Balakrishna Nagalla

@apolloimsr.edu.in

HoD,Statistics
Apollo Institute of Medical Sciences and Research/Former Scientist ICMR-National Institute of Nutrition



              

https://researchid.co/drnbkaimsr

RESEARCH INTERESTS

Data Analysis on Nutrition,Public Health & Medicine

235

Scopus Publications

37215

Scholar Citations

62

Scholar h-index

175

Scholar i10-index

Scopus Publications

  • Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
    Nowell H Phelps, Rosie K Singleton, Bin Zhou, Rachel A Heap, Anu Mishra, James E Bennett, Christopher J Paciorek, Victor PF Lhoste, Rodrigo M Carrillo-Larco, Gretchen A Stevens,et al.

    Elsevier BV

  • Sugar-sweetened beverage intakes among adults between 1990 and 2018 in 185 countries
    Laura Lara-Castor, Renata Micha, Frederick Cudhea, Victoria Miller, Peilin Shi, Jianyi Zhang, Julia R. Sharib, Josh Erndt-Marino, Sean B. Cash, Dariush Mozaffarian,et al.

    Springer Science and Business Media LLC
    AbstractSugar-sweetened beverages (SSBs) are associated with cardiometabolic diseases and social inequities. For most nations, recent estimates and trends of intake are not available; nor variation by education or urbanicity. We investigated SSB intakes among adults between 1990 and 2018 in 185 countries, stratified subnationally by age, sex, education, and rural/urban residence, using data from the Global Dietary Database. In 2018, mean global SSB intake was 2.7 (8 oz = 248 grams) servings/week (95% UI 2.5-2.9) (range: 0.7 (0.5-1.1) in South Asia to 7.8 (7.1-8.6) in Latin America/Caribbean). Intakes were higher in male vs. female, younger vs. older, more vs. less educated, and urban vs. rural adults. Variations by education and urbanicity were largest in Sub-Saharan Africa. Between 1990 and 2018, SSB intakes increased by +0.37 (+0.29, +0.47), with the largest increase in Sub-Saharan Africa. These findings inform intervention, surveillance, and policy actions worldwide, highlighting the growing problem of SSBs for public health in Sub-Saharan Africa.

  • Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
    , Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Anu Mishra, Victor P. F. Lhoste,et al.

    Springer Science and Business Media LLC
    AbstractFasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.

  • Five-year outcomes of off and on-pump CABG: Insights from PROMOTE Patency Trial
    Lokeswara Rao Sajja, Kunal Sarkar, Gopichand Mannam, Chandrasekhar Padmanabhan, Pradeep Narayan, Devanish NH Kamtam, Nagalla Balakrishna, Venkata Krishna Kumar Kodali, Anvay Mulay, Sanjeeth Peter,et al.

    SAGE Publications
    Background There are limited studies reporting follow-up outcome data comparing of off-pump coronary artery bypass (OPCAB) with on-pump (ONCAB) technique. The aim of the study was to report the 5-year clinical outcomes of OPCAB and ONCAB in a post hoc analysis of the PROMOTE patency trial. Methods From March 2016 through March 2017, a total of 321 patients undergoing coronary artery bypass grafting (CABG) were randomised to either the off-pump or the on-pump technique. Data on all-cause mortality, myocardial infarction (MI), cerebrovascular accident (CVA), repeat revascularisation and need for renal replacement therapy (RRT) were recorded. The composite and each of these individual outcomes are reported at 5-year interval. Results The mean follow-up period was 65.9 months (±3.39). A total of 275 (85.93%) patients followed up at the 5-year interval who underwent CABG by the off-pump ( n  =  158) and the on-pump ( n  =  162) technique. The all-cause mortality was 8.9% and 5.7% in ONCAB and OPCAB, respectively (hazard ratio [HR]  =  0.62; 95% confidence interval [CI] 0.25–1.57, p  =  0.31). The composite of all-cause mortality, non-fatal MI, non-fatal CVA, RRT and need for repeat revascularisation was comparable in both groups (7.1% vs. 11.9%, HR  =  0.57; 95% CI 0.25–1.31, p  =  0.18 in OPCAB and ONCAB, respectively). The rates of 5-year non-fatal MI ( p  =  0.2), non-fatal CVA ( p  =  0.36) and need for repeat revascularisation ( p  =  1) were similar in both groups. A sub-group analysis did not show any significant interaction or effect modification with either of the techniques. Conclusions The 5-year clinical outcomes of OPCAB are comparable to ONCAB in low-risk patients undergoing CABG. Off-pump coronary artery bypass had no additional benefit in any subgroup.

