Dr Nikhil Srivastava

Scopus Publications

Why does India need more research-driven teaching – learning?
Nikhil Srivastava
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2026
Metagenomics as an Effective Diagnostic Approach for Exploring Oral Microbial Diversity and Dental Diseases: A Narrative Review
Tarun Walia, Nikhil Srivastava, Raghavendra M Shetty, Vivek Rana
International Journal of Clinical Pediatric Dentistry, 2026
Aim and background: The oral cavity harbors a diverse microbiota that significantly influences oral health and disease. Conventional microbiological techniques have limitations in detecting the full range of microbial species, particularly those that are uncultivable. Metagenomics, through culture-independent, high-throughput sequencing methods, offers a comprehensive approach to studying oral microbial diversity. This narrative review aims to evaluate the role of metagenomics in exploring the oral microbiome and its association with dental diseases. Methods: hybridization (FISH), and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), and discussed the integration of artificial intelligence (AI) in metagenomic data interpretation. Results: are implicated in persistent infections. In periodontitis, a dysbiotic microbial shift has been associated with the presence of complex microbial consortia, including red and orange complex bacteria. Conclusion: Metagenomics is a powerful diagnostic tool that provides an in-depth characterization of the complex microbial ecosystem of the oral cavity. It offers diagnostic potential through early and accurate detection of pathogenic shifts, promotes personalized treatment planning, and opens avenues for the development of potential biomarkers of disease progression. Clinical significance: The integration of metagenomics into dental practice can revolutionize caries risk assessment, treatment precision, and disease prevention strategies. Although challenges such as high cost, data complexity, and lack of standardization remain, ongoing advancements in sequencing technologies and bioinformatics are expected to enhance its accessibility and clinical relevance. How to cite this article: Metagenomics as an Effective Diagnostic Approach for Exploring Oral Microbial Diversity and Dental Diseases: A Narrative Review. Int J Clin Pediatr Dent 2026;19(2):278-284.
Techniques and outcomes in prosthetic rehabilitation for patients with ectodermal dysplasia: a systematic review
S. Tomar, N. Srivastava, V. Rana, R. Goswami, N. Kaushik, D. Saxena, T. Pruthi, P. Rawat, N. Kaur
European Archives of Paediatric Dentistry, 2026
Unesthetic to Esthetic Space Maintainers: A Case Report
Noopur Kaushik, Nikhil Srivastava, Vivek Rana, Nishtha Gosain
Journal of South Asian Association of Pediatric Dentistry, 2026
Premature loss of primary teeth is common in pediatric dentistry, often leading to arch integrity issues and requiring intervention to prevent misalignment.Space maintainers help preserve space for proper permanent tooth eruption.While traditional metal space maintainers are effective, they have esthetic and biocompatibility limitations.PEEK (polyether ether ketone), a high-performance, biocompatible thermoplastic, offers superior strength, durability, and esthetics.Its digital fabrication via computer-aided design and computer-aided manufacturing (CAD-CAM) ensures precise customization, improving patient acceptance and aligning with modern dentistry trends.A 7-year-old patient presented with pain in the lower left back tooth.Examination revealed gross decay in tooth 74, requiring extraction and placement of a PEEK band and loop space maintainer for tooth 75.The esthetic appeal of PEEK addressed parental concerns.Follow-ups at 3 and 6 months showed excellent function, biocompatibility, and patient satisfaction, reinforcing PEEK as a promising alternative for space maintenance.
Knowledge, practice, and experience of regenerative endodontic therapy among pediatric dentists and postgraduate students in India
Riya Marie Johnson, Nidhi Sharawat, Vijay Prakash Mathur, Nitesh Tewari, Hani Nazzal, Morankar Rahul, Kalpana Bansal, Nikhil Srivastava, Mousumi Goswami
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2026
Introduction: Regenerative endodontic therapy (RET) is a novel technique that offers a biological alternative for managing immature permanent teeth with necrotic pulps. This cross-sectional study aimed to assess the knowledge, attitude, practice, and experience regarding RET among pediatric dentists (specialists) and postgraduate students (students) in India. Materials and Methods: The sample size was estimated as 195 participants in two groups (specialists and students). A structured, validated online “Bristol questionnaire” was used with permission. The questionnaire was sent to randomly selected members of the National Society of Pediatric Dentistry. The data were collected and analyzed using descriptive statistics, Chi-square, and Fisher’s exact tests. Results: A total of 415 responses were analyzed, of which 214 (51.6%) respondents were specialists and 201 (48.4%) were students. RET was practiced by 74% of respondents, with a significantly higher adoption rate among the participants who had completed MDS ( P = 0.03). Most respondents had performed fewer than five RET cases. Triple antibiotic paste and NaOCl were commonly used as intracanal medicaments and root canal irrigants, respectively. Mineral trioxide aggregate was the preferred material for coronal sealing. Although 72.5% of respondents reported clinical success, nearly half of the respondents considered root development outcomes to be unpredictable. Conclusions: Pediatric dentists (specialists and students) reported to practice RET, but there were variabilities in the protocols followed for case selection and treatment. The belief in RET leading to healing with or without the maturation of the root was apparent. The need for improved educational initiatives and clinical exposure to RET within pediatric dental training in India was expressed.
Obturation of Primary Teeth: Time to Redefine Objectives and Techniques
Nikhil Srivastava, Noopur Kaushik
International Journal of Clinical Pediatric Dentistry, 2025
Obturation creates a seal along the root canal, preventing fluid movement and blocking potential entry points for bacteria found between the periodontal tissues and the root canal system. Several techniques are used for obturating primary tooth canals, including tuberculin syringe, disposable injection technique, manual incremental lateral condensation, Jiffy tubes, Navi-tip, lentulo spiral (hand-held or rotary), past inject, and endodontic pressure syringe. These methods only prioritize cost-effectiveness, ease of use, and material control for successful outcomes. However, to date, no classification has been proposed for the method of material placement in the root canal. Thus, this article highlights the obturating methods in the direction of placement of material and proposes a newer classification for the criteria of obturation, which can significantly influence the success rate of the endodontic therapy. How to cite this article: Srivastava N, Kaushik N. Obturation of Primary Teeth: Time to Redefine Objectives and Techniques. Int J Clin Pediatr Dent 2025;18(11):1407-1411.
Evaluation of the Physical Properties of Different Modifications of Glass Ionomer Dental Restorative Materials in Primary Dentition: A Comparative Ex Vivo Study
Vivek Mehta, Nikhil Srivastava, Saif Ali Chaudhry, Vivek Rana
International Journal of Clinical Pediatric Dentistry, 2025
Objectives: This study aimed to evaluate and compare the physical properties of different modifications of glass ionomer cement, namely giomer, zirconomer, and type IX glass ionomer cement (GIC) (pediatric), with resin-modified glass ionomer cement (RMGIC) in the primary dentition in terms of their compressive strength (CS), flexural strength (FS), wear resistance, and microleakage. Materials and methods: = 14) were prepared and subjected to thermocycling after storage in distilled water for 24 hours. After applying two coats of nail varnish 1 mm short of the restorative margins, samples were sectioned buccolingually and immersed in methylene blue dye for 24 hours. The evaluation of the cut sections was done using a stereomicroscope. The data obtained were subjected to statistical analysis. Results: Type IX GIC (pediatric) exhibited significantly greater CS, FS, and wear resistance in primary teeth as compared to RMGIC, giomer, and zirconomer in primary teeth. However, there was no significant difference in microleakage among the tested restorative materials. Conclusion: and clinical trials with large sample sizes are recommended to validate these results. Clinical relevance: Although GIC is the most frequently used dental material for restorative purposes in pediatric dentistry, the long-term success of conventional GIC is questionable due to suboptimal physical properties. The results of the study will help restore primary teeth with improved physical properties and long-term success. How to cite this article: Study. Int J Clin Pediatr Dent 2025;18(S-1):S86-S93.
Comparative evaluation of fluoride release from different modifications of glass ionomer dental restorative material in primary teeth at different time intervals: An ex vivo study
Vivek Mehta, Nikhil Srivastava, Saif Ali Chaudhry, Vivek Rana
Journal of Oral Biology and Craniofacial Research, 2025
Purpose: This ex vivo study aims to evaluate and compare the fluoride-releasing capabilities of different modifications of Glass ionomer cement, namely Giomer, Zirconomer, and Pediatric GIC (type IX) with Resin-modified Glass ionomer cement (RMGIC) in the primary dentition at first, fourteenth, and twenty-eighth days. Materials and methods: Fifty-six extracted human primary molars were allocated into four groups: Group 1, Resin-modified GIC; Group 2, Giomer; Group 3, Zirconomer; and Group 4, Pediatric GIC (type IX). The tooth samples (n = 14) were restored as per the manufacturer's instructions after making class II cavities in primary molars. Extracted tooth specimens were placed in deionized water, and the fluoride ions released were measured for 28 days. The tooth samples were evaluated for cumulative fluoride levels at the end of 24 h, 14th day, and 28th day under normal atmospheric conditions, using a fluoride ion-selective electrode (Orion STAR-A214 Ion analyzer). The data obtained was subjected to statistical analysis, and the results are discussed herein. Results: Fluoride ions releasing capability was exhibited by primary teeth restored with all the above-mentioned materials. The primary teeth restored with Zirconomer exhibited significantly higher fluoride-releasing capability among the above-compared materials, and the primary teeth restored with Giomer exhibited the least fluoride ions release on 24 h, 14th day, and 28th day, and the difference of fluoride ions releasing ability between the four groups was statistically significant at each time interval (P < 0.001). Conclusion: The primary teeth restored with Zirconomer exhibited superior fluoride-releasing ability compared to other restorative materials. Therefore, Zirconomer can be a promising restorative material for primary teeth due to its enhanced anti-caries effect.
Retention of resin-based versus glass ionomer pit and fissure sealants in permanent molars: A systematic review of randomized clinical trials
Navpreet Kaur, Nikhil Srivastava, Vivek Rana, Noopur Kaushik, Tushar Pruthi, Akanksha Sirohi
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2025
Background: Pit and fissure sealants are a preventive strategy against occlusal caries in children. Resin-based sealants (RSs) are considered the gold standard because of their superior retention, while glass ionomer sealants (GIS) offer fluoride release and moisture tolerance. However, their comparative long-term performance remains unclear. Objective: To systematically compare retention rates, caries-preventive efficacy, and clinical performance of resin-based and GISs in children’s permanent molars. Materials and Methods: We searched PubMed, Scopus, Web of Science, and Google Scholar from database inception through September 30, 2025, for randomized controlled trials (RCTs) comparing resin based and GISs in permanent molars. The search strategy combined Medical Subject Heading and free-text terms related to sealants, permanent teeth, and pediatric populations. Risk of bias (RoB) was assessed using the Cochrane RoB 2.0 (RoB-2) tool. Certainty of evidence was not graded using GRADE. Results: A total of 13 RCTs were included. RSs showed consistently higher retention rates than GISs, while caries-preventive efficacy was generally comparable. Considerable heterogeneity was observed ( I 2 = 86.6%) due to differences in populations, sealant materials, and follow-up durations. RoB was assessed using the RoB-2 tool, and publication bias was evaluated using funnel plots and Egger’s test, which did not indicate small-study effects. Conclusion: RS outperforms GIS in retention, but both materials show comparable caries-preventive efficacy. GIS remains a viable alternative where isolation is difficult. Long-term RCTs with standardized outcome reporting are needed.
Efficacy of Ion-releasing Pit and Fissure Sealants Compared with Other Modified Pit and Fissure Sealants when Subjected to Heat and Ultrasonic Vibration: An Ex Vivo Comparison
Sakshi Bhardwaj, Vivek Rana, Noopur Kaushik, Nikhil Srivastava, Nishtha Gosain
International Journal of Clinical Pediatric Dentistry, 2025
Background: Pit and fissure sealants are important tools for the prevention of dental caries on the occlusal surfaces, but despite sealing the deep pits and fissures, occlusal dental caries continues to be a major problem due to incomplete penetration and loss of retention of the material, leading to microleakage. Aim: To evaluate the efficacy of recently introduced ion-releasing pit and fissure sealants in comparison to fluoride-releasing and amorphous calcium phosphate (ACP)-containing sealants in terms of their penetration depth and microleakage when subjected to heat and ultrasonic vibration postsalivary contamination. Study design: comparative study. Materials and methods: = 16) based on the method of sealant placement-A (conventional), B (heat), and C (ultrasonic vibration). After cleaning the occlusal surfaces, occlusal surfaces were etched and the sealants were applied as per groups and subgroups. Samples were then placed in basic fuchsin dye for 24 hours. The crowns were sectioned and examined under a stereomicroscope for penetration depth and microleakage analysis. Statistical analysis: test. Results: < 0.005). Conclusion: Ion-releasing pit and fissure sealant (group 1) placed through ultrasonic vibration proved to be the best in terms of maximum penetration depth and minimum microleakage. Clinical relevance: Bioactive pit and fissure sealants provide greater mechanical strength, penetration depth, and least microleakage compared to the other sealants, that is, ACP-containing and fluoride-releasing sealants. Additionally, the sealants can be treated with heat and vibration to increase the material's viscosity, thereby improving its properties. How to cite this article: Comparison. Int J Clin Pediatr Dent 2025;18(7):864-870.
Efficacy of 3D-printed Space Maintainers in Comparison to Conventional and Prefabricated Space Maintainers: A Randomized Control Trial
Navpreet Kaur, Vivek Rana, Noopur Kaushik, Nikhil Srivastava, Shreya Kapoor
International Journal of Clinical Pediatric Dentistry, 2025
Color Stability of Intracoronal Restorations in Primary Dentition Postexposure to Indian Foods and Beverages: An Ex Vivo Evaluation
Vivek Rana, Noopur Kaushik, Nikhil Srivastava, Tushar Pruthi, Kanishka Gautam
International Journal of Clinical Pediatric Dentistry, 2025
Accuracy of Different Dental Age Estimation Methods Using Cone Beam Computed Tomography: A Comparative Study
Vivek Rana, Noopur Kaushik, Nikhil Srivastava, Ashima Tyagi, Sumit Goel, Amit K Khera
International Journal of Clinical Pediatric Dentistry, 2024
The imperative role of oral pathologists in paediatric dental practice
Nikhil Srivastava
Journal of Oral and Maxillofacial Pathology, 2024
Efficacy of different endodontic irrigants in the lesion sterilization and tissue repair technique in primary molars: A randomized controlled clinical trial
Anukriti Dimri, Nikhil Srivastava, Vivek Rana, Noopur Kaushik
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2024
Tobacco cessation center in a dental college: An 8 year institution-based study
Swati Gupta, Nikhil Srivastava, Sumit Goel, Nagaraju Kamarthi, Sangeeta Malik, Abhinav Sharma, Khushboo Bhalla
Journal of Cancer Research and Therapeutics, 2023
Reliability of three pain assessment tools in children requiring dental treatment: A comparative clinical study
Priya Nagarwal, Vivek Rana, Nikhil Srivastava, Noopur Kaushik, Tushar Pruthi
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2023
Comparative evaluation of antibacterial efficacy of active oxygen containing versus other dentifrices against Streptococcus mutans count in children with early childhood caries: A clinico-microbiological study
Tanvi Jindal, Nikhil Srivastava, Vivek Rana, Noopur Kaushik, Preeti Sharma, Tushar Pruthi
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2023
Peripheral cemento-ossifying fibroma - A rare case report
Noopur Kaushik, Nikhil Srivastava, Vivek Rana, Chirag Suhane
Journal of Cancer Research and Therapeutics, 2022
Total crown replacement technique: A biological treatment option for grossly destructed primary molars
Nikhil Srivastava, Vivek Rana, Pratik Pande, Preeti Singh
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2021
Efficacy of root canal instrumentation and fracture strength assessment in primary molars after preparing two different shapes of access cavity: An ex vivo histological study
Yashika Singhal, Vandana Reddy
International Journal of Clinical Pediatric Dentistry, 2021
Comparison of the conventional band and loop space maintainers with modified space maintainers: A split-moutrandomized clinical trial
Vivek Rana, Noopur Kaushik, Nikhil Srivastava, Manisha Tyagi, Elizabeth Moirangthem, Vidisha Gaur
International Journal of Clinical Pediatric Dentistry, 2021
Effectiveness of different behavior guidance techniques in managing children with negative behavior in a dental setting: A randomized control study
Pratik Pande, Vivek Rana, Nikhil Srivastava, Noopur Kaushik
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2020
Clinical evaluation of restoration of grossly carious primary teeth using biological approach
Preeti Singh
International Journal of Clinical Pediatric Dentistry, 2020
Assessment of intraoral findings of neonates, born in and around Meerut City
Preetika Chandna, Madan M Niranjan
International Journal of Clinical Pediatric Dentistry, 2020
Compound Odontome: A Case Report
Vivek Rana, Prerna Panthri, Vrinda Sharma
International Journal of Clinical Pediatric Dentistry, 2019
Isolation of Scardovia wiggsiae using real-time polymerase chain reaction from the saliva of children with early childhood caries
Preetika Chandna, Nikhil Srivastava, Alpana Sharma, Vrinda Sharma, Nidhi Gupta, VivekKumar Adlakha
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2018
Peripheral and central giant cell lesions in children: Institutional experience at Subharti Dental College and Hospital
Preetika Chandna, Nikhil Srivastava, Vishal Bansal, Vijay Wadhwan, Prajesh Dubey
Indian Journal of Medical and Paediatric Oncology, 2017
Diagnostic potential of inflammatory biomarkers in early childhood caries - A case control study
Vrinda Sharma, Nidhi Gupta, Nikhil Srivastava, Vivek Rana, Preetika Chandna, Savita Yadav, Alpana Sharma
Clinica Chimica Acta, 2017
Non suicidal self injury resulting in dental trauma in an adolescent
Preetika Chandna, Nikhil Srivastava, Vivek Kumar Adlakha, Prerna Panthri
Dental Traumatology, 2016
Remineralizing agents: The next frontier
Preetika Chandna, Nikhil Srivastava, Sabika Ali
Current Clinical Pharmacology, 2016
Management of grossly decayed primary anteriors using various intracanal post systems: A clinical study
Manjul Mehra, Rashu Grover, InderKumar Pandit, Nikhil Srivastava, Neeraj Gugnani, Monika Gupta
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2016
Clinical comparison of various esthetic restorative options for coronal build-up of primary anterior teeth
GulsheenKaur Kochhar, Himanshu Duhan, InderKumar Pandit, Nikhil Srivastava, Neeraj Gugnani, Monika Gupta
Dental Research Journal, 2015
Palatal mucormycosis in an infant
Journal of Dentistry for Children, 2015
Alterations in the mechanical properties of the extracted human teeth to be used as biological restorations on storing them in different storage media: An in vitro study
Pallavi Kantoor, Nikhil Srivastava, Vivek Rana, Vivek K. Adlakha
Dental Traumatology, 2015
Obsessive compulsive disorder in dental setting
Preetika Chandna, Nikhil Srivastava, VivekKumar Adlakha
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2014
Stem cell research: Applicability in dentistry
Shivani Mathur, Rahul Chopra, I. K. Pandit, Nikhil Srivastava, Neeraj Gugnani
