Dr.Biswa Mohan Sahoo
@rips.ac.in
Professor & Research Coordinator
RolandInstitute of Pharmaceutical Sciences
Dr. Biswa Mohan Sahoo is currently working as an Professor & Research Coordinator of Roland Institute of Pharmaceutical Sciences (Biju Patnaik University of Technology Nodal Centre of Research) Odisha, India. He has published and presented several research papers, review articles in peer reviewed journals. His area of research includes microwave synthesis and pharmacological screening of heterocyclic compounds. He is authored in various book chapters entitled “Therapeutic Potentials of Pyrimidine Derivative”, “Medicinal and Pharmacological Importance of Thiazolidinone Derivatives” (Nova Science Publisher) and “Microwave Synthetic Technology: An Eco-friendly Approach in Organic Synthesis” (CRC Press, Taylor & Francis Group Publisher).
EDUCATION
B. Pharm. Degree in the year 2005 from Berhampur University, Berhampur, Odisha, India.
Master degree from Department of Medicinal Chemistry, L.M College of Pharmacy, Gujarat, India.
Doctor of Pharmacy from School of Pharmaceutical Education and Research (SPER), Berhampur University, India in 2013.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
V. Kanchana, L. Mayavan, A. Kistan, and S. Mohan
Rasayan Journal of Chemistry
The preparation of Chalcones and Pyrazoline derivatives from different aromatic ketones and substituted aldehydes is detailed. Chalcones were produced by reacting aldehydes with substituted aromatic ketones, such as acetophenones, in the Claisen-Schmidt condensation reaction. Cyclohexenone derivatives are produced when ethyl aceto aromatic ketones undergo base-catalyzed cyclo-condensation to Chalcones under microwave radiation. The synthesized compounds are characterized using spectrum techniques from 1H NMR, 13C NMR, and IR. These are examined for their antioxidant qualities as well as their antibacterial action against Staphylococcus aureus, Escherichia coli, Aspergillus niger, and Aspergillus flavus.
Biswa Mohan Sahoo, Pallepogu Venkateswara Rao, and Naidu Srinivasa Rao
Bentham Science Publishers Ltd.
Background: A novel, simple, efficient, rapid, and precise reverse-phase highperformance liquid chromatography (RP-HPLC) method was developed for the estimation of Tenofovir and Emtricitabine in the bulk and pharmaceutical dosage form. The currently developed method was subsequently validated according to ICH guidelines in terms of linearity, accuracy, precision, the limit of detection, the limit of quantification, robustness, etc. Methods: The separation of the selected drugs was optimized after several trials including change of mobile phase and its composition, stationary phase, flow rate, column temperature, etc. The separation was performed by using an Inertsil ODS C18 column (250 mm x 4.6 mm, 5μ) and UV absorption was measured at 231 nm. Methanol: Acetonitrile: Water was selected as the mobile phase in the ratio of 50:20:30 (V/V/V) at a flow rate of 1 mL/min. As per International Conference on Harmonization (ICH) Q2 R1 guidelines, several validation parameters were evaluated which include specificity, linearity, precision, accuracy, the limit of detection (LOD), and the limit of quantitation (LOQ). Results: The acceptable degree of linearity range was found to be 40-100 μg/mL. The standard solution exhibited retention times of 3.06 minutes and 5.07 minutes for Tenofovir and Emtricitabine respectively. The LOD and LOQ obtained were 0.05 μg/ml and 0.02 μg/mL, 15 μg/mL, and 0.08 μg/mL for Tenofovir and Emtricitabine respectively. The percent recovery was found to be 98 to 102%. Conclusion: Hence, the proposed method is simple, selective, and specifically meets the requirements of ICH guidelines for the validation of the analytical method.
Dipthi Shree, Chinam Niranjan Patra, and Biswa Mohan Sahoo
Bentham Science Publishers Ltd.
