacterial ocular infections and their efficacy against MCF7, HT29, and HepG2 cancer cells. Through comprehensive GC-MS analysis, a diverse array of phytochemicals was identified within Buddleja polystachya stem and leaves extracts, including carbohydrates, phenolic derivatives, fatty acids, and steroidal components. The extracts were then evaluated for their biological activities, revealing significant antimicrobial properties against a range of bacterial strains implicated in ocular infections. The research findings demonstrate that stem extracts derived from Buddleja polystachya demonstrated high to moderate cytotoxic effects on cancer cell lines MCF7, HT29, and HepG2. Notably, these effects were characterized by varying IC50 values, which suggest distinct levels of sensitivity. In contrast, leaf extracts exhibited reduced cytotoxicity when tested against all these cell lines, although they did so with a significantly higher cytotoxicity aganist HepG2 cells. The results of this investigation highlight the potential therapeutic utilization of Buddleja polystachya extracts in the management of ocular infections and cancer. These results support the need for additional research to elucidate the underlying mechanisms of action of these extracts and explore their potential as drugs.

  • Structural, dynamic behaviour, in-vitro and computational investigations of Schiff’s bases of 1,3-diphenyl urea derivatives against SARS-CoV-2 spike protein
    Saeed Ullah, Atta Ullah, Muhammad Waqas, Sobia Ahsan Halim, Anam Rubbab Pasha, Zahid Shafiq, Suraj N. Mali, Rahul D. Jawarkar, Ajmal Khan, Asaad Khalid,et al.
    Springer Science and Business Media LLC
    AbstractThe COVID-19 has had a significant influence on people's lives across the world. The viral genome has undergone numerous unanticipated changes that have given rise to new varieties, raising alarm on a global scale. Bioactive phytochemicals derived from nature and synthetic sources possess lot of potential as pathogenic virus inhibitors. The goal of the recent study is to report new inhibitors of Schiff bases of 1,3-dipheny urea derivatives against SARS COV-2 spike protein through in-vitro and in-silico approach. Total 14 compounds were evaluated, surprisingly, all the compounds showed strong inhibition with inhibitory values between 79.60% and 96.00% inhibition. Here, compounds 3a (96.00%), 3d (89.60%), 3e (84.30%), 3f (86.20%), 3g (88.30%), 3h (86.80%), 3k (82.10%), 3l (90.10%), 3m (93.49%), 3n (85.64%), and 3o (81.79%) exhibited high inhibitory potential against SARS COV-2 spike protein. While 3c also showed significant inhibitory potential with 79.60% inhibition. The molecular docking of these compounds revealed excellent fitting of molecules in the spike protein receptor binding domain (RBD) with good interactions with the key residues of RBD and docking scores ranging from − 4.73 to − 5.60 kcal/mol. Furthermore, molecular dynamics simulation for 150 ns indicated a strong stability of a complex 3a:6MOJ. These findings obtained from the in-vitro and in-silico study reflect higher potency of the Schiff bases of 1,3-diphenyl urea derivatives. Furthermore, also highlight their medicinal importance for the treatment of SARS COV-2 infection. Therefore, these small molecules could be a possible drug candidate.

  • Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
    Nasreddine El Omari, Saad Bakrim, Asaad Khalid, Ashraf N. Abdalla, Mohamed A. M. Iesa, Kawtar El Kadri, Siah Ying Tang, Bey Hing Goh, and Abdelhakim Bouyahya
    Springer Science and Business Media LLC
    AbstractUntil recently, the main pharmaceuticals used to control cholesterol and prevent cardiovascular disease (CVD) were statin-related drugs, known for their historical side effects. Therefore, there is growing interest in exploring alternatives, such as nutritional and dietary components, that could play a central role in CVD prevention. This review aims to provide a comprehensive understanding of how natural phytosterols found in various diets combat CVDs. We begin with a description of the overall approach, then we explore in detail the different direct and indirect mechanisms that contribute to reducing cardiovascular incidents. Phytosterols, including stigmasterol, β-sitosterol, ergosterol, and fucosterol, emerge as promising molecules within nutritional systems for protection against CVDs due to their beneficial effects at different levels through direct or indirect cellular, subcellular, and molecular mechanisms. Specifically, the mentioned phytosterols exhibit the ability to diminish the generation of various radicals, including hydroperoxides and hydrogen peroxide. They also promote the activation of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione, while inhibiting lipid peroxidation through the activation of Nrf2 and Nrf2/heme oxygenase-1 (HO-1) signaling pathways. Additionally, they demonstrate a significant inhibitory capacity in the generation of pro-inflammatory cytokines, thus playing a crucial role in regulating the inflammatory/immune response by inhibiting the expression of proteins involved in cellular signaling pathways such as JAK3/STAT3 and NF-κB. Moreover, phytosterols play a key role in reducing cholesterol absorption and improving the lipid profile. These compounds can be used as dietary supplements or included in specific diets to aid control cholesterol levels, particularly in individuals suffering from hypercholesterolemia. Graphical Abstract

  • Identification of new potent NLRP3 inhibitors by multi-level in-silico approaches
    Chandni Hayat, Vetriselvan Subramaniyan, Mubarak A. Alamri, Ling Shing Wong, Asaad Khalid, Ashraf N. Abdalla, Sahib Gul Afridi, Vinoth Kumarasamy, and Abdul Wadood
    Springer Science and Business Media LLC
    AbstractNod-like receptor protein 3 (NLRP-3), is an intracellular sensor that is involved in inflammasome activation, and the aberrant expression of NLRP3 is responsible for diabetes mellitus, its complications, and many other inflammatory diseases. NLRP3 is considered a promising drug target for novel drug design. Here, a pharmacophore model was generated from the most potent inhibitor, and its validation was performed by the Gunner-Henry scoring method. The validated pharmacophore was used to screen selected compounds databases. As a result, 646 compounds were mapped on the pharmacophore model. After applying Lipinski's rule of five, 391 hits were obtained. All the hits were docked into the binding pocket of target protein. Based on docking scores and interactions with binding site residues, six compounds were selected potential hits. To check the stability of these compounds, 100 ns molecular dynamic (MD) simulations were performed. The RMSD, RMSF, DCCM and hydrogen bond analysis showed that all the six compounds formed stable complex with NLRP3. The binding free energy with the MM-PBSA approach suggested that electrostatic force, and van der Waals interactions, played a significant role in the binding pattern of these compounds. Thus, the outcomes of the current study could provide insights into the identification of new potential NLRP3 inflammasome inhibitors against diabetes and its related disorders.

  • Prospective virtual screening combined with bio-molecular simulation enabled identification of new inhibitors for the KRAS drug target
    Amar Ajmal, Hind A Alkhatabi, Roaa M. Alreemi, Mubarak A. Alamri, Asaad Khalid, Ashraf N. Abdalla, Bader S. Alotaibi, and Abdul Wadood
    Springer Science and Business Media LLC
    AbstractLung cancer is a disease with a high mortality rate and it is the number one cause of cancer death globally. Approximately 12–14% of non-small cell lung cancers are caused by mutations in KRASG12C. The KRASG12C is one of the most prevalent mutants in lung cancer patients. KRAS was first considered undruggable. The sotorasib and adagrasib are the recently approved drugs that selectively target KRASG12C, and offer new treatment approaches to enhance patient outcomes however drug resistance frequently arises. Drug development is a challenging, expensive, and time-consuming process. Recently, machine-learning-based virtual screening are used for the development of new drugs. In this study, we performed machine-learning-based virtual screening followed by molecular docking, all atoms molecular dynamics simulation, and binding energy calculations for the identifications of new inhibitors against the KRASG12C mutant. In this study, four machine learning models including, random forest, k-nearest neighbors, Gaussian naïve Bayes, and support vector machine were used. By using an external dataset and 5-fold cross-validation, the developed models were validated. Among all the models the performance of the random forest (RF) model was best on the train/test dataset and external dataset. The random forest model was further used for the virtual screening of the ZINC15 database, in-house database, Pakistani phytochemicals, and South African Natural Products database. A total of 100 ns MD simulation was performed for the four best docking score complexes as well as the standard compound in complex with KRASG12C. Furthermore, the top four hits revealed greater stability and greater binding affinities for KRASG12C compared to the standard drug. These new hits have the potential to inhibit KRASG12C and may help to prevent KRAS-associated lung cancer. All the datasets used in this study can be freely available at (https://github.com/Amar-Ajmal/Datasets-for-KRAS).

