Researcher and academician with an extensive experience of teaching UG and PG students of Dentistry. Have a special interest teaching students and in patient education as a responsibility of the fraternity. Several of my research publications have been featured in international journals on dentistry in the area of Oral Pathology, Histopathology and Microbiology. Eager to learn new interdisciplinary skills.
I am also an YouTuber and a 3D animation designer for modules on histopathology. Educational videos on tooth carving, 3D animation, comic series for patient education on oral health.
EDUCATION
MDS ORAL PATHOLOGY
RESEARCH INTERESTS
oral cancer ,oral diseases ,3D animation INDIAN SIGN LANGUAGE PATIENT EDUCATION
50
Scopus Publications
Scopus Publications
Odontome-A Single-institutional Cross-sectional Study of 31 Years from Mumbai and Case Report with Modified Gallego’s Stain Sandhya Tamgadge, Treville Pereira, Rishikesh Mehta, Asma Wagle, Avinash Tamgadge, Ketaki Bhor Journal of Microscopy and Ultrastructure, 2026 Background: Odontomas are the most prevalent type of benign odontogenic tumor. They are made up of several dental hard and soft tissues arranged in diverse patterns. They have slowed growth and normally do not have any symptoms to go along with it. They are not regarded as real neoplasms and are more commonly referred to as hamartomas. There have been very few retrospective studies published in the literature. Objective: The aim of this study was to examine the clinical findings and histological aspects of 17 odontoma cases as a single-institutional investigation. Materials and Methods: It is a study that was conducted in the past. Data from 17 odontoma cases were collected, then separated, and statistically analyzed based on the number of instances reported, the kind of odontoma, the site of occurrence, age, sex, clinical and histological features, and so on. A brief case report is also provided. Results: Of the 17 cases of odontoma reported, 14 were complex odontoma and only 3 were compound odontoma. The age group of 20–29 years had the highest incidence. It was discovered more commonly in the lower jaw than in the maxilla. Conclusion: The study indicated a higher prevalence of complex odontomas than compound odontomas in males aged 20–29 years (third decade of life). Early detection and treatment are critical for avoiding disparities.
Patch-Based Oral Cancer Detection Using Vision Transformers and Quantitative Patch Scoring Eranjoli Nalupurakkal Subhija, Sandhya Tamgadge, Vaninirappuputhenpurayil Gopalan Reju International Journal of Imaging Systems and Technology, 2026 This work aims to propose an algorithm to select interpretable and diverse patches from histopathology images, discarding irrelevant areas, for the computer‐aided diagnosis of breast and oral cancer. The proposed patch selection algorithm uses ResNet 50 features combined with Rotary Position Embedding for Vision Transformers with learned positional encoding. To evaluate patch interpretability and diversity, attention scores and cosine similarity are applied. This patch value metric identifies four key patches that contribute most to diagnosis while preserving diversity. Features from these selected patches are extracted using three pre‐trained networks, normalized via p ‐norm pooling, and classified through belief‐based fusion to ensure interpretability and diagnostic relevance in histopathological analysis. The proposed patch selection framework was evaluated on a publicly available breast and oral cancer histopathology datasets, achieving an accuracy of 98.46% and 97.84%, respectively, outperforming existing breast and oral cancer detection techniques. In addition, when evaluated on an independent oral cancer histopathology dataset using the model trained on the initial oral dataset, the framework maintained strong generalization capability. The proposed patch selection algorithm delivers improved diagnostic accuracy with optimized training and demonstrates strong generalization across both breast and oral cancer histopathology datasets. It provides an interpretable and effective framework for patch‐based classification, enhancing diagnostic reliability for pathologists and offering a robust solution for multi‐tissue cancer analysis.
Red Blood Cells in Health and Disease Aradhya Giri, Sandhya Tamgadge Journal of Microscopy and Ultrastructure, 2025 Red blood cells (RBCs) play a crucial role in the normal functioning of the human body, primarily through their ability to transport oxygen and carbon dioxide. Various diseases, including anemia and other hemolytic disorders, can arise when there is an abnormality in RBC structure or function. The pathophysiology of other conditions, such as cancer and cardiovascular disease can also involve changes in RBCs. Advances in RBC research have led to a better understanding of their structure, function, and pathophysiology. The COVID-19 pandemic has also highlighted the critical role of RBCs in disease pathology, with research suggesting that RBCs may be directly affected by the virus. This review provides a comprehensive overview of the current state of RBCs in health and disease, including recent advances in diagnosis, treatment, and the role of RBCs in disease pathology.
Pleomorphic Adenoma in an Immunocompromised Patient Cathy Babu, Sandhya Tamgadge, Treville Pereira, Vishal Punjabi Journal of Microscopy and Ultrastructure, 2025 Salivary gland tumors are known for its rarity and almost 30%–40% occur in the minor salivary glands, out of which, pleomorphic adenoma (PA) is rated to be the most common benign salivary gland neoplasm. This term was first termed by Willis and is called so, because of the ability of the cells of this tumor to differentiate into epithelial cells and mesenchymal cells, which gives it an unusual histologic pattern. Literature reports most PAs to be associated with parotid salivary glands and palatal salivary glands, the latter being the most common intraoral site of origin. Interestingly, no case reports have been published of a palatal PA in an immunocompromised individual. We report a unique case of a PA arising on the hard palate of a 54-year-old male human immunodeficiency virus-acquired immunodeficiency syndrome patient.
Malignant Non‑Odontogenic Tumors of the Oral Cavity – Single Institutional Retrospective Study of Three Decades Sandhya Tamgadge, A. K. Anjali, Treville Pereira, Yash Deshmukh, Jayan Mehta, Shubham Kharat, Cathy Babu Indian Journal of Community Medicine, 2025 Malignant non-odontogenic tumors of the oral cavity remain understudied in India, despite their global prevalence. This retrospective analysis examined cases from a single institution in Maharashtra between 1990 and 2021, focusing on patient demographics, clinical presentations, and histopathological features. Oral squamous cell carcinoma (OSCC) emerged as the predominant malignancy, with epithelial malignancies accounting for 98.6% of cases. A slight male predominance was observed. Buccal mucosa was the most frequent site of occurrence, with tobacco chewing identified as the primary risk factor. This study underscores the need for increased attention to oral malignancies in routine medical examinations and calls for more comprehensive statistical analysis to inform clinical practice and public health strategies.
Histology of Dentine and Dentinogenesis Sandhya Tamgadge, Avinash Tamgadge Oral Histology and Oral Histopathology A Practical Guide for Dental Students and A Companion to Pathologists, 2025
Odontoma-Basic Third Dimensional Histopathology Model Using 3D Animation Software and Clay Model Sandhya Tamgadge, Avinash P. Tamgadge, Amisha Nayak Journal of Microscopy and Ultrastructure, 2024 Background: Oral lesions of the jaw has been well explained in the literature through high-quality 2D clinical, radiographic, and histopathological images. But the clinicians and most of the times students too, don’t understand the histopathological aspect through the description of text and existing 2D images. This article is preliminary attempt to explain the key events of histopathological aspects of odontoma in third dimension and clay models in a life-like manner which author herself has designed, for better understanding not only by oral and general pathologists, and students but also by patients, which is the unique feature of this short manuscript. Aim: To create 3D animation video and images of odontoma using various 3D animation softwares and clay models. Methodology: Preliminary 3D images and videos on histopathological aspect of odontoma were designed by using 3Dmax (Autodesk Media and Entertainment) and Adobe premiere pro 5.5 software which is a video editing software (Adobe Systems). Additionally models were prepared using kids’ colourful clay material. Observation: The clay model and 3D animation videos gave life like picture of a disease. Conclusion: 3D animation and clay models to explain histopathology has promising future for histology and histopathology.
Oral verruciform xanthoma (OVX) of lower labial mucosa, presenting as a plaque in tobacco users: an unusual case report with literature review Sandhya Tamgadge, Treville Pereira, Aditi Vaidya, Vishal Punjabi Ecancermedicalscience, 2024 Oral verruciform xanthoma (OVX) is an uncommon lesion known for its wart-like appearance, primarily affecting the oral mucosa. This case report delves into a distinctive presentation of OVX, a rare benign lesion typically characterised by its manifestation as a white plaque in the oral cavity. Clinical features, histological findings, pathogenesis and their implications in the context of differential diagnosis has been discussed. The patient had a history of regular tobacco use, and despite initially presenting as a white plaque, the histopathological and immunohistochemical features strongly suggested verruciform xanthoma.
Oral Mucous Membrane Pemphigoid Cathy Babu, Sandhya Tamgadge, Rutuja Gajanan Vidhale, Treville Pereira Journal of Microscopy and Ultrastructure, 2024 Pemphigoid is a group of rare autoimmune diseases affecting the skin and the mucous membrane in which the autoantibodies are directed against the basement membrane zone target antigens causing subepithelial blistering. Oral health professionals are usually the first to identify as more than 90% of cases show oral lesions initially. A lack of diagnostic criteria can lead to misdiagnosis and delay in treatment. We report a unique case of mucous membrane pemphigoid devoid of ocular or cutaneous involvement.
Tyrosine crystal deposition in pleomorphic adenoma: a rare presentation in a male smoker with long-term follow-up Sandhya Tamgadge, Gokul Venkateshwar, Treville Pereira, Avinash Tamgadge, Simran Pethani Ecancermedicalscience, 2024 This case report presents the diagnosis and management of a pleomorphic adenoma in a 55-year-old male smoker with a habit of smoking tobacco for 6 years. The patient presented with a chief complaint of swelling in the posterior palatal region. Clinical examination revealed a well-circumscribed, non-tender, firm swelling in the palatal region. An incisional biopsy followed by surgical excision was performed, and histopathological evaluation confirmed the diagnosis of pleomorphic adenoma. Tyrosine crystals were observed within the tumour stroma, providing additional diagnostic insight. A 10-year post-operative follow-up revealed no recurrence of the lesion.
Writing oral pathology biopsy report: A guide for beginners Journal of Experimental Therapeutics and Oncology, 2018
Recurrent psammomatoid juvenile ossifying fibroma with aneurysmal bone cyst: An unusual case presentation Iranian Journal of Medical Sciences, 2017
Association of candida sp. With the degrees of dysplasia and oral cancer: A study by calcofluor white under fluorescent microscopy Iranian Journal of Pathology, 2017
Comparative study of clinical staging of oral submucous fibrosis with qualitative analysis of collagen fibers under polarized microscopy Iranian Journal of Pathology, 2015