Abstract: Since ancient times, traditional herbs have been widely used around the world for health promotion and therapy. Obesity is a complex metabolic disorder and is becoming a mammoth problem that adversely affects an individual’s quality of life. Conventional therapy for the management of obesity mainly involves the use of synthetic moiety and bariatric surgical procedures which has severe side effects and patient non-compliance. To circumvent these limitations, plant-derived medicines are utilized which are safe, effective, economic, and easily available. The advancement of nanotechnology enables the development of novel strategies that could potentiate the therapeutic efficacy of the phytoconstituents with minimal toxic effects and promotes the controlled release of the plant bioactive compounds. Moreover, great efforts have been made through targeted nanotechnology-based herbal treatment, where novel nanocarriers are employed as herbal drug delivery vehicles to improve the pharmacokinetics of antiobesity drugs. The recent advancement in phytonanotechnology have opened an avenue to explore novel carriers to utilize bioactive compounds in biomedical and therapeutic applications. In the current review, an extensive search is conducted for the existing original research articles using databases i.e., Google Scholar, PubMed, ScienceDirect, Embase, Baidu, etc. Further, painstaking efforts are made to compile and update the novel herbal nanocarriers such as liposomes, solid lipid nanoparticles, etc. which are widely used for the treatment of obesity. This article portrays a comprehensive survey of the novel strategies employed by the innovators working exclusively on herbal drug delivery systems. The recent development of nanotechnology-based herbal drug delivery has a wide range of biomedical applications and has provided an unprecedented opportunity to improve the treatment of obesity and obesity-related comorbidities. Furthermore, the advancement of phytopharmacological science has led to several novel strategies with improved nanotherapeutics for the management of obesity. Scientific research is still being carried out in the field of nanotechnology for a better perspective on herbal drug delivery for obesity treatment over conventional therapy.
Biswa Mohan Sahoo, Bimal Krishna Banik, Abhishek Tiwari, Varsha Tiwari, Adya Jain, and Preetismita Borah
Walter de Gruyter GmbH
Abstract Organotellurium compounds define the compounds containing carbon (organic group) and tellurium bond (C–Te). The first organic compound containing tellurium was prepared by Wohler in 1840 after the discovery of the metal by the Austrian chemist F. J. Muller von Reichenstein in the year 1782. The term tellurium was derived from Latin tellus. Tellurium was observed first time in ores mined in the gold districts of Transylvania. Naturally occurring tellurium compounds are present in various forms based on their oxidation states such as TeO2 (+4) and TeO3 (+6). These oxidation states of tellurium compounds are more stable as compared to the other oxidation states. Tellurium is a rare element and is considered a non-essential, toxic element. Tellurium possesses only one crystalline form which consists of a network of spiral chains similar to that of hexagonal selenium. Tellurium is used for the treatment and prevention of microbial infections prior to the development of antibiotics. Hence, the utilization of organotellurium compounds plays a significant role as reagents and intermediates in various organic syntheses.
N. Raghavendra Babu, B. M. Sahoo, T. Radhika, B. Kumar C, and N. Malothu
Pleiades Publishing Ltd
Dipthi Shree, Chinam N. Patra, Debashish Ghose, Goutam K. Jena, Biswa M. Sahoo, Kahnu C. Panigrahi, and Jammula Sruti
Bentham Science Publishers Ltd.
Background: Cinacalcet HCl is a calcimimetic, BCS class IV drug with low oral bioavailability. Polymeric nanoparticles are widely used as biomaterials owing to their biocompatibility, biodegradability, varied structures, low toxicity, and simple and easy formulation process. Objective: The aim of the study was to enhance the oral bioavailability of poorly water-soluble drug, i.e., cinacalcet HCl, by using a suitable particulate nanocarrier system, i.e., polymeric nanoparticles. Methods: Biodegradable Cinacalcet HCl (CH)-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by nanoprecipitation method using Poloxamer-188 as a stabilizer. The experimental parameters, like polymer concentration, stabilizer concentration, temperature, and RPM speed, were optimized. An optimized polymeric nanoparticle formulation PNP (F8) was solidified by adsorption on the porous carrier sylysia 350. Results: PNP (F8) exhibited a particle size of 155 nm with low PDI (0.231) and high zeta potential (- 21.3 mV). In vitro diffusion study revealed sustained release of CH for 24 h for both PNP (F8) and solidified PNP (F8). Pharmacokinetics after oral administration of PNP (F8) and solidified PNP (F8) exhibited a 5-fold increase in bioavailability. Thus, both PNP (F8) and solidified PNP (F8) showed significant improvement in oral bioavailability. Conclusion: Adsorption of polymeric nanoparticles onto porous carriers like sylysia 350 can be considered as a promising approach for long-term stability.