  • Protective and stochastic correlation between infectious diseases and autoimmune disorders
    Sara Aboulaghras, Abdelhakim Bouyahya, Kawtar El Kadri, Asaad Khalid, Ashraf N. Abdalla, Rym Hassani, Learn-Han Lee, and Saad Bakrim
    Elsevier BV

  • A paradigm shift in the detection of bloodborne pathogens: Conventional approaches to recent detection techniques
    Sonali Khanal, Manjusha Pillai, Deblina Biswas, Muhammad Torequl Islam, R. Verma, Kamil Kuča, Dinesh Kumar, A. Najmi, Khalid Zoghebi, Asaad Khalid and Syam Mohan

    Bloodborne pathogens (BBPs) pose formidable challenges in the realm of infectious diseases, representing significant risks to both human and animal health worldwide. The review paper provides a thorough examination of bloodborne pathogens, highlighting the serious worldwide threat they pose and the effects they have on animal and human health. It addresses the potential dangers of exposure that healthcare workers confront, which have affected 3 million people annually, and investigates the many pathways by which these viruses can spread. The limitations of traditional detection techniques like PCR and ELISA have been criticized, which has led to the investigation of new detection methods driven by advances in sensor technology. The objective is to increase the amount of knowledge that is available regarding bloodborne infections as well as effective strategies for their management and detection. This review provides a thorough overview of common bloodborne infections, including their patterns of transmission, and detection techniques.

  • Exploring the chemistry, biological effects, and mechanism insights of natural coumaroyltyramine: First report
    Saad Bakrim, Youssef Elouafy, Jihane Touhtouh, Tarik Aanniz, Kawtar El Kadri, Asaad Khalid, Shereen Fawzy, M. Ahmed Mesaik, Learn-Han Lee, Imane Chamkhi,et al.
    Elsevier BV

  • Targeting glucosyltransferases to combat dental caries: Current perspectives and future prospects
    Lubna Atta, Mamona Mushtaq, Ali Raza Siddiqui, Assad Khalid, and Zaheer Ul-Haq
    Elsevier BV

  • Disrupting protease and deubiquitinase activities of SARS-CoV-2 papain-like protease by natural and synthetic products discovered through multiple computational and biochemical approaches
    Muhammad Waqas, Saeed Ullah, Atta Ullah, Sobia Ahsan Halim, Najeeb Ur Rehman, Asaad Khalid, Amjad Ali, Ajmal Khan, Simon Gibbons, Rene Csuk,et al.
    Elsevier BV

  • Examining the potential of peppermint essential oil-infused pectin and kappa-carrageenan composite films for sustainable food packaging
    Saurabh Bhatia, Aysha Salim Alhadhrami, Yasir Abbas Shah, Tuba Esatbeyoglu, Esra Koca, Levent Yurdaer Aydemir, Ahmed Al-Harrasi, Syam Mohan, Asim Najmi, and Asaad Khalid
    Elsevier BV

  • Precision arrows: Navigating breast cancer with nanotechnology siRNA
    Nandani Jayaswal, Shriyansh Srivastava, Sachin Kumar, Sathvik Belagodu Sridhar, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Hassan A. Alhazmi, Syam Mohan, and Murtaza M. Tambuwala
    Elsevier BV