  • Out of Pocket Expenditure and Utilization of Government Financial Assistance Among Women Who Had Institutional Delivery in An Urban Slum of Telangana, India
    Pavani Varma, Anu Mohandas, Siddu Anushruthi, Nagalla Balakrishna, Snigdha Pattnaik, Dilip Mathai, and Biranchi Narayan Das

    Medsci Publications
    Background: Out of Pocket Expenditure (OOPE) are expenditures directly made by households at the point of receiving health care. In Telangana State the average OOPE per delivery in public health facility is Rs. 3846. The study helps to know the OOPE among mothers undergoing institutional deliveries and emphasise on the expenditure even after utilising the government financial assistance. Objectives: To estimate the OOPE among women undergoing institutional delivery and to find its association with government financial assistance utilization and socio-demographic factors. Methodology: A community based cross sectional study was done among 200 mothers who delivered recently residing in an urban slum under our health and training centre. Ethical clearance was taken before the conduct of study. Results: The median direct out of pocket expenditure among mothers in our study was Rs.500 i.e., 6.6 $ (0 to 1600). OOPE was present among 68.5% of mothers. Availability of government financial assistance, age and occupation of the mother and type of delivery was found to be significantly associated with p value <0.05. Conclusion: The financial assistance definitely reduced the burden of OOPE among the mothers. The implementation of such schemes is important and needs to be evaluated time to time to ensure proper reach of its benefits to the community.

  • Assessment of virgin coconut oil in a balanced diet on indicators of cardiovascular health in non-obese volunteers: A human metabolic study
    Shanmugam Murugaiha Jeyakumar, Korrapati Damayanti, Laxmi Rajkumar Ponday, Vani Acharya, Swarupa Rani Koppala, Uday Kumar Putcha, Balakrishna Nagalla, and Ayyalasomayajula Vajreswari

    Elsevier BV

  • Exploring urinary extracellular vesicles for organ transplant monitoring: A comprehensive study for detection of allograft dysfunction using immune-specific markers
    Anula Divyash Singh, Balakrishna Nagalla, Sreekanth Patnam, G. Satyanaryana, Ravi Andrews, Aswini Kumar Panigrahi, Soma Sekhar Mudigonda, Sanjay Maitra, Aravind Kumar Rengan, and Manda Venkata Sasidhar

    Elsevier BV

  • Female gender does not have any significant impact on the early postoperative outcomes after coronary artery bypass grafting: a propensity-matched analysis
    Lokeswara Rao Sajja, Gopichand Mannam, Devanish Narasimhasanth Kamtam, and Nagalla Balakrishna

    Springer Science and Business Media LLC

  • Children’s and adolescents’ rising animal-source food intakes in 1990–2018 were impacted by age, region, parental education and urbanicity
    Victoria Miller, Patrick Webb, Frederick Cudhea, Jianyi Zhang, Julia Reedy, Peilin Shi, Josh Erndt-Marino, Jennifer Coates, Renata Micha, Dariush Mozaffarian,et al.

    Springer Science and Business Media LLC
    AbstractAnimal-source foods (ASF) provide nutrition for children and adolescents’ physical and cognitive development. Here, we use data from the Global Dietary Database and Bayesian hierarchical models to quantify global, regional and national ASF intakes between 1990 and 2018 by age group across 185 countries, representing 93% of the world’s child population. Mean ASF intake was 1.9 servings per day, representing 16% of children consuming at least three daily servings. Intake was similar between boys and girls, but higher among urban children with educated parents. Consumption varied by age from 0.6 at <1 year to 2.5 servings per day at 15–19 years. Between 1990 and 2018, mean ASF intake increased by 0.5 servings per week, with increases in all regions except sub-Saharan Africa. In 2018, total ASF consumption was highest in Russia, Brazil, Mexico and Turkey, and lowest in Uganda, India, Kenya and Bangladesh. These findings can inform policy to address malnutrition through targeted ASF consumption programmes.

  • Incident type 2 diabetes attributable to suboptimal diet in 184 countries
    Meghan O’Hearn, Laura Lara-Castor, Frederick Cudhea, Victoria Miller, Julia Reedy, Peilin Shi, Jianyi Zhang, John B. Wong, Christina D. Economos, Renata Micha,et al.