Abhishek Tiwari, Binita Palaria, Varsha Tiwari, Ramsha Aslam, Ashok Kumar, Biswa Mohan Sahoo, Manish Kumar, Sunil Singh, and Suresh Kumar
Bentham Science Publishers Ltd.
Abstract: Nanostructured lipid carriers (NLCs) are considered second-generation lipid-based pharmaceutical formulations in drug delivery systems. It is a more efficient drug delivery system that includes the development of a nano-particulate system, and it is superior to the conventional drug delivery system. Among all available nanoparticles, NLC has gained more attention due to its superior characteristics, such as being lipophilic, biodegradable, and biocompatible. This lipid nanoparticulate system is more advantageous over liposomes, microparticles, emulsions, and solid lipid nanoparticles. NLCs have emerged as a promising carrier for the delivery of targeted drug substances via oral, parenteral, topical, pulmonary, transdermal, and ocular routes. These nanocarriers are utilized for the delivery of both lipophilic as well as hydrophilic drugs. NLCs are composed of a matrix of physiological lipids, i.e., solid lipid and liquid lipid, emulsifiers, and water. NLCs provide an opportunity for large-scale production, ease of preparation with enhanced encapsulation, targeted efficiency, and reduced toxic effects. This review is focused on the advantages, limitations, methods of preparation, characterization, and applications of NLCs.
Dipthi Shree, Chinam Niranjan Patra, and Biswa Mohan Sahoo
Bentham Science Publishers Ltd.
Background: Active pharmaceutical ingredient to be administered in a suitable dosage form is usually incorporated with an inert substance (excipient) to achieve a necessary therapeutic effect. Pharmaceutical excipient plays a prominent role in the drug delivery system. Thus, the exploration of novel excipients is indispensable to aid in formulating the new chemical entity. This review discusses novel lipid excipient Compritol for devising as an efficient drug delivery system and its utility in the pharmaceutical and cosmeceutical industries. Summary: In this review manuscript, the potential pharmaceutical and cosmeceutical applicability of compritol as a novel excipient has been highlighted. An extensive search of the literature was done using the existing original research papers. Furthermore, painstaking efforts were made to compile and update the information using databases viz., PubMed, Science Direct, Google Scholar, etc. The applications of various grades of compritol are enumerated in the form of tables.
Biswa Mohan Sahoo, Bimal Krishna Banik, Bera Venkata Varaha Ravi Kumar, Krishna Chandra Panda, Abhishek Tiwari, Varsha Tiwari, Sunil Singh, and Manish Kumar
Bentham Science Publishers Ltd.
Abstract: Microwave radiation is used as a heating source during the synthesis of heterocyclic compounds. The heating mechanisms involved in microwave-induced synthesis include dipolar polarization and ionic conduction. This heating technology follows the green protocol as it involves the use of recyclable organic solvents during synthesis. The microwave heating approach offers a faster rate of reaction, easier work-up procedure, and higher product yield with purity and also reduces environmental pollution. So, microwave heating is applied as a sustainable technology for the efficient production of pyrimidine compounds as one of the heterocyclic moieties. Pyrimidine is a six-membered nitrogenous heterocyclic compound that plays a significant role due to several therapeutic applications. This moiety acts as an essential building block for generating drug candidates with diverse biological activities, including anti-cancer (capecitabine), anti-thyroid (propylthiouracil), antihistaminic (pemirolast), antimalarial (pyrimethamine), antidiabetic (alloxan), antihypertensive (minoxidil), anti-inflammatory (octotiamine), antifungal (cyprodinil), antibacterial (sulfamethazine), etc. This review is focused on the synthesis of pyrimidine analogs under microwave irradiation technique and the study of their therapeutic potentials.