  • Identification of Novel Antileishmanial Chemotypes By High-Throughput Virtual and In Vitro Screening
    Huma Khan, Mohammed Ageeli Hakami, Mubarak A. Alamri, Bader S. Alotaibi, Nazif Ullah, Rasool Khan, Asaad Khalid, Ashraf N. Abdalla, and Abdul Wadood
    Springer Science and Business Media LLC

  • Phytoconstituents with cardioprotective properties: A pharmacological overview on their efficacy against myocardial infarction
    Aman Ullah, Nada M. Mostafa, Sobia Ahsan Halim, Esraa A. Elhawary, Ain Ali, Rohail Bhatti, Usman Shareef, Waiel Al Naeem, Asaad Khalid, Hamdy Kashtoh,et al.
    Wiley
    AbstractMyocardial infarction (MI) is considered one of the most common cardiac diseases and major cause of death worldwide. The prevalence of MI and MI‐associated mortality have been increasing in recent years due to poor lifestyle habits viz. residency, obesity, stress, and pollution. Synthetic drugs for the treatment of MI provide good chance of survival; however, the demand to search more safe, effective, and natural drugs is increasing. Plants provide fruitful sources for powerful antioxidant and anti‐inflammatory agents for prevention and/or treatment of MI. However, many plant extracts lack exact information about their possible dosage, toxicity and drug interactions which may hinder their usefulness as potential treatment options. Phytoconstituents play cardioprotective role by either acting as a prophylactic or adjuvant therapy to the concurrently used synthetic drugs to decrease the dosage or relief the side effects of such drugs. This review highlights the role of different herbal formulations, examples of plant extracts and types of several isolated phytoconstituents (phenolic acids, flavonoids, stilbenes, alkaloids, phenyl propanoids) in the prevention of MI with reported activities. Moreover, their possible mechanisms of action are also discussed to guide future research for the development of safer substitutes to manage MI.

  • Identification of novel NLRP3 inhibitors as therapeutic options for epilepsy by machine learning-based virtual screening, molecular docking and biomolecular simulation studies
    Maryam Zulfat, Mohammed Ageeli Hakami, Ali Hazazi, Arif Mahmood, Asaad Khalid, Roaya S. Alqurashi, Ashraf N. Abdalla, Junjian Hu, Abdul Wadood, and Xiaoyun Huang
    Elsevier BV

RECENT SCHOLAR PUBLICATIONS

  • The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications
    AH Alghamdi, AAE Ahmed, AN Abdalla
    Phytomedicine Plus 5 (1), 100651 2025

  • Recent advances in the use of essential oils and their nanoformulations for wound treatment
    I Mssillou, FEZ Amrati, H Saghrouchni, Y El Abdali, Y Lefrioui, GES Batiha, ...
    Burns 51 (1), 107260 2025

  • Development and Characterization of Potato Starch–Pectin‐Based Active Films Enriched With Juniper Berry Essential Oil for Food Packaging Applications
    S Bhatia, M Jawad, S Chinnam, A Al‐Harrasi, YA Shah, TS Khan, ...
    Food Science & Nutrition 13 (1), e4688 2025

  • Identification of potential natural product inhibitors against the Mpro enzyme of Covid-19: a computational study
    A Zeb, BS Alotaibi, M Haroon, M Sameer, MA Alamri, A Khalid, A Wadood
    Chemical Papers 79 (1), 533-543 2025

  • Discovery of novel natural inhibitors against SARS-CoV-2 main protease: a rational approach to antiviral therapeutics
    M Waqas, S Ullah, SA Halim, I Ullah, NU Rehman, A Jan, A Khalid, A Ali, ...
    Current Medicinal Chemistry 2025

  • In-silico identification of potential peptide inhibitors to disrupt NLRP3 inflammasome complex formation by blocking NLRP3-ASC pyrin-pyrin interactions
    M Zulfat, HA Alkhatabi, RM Alreemi, MA Alamri, A Khalid, AN Abdalla, ...
    Journal of Biomolecular Structure and Dynamics, 1-12 2024