International Journal of Oral and Maxillofacial Implants, 2014
Space maintainers in dentistry: Past to present
Vikas Setia
Journal of Clinical and Diagnostic Research, 2013
A study of root canal morphology of human primary incisors and molars using cone beam computerized tomography: An in vitro study
Vivek Gaurav, Nikhil Srivastava, Vivek Rana, VivekKumar Adlakha
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2013
Comparative evaluation of microleakage of various retrograde filling materials: An in vitro study
Virat Galhotra, Anjali Sofat, InderK Pandit, RamandeepSingh Gambhir, Nikhil Srivastava, Neeraj Gugnani
Journal of Natural Science Biology and Medicine, 2013
Clinical efficacy of various root canal obturating methods in primary teeth: A comparative study
European Journal of Paediatric Dentistry, 2013
Biological restoration of a grossly decayed deciduous mandibular molar
Journal of Clinical and Diagnostic Research, 2012
An evaluation of microleakage of various glass ionomer based restorative materials in deciduous and permanent teeth: An in vitro study
Teena Singla, I.K. Pandit, Nikhil Srivastava, Neeraj Gugnani, Monika Gupta
Saudi Dental Journal, 2012
Light induced fluorescence evaluation: A novel concept for caries diagnosis and excavation
Neeraj Gugnani, Nikhil Srivastava, Shalini Gugnani, IK Pandit, Monika Gupta
Journal of Conservative Dentistry, 2011
An evaluation of different caries removal techniques in primary teeth: A comparitive clinical study
Gulsheen Kaur Kochhar, Nikhil Srivastava, IK Pandit, Neeraj Gugnani, Monika Gupta
Journal of Clinical Pediatric Dentistry, 2011
Plaque removal efficacy of powered and manual toothbrushes under supervised and unsupervised conditions: A comparative clinical study
S Kallar, IK Pandit, N Srivastava, N Gugnani
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2011
Comparative evaluation of shear bond strength of various esthetic restorative materials to dentin: An in vitro study
N Manuja, IK Pandit, N Srivastava, N Gugnani, R Nagpal
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2011
Technique-sensitivity of dentin-bonding agent application: The effect on shear bond strength using one-step self-etch adhesive in primary molars: An in vitro study
S Bansal, IK Pandit, N Srivastava, N Gugnani
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2010
Comparative evaluation of 2% sodium fluoride iontophoresis and other cavity liners beneath silver amalgam restorations
M Gupta, IK Pandit, N Srivastava, N Gugnani
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2010
An evaluation of various materials and tooth preparation designs used for reattachment of fractured incisors
Megha Bhargava, Inder Kumar Pandit, Nikhil Srivastava, Neeraj Gugnani, Monika Gupta
Dental Traumatology, 2010
Why the carioprotective potential of luting cements crucial
M Rohilla, IK Pandit, N Srivastava
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2009
Various methods of caries removal in children: A comparative clinical study
L Verma, IK Pandit, N Srivastava, N Gugnani, M Gupta
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2007
Endodontic treatment of a multirooted permanent maxillary canine
Journal of Dentistry for Children, 2007
A comparative evaluation of the fracture strength of pulpotomized primary molars restored with various restorative materials
Sidhi Passi, I. Pandit, Nikhil Srivastava, Neeraj Gugnani, Monika Gupta
Journal of Clinical Pediatric Dentistry, 2007
Genetic engineering and dental caries.
Indian Journal of Dental Research Official Publication of Indian Society for Dental Research, 2003
Fused supernumeraries in deciduous dentition: a case report.
Journal of the Indian Society of Pedodontics and Preventive Dentistry, 2003
Foreign body in the periradicular area
N SRIVASTAVA, N VINEETA
Journal of Endodontics, 2001
An inverted supernumerary tooth: Report of case
Journal of Dentistry for Children, 2001

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