Abhishek Tiwari, Varsha Tiwari, Biswa Mohan Sahoo, Bimal Krishna Banik, Manish Kumar, and Navneet Verma
Bentham Science Publishers Ltd.
Abstract: Right from the breakthrough of carbapenems since 1976, many schemes on synthesis, structure-activity relationship (SAR), and biological activities have been carried out, and several carbapenems have been developed, including parentally active carbapenems like imipenem, doripenem, biapenem, meropenem, ertapenem, panipenem, razupenem, tomopenem, cilastatin, whereas orally active carbapenems like GV-118819, GV-104326, CS-834, L-084, DZ-2640, CL 191, 121, L-646, 591, S-4661, ER-35768, MK-826. Prodrugs of carbapenem with increased bioavailability include temopenem, tebipenem, sanfetrinem, LK-157, and CP 5484. Merck, Glaxo Welcome Research Group, Johnson & Johnson, Sankyo Group and Dai-ichi Group, and Wyeth-Ayerst Group were among the businesses that produced carbapenems. The Witting reaction, Mitsunobu reaction, Dieckmann reaction, palladium-catalyzed hydrogenolysis, E. coli-based cloned synthesis, and biosynthetic enzymes such as carbapenem synthetase (carA), carboxymethylproline synthase (carB), carbapenem synthase (carC). Carbapenems are biologically in infections like urinary tract infections, bloodstream infections, tuberculosis, intra-abdominal infections, and pathogens like anaerobes, gram-positive and gram-negative bacteria.
Krishna Chandra Panda, B.V.V. Ravi Kumar, Biswa Mohan Sahoo, Balakumar Chandrasekaran, and Parijat Swain
Bentham Science Publishers Ltd.
Background: Molecular docking study is used significantly in the drug discovery process for predicting the interaction between drug and receptor. This technique has been used commonly to identify the binding affinity and orientation of drug molecules at the binding site of the target. The main objectives of docking studies include accurate modeling of molecular structure and precise prediction of the biological activity of the drug molecules. Methods: Based on this concept, a series of 2-amino-6-(substituted phenyl)-4-oxo-4,5-dihydropyrimidine-5-carbonitrile derivatives have been designed and synthesized via multi-component reaction. The synthetic protocol involves the one-pot, three-component reaction be-tween equimolar quantities of substituted benzaldehydes, ethyl cyanoacetate, and guanidine in an ethanolic sodium hydroxide solution. Results: The characterization of the titled compounds was carried out by assessing infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), and mass spectrometry (MS) data. The synthesized compounds were screened for their in vitro anti-mycobacterial activity by using the luciferase reporter phage (LRP) assay method. Conclusion: The determination of anti-mycobacterial activity was carried out in terms of the percent reduction in the relative light unit (RLU). The test compounds displayed significant ac-tivity against Mycobacterium strain H37Rv in comparison to isoniazid as a standard drug.
Biswa Mohan Sahoo, Bimal Krishna Banik, Abhishek Tiwari, Varsha Tiwari, and Manoj Kumar Mahapatra
Bentham Science Publishers Ltd.