  • Elucidating the interactions of advanced glycation end products with RAGE, employing molecular docking and MD simulation approaches: Implications of potent therapeutic for
    C Hayat, M Yaseen, S Ahmad, K Khalid, MA Alamri, A Khalid, SQ Shah, ...
    Journal of Molecular Liquids 416, 126467 2024

  • Investigating the role of Sterol C24-Methyl transferase mutation on drug resistance in leishmaniasis and identifying potential inhibitors
    H Khan, M Waqas, B Khurshid, N Ullah, A Khalid, AN Abdalla, MA Alamri, ...
    Journal of Biomolecular Structure and Dynamics 42 (19), 10374-10387 2024

  • NMR metabolic profiling and biological activities of different extracts from a Turkish herbal tea-Clinopodium nepeta subsp. glandulosum
    F Guzzo, C Raucci, G Zengin, G Emre, A Khalid, MF Mahomoodally, ...
    Biochemical Systematics and Ecology 117, 104908 2024

  • Unveiling the molecular mechanisms: dietary phytosterols as guardians against cardiovascular diseases
    N El Omari, S Bakrim, A Khalid, AN Abdalla, MAM Iesa, K El Kadri, ...
    Natural Products and Bioprospecting 14 (1), 27 2024

  • Novel natural inhibitors for glioblastoma by targeting epidermal growth factor receptor and phosphoinositide 3-kinase
    A Ullah, S Ullah, M Waqas, M Khan, NU Rehman, A Khalid, A Jan, S Aziz, ...
    Current Medicinal Chemistry 31 (40), 6596-6613 2024

  • Therapeutic Potential of 6-Amino Flavone: A Novel Approach for Diabetes and Inflammation via TNF-α/p-IRS Signaling Pathway in Albino Mice
    Z Amin, M Husn, W Fayaz, SA Shah, A Wadood
     2024

  • Contribution of Mushroom Farming to Mitigating Food Scarcity: Current Status, Challenges and Potential Future Prospects in Pakistan
    A Khan, W Murad, S Ali, SS Shah, SA Halim, A Khalid, H Kashtoh, A Khan, ...
    Heliyon 2024

  • Shifting paradigms: The promise of allosteric inhibitors against dengue virus protease
    M Mushtaq, AR Siddiqui, S Shafeeq, A Khalid, Z Ul-Haq
    International Journal of Biological Macromolecules, 137056 2024

  • Subtractive genomics integrated with deep learning, molecular docking, and MD simulation decipher therapeutic drug targets and their potential inhibitors against Nocardia
    FM Almufarriji, A Ajmal, BS Alotaibi, MA Alamri, A Khalid, A Wadood
    Chemical Papers, 1-12 2024

  • Cytotoxic activity, selectivity, and clonogenicity of fruits and resins of Saudi medicinal plants against human liver adenocarcinoma
    AH Alghamdi, AAE Ahmed, M Bashir, H Abdalgadir, A Khalid, ...
    Drug Target Insights 18, 84 2024

  • A paradigm shift in the detection of bloodborne pathogens: conventional approaches to recent detection techniques
    S Khanal, M Pillai, D Biswas, MT Islam, R Verma, K Kuca, D Kumar, ...
    EXCLI journal 23, 1245 2024

  • Synthesis of Novel Indolyl Aryl Sulfone-clubbed Hydrazone Derivatives as Potential HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Molecular Modeling and QSAR Studies
    H Ali, A Latif, M Ali, M Waqas, M Ahmad, A Khalid, A Khan, A Al-Harrasi
    Current medicinal chemistry 2024

  • Unveiling the Biological Effects and Pharmacological Properties of Sorbifolin: a Comprehensive Review
    O Belmehdi, I Mssillou, A Khalid, AN Abdalla, M Almalki, RS Alqurashi, ...
    Chemistry & Biodiversity, e202401463 2024

  • Disrupting protease and deubiquitinase activities of SARS-CoV-2 papain-like protease by natural and synthetic products discovered through multiple computational and biochemical
    M Waqas, S Ullah, A Ullah, SA Halim, NU Rehman, A Khalid, A Ali, ...
    International Journal of Biological Macromolecules 277, 134476 2024