    Springer Science and Business Media LLC
    AbstractThe global burden of diet-attributable type 2 diabetes (T2D) is not well established. This risk assessment model estimated T2D incidence among adults attributable to direct and body weight-mediated effects of 11 dietary factors in 184 countries in 1990 and 2018. In 2018, suboptimal intake of these dietary factors was estimated to be attributable to 14.1 million (95% uncertainty interval (UI), 13.8–14.4 million) incident T2D cases, representing 70.3% (68.8–71.8%) of new cases globally. Largest T2D burdens were attributable to insufficient whole-grain intake (26.1% (25.0–27.1%)), excess refined rice and wheat intake (24.6% (22.3–27.2%)) and excess processed meat intake (20.3% (18.3–23.5%)). Across regions, highest proportional burdens were in central and eastern Europe and central Asia (85.6% (83.4–87.7%)) and Latin America and the Caribbean (81.8% (80.1–83.4%)); and lowest proportional burdens were in South Asia (55.4% (52.1–60.7%)). Proportions of diet-attributable T2D were generally larger in men than in women and were inversely correlated with age. Diet-attributable T2D was generally larger among urban versus rural residents and higher versus lower educated individuals, except in high-income countries, central and eastern Europe and central Asia, where burdens were larger in rural residents and in lower educated individuals. Compared with 1990, global diet-attributable T2D increased by 2.6 absolute percentage points (8.6 million more cases) in 2018, with variation in these trends by world region and dietary factor. These findings inform nutritional priorities and clinical and public health planning to improve dietary quality and reduce T2D globally.

  • Diminishing benefits of urban living for children and adolescents’ growth and development
    , Anu Mishra, Bin Zhou, Andrea Rodriguez-Martinez, Honor Bixby, Rosie K. Singleton, Rodrigo M. Carrillo-Larco, Kate E. Sheffer, Christopher J. Paciorek, James E. Bennett,et al.

    Springer Science and Business Media LLC
    AbstractOptimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.

  • Author Correction: Global dietary quality in 185 countries from 1990 to 2018 show wide differences by nation, age, education, and urbanicity (Nature Food, (2022), 3, 9, (694-702), 10.1038/s43016-022-00594-9)
    Victoria Miller, Patrick Webb, Frederick Cudhea, Peilin Shi, Jianyi Zhang, Julia Reedy, Josh Erndt-Marino, Jennifer Coates, Dariush Mozaffarian, Murat Bas,et al.

    Springer Science and Business Media LLC

  • Impact of COVID-19 during pregnancy on placental pathology, maternal and neonatal outcome – A cross-sectional study on anemic term pregnant women from a tertiary care hospital in southern India
    M. V. Surekha, N. Suneetha, N. Balakrishna, Uday Kumar Putcha, K. Satyanarayana, J. J. Babu Geddam, Pagidoju Sreenu, B. Tulja, Raja Sriswan Mamidi, Guy A. Rutter,et al.

    Frontiers Media SA
    BackgroundSARS-CoV-2 infection during pregnancy may cause adverse maternal, neonatal and placental outcomes. While tissue hypoxia is often reported in COVID-19 patients, pregnant women with anemia are suspected to be more prone to placental hypoxia-related injuries.MethodsThis hospital-based cross-sectional study was conducted between August-November 2021, during COVID-19 second wave in India. Term pregnant women (N=212) admitted to hospital for delivery were enrolled consecutively. Since hospital admission mandated negative RT-PCR test for SARS-CoV-2 virus, none had active infection. Data on socio-demography, COVID-19 history, maternal, obstetric, and neonatal outcomes were recorded. Pre-delivery maternal and post-delivery cord blood samples were tested for hematological parameters and SARS-CoV-2 IgG. Placentae were studied for histology.ResultsOf 212 women, 122 (58%) were seropositive for SARS-CoV-2 IgG, but none reported COVID-19 history; 134 (63.2%) were anemic. In seropositive women, hemoglobin (p=0.04), total WBC (p=0.009), lymphocytes (p=0.005) and neutrophils (p=0.02) were significantly higher, while ferritin was high, but not significant and neutrophils to lymphocytes (p=0.12) and platelets to lymphocytes ratios (p=0.03) were lower. Neonatal outcomes were similar. All RBC parameters and serum ferritin were significantly lower in anemic mothers but not in cord blood, except RDW that was significantly higher in both, maternal (p=0.007) and cord (p=0.008) blood from seropositive anemic group compared to other groups. Placental histology showed significant increase in villous hypervascularity (p=0.000), dilated villous capillaries (p=0.000), and syncytiotrophoblasts (p=0.02) in seropositive group, typically suggesting placental hypoxia. Maternal anemia was not associated with any histological parameters. Univariate and multivariate logistic regression analyses of placental histopathological adverse outcomes showed strong association with SARS-CoV-2 seropositivity but not with maternal anemia. When adjusted for several covariates, including anemia, SARS-CoV-2 seropositivity emerged as independent risk factor for severe chorangiosis (AOR 8.74, 95% CI 3.51-21.76, p<0.000), dilated blood vessels (AOR 12.74, 95% CI 5.46-29.75, p<0.000), syncytiotrophoblasts (AOR 2.86, 95% CI 1.36-5.99, p=0.005) and villus agglutination (AOR 9.27, 95% CI 3.68-23.32, p<0.000).ConclusionAsymptomatic COVID-19 during pregnancy seemed to be associated with various abnormal placental histopathologic changes related to placental hypoxia independent of maternal anemia status. Our data supports an independent role of SARS-CoV-2 in causing placental hypoxia in pregnant women.