Abstract: Thiadiazole is a paradigm of five membered heterocyclic compound that contains two nitrogens and one sulphur as heteroatoms with molecular formula C2H2N2S. Thiadiazole is mainly present in four isomeric forms such as 1,2,3-thiadiazole, 1,2,4-thiadiazole, 1,2,5-thiadiazole and 1,3,4-thiadiazole. Out of these isomers, 1,3,4-thiadiazole has attracted remarkable attention in the field of medicinal chemistry. Some of the drugs containing 1,3,4-thiadiazole moiety are used clinically and are available in the market including Sulphamethizole (Antibacterial), Acetazolamide (Diuretic), Azetepa (Antineoplastic), Cefazolin (Antibiotic), Megazol (Antiprotozoal), Atibeprone (anti-depressant). Several greener approaches are applied for the synthesis of thiadiazole scaffolds including microwave irradiation, ultrasonic irradiation, grinding, ball milling technique, etc. These methods are eco-friendly, nonhazardous, reproducible, and economical approach. Based on these Green chemistry approaches, thiadiazole derivatives are synthesized from thiosemicarbazide. The functionalization of these heterocyclic compounds generates thiadiazole derivatives with diverse chemical structures. This review covers green synthesis, biological potentials, and structure activity relationship study of thiadiazole analogs.
Shikha Sharma, Biswa Mohan Sahoo, and Bimal Krishna Banik
Bentham Science Publishers Ltd.
Abstract: In the past few years, scientists have learned more about how the human body uses D-amino acids and how their synthesis occurs. This has rekindled interest in researching them. D-amino acids are known to be important in an extensive variety of physiologic operations taking place inside the human body. The correlation between these radicals and the physiology of human beings is that D-aspartate and D-serine affect nerve signalling. Along with these, several other D-amino acids have also been linked to adjusting acquired immunity and the outcome of the gut barrier. Importantly, several conditions, including psychosis and amyotrophic lateral sclerosis, as well as age-related conditions, including cataracts and atherosclerosis, have been linked to the existence of D-amino acids within the human body. Also, there is more and more evidence that radicals interpret a role in the cause, progression, and treatment of cancer. This article will review the many approaches to synthesizing D-amino acids and their impact on the environment, animals, and the human body. In addition, scientific information addressing the methods of cytostatic action of D-amino acids as well as their prospective applications in industry and medicine, is included in this article.
Abhishek Tiwari, Varsha Tiwari, Bimal Krishna Banik, and Biswa Mohan Sahoo
Bentham Science Publishers Ltd.
Abstract: Tempol (TP) was introduced in 1960 by Lebedev and Kazarnovskii and is an excellent catalyst extensively used in the synthesis and oxidation of various reagents. 4-Hydroxy-2,2,6,6- tetramethylpiperidin-1-oxyl (TP) has also been explored against various disorders like inflammation, superoxide anion-influenced molecular linked behavioural modifications, radical capturing, cardioprotective, protective ocular damage, against skin burns, fibrocystic diseases, breast cancer prevention, respiratory infections, alopecia, and cerebral malaria, etc. This review article comprises five major aspects of TP namely (a) Approx. 25 different Synthesis schemes of TP (b) major reactions catalysed by TP (c) Therapeutic potential of TP. It also provides scientific information that supports the use of TP which may be proven as a “MIRACLE” drug for the treatment of numerous disorders namely in reducing the reactive oxygen species, superoxide mutases, vision disorders, cancer as well as in covid. It also possesses a significant role in minimising side effects in combination therapy. This review will be beneficial to researchers, healthcare, and academic professionals for further research.
Shikha Sharma, Biswa Mohan Sahoo, and Bimal Krishna Banik
Bentham Science Publishers Ltd.
Abstract: More than two hundred years ago, taurine was first isolated from materials derived from animals. It is abundantly found in a wide range of mammalian and non-mammalian tissues and diverse environments. Taurine was discovered to be a by-product of the metabolism of sulfur only a little over a century and a half ago. Recently, there has been a renewed academic interest in researching and exploring various uses of the amino acid taurine, and recent research has indicated that it may be useful in the treatment of a variety of disorders, including seizures, high blood pressure, cardiac infarction, neurodegeneration, and diabetes. Taurine is currently authorised for the therapy of congestive heart failure in Japan, and it has shown promising results in the management of several other illnesses as well. Moreover, it was found to be effective in some clinical trials, and hence it was patented for the same. This review compiles the research data that supports the prospective usage of taurine as an antibacterial, antioxidant, anti-inflammatory, diabetic, retinal protective, and membrane stabilizing agent, amongst other applications.
Krishna Chandra Panda, Ravi Kumar Venkata Varaha Bera, Biswa Mohan Sahoo, and Parijat Swain
Bentham Science Publishers Ltd.
Background: Green strategy involves the design, synthesis, processing, and use of chemical substances by eliminating the generation of chemical hazards. This approach focuses on atom economy, use of safer solvents or chemicals, consumption of energy, and decomposition of the chemical substances to non-toxic materials which are eco-friendly. Objective: So, the microwave irradiated heating method is considered a green and sustainable technique for the development of novel heterocyclic scaffold-like isoxazole derivatives via chalcones. Isoxazole derivatives play a vital role due to their diverse pharmacological activities such as antibiotic (Sulfamethoxazole, Cloxacillin, Flucloxacillin, Cycloserine), anti-fungal (Drazoxolon), Antirheumatic (Leflunomide), antidepressant (Isocarboxazid), antineoplastic (Acivicin), anticonvulsant (Zonisamide), antipsychotic (Risperidone) and anti-inflammatory drugs (Valdecoxib), etc. Methods: The isoxazole derivatives were synthesized with the help of microwave irradiation that follows green chemistry protocol. Results: The titled compounds were subjected to antiepileptic evaluation to determine their therapeutic potential. Conclusion: The use of microwave radiation enhances the rate of the reaction which leads to high selectivity with improved product yields in comparison with the traditional heating methods. The tested compounds exhibited promising antiepileptic activity as compared to the standard drug (Phenytoin).
Abhishek Tiwari, Varsha Tiwari, Suresh Kumar, Manish Kumar, Renu Saharan, Navneet Varma, Biswa Mohan Sahoo, Deepak Kaushik, and Rajeev Kumar Sharma
Bentham Science Publishers Ltd.
Background: Cancer is a leading cause of death for people worldwide, in addition to the rise in mortality rates attributed to the Covid epidemic. This allows scientists to do additional research. Here, we have selected Integerrimide A, cordy heptapeptide, and Oligotetrapeptide as the three cyclic proteins that will be further studied and investigated in this context. Methods: Docking research was carried out using the protein complexes 1FKB and 1YET, downloaded from the PDB database and used in the docking investigations. Cyclopeptides have been reported to bind molecularly to human HSP90 (Heat shock protein) and FK506. It was possible to locate HSP90 in Protein Data Banks 1YET and 1FKB. HSP90 was retrieved from Protein Data Bank 1YET and 1FKB. Based on these findings, it is possible that the anticancer effects of Int A, Cordy, and Oligo substances could be due to their ability to inhibit the mTOR rapamycin binding domain and the HSP90 Geldanamycin binding domain via the mTOR and mTOR chaperone pathways. During the calculation, there were three stages: system development, energy reduction, and molecular dynamics (also known as molecular dynamics). Each of the three compounds demonstrated a binding affinity for mTOR's Rapamycin binding site that ranged from -6.80 to -9.20 Kcal/mol (FKB12). Results: An inhibition constant Ki of 181.05 nM characterized Cordy A with the highest binding affinity (-9.20 Kcal/mol). Among the three tested compounds, Cordy A was selected for MD simulation. HCT116 and B16F10 cell lines were used to test each compound's anticancer efficacy. Doxorubicin was used as a standard drug. The cytotoxic activity of substances Int A, Cordy A, and Oligo on HCT116 cell lines was found to be 77.65 μM, 145.36 μM, and 175.54 μM when compared to Doxorubicin 48.63 μM, similarly utilizing B16F10 cell lines was found to be 68.63 μM, 127.63 μM, and 139.11 μM to Doxorubicin 45.25 μM. Conclusion: Compound Cordy A was more effective than any other cyclic peptides tested in this investigation.
N. Jain, M. Tailang, H. Jain, B. Chandrasekaran, B. Sahoo, Anand Subramanian, N. Thangavel, Afaf A Aldahish, K. Chidambaram, M. Alagusundaram,et al.
Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been implicated in immunopathogenesis of COVID-19 infection under different stages such as viral entry, escaping innate immunity, replication, and subsequent inflammatory processes. Prompted by this fact and prior utilization as an immunomodulatory agent for several autoimmune, allergic, and inflammatory conditions, Jakinibs have been recognized as validated small molecules targeting the rapid release of proinflammatory cytokines, primarily IL-6, and GM-CSF. Various clinical trials are under investigation to evaluate Jakinibs as potential candidates for treating COVID-19. Till date, there is only one small molecule Jakinib known as baricitinib has received FDA-approval as a standalone immunomodulatory agent in treating critical COVID-19 patients. Though various meta-analyses have confirmed and validated the safety and efficacy of Jakinibs, further studies are required to understand the elaborated pathogenesis of COVID-19, duration of Jakinib treatment, and assess the combination therapeutic strategies. In this review, we highlighted JAK-STAT signalling in the pathogenesis of COVID-19 and clinically approved Jakinibs. Moreover, this review described substantially the promising use of Jakinibs and discussed their limitations in the context of COVID-19 therapy. Hence, this review article provides a concise, yet significant insight into the therapeutic implications of Jakinibs as potential anti-COVID agents which opens up a new horizon in the treatment of COVID-19, effectively.
Dipthi Shree, Chinam N. Patra, and Biswa M. Sahoo
Bentham Science Publishers Ltd.
Background and objective: In the pharmaceutical era, nanoscience and nanotechnology have been revolutionary as substantial and scientific growth with the development of several innovative nanocarriers to amplify the therapeutic worth. In particular, the invention of nanomedicine is impetuous to developing nanocarriers, enabling the phytoconstituents to encapsulate within the smart carrier to boost nanotherapeutics. Thus, herbal drugs molded-in novel nanocarriers have been extensively investigated as they are the most promising drug delivery system. Herbal-based polymeric nanoparticles are the most prominent and emerging polymeric nanocarrier that have gained much research attention in the field of novel drug delivery systems. Methods: In herbal drug delivery technologies, the advancement of phytopharmacological science has led to the elucidation of the composition of phytoconstituents and their biological activities. By fabricating herbal medicaments in nano-size-form, there are considerable chances to circumvent poor bioavailability, in vivo degradation and toxicity, uneven drug distribution, intestinal absorption, and non-specific site of action. The combinatorial strategy of employing both herbal drugs and nanotechnology enables potentiation of the therapeutics, reducing the required dose and unwanted toxic effects. The herbal nanosystem has the potential to convey the active constituents in a controlled manner to the targeted site with greater therapeutic value compared to the conventional system. In this current manuscript, sterling efforts were made to gather information from the existing original research papers using databases viz., Google Scholar, Pubmed, Embase, Scopus, Baidu, Web of Science, etc. Furthermore, painstaking efforts were made to compile and update potential pharmaceutical and cosmeceutical applications of herbal-based polymeric nanoparticles in the form of tables. This article portrays a comprehensive recent finding that formulation scientists are working on novel herbal nanocarriers to pave the way for future research in the field of pharmaceutical nanotechnology. Conclusion: The herbal extracts encapsulated within the nanocapsule or nanosphere are an effective and emerging way for the herbal drug delivery to the intended site of action with pronounced therapeutic worth. Therefore, extensive scientific research is still being carried out in the field of herbal drug technology, which offers several positive aspects to impart the phytoconstituents to the intended sites and is a considerably promising herbal drug delivery system for controlled drug delivery and targeting.
Smitapadma Mohanty
Medic Scientific
As new technologies are invented, research in the discovery of new active pharmaceutical moieties is reverberating now a day. Drug solubility is an extensive challenge for formulation scientists as approximately 35-40% of newly discovered drugs show lipophilicity. Low solubility is a rate limiting step for drug dissolution and extends of drug absorption to the systemic circulation. Poor dissolution results in low bioavailability, leading to difficulty to achieve desired therapeutic effect. Drug solubility can be increased by different methods like micronization, solid dispersion, salt formation, complexation etc. Self-micro emulsifying Drug Delivery System (SMEDDS) is in fame for enhancing solubility of poorly aqueous soluble drugs. Self-emulsifying drug delivery system, Self-micro emulsifying drug delivery system (SMEDDS) are isotropic mixers of oil, surfactant, drug and co-solvent which spontaneously form transparent micro-emulsions. When SMEDDS formulation administered orally, the solution disperses in GI fluid and instantly forms a fine emulsion by which drug gets a larger surface area which leads to quick dissolution of the drug. Objective of the present review is to update about advancements associated with SMEDDS preparation. It elaborates the evaluation tests required to analyse selfmicro emulsifying drug delivery systems. This review article also highlights on recent patents on SEDDS, SMEDDS and SNEDDS formulations.
Dipthi Shree, Chinam Niranjan Patra, and Biswa Mohan Sahoo
Bentham Science Publishers Ltd.
Background and Objective: In the present scenario, the use of novel nanocarriers to provide a better therapy regimen is noteworthy. Nanotechnology with the advanced system enables the herbs for encapsulation within the smart carrier and boosts the nanotherapeutic. These emerging innovations of herbal nanocarriers have paved the way for dermal targeting by eliciting the desired response for particular diseases. Method: In this current manuscript, an extensive search is conducted for the original research papers using databases, viz., Google Scholar, PubMed, Science Direct, etc. Furthermore, painstaking efforts are made to compile and update the novel herbal nanocarriers, such as liposomes, ethosomes, transferosomes, niosomes, nanoemulsions, nanogels, nanostructured lipid carriers, solid lipid carriers, etc., which are mostly used for the treatment of several skin maladies, viz., eczema, psoriasis, acne, etc. This article highlights the recent findings that the innovators are exclusively working on herbal drug delivery systems for dermal targeting, and these are enumerated in the form of tables. Conclusion: Herbal formulations employing a suitable nanocarrier could be a promising approach for the treatment of several pathological conditions, including skin ailments. Therefore, scientific research is still being carried out in this specific area for a better perspective in herbal drug delivery and targeting.
Sarita Das, Biswa Mohan Sahoo, and Subrat Kumar Bhattamisra
Bentham Science Publishers Ltd.
Background: The whole plant of Boerhaavia diffusa L. (BD) has wide ethnomedicinal and ethnopharmacological applications. It is a versatile medicinal herb with tremendous antioxidant potential, used commonly in Asian and African countries for a variety of Ayurvedic formulations as a “Rasayan” or Rejuvenator. Objective: This paper is aimed at providing an extensive study of the phytochemistry and pharmacology of BD to support its ethnopharmacological uses and the effectiveness of different active constituents present in BD. We believe that this paper will provide an insight into various trends and advances for future studies on BD. Methods: All relevant information was collected from worldwide accepted search engines and databases, i.e., Google, Pub Med, Elsevier, Science Direct and Web of Science, etc. Results: Based on the study conducted for this paper, it was found that BD is a rich source of several phytochemicals that are extracted from its roots and aerial parts. Among them, secondary metabolites such as alkaloids, phenolics, flavonoids, isoflavonoids, rotenoids, glycosides, steroids, and lignans are the most important ones. The crude extract and the isolated phytochemicals are reported to have impressive bioactivities such as immunomodulatory, hepatoprotective, renoprotective, cardioprotective, antidiabetic, anti-inflammatory, antifertility, antioxidant, anticancer, and antimicrobial properties. Conclusion: The immense therapeutic potential of BD has been explored in many experiments, which validates its traditional uses. However, reports from clinical trials and the specific interaction of isolated phytoconstituents with microbial toxins or molecular markers of pathogenesis are meager. Therefore, further studies can be undertaken to elucidate the molecular cross-talk between the major therapeutic components with pathological biomolecules.