Biosurfactant: green additives for the next generation pharmaceutical formulations Pramita Kar, Sanjukta Sen, Dibya Sinha, Dipanjan Karati, Nilanjan Pahari, Abhiroop Sengupta, Biresh Kumar Sarkar, Ayon Dutta, Dipanjana Ash, Swarupananda Mukherjee International Journal of Polymeric Materials and Polymeric Biomaterials, 2026 Surfactants are a significant class of additives that are often used as emulsifiers, stabilizers, and solubilizers in the majority of compositions. Although they are utilized in many formulations, the synthetic surfactants that make up current medication delivery methods are linked to several adverse consequences. Therefore, a new class of surface-active agents-known as biosurfactants, is derived from the metabolites of bacteria, yeast, and fungus to mitigate the issues related to traditional surfactants. The potential to reach new markets through creative formulations is strengthened by the fact that biosurfactants have the same functions as synthetic equivalents and can work in concert with other molecules to improve performance. Different forms of biosurfactants, their physicochemical characteristics, benefits and limitations, regulatory status, and their specific medicinal uses are rigorously examined in this article. However, because their application is limited by the expensive cost of manufacture and the absence of thorough toxicity testing, further study should be conducted. The purpose of this study is to investigate the potential of biosurfactants in medication delivery, highlighting their advantages, current challenges, and future prospects. Researchers can create more effective and long-lasting therapeutic treatments by comprehending the processes and interactions between biosurfactants and different drug scaffolds.
Enhancing vaginal drug delivery: the nanoemulsion gel strategy Biswajit Basu, Dipanjana Ash, Ayon Dutta, Rajdip Goswami, Swarnali Dutta, Kevin Garala, Gehan M. Elossaily, Devesh U. Kapoor, Bhupendra G. Prajapati Zeitschrift Fur Naturforschung Section C Journal of Biosciences, 2025 In the 21st century, 75 % of women encounter vaginal malfunctions (cervicitis, mucoid ectopy, aerobic vaginitis, candidiasis, bacterial vaginosis, degenerated vaginitis, desquamative chronic vaginitis, and sexually transmitted infections) that clinically manifest as irritation, awkwardness, irregular bleeding, or evacuation. Vaginal drug delivery, an approach to treat the aforementioned diseases, primarily focuses on vaginal epithelium thickness, cyclic changes, vaginal secretions, mucus and enzymatic activity, pH, local microflora, and the presence of efflux transporters for their fabrication. There has been a growing interest in nanoemulsion gel for drug delivery to the vagina in comparison to conventional vaginal delivery systems (rings and gels). This review provides an in-depth examination of nanoemulsion gel formulation, highlighting key considerations such as the choice of vehicles, gel-forming agents, and permeation enhancers. It further explores formulation techniques, stability issues, and novel approaches like mucoadhesive and controlled-release systems. The biocompatibility and safety of nanoemulsion gels are also critically assessed, along with regulatory aspects. The paper underscores the growing significance of these formulations in the management of various vaginal conditions, including infections, hormonal therapies, and contraceptive applications. As nanoemulsion gels continue to evolve, their role in optimizing vaginal drug delivery systems offers considerable potential for improving therapeutic outcomes and patient compliance.