  • Assessment of Knowledge and Awareness Among the Stakeholders of Clinical Research at the Site: A Collaborative, Electronic-Survey Approach to Identify the Indicators of Quality
    Chandana Pal, Aravind Kumar Rengan, Latha Moodahadu, Jayanthi Swaminathan, and Balakrishna Nagalla

    Bentham Science Publishers Ltd.
    Background: There has been a concern in the quality of clinical trials conducted in terms of data integrity, accuracy or ethical conduct. This study aimed to assess the tangible gap existing in knowledge and application of rules and guidelines among Researcher, Research staff (RS) and Eth-ics Committee (EC) members - the three research stakeholders at the study sites. Method: A validated e-questionnaire with details for demography, role, years of experience, affilia-tion and questions on knowledge and understanding about their clinical research functions based on the New Drugs and Clinical Trials (NDCT) Rules 2019, including: ‘Role and responsibility, Regula-tions, Reporting timelines, Documentation, Conflict of interest and Miscellaneous’ was circulated among the seven research sites of one organization with their fourteen Institutional ECs as part of the planned annual survey. Responses with >60% correct answers were arbitrarily considered to rep-resent adequate knowledge Results: Of 201participants, there were 27.4% Researchers, 50.2% were from the EC and 22.4% RS. A greater proportion of Researchers had >5 years (43.6%) of experience. The mean ±SD of correct an-swers obtained was 66.9±14.77 and was statistically significant (p<0.05) among the groups, highest for EC members (71.4±11.51), those with 2-5 years of experience (68.4±14.40), and least for the RS (56.8±11.93). Researchers (> 90%) were aware of their role in the clinical trial agreement and importance of the trial registration in Clinical Trials Registry-India. There were gaps in the Informed Consent (IC) process and post-trial access. Awareness regarding the IC process was adequate among the RS (84%). Awareness that the re-sponsibility of all delegation at site finally lies with the Researchers was adequate (60%) but 20% wrongly believed that the sponsor can have access to subject identification details. Deficiencies were noted regarding documentation, NDCT rules -2019 and serious adverse event (SAE) reporting process. Five percent answered that Data Clarification Forms were generated after reviewing the case report forms. The awareness that NDCT rules-2019 was not for medical devices, student pro-jects or Investigator Initiated Studies was inadequate (56%). The EC members’ awareness in roles and responsibilities was adequate (≥ 90%). Knowledge gaps were noted in EC monitoring of the ongoing trials (32%), and SAE reporting on SUGAM portal (8.8%), where stakeholders can access the regulator's web services using a single window interface for clinical trial related activities. Conclusion: There are gaps in the knowledge of the 3 stakeholders at site. Identifying and rectifying the gray areas will have the site better placed in performance. There is a need for regular training and assess-ments.

  • Pre-operative mapping and structured reporting of pelvic endometriotic lesions on dynamic ultrasound and its correlation on laparoscopy using the #ENZIAN classification
    Vimee Bindra, Nori Madhavi, Girija Shankar Mohanty, K. Nivya, and N. Balakrishna

    Springer Science and Business Media LLC


  • Energy expenditure in COVID-19 mechanically ventilated patients: A comparison of three methods of energy estimation
    Sanjith Saseedharan, Radha Reddy Chada, Vaijayanti Kadam, Annapurna Chiluka, and Balakrishna Nagalla