MOST CITED SCHOLAR PUBLICATIONS

  • Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in
    AJ Ferrari, DF Santomauro, A Aali, YH Abate, C Abbafati, H Abbastabar, ...
    The Lancet 403 (10440), 2133-2161 2024
    Citations: 561

  • Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants
    I Orhan, B Şener, MI Choudhary, A Khalid
    Journal of Ethnopharmacology 91 (1), 57-60 2004
    Citations: 442

  • Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
    SE Vollset, HS Ababneh, YH Abate, C Abbafati, R Abbasgholizadeh, ...
    The Lancet 403 (10440), 2204-2256 2024
    Citations: 227

  • Medicinal plants and isolated molecules demonstrating immunomodulation activity as potential alternative therapies for viral diseases including COVID-19
    HA Alhazmi, A Najmi, SA Javed, S Sultana, M Al Bratty, HA Makeen, ...
    Frontiers in immunology 12, 637553 2021
    Citations: 138

  • Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut
    AH Gilani, MN Ghayur, ZS Saify, SP Ahmed, MI Choudhary, A Khalid
    Life Sciences 75 (20), 2377-2389 2004
    Citations: 134

  • Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa
    S Parveen, A Khalid, A Farooq, MI Choudhary
    Phytochemistry 58 (6), 963-968 2001
    Citations: 116

  • Phytochemical, Cytotoxic, and Antimicrobial Evaluation of the Fruits of Miswak Plant, Salvadora persica L.
    M Al Bratty, HA Makeen, HA Alhazmi, SM Syame, AN Abdalla, ...
    Journal of Chemistry 2020 (1), 4521951 2020
    Citations: 113

  • Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer’s
    MI Choudhary, SA Nawaz, MK Azim, MN Ghayur, MA Lodhi, S Jalil, ...
    Biochemical and biophysical research communications 332 (4), 1171-1179 2005
    Citations: 112

  • New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities
    MN Akhtar, MI Choudhary, Y Tsuda, B Sener, A Khalid, M Parvez
    Chemical and Pharmaceutical Bulletin 50 (8), 1013-1016 2002
    Citations: 98

  • A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional sudanese plants with anti-diabetic potential
    Y Hilmi, MF Abushama, H Abdalgadir, A Khalid, H Khalid
    BMC complementary and alternative medicine 14, 1-5 2014
    Citations: 83

  • Muscarinic, Ca++ antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia
    MN Ghayur, AH Gilani, T Ahmed, A Khalid, SA Nawaz, JM Agbedahunsi, ...
    Journal of Pharmacy and Pharmacology 60 (10), 1375-1383 2008
    Citations: 79

  • Kinetics and structure–activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases
    A Khalid, S Anjum, MR Khan, MI Choudhary
    Bioorganic & medicinal chemistry 12 (9), 1995-2003 2004
    Citations: 68

  • Presence of antispasmodic, antidiarrheal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna
    AH Gilani, MN Ghayur, A Khalid, MI Choudhary
    Planta Medica 71 (02), 120-125 2005
    Citations: 63

  • New cholinesterase inhibiting steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin
    SK Kalauni, MI Choudhary, A Khalid, MD Manandhar, F Shaheen, ...
    Chemical and pharmaceutical bulletin 50 (11), 1423-1426 2002
    Citations: 63

  • New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids
    A -Rahman, A Khalid, N Sultana, M Nabeel Ghayur, M Ahmed Mesaik, ...
    Journal of enzyme inhibition and medicinal chemistry 21 (6), 703-710 2006
    Citations: 61

  • Cholinesterase inhibitory and spasmolytic potential of steroidal alkaloids
    A Khalid, MN Ghayur, F Feroz, AH Gilani, MI Choudhary
    The Journal of steroid biochemistry and molecular biology 92 (5), 477-484 2004
    Citations: 61

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