Lipid-Based Nanocarriers for Nucleic Acids and Proteins: Liposomes, Solid Lipid Nanoparticles, Nanostructured Lipid Carriers Biswajit Basu, Ayon Dutta, Dipanjana Ash, Bhupendra Prajapati, Swarupananda Mukherjee Nanocarriers for Nucleic Acids and Proteins, 2025 Lipid-based nanocarriers (self-nanoemulsifying vehicle, nanoemulsion, nanoemulgel, solid lipid nanoparticle, lipospheres, and lipid—drug conjugate, nanovesicular systems such as liposomes, niosomes, phytosomes, herbosomes, and ethosomes) have gained popularity for protein and nucleic acid messenger RNA (mRNA), small interfering RNA (siRNA), short hairpin RNA (shRNA), Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9 (CRISPR/Cas9)) delivery at the targeted site with significant pharmacokinetic profile in the treatment of cancer, autoimmune diseases, cardiac and neurological disorders attributing to their biodegradability, stability, ability to modify the surface-volume ratio of nanoranged particles, lack of toxicity-related concerns (immunogenicity), and capacity to generate a complex (Lipoplex) via strong electrostatic interaction of DNA or RNA with anionic and/or cationic groups of lipids. The drug loading mechanisms of aforementioned nanocarriers are varied, such as hydrophobic ion pairing, narrow size distribution strategy, and spacious crystal matrix development for solid lipid nanoparticles and nanovesicular systems, respectively. The present chapter focuses on the current approaches of nucleic and protein delivery for gene-related therapy. The targeting strategy with surface modification and encapsulation benefit of nucleic acid and protein in lipid-based nanovehicles are also explored in the chapter. In this regard, the chapter contributes an insightful perspective to scientists for developing clinical research in the future.
Exploring the Impact of Polysaccharide-Based Nanoemulsions in Drug Delivery Biswajit Basu, Srabona Dutta, Monosiz Rahaman, Swarnali Dutta, Mohd Nazam Ansari, Bhupendra G. Prajapati, Ayon Dutta, Sourav Ghosh Journal of Biomedical Materials Research Part B Applied Biomaterials, 2025 Nanoemulsions are tiny mixtures of water and oil stabilized by surfactants, and they have become increasingly popular across various industries, including medicine. With droplet sizes in the nanometer scale, these mixtures are both compact and effective. This discussion explores the potential of polysaccharide‐based nanotechnology as an innovative approach to drug delivery. Nanoemulsions offer several benefits, such as enhanced drug solubility and bioavailability, which are crucial for drugs that poorly dissolve in water. The incorporation of natural polysaccharides as emulsifiers in these nanoemulsions ensures their biocompatibility and safety within the body. Additionally, nanoemulsions can facilitate a sustained release of medications, allowing for gradual drug release over an extended period. This controlled release can be achieved through the careful selection and formulation of polysaccharides. This review addresses the methods for producing polysaccharide‐based nanoemulsions and examines their physical and chemical properties. It highlights the influence of polysaccharide molecular weight and structure on the stability of nanoemulsions and the effectiveness of drug encapsulation. By understanding these factors, researchers can develop more efficient and safe drug delivery systems utilizing nanoemulsions. Additionally, the present article provides explicit and thorough information about the use of NPLS‐based nano‐carriers encapsulating a number of drugs designed to treat a variety of conditions, such as diabetes, cancer, HIV, malaria, cardiovascular and respiratory diseases, and skin diseases. For this reason, it is very important to review the most recent developments in polysaccharide‐based nano‐biocarriers in drug delivery and their application in the treatment of diseases. In this work, we concentrated on the preparation of polysaccharide‐based nano‐biocarriers, commonly used polysaccharides for the preparation of nano‐biocarriers, and drugs loaded on polysaccharide‐based nano‐biocarriers to treat diseases. In the near future, polysaccharide‐based nano‐biocarriers will be used more and more frequently in drug delivery and disease treatment.