    Wiley
    AbstractBackgroundIndirect calorimetry (IC) is the gold standard for measuring resting energy expenditure. Energy expenditure (EE) estimated by ventilator‐derived carbon dioxide consumption (EEVCO2) has also been proposed. In the absence of IC, predictive weight‐based equations have been recommended to estimate daily energy requirements. This study aims to compare simple predictive weight‐based equations with those estimated by EEVCO2 and IC in mechanically ventilated patients of COVID‐19.MethodsRetrospective study of a cohort of critically ill adult patients with COVID‐19 requiring mechanical ventilation and artificial nutrition to compare energy estimations by three methods through the calculation of bias and precision agreement, reliability, and accuracy rates.ResultsIn 58 mechanically ventilated patients, a total of 117 paired measurements were obtained. The mean estimated energy derived from weight‐based calculations was 2576 ± 469 kcal/24 h, as compared with 1507 ± 499 kcal/24 h when EE was estimated by IC, resulting in a significant bias of 1069 kcal/day (95% CI [−2158 to 18.7 kcal]; P < 0.001). Similarly, estimated mean EEVCO2 was 1388 ± 467 kcal/24 h when compared with estimation of EE from IC. A significant bias of only 118 kcal/day (95% CI [−187 to 422 kcal]; P < 0.001), compared by the Bland‐Altman plot, was noted.ConclusionThe energy estimated with EEVCO2 correlated better with IC values than energy derived from weight‐based calculations. Our data suggest that the use of simple predictive equations may potentially lead to overfeeding in mechanically ventilated patients with COVID‐19.

  • Repeatability of choroidal thickness measurements in healthy subjects using RTVue XR optical coherence tomography
    Tarannum Mansoori, Aknoor Sree Ram Charan, Narala Suresh, Veerendranath Pesala and B. Nagalla


    Purpose: To determine the intrasession, intraobserver, interobserver, and repeatability of choroidal thickness measurements in the healthy subjects imaged on enhanced depth imaging system of RTVue XR spectral domain optical coherence tomography (OCT). Methods: In this prospective, cross-sectional study, seventy eyes of 70 healthy volunteers with no known ocular disease were imaged using high-density scanning protocol of RTVue XR OCT. In a single imaging session, three sequential 12 mm macular-enhanced depth horizontal line scans were obtained through the fovea. Two experienced examiners measured the subfoveal choroidal thickness (SFCT), choroidal thickness at 500 μm nasally and temporally from the fovea in all the eyes, using the manual calipers provided in the software. The graders were masked to each other's measurement readings. The coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were used to measure the reliability within graders. Intergrader variability was assessed using Bland-Altman method and 95% limits of agreement (LoA). Results: Intragrader CR for grader one was 4.11 μm (95% confidence interval [CI], −2.84–11.06) for SFCT and 5.73 μm (95% CI, −3.71–15.16) for the grader two. Intragrader ICC of grader one ranged from 0.996 for SFCT to 0.994 for temporal choroidal thickness. Intragrader ICC of grader two ranged from 0.993 for temporal choroidal thickness to 0.991 for SFCT. Intergrader CR ranged from 5.24 μm (95% CI, −4.66–15.15) for SFCT to 5.89 μm (95% CI, −7.27–19.04) for temporal choroidal thickness. Intergrader 95% LoA for SFCT, nasal and temporal choroidal thickness were, −15.84–12.15 μm, −15.99–17.7 μm, and − 19.12–15.57 μm, respectively. Conclusion: Choroidal thickness measurements can be quantified with good repeatability using RTVue XR OCT, which would be useful in patients with chorioretinal diseases.




  • Intra-session repeatability of iridocorneal angle measurements in normal subjects and glaucoma patients using Scheimpflug-Placido disc topographer
    Tarannum Mansoori and Nagalla Balakrishna

    Medknow
    Dear Editor, Quantitative iridocorneal angle (ICA) measurement is essential in planning implantable collamer lens (ICL) surgery and to measure angle widening after laser peripheral iridotomy (LPI) in primary angle‐closure glaucoma (PACG). Sirius Scheimpflug‐Placido disc topographer (SCHWIND eye‐tech‐solutions, Kleinostheim, Germany) combines placido corneal topography with rotating Scheimpflug camera to measure ICA.

  • Global, regional, and national consumption of animal-source foods between 1990 and 2018: findings from the Global Dietary Database
    Victoria Miller, Julia Reedy, Frederick Cudhea, Jianyi Zhang, Peilin Shi, Josh Erndt-Marino, Jennifer Coates, Renata Micha, Patrick Webb, Dariush Mozaffarian,et al.

    Elsevier BV

  • Diagnostic Values of Laboratory Biomarkers in Predicting a Severe Course of COVID-19 on Hospital Admission
    Anusha Tummala, Venkat Ramesh, Nagalla Balakrishna, Rajeswari Koyyada, Anula Divyash Singh, Sreekanth Patnam, M. Satish Kumar, Sneha Varahala, Sasidhar V. Manda, and Suneetha Narreddy

    Hindawi Limited
    Objective. We intend to identify differences in the clinicodemographic and laboratory findings of COVID-19 patients to predict disease severity and outcome on admission. Methods. This single-centred retrospective study retrieved laboratory and clinical data from 350 COVID-19 patients on admission, represented as frequency tables. A multivariate regression model was used to assess the statistically significant association between the explanatory variables and COVID-19 infection outcomes, where adjusted odds ratio (AOR), p value, and 95% CI were used for testing significance. Results. Among the 350 COVID-19 patients studied, there was a significant increase in the WBC count, neutrophils, aggregate index of systemic inflammation (AISI), neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte and platelet ratio (NLPR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), D-dimer, interleukin-6 (IL-6), ferritin, lactate dehydrogenase (LDH), prothrombin time (PT), glucose, urea, urea nitrogen, creatinine, alanine phosphatase (ALP), and aspartate aminotransferase (AST) and a significant decrease in lymphocytes, eosinophils, total protein, albumin, prealbumin serum, and albumin/globulin (A/G) ratio in the severe group when compared with the mild and moderate groups. However, after adjusting their age, gender, and comorbidities, WBC count (adjusted odds ratio   AOR = 6.888 , 95% CI = 1.590 -29.839, p = 0.010 ), neutrophils ( AOR = 5.912 , 95% CI = 2.131 -16.402, p = 0.001 ), and urea ( AOR = 4.843 , 95% CI = 1.988 -11.755, p = 0.001 ) were strongly associated with disease severity. Interpretation and Conclusion. On admission, WBC count, neutrophils, and urea, with their cut of values, can identify at-risk COVID-19 patients who could develop severe COVID-19.

  • Mini Female Health Program for detection of non-communicable diseases in Women - In a urban teaching hospital in India
    Prashanthi Vidyasagar Sangu, Nagalla Balakrishna, Bhargav Challapalli, and Keerthana Ravikanti

    SAGE Publications
    Background: Prevalence of non-communicable diseases (NCDs) is increasing with women affected at an early age. The Mini Female Health Program (MFHP) is a simple screening package to detect NCDs in women. Objective: Determine the prevalence of selected NCDs in a hospital-based outpatient setting using MFHP. Methods: A cross-sectional observational study was conducted in an urban teaching hospital in India. MFHP included medical history, physical examination and investigations. NCDS of interest included anaemia, thyroid disorders, hypertension, diabetes, and obesity. Analysis was performed on groups stratified by age groups (18–30, 31–40 and > 41 years). Between group comparison and association of hypertension with other variables was undertaken. Results: Final analysis included 468 women, of whom 49.8%, 29.9%, and 20.3% were between 18–30, 31–40, and >41 years, respectively. Central obesity was most common NCD (waist to height ratio (WHR) > 0.5 (72.7%), waist circumference (WC) > 80 cm (62.7%)) followed by generalized obesity (body mass index (BMI) > 25 kg/m2 (52.4%)), anaemia (52.6%), thyroid disorders (27.4%), hypertension (14.1%) and diabetes (5.1%). Half of the women between 18 and 30 years were either overweight (BMI: 23–25 kg/m2) or obese. Increasing age was associated with a significant increase in the prevalence of hypertension, diabetes, thyroid disorders and obesity, but not anaemia. Only 9.8% of women were without an NCD with 17.3% having one NCD and 72.8% reporting multiple NCDs. Hypertension was strongly associated with age and WHR in multivariate regression analysis. Conclusion: The MFHP has highlighted the high prevalence of NCDs in women, particularly in young women demonstrating the value of simple screening programme in routine clinical care.

RECENT SCHOLAR PUBLICATIONS

  • Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
    NH Phelps, RK Singleton, B Zhou, RA Heap, A Mishra, JE Bennett, ...
    The Lancet 2024

  • Nutritional Delivery and Adequacy during Bile Reinfusion in Post-Surgical Patients
    RR Chada, M Jaggumanthri, R Kathpaul, GV Rao, B Nagalla
    Medical Research Archives 12 (2) 2024

  • Prevalence of Second Hand Smoke Exposure and Measures to Overcome: A Cross Sectional Study among Youth in Urban Hyderabad
    P Varma, A Mohandas, S Rudrashetty, KSV Prasad, N Balakrishna, ...
    Indian Journal of Public Health 68 (1), 106-109 2024

  • Differential Expression of SRY-Related HMG-Box Transcription Factor 2, Oligodendrocyte Lineage Transcription Factor 2, and Zinc Finger E-Box Binding Homeobox 1 in Serum-Derived
    S Patnam, B Majumder, P Joshi, AD Singh, B Nagalla, D Kumar, ...
    ACS Pharmacology & Translational Science 7 (1), 137-149 2023

  • Association between ABO blood groups and their clinical indices during COVID-19 infection
    S Patnam, S Ranganathan, N Balakrishna, AD Singh, R Koyyada, ...
    Asian Journal of Transfusion Science 2023

  • Five-year outcomes of off and on-pump CABG: Insights from PROMOTE Patency Trial
    LR Sajja, K Sarkar, G Mannam, C Padmanabhan, P Narayan, ...
    Asian Cardiovascular and Thoracic Annals 31 (8), 659-666 2023

  • Is there an Association between Surgeons’ Experience and Implant Survival following Total Knee Arthroplasty? 10 Survivals of My First 60 Total Knee Arthroplasty and Review of
    M Aachi, T Sripurapu, S Abburu, B Nagalla, S Badugu, J Srivaram
    Journal of Telangana Orthopaedic Surgeons Association 1 (1), 10-14 2023

  • Out of Pocket Expenditure and Utilization of Government Financial Assistance Among Women Who Had Institutional Delivery in An Urban Slum of Telangana, India
    P Varma, A Mohandas, S Anushruthi, N Balakrishna, S Pattnaik, D Mathai, ...
    National Journal of Community Medicine 14 (09), 575-580 2023

  • Assessment of virgin coconut oil in a balanced diet on indicators of cardiovascular health in non-obese volunteers: A human metabolic study
    SM Jeyakumar, K Damayanti, LR Ponday, V Acharya, SR Koppala, ...
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews 17 (9), 102844 2023

  • Exploring urinary extracellular vesicles for organ transplant monitoring: A comprehensive study for detection of allograft dysfunction using immune-specific markers
    AD Singh, B Nagalla, S Patnam, G Satyanaryana, R Andrews, ...
    Clinica Chimica Acta 548, 117525 2023

  • Children's and adolescents' rising animal-source food intakes in 1990-2018 were impacted by age, region, parental education and urbanicity
    F Miller, V., Webb, P., Cudhea
    Nat Food 4, 305-319 2023

  • Incident type 2 diabetes attributable to suboptimal diet in 184 countries.
    F O’Hearn, M., Lara-Castor, L., Cudhea
    Nat Med 29, 982-995 2023

  • Diminishing benefits of urban living for growth and development of school-aged children and adolescents in the 21st century
    A Mishra, B Zhou, A Rodriguez-Martinez, H Bixby, R Singleton, ...
    Nature Publishing Group 2023

  • Impact of COVID-19 during pregnancy on placental pathology, maternal and neonatal outcome–A cross-sectional study on anemic term pregnant women from a tertiary care hospital in
    MV Surekha, N Suneetha, N Balakrishna, UK Putcha, K Satyanarayana, ...
    Frontiers in Endocrinology 14, 1092104 2023

  • Food safety knowledge and practices of street food handlers for designing training module-a needs assessment study
    A Sabbithi, RN Kumar, SRM Gavaravarapu, N Balakrishna, VS Rao
    Journal of Food Safety and Hygiene 9 (1), 24-37 2023

  • Female gender does not have any significant impact on the early postoperative outcomes after coronary artery bypass grafting: a propensity-matched analysis
    S Lokeswara Rao, M Gopichand, NK Devanish, N Balakrishna
    Indian Journal of Thoracic and Cardiovascular Surgery 2023

  • Anomalous marginal insertion of umbilical cord in placentas of COVID-19-affected pregnant mothers: a cross-sectional study
    SM Venkata, N Suneetha, N Balakrishna, K Satyanarayana, JJB Geddam, ...
    Cureus 15 (1) 2023

  • Topography and Choroidal Thickness Measurement in Healthy Asian Indian Subjects using RTVue XR 100 Optical Coherence Tomography
    T Mansoori, ASR Charan, B Nagalla
    Middle East African Journal of Ophthalmology 30 (1), 19-23 2023

  • Global variations in diabetes mellitus based on fasting glucose and haemogloblin A1c
    B Zhou, KE Sheffer, JE Bennett, EW Gregg, G Danaei, RK Singleton, ...
    Nature Publishing Group 2023

  • Therapeutic efficacy of bone marrow aspirate and platelet enriched plasma (autologous) studied in osteoarthritic patients - proof of concept study
    SBBN 2. Venkatesh Movva , Vijayalakshmi Venkatesan , Syed Khaleel , Sunitha ...
    World Journal of Pharmaceutical Research 12 (13), 1163-1179 2023

MOST CITED SCHOLAR PUBLICATIONS

  • Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128•9 million
    NCDRFC NCD-RisC)
    Lancet 2017
    Citations: 7732

  • Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19•2 million participants
    NCDRF Collaboration
    Lancet 387, 1377-96 2016
    Citations: 5556

  • Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4•4 million participants
    NCD Risk Factor Collaboration (NCD-RisC)†
    The Lancet 387 (10027), 1513-1530 2016
    Citations: 4090

  • Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 191 million participants
    NCDRFC NCD-RisC).
    Lancet 389 (10064), 37-55 2017
    Citations: 2666

  • Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104
    B Zhou, RM Carrillo-Larco, G Danaei, LM Riley, CJ Paciorek, GA Stevens, ...
    The Lancet 398 (10304), 957-980 2021
    Citations: 1878

  • Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide
    J Powles, S Fahimi, R Micha, S Khatibzadeh, P Shi, M Ezzati, RE Engell, ...
    BMJ open 3 (12), e003733 2013
    Citations: 1011

  • Indigenous and tribal peoples' health (The Lancet–Lowitja Institute Global Collaboration): a population study
    I Anderson, B Robson, M Connolly, F Al-Yaman, E Bjertness, A King, ...
    The Lancet 388 (10040), 131-157 2016
    Citations: 979

  • Rising rural body-mass index is the main driver of the global obesity epidemic in adults

    Nature 569 (7755), 260-264 2019
    Citations: 712

  • A century of trends in adult human height
    NCDRFC NCD-RisC)
    eLife 5, e13410 2016
    Citations: 613

  • Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys
    R Micha, S Khatibzadeh, P Shi, S Fahimi, S Lim, KG Andrews, RE Engell, ...
    Bmj 348 2014
    Citations: 593

  • Global, regional, and national consumption of sugar-sweetened beverages, fruit juices, and milk: a systematic assessment of beverage intake in 187 countries
    GM Singh, R Micha, S Khatibzadeh, P Shi, S Lim, KG Andrews, RE Engell, ...
    PloS one 10 (8), e0124845 2015
    Citations: 551

  • Estimated global, regional, and national disease burdens related to sugar-sweetened beverage consumption in 2010
    GM Singh, R Micha, S Khatibzadeh, S Lim, M Ezzati, D Mozaffarian
    Circulation 132 (8), 639-666 2015
    Citations: 495

  • Global, regional and national consumption of major food groups in 1990 and 2010: a systematic analysis including 266 country-specific nutrition surveys worldwide
    R Micha, S Khatibzadeh, P Shi, KG Andrews, RE Engell, D Mozaffarian
    BMJ open 5 (9), e008705 2015
    Citations: 459

  • Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based
    A Rodriguez-Martinez, B Zhou, MK Sophiea, J Bentham, CJ Paciorek, ...
    The Lancet 396 (10261), 1511-1524 2020
    Citations: 344

  • Factors affecting prevalence of overweight among 12‐to 17‐year‐old urban adolescents in Hyderabad, India
    A Laxmaiah, B Nagalla, K Vijayaraghavan, M Nair
    Obesity 15 (6), 1384-1390 2007
    Citations: 301

  • Does maternal autonomy influence feeding practices and infant growth in rural India?
    MR Shroff, PL Griffiths, C Suchindran, B Nagalla, S Vazir, ME Bentley
    Social science & medicine 73 (3), 447-455 2011
    Citations: 285

  • Cluster‐randomized trial on complementary and responsive feeding education to caregivers found improved dietary intake, growth and development among rural Indian toddlers
    S Vazir, P Engle, N Balakrishna, PL Griffiths, SL Johnson, ...
    Maternal & child nutrition 9 (1), 99-117 2013
    Citations: 281

  • The burden of child and maternal malnutrition and trends in its indicators in the states of India: the Global Burden of Disease Study 1990–2017
    S Swaminathan, R Hemalatha, A Pandey, NJ Kassebaum, A Laxmaiah, ...
    The Lancet Child & Adolescent Health 3 (12), 855-870 2019
    Citations: 243

  • Bone status of Indian women from a low-income group and its relationship to the nutritional status
    V Shatrugna, B Kulkarni, PA Kumar, KU Rani, N Balakrishna
    Osteoporosis International 16, 1827-1835 2005
    Citations: 203

  • Breakfast eating habit and its influence on attention-concentration, immediate memory and school achievement
    NS Gajre, S Fernandez, N Balakrishna, S Vazir
    Indian pediatrics 45 (10), 824 2008
    Citations: 201