Shilpa Khanna Arora

RESEARCH, TEACHING, or OTHER INTERESTS

Pediatrics, Perinatology and Child Health, Oncology

Scopus Publications

Hepcidin Levels in Response to Oral Iron Therapy in Children with Anemia
Tanya Singh, Shilpa Khanna Arora, Parul Goyal, and Alok Hemal
Springer Science and Business Media LLC



Unusual case of 'scorbutic proptosis'
Shilpa Khanna Arora, Manisha Jana, and Rachna Seth
BMJ
Proptosis is a frequent presenting symptom/sign of many paediatric malignancies. Acute-onset proptosis is an ophthalmic emergency that can endanger vision if not treated promptly. Appropriate treatment must be instituted only after investigating for the underlying aetiology. Here, we report a developmentally delayed boy in middle childhood who presented with recent onset bilateral proptosis. Clinical examination followed by radiological evaluation suggested scurvy to be the underlying cause and vitamin C supplementation led to prompt reversal of proptosis. The relevant literature has been reviewed and presented here to apprise the paediatric oncologists about this rare but easily treatable cause of proptosis.


Unusual Presentation of Myeloid Sarcoma as Thigh Mass
Sneh Yadav, Shilpa Khanna Arora, Alok Hemal, Sonia Sandip, Geetika Sharma, Prakhya Lalita Jyotsana, and Shivkumar M Biradar
Elsevier BV



Outcomes after Immunosuppressive Therapy for Aplastic Anemia: A Single Centre Experience from Northern India
Nitish Kumar, Alok Hemal, Aditya Sangwan, and Shilpa Khanna Arora
Springer Science and Business Media LLC



Mutation spectrum and enzyme profiling of G6PD deficiency in neonates of north India: a prospective study
Upasana Bhattacharyya, Preeti Deswal, Sunil Kumar Polipalli, Diksha Sharma, Manpreet Kaur, Madhulika Kabra, Neerja Gupta, Ramesh Agarwal, A. K. Deorari, V. K. Paul,et al.
Springer Science and Business Media LLC



Axillary lymph node in extra-ocular retinoblastoma - Benign or malignant?
Shubha Gadde Ravindra, Sambit Sagar, Shilpa Khanna Arora, Rachna Seth, Neiwete Lomi, and Rakesh Kumar
Medknow
A 1-year-old male child presented with whitish discoloration of pupil of the left eye and swelling over the left axilla. A contrast-enhanced magnetic resonance imaging of the brain and orbits performed revealed left eye extra-ocular retinoblastoma. 18F-fluorodeoxyglucose positron emission tomography/computed tomography scan was done in this child as a part of baseline staging of retinoblastoma in an ongoing research project. The scan revealed left eye extra-ocular retinoblastoma along with calcified left axillary level I lymph node.


Paediatric orbital ultrasound: Tips and tricks
Amit Gupta, Shilpa Khanna Arora, Rachna Seth, Rakesh Kumar, and Manisha Jana
Wiley
The orbital structures are ideally suited for ultrasound examination due to their superficial location and cystic composition of the eye. However, orbital ultrasound remains an underutilised modality due to preference for other cross‐sectional modalities in general practice.


Predictors of severe dengue amongst children as per the revised WHO classification
Devki Nandan, ShilpaKhanna Arora, Anu Sharma, Pronita Benerjee, and DhirendraPratap Singh
Medknow
Background & objectives: World Health Organization (WHO) revised its guidelines for classification and management of dengue in 2009. This revised system was found out to have good sensitivity and negative predictive value but poor specificity as well as positive predictive value. Methods: This retrospective study was carried out in a tertiary care hospital of Delhi, India to assess factors predicting the occurrence of severe dengue in children as per the revised classification. A total of 647 suspected dengue cases were admitted in the hospital in the year 2015. Detailed clinical and epidemiological data of 170 patients who were confirmed as dengue either by NS1 antigen test or by serology (Ig M positive) were recorded and statistically analyzed. Results: The number of laboratory-confirmed cases was 170 and included thirty (17.65%) dengue fever (DF), 106 (62.35%) dengue with warning signs (DWS) and 34 (20.0%) severe dengue (SD) patients. Regression analysis revealed that presence of vomiting, altered sensorium, shock, peri-orbital edema, hepatomegaly, splenomegaly, severe anemia, thrombocytopenia, elevated urea and creatinine, decreased total protein and globulin were significantly associated with occurrence of severe disease. Interpretation & conclusion: The addition of clinical features (peri-orbital edema and splenomegaly); and laboratory findings (elevated urea and creatinine, decreased serum protein and globulin) might help improve the sensitivity and specificity of the revised WHO dengue classification in predicting severe dengue.


Intussusception in a child with Acute Lymphoblastic Leukemia: a remarkable presentation with literature review – a case report
Ankur Majumder, Sunayana Misra, Vijay Kumar, and Shilpa Khanna Arora
Springer Science and Business Media LLC
Abstract Background Gastrointestinal complications are not uncommon in patients of Acute Leukemia. Intussusception as a complication in leukemia, although described, is exceedingly rare. Also, it is usually seen after chemotherapy and not as a part of the native disease process. This case report aims to highlight such a rare association which warrants clinical and pathological attention. Case presentation A 14 year old male presented with an acute abdomen. Initial routine investigations revealed a deranged blood picture. On further examination of bone marrow aspirate, biopsy and detailed immunohistochemical studies a diagnosis of B-Acute Lymphoblastic Leukemia (B-ALL) was made. Concurrent ultrasound of the abdomen to find a cause for severe abdominal pain revealed an Ileo-colic intussusception. The patient was started on steroids; however he succumbed to his illness after two days, before surgery could be attempted. Conclusion Rare presentations of relatively common diseases are a hurdle for timely and effective medical intervention. Although a rare condition in itself in leukemic patients, the occurrence of Intussusception in this particular patient, especially when no chemotherapy was initiated, is a very rare event. This case report was made to add to the relatively scarce literature available on this particular association. As it is a surgically treatable condition and since delay in diagnosis may lead to poorer prognosis, possibility of co-existence of ALL and intussusception should be borne in mind by all treating physicians and hematopathologists for effective patient care.


Psychiatric Problems Amongst Adolescents Living With HIV at a Tertiary Care Centre in India
Renu Pilania, Alok Hemal, Sheetal Agarwal, Ram Pratap Beniwal, and Shilpa Khanna Arora
Springer Science and Business Media LLC



Pediatric HIV Disclosure in Northern India: Evaluation of Its Prevalence, Perceptions amongst Caregivers, and Its Impact on CLHIV
Rajesh Meena, Alok Hemal, and Shilpa Khanna Arora
Hindawi Limited
Background. With improving standards of care of children living with HIV (CLHIV), pediatric HIV related mortality rates are declining. New challenges like HIV status disclosure are emerging which need to be addressed to ensure their smooth transition into adulthood. Poor disease disclosure rates are observed in CLHIV globally. Aims. This study was done to assess the prevalence of HIV disclosure in North Indian CLHIV, know the perceptions of caregivers regarding disclosure, and evaluate the impact of disclosure on CLHIV. Methods. It was a questionnaire based cross-sectional study carried out amongst 144 caregivers of CLHIV aged 6-16 years attending the pediatric HIV clinic of a tertiary care teaching hospital. Results. Though the majority (93.8%) caregivers felt that it is important to disclose but only 33% of the children were actually disclosed. Eighty five percent felt that disclosure must be done by one of the family members and correspondingly 73% of the disclosed children were actually disclosed by their parents. Forty seven percent believed that the most appropriate age for disclosure is 10-12 years. The mean age at which disclosure was actually done was 11.06 ± 1.62 years. Comparison of the disclosed and undisclosed CLHIV revealed that the disclosed group had significantly higher age, longer duration of taking ART, and higher proportion of paternal orphans. Age of the CLHIV was the only significant factor for disclosure. Several reasons were cited by the caregivers for nondisclosure. The caregivers observed improved drug adherence in 47.9% of the children following disclosure. Conclusions. There is a need to develop region specific pediatric HIV disclosure guidelines keeping in mind the caregivers’ perceptions. The guidelines must be age appropriate, systematic, and socioculturally acceptable. The most suitable age for disclosure appears to be 10-12 years. Involvement of caregivers and health care providers in the process is a must.


Writing methods: How to write what you did?
Shilpa Khanna Arora and Dheeraj Shah
Springer Science and Business Media LLC



Successful non-operative management of cauda equina syndrome in a case of thalassemia major
Rohit Khurana, Shilpa Khanna Arora, Alok Hemal, and Sumit Arora
Elsevier BV



Microbiome: Paediatricians’ perspective
ShilpaKhanna Arora, Pooja Dewan, and Piyush Gupta
Medknow
Millions of microorganisms inhabit the human body and affect its homeostasis in multiple ways. Alterations in this microbial community have implications for the health and survival of the human hosts. It is believed that these microorganisms should be included as part of the human genome because of their influence on human physiology hence the term “microbiome” is commonly used to refer to these microbes along with their genetic make-up and their environmental interactions. In this article we attempt to provide an insight into this recently discovered vital organ of the human body which is yet to be fully explored. We herein discuss the composition and role of microbiome in human health and disease with a special emphasis in children and culture-independent techniques employed in mapping of the microbiome. Alteration in the gut microbiome has been associated with causation of several paediatric diseases like infantile colic, necrotizing enterocolitis, asthma, atopy, obesity, type -1 diabetes, and autism. Atopic dermatitis and psoriasis have also been associated with changes in the cutaneous microbiome. Respiratory microbial imbalances during infancy have been linked with wheezing and bronchial asthma. Dysbiosis in the regional microbiome has been linked with caries, periodontitis, and chronic rhinosinusitis. The future therapeutic implications of this rapidly evolving area of research are also highlighted.


Defining and measuring vulnerability in young people
Dheeraj Shah, ShilpaKhanna Arora, Sanjay Chaturvedi, and Piyush Gupta
Medknow
Adolescents and youth, together addressed as “young people”, form the future building blocks of any society. They being most energetic and dynamic, tend to get involved in high-risk behaviors making themselves susceptible to criminal offences, accidents, physical injuries, emotional trauma, and medical problems — some of them extremely serious like transmission of human immunodeficiency virus (HIV). The concept of vulnerability is applicable to all the people who are more exposed to risks than their peers like the young people. In order to deal with social evils like criminal offences, domestic violence, sexual abuse, HIV, etc. we need to define vulnerability and understand the factors that influence it. This review also attempts to summarize the indicators of vulnerability and the data currently available to estimate its burden in India. Measuring the magnitude of vulnerability by means of certain indicators/variables might help us in devising tools to assess this poorly defined entity. This may also evolve a conceptual framework on which targeted remedial interventions can be devised and implemented.


Severe thrombocytopenia with bleeding secondary to acute viral hepatitis a




Pulmonary tuberculosis: A predominant cause of childhood bronchiectasis in India




Comparison of Bone Mineral Density in Thalassemia Major Patients with Healthy Controls
Mahesh Chand Meena, Alok Hemal, Mukul Satija, Shilpa Khanna Arora, and Shahina Bano
Hindawi Limited
Chronic hemoglobinopathies like thalassemia are associated with many osteopathies like osteoporosis.Methods. This observational study was carried out to compare the bone mineral density (BMD) in transfusion dependent thalassemics with that of healthy controls. Thirty-two thalassemia patients, aged 2–18 years, and 32 age and sex matched controls were studied. The bone mineral concentration (BMC) and BMD were assessed at lumbar spine, distal radius, and neck of femur. Biochemical parameters like serum calcium and vitamin D levels were also assessed.Results. The BMC of neck of femur was significantly low in cases in comparison to controls. We also observed significantly lower BMD at the lumbar spine in cases in comparison to controls. A significantly positive correlation was observed between serum calcium levels and BMD at neck of femur.Conclusion. Hence, low serum calcium may be used as a predictor of low BMD especially in populations where incidence of hypovitaminosis D is very high.


Giant primary cerebral hydatid cyst: A rare cause of childhood seizure
ShilpaKhanna Arora, Anju Aggarwal, and Varsha Datta
Medknow
We report a 9-year-old girl who presented with focal seizures, hemiparesis, headache, vomiting and bilateral optic atrophy. CT scan revealed a giant solitary cyst in the left parietal lobe. Serology and histopathology of the excised cyst confirmed the diagnosis of neurohydatidosis which is a rare cause of childhood seizure.


Estimation of gestational age, using neonatal anthropometry: A cross-sectional study in India




Dengue encephalitis in children
Shilpa Khanna Arora, Anju Aggarwal, and Hema Mittal
Scientific Scholar



Clinicohematological profile and platelet trends in children with dengue during 2010 epidemic in North India
Hema Mittal, M. M. A. Faridi, Shilpa Khanna Arora, and Rahul Patil
Springer Science and Business Media LLC



Immune response to second dose of MMR vaccine in Indian children




Meconium peritonitis presenting as abdominal calcification: Three cases with different pathology
P Dewan, M M A Faridi, R Singhal, S K Arora, V Rathi, S Bhatt, and S K Aggarwal
Informa UK Limited
Abstract Intra-abdominal calcification is uncommon in newborns and has several causes of which meconium peritonitis is the most frequent. Three neonates with intra-abdominal calcification as a complication of meconium peritonitis are presented. The types of meconium peritonitis were cystic, meconium pseudocyst and meconium ascites. Two required surgical intervention. Meconium peritonitis should be considered in newborns with intra-abdominal calcification.


An unusual presentation of hemophilia B: pseudotumor of proximal tibia.

RECENT SCHOLAR PUBLICATIONS

Outcomes after Immunosuppressive Therapy for Aplastic Anemia: A Single Centre Experience from Northern India
N Kumar, A Hemal, A Sangwan, SK Arora
Indian Journal of Hematology and Blood Transfusion, 1-6 2024



Unusual Presentation of Myeloid Sarcoma as Thigh Mass
S Yadav, SK Arora, A Hemal, S Sandip, G Sharma, PL Jyotsana, ...
Journal of Pediatric Health Care 2024



Hepcidin levels in response to oral iron therapy in children with anemia
T Singh, SK Arora, P Goyal, A Hemal
Indian Pediatrics 61 (9), 823-827 2024



Unusual case of ‘scorbutic proptosis’
SK Arora, M Jana, R Seth
BMJ Case Reports CP 17 (1), e253380 2024



Vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia
D Tanwar, A Hemal, D Sachan, SK Arora
Pediatric Hematology Oncology Journal 9 (4), S66 2024



Ocular manifestations in children with acute leukemia
A Durai, A Hemal, MD Singh, SK Arora
Pediatric Hematology Oncology Journal 9 (4), S66 2024



Volume 61, January-December, 2024
Y Abdelmeguid, S Abdulrahman, T Abiramalatha, AM Abraham, ...
Indian Pediatrics 61 2024



Spectrum of psychiatric manifestations in children with acute lymphoblastic leukemia in a tertiary care centre
S Arora, B Kumar, A Hemal, RP Beniwal
Pediatric Hematology Oncology Journal 9 (4), S36 2024



Axillary Lymph Node in Extra-Ocular Retinoblastoma–Benign or Malignant?
SG Ravindra, S Sagar, SK Arora, R Seth, N Lomi, R Kumar
Indian Journal of Nuclear Medicine 38 (3), 305-306 2023



Double trouble: Atypical presentation of myeloid sarcoma as thigh mass complicated by hypercalcemia in a challenging clinical encounter
SK Arora, S Yadav, A Hemal, S Sandeep, G Sharma, PL Jyotsana
Pediatric Hematology Oncology Journal 8 (4), S86 2023



Serum survivin for early detection of retinoblastoma
SK Arora, N Lomi, M Jana, L Singh, S Kashyap, S Pathy, RM Pandey, ...
Pediatric Hematology Oncology Journal 8 (4), S45 2023



Paediatric orbital ultrasound: Tips and tricks
A Gupta, SK Arora, R Seth, R Kumar, M Jana
Australasian Journal of Ultrasound in Medicine 25 (4), 200-206 2022



An Unusual Case of “Scorbutic Proptosis”
S Arora, M Jana, R Seth
Authorea Preprints 2022



Serum survivin as biomarker in retinoblstoma: Hope or hype?
SK Arora, R Seth, RM Pandey, S Kashyap, S Pathy, M Jana, JP Meena, ...
Pediatric Hematology Oncology Journal 7 (4), S45 2022



Evaluation of serum hepcidin levels following oral iron therapy in children of iron deficiency anemia aged 2-12 years
T Singh, SK Arora, P Goyal, A Hemal
Pediatric Hematology Oncology Journal 6 (4), S40-S41 2021



Intussusception in a child with Acute Lymphoblastic Leukemia: a remarkable presentation with literature review–a case report
A Majumder, S Misra, V Kumar, SK Arora
Journal of the Egyptian National Cancer Institute 33, 1-5 2021



Predictors of severe dengue amongst children as per the revised WHO classification
SK Arora, D Nandan, A Sharma, P Benerjee, DP Singh
Journal of Vector Borne Diseases 58 (4), 329-334 2021



Is There A Need to Supplement Transfusion-Dependent Thalassemics with Vitamin B12?
A Sharma, SK Arora, A Hemal, V Kumar
MAMC Journal of Medical Sciences 7 (1), 72-76 2021



Psychiatric problems amongst adolescents living with HIV at a tertiary care centre in India
R Pilania, A Hemal, S Agarwal, RP Beniwal, SK Arora
Indian Pediatrics 57, 1026-1028 2020



IAP Textbook of Vaccines
VM Vashishtha, A Kalra
Jaypee Brothers Medical Publishers 2020

MOST CITED SCHOLAR PUBLICATIONS

Defining and measuring vulnerability in young people
SK Arora, D Shah, S Chaturvedi, P Gupta
Indian Journal of Community Medicine 40 (3), 193-197 2015
Citations: 171



Clinicohematological profile and platelet trends in children with dengue during 2010 epidemic in north India
H Mittal, MMA Faridi, SK Arora, R Patil
The Indian Journal of Pediatrics 79, 467-471 2012
Citations: 81



Immune response to second dose of MMR vaccine in Indian children
S Gomber, SK Arora, S Das, VG Ramachandran
Indian Journal of Medical Research 134 (3), 302-306 2011
Citations: 54



Impact of an educational film on parental knowledge of children with cerebral palsy
SK Arora, A Aggarwal, H Mittal
International journal of pediatrics 2014 (1), 573698 2014
Citations: 43



Estimation of gestational age, using neonatal anthropometry: a cross-sectional study in India
R Thawani, P Dewan, MMA Faridi, SK Arora, R Kumar
Journal of Health, Population, and Nutrition 31 (4), 523 2013
Citations: 43



Comparison of bone mineral density in thalassemia major patients with healthy controls
MC Meena, A Hemal, M Satija, SK Arora, S Bano
Advances in hematology 2015 (1), 648349 2015
Citations: 34



Microbiome: paediatricians’ perspective
SK Arora, P Dewan, P Gupta
Indian Journal of Medical Research 142 (5), 515-524 2015
Citations: 32



Role of organochlorine pesticides in children with idiopathic seizures
SK Arora, P Batra, T Sharma, BD Banerjee, S Gupta
International Scholarly Research Notices 2013 (1), 849709 2013
Citations: 23



Predictors of severe dengue amongst children as per the revised WHO classification
SK Arora, D Nandan, A Sharma, P Benerjee, DP Singh
Journal of Vector Borne Diseases 58 (4), 329-334 2021
Citations: 21



Giant primary cerebral hydatid cyst: A rare cause of childhood seizure
SK Arora, A Aggarwal, V Datta
Journal of Pediatric Neurosciences 9 (1), 73-75 2014
Citations: 18



Writing Methods: how to write what you did?
S Arora, D Shah
Indian pediatrics 53 (4) 2016
Citations: 12



Dengue encephalitis in children
SK Arora, A Aggarwal, H Mittal
Journal of Neurosciences in Rural Practice 3 (2), 228 2012
Citations: 11



Pediatric HIV disclosure in northern india: evaluation of its prevalence, perceptions amongst caregivers, and its impact on CLHIV
R Meena, A Hemal, SK Arora
AIDS Research and Treatment 2018 (1), 2840467 2018
Citations: 9



An unusual presentation of hemophilia B: pseudotumor of proximal tibia.
S Mittal, S Arora, S Khanna, L Maini, VK Gautam
American Journal of Orthopedics (Belle Mead, NJ) 40 (7), E138-40 2011
Citations: 9



Giant intramuscular calcifying aponeurotic fibroma of gluteus maximus: case report
S Arora, D Sabat, SK Arora, V Kumar, Saran
Annals of tropical paediatrics 30 (3), 259-263 2010
Citations: 8



IAP Textbook of Vaccines
VM Vashishtha, A Kalra
Jaypee Brothers Medical Publishers 2020
Citations: 7



Acute lymphoblastic leukemia presenting as nephromegaly in a child: a rare case report
SK Arora, S Swarnim, A Hemal, N Bidhuri
The Turkish Journal of Pediatrics 61 (1), 97-101 2019
Citations: 7



A statistical analysis of completeness of earthquake data of peninsular India and its implications for seismicity evaluation
S Gupta, SK Arora
Geological Society of India 55 (5), 481-491 2000
Citations: 6



Primary aneurysmal bone cyst of the proximal tibia crossing the open physis
S Arora, D Sabat, SK Arora, V Kumar, RK Saran
Journal of Orthopaedic Science 16, 665-669 2011
Citations: 5



Meconium peritonitis presenting as abdominal calcification: three cases with different pathology
P Dewan, MMA Faridi, R Singhal, SK Arora, V Rathi, S Bhatt, ...
Annals of tropical paediatrics 31 (2), 163-167 2011
Citations: 4