Advances in neurodegenerative disorder diagnoses Neurodegenerative Disorders from Pathogenesis to Clinical Approaches, 2025
Micro and nanoemulsions in colorectal cancer Biswajit Basu, Kevinkumar Garala, Ayon Dutta, Rachana Joshi, Bhupendra G. Prajapati, Swarupananda Mukherjee, Dipanjan Karati, Sudarshan Singh, Himanshu Paliwal Colorectal Cancer Disease and Advanced Drug Delivery Strategies, 2024
Dendrimers: A Lipid-Based Drug Delivery System Biswajit Basu, Ayon Dutta, Dipanjana Ash, Bhupendra Prajapati, Kevinkumar Garalae Lipid Based Drug Delivery Systems Principles and Applications, 2023
Ethosomes: A Lipid-Based Drug Delivery System Biswajit Basu, Ayon Dutta, Akshay Parihar, Bhupendra Prajapati, Raja Majumdere Lipid Based Drug Delivery Systems Principles and Applications, 2023
Effect of Indian Spices on Metabolic Syndrome, Brain, and Cognitive Disorders Medicinal Spices and Herbs from India Volume 1 Introduction Therapeutic Properties and Commercial Products, 2004
RECENT SCHOLAR PUBLICATIONS
Biosurfactant: Green additives for the next generation pharmaceutical formulations P Kar, S Sen, D Sinha, D Karati, N Pahari, A Sengupta, BK Sarkar, A Dutta, ... International Journal of Polymeric Materials and Polymeric Biomaterials 75 … , 2026 2026 Citations: 1
Design, Optimization and Pharmacokinetic Profiling of BCS Class II Drug Loaded Oral Self Nanoemulsifying System A Dutta, S Mukherjee, B Basu, DR Kar AAPS PharmSciTech 27 (4), 203 , 2026 2026
Design and optimization of diacerein loaded lipid nanocarriers: Characterization, in vitro and in vivo evaluation for anti-arthritic activity S Mukherjee, P Ghosh, S Naskar, I Ehsan, T Roy, A Dutta, S Paul, A Jana, ... Nanomedicine: Nanotechnology, Biology and Medicine, 102914 , 2026 2026
Application of synthetic biology in biosynthesized pharmaceuticals D Ash, A Dutta, B Basu, BG Prajapati Synthetic Biology and its Consequences in Present Healthcare, 253-263 , 2026 2026
Application of synthetic biology in vaccine development A Dutta, D Ash, B Basu, BG Prajapati Synthetic Biology and its Consequences in Present Healthcare, 113-122 , 2026 2026
Modified Release Interpenetrating Polymeric Network Hydrogel Beads of Montelukast Sodium Via Box Behnken Design B Basu, A Dutta, D Ash, AJ Rathod, BG Prajapati, S Mukherjee Current Drug Therapy 20 (9), 1301-1315 , 2025 2025
Enhancing vaginal drug delivery: the nanoemulsion gel strategy B Basu, D Ash, A Dutta, R Goswami, S Dutta, K Garala, GM Elossaily, ... Zeitschrift für Naturforschung C 80 (11-12), 657-671 , 2025 2025 Citations: 8
Jormulation and development of K15M based gallic acid hydrogel J Banerjee, A Dutta Brinware University , 2025 2025
Formulation and evaluation of solid snedds for the improvement of solubility and dissolution property of a poorly water soluble drug T Das, A Dutta, B Pathak Brinware University , 2025 2025
Formulation and development of metronidazole based anti bacterial topical Organo Gel PK Mondal, A Dutta Brinware University , 2025 2025
Formulation and development of hpmck4 based gallic acid hydrogel NR Khatun, A Dutta Brinware University , 2025 2025
Stem Cell Therapy: Skin Aging Blocking D Ash, S Sen, S Shaw, A Dutta, L Kumari, S Mukherjee Stem Cell Therapy in Dermatological Disorders, 163-193 , 2025 2025
DoE-based Chlorthalidone Self-nanoemulsifying System: An Approach to Enhance In Vitro Dissolution Profile of BCS Class IV Drug A Dutta, S Mukherjee, B Basu, DR Kar, B Prajapati BioNanoScience 15 (3), 457 , 2025 2025 Citations: 5
Nanoemulsions in skin cancer therapy: a promising frontier B Basu, A Dutta, D Ash, B Prajapati Current Pharmaceutical Biotechnology 26 (12), 1825-1840 , 2025 2025 Citations: 7
An Insight into Cubosomal Drug Delivery Approaches: An Explicative Review S Mukherjee, A Dutta, D Ash, D Karati Pharmaceutical Nanotechnology 13 (4), 794-803 , 2025 2025
Smart multifunctional nanoparticles in Cancer Theranostics: Progress and Prospect D Karati, S Mukherjee, A Dutta, D Ash, SC Ganguly, A Acharya, B Basu Pharmaceutical Nanotechnology 13 (4), 726-738 , 2025 2025 Citations: 2
Recent advancements in the diagnosis and management of cancer using biomaterials-fabricated nanofibers: a review B Basu, A Dutta, D Ash, K Garala, S Singh, BG Prajapati Current Medicinal Chemistry 32 (22), 4376-4400 , 2025 2025 Citations: 7
Exploring the Impact of Polysaccharide‐Based Nanoemulsions in Drug Delivery B Basu, S Dutta, M Rahaman, S Dutta, MN Ansari, BG Prajapati, A Dutta, ... Journal of Biomedical Materials Research Part B: Applied Biomaterials 113 (5 … , 2025 2025 Citations: 9
Unlocking the potential of RNA nanoparticles: a breakthrough approach to overcoming challenges in colon cancer treatment D Karati, S Mukherjee, B Basu, KK Garala, A Dutta, BG Prajapati, ... Current Pharmaceutical Biotechnology 26 (7), 992-1013 , 2025 2025 Citations: 3
Advanced targeted drug delivery of bioactive nanomaterials in the management of cancer B Basu, KK Garala, R Patel, A Dutta, D Ash, B Prajapati, S Singh, SK Jha Current Medicinal Chemistry 32 (14), 2711-2730 , 2025 2025 Citations: 13
MOST CITED SCHOLAR PUBLICATIONS
Micro and nanoemulsions in colorectal cancer B Basu, K Garala, A Dutta, R Joshi, BG Prajapati, S Mukherjee, D Karati, ... Colorectal Cancer, 259-286 , 2024 2024.0 Citations: 16
Advanced targeted drug delivery of bioactive nanomaterials in the management of cancer B Basu, KK Garala, R Patel, A Dutta, D Ash, B Prajapati, S Singh, SK Jha Current Medicinal Chemistry 32 (14), 2711-2730 , 2025 2025.0 Citations: 13
Medical application of liposomes B Basu, B Prajapati, A Dutta, H Paliwal Journal of Exploratory Research in Pharmacology 9 (1), 13-22 , 2024 2024.0 Citations: 12
Methylphenidate fast dissolving films: development, optimization using simplex centroid design and in vitro characterization B Biswajit, A Mankad, A Dutta Turkish journal of pharmaceutical sciences 19 (3), 251 , 2022 2022.0 Citations: 12
Exploring the Impact of Polysaccharide‐Based Nanoemulsions in Drug Delivery B Basu, S Dutta, M Rahaman, S Dutta, MN Ansari, BG Prajapati, A Dutta, ... Journal of Biomedical Materials Research Part B: Applied Biomaterials 113 (5 … , 2025 2025.0 Citations: 9
Enhancing vaginal drug delivery: the nanoemulsion gel strategy B Basu, D Ash, A Dutta, R Goswami, S Dutta, K Garala, GM Elossaily, ... Zeitschrift für Naturforschung C 80 (11-12), 657-671 , 2025 2025.0 Citations: 8
Nanoemulsions in skin cancer therapy: a promising frontier B Basu, A Dutta, D Ash, B Prajapati Current Pharmaceutical Biotechnology 26 (12), 1825-1840 , 2025 2025.0 Citations: 7
Recent advancements in the diagnosis and management of cancer using biomaterials-fabricated nanofibers: a review B Basu, A Dutta, D Ash, K Garala, S Singh, BG Prajapati Current Medicinal Chemistry 32 (22), 4376-4400 , 2025 2025.0 Citations: 7
DoE-based Chlorthalidone Self-nanoemulsifying System: An Approach to Enhance In Vitro Dissolution Profile of BCS Class IV Drug A Dutta, S Mukherjee, B Basu, DR Kar, B Prajapati BioNanoScience 15 (3), 457 , 2025 2025.0 Citations: 5
Ethosomes: A Lipid-based drug delivery system B Basu, A Dutta, A Parihar, B Prajapati, R Majumder Lipid-Based Drug Delivery Systems, 223-297 , 2023 2023.0 Citations: 5
Dendrimers: A Lipid-Based Drug Delivery System B Basu, A Dutta, D Ash, B Prajapati, K Garala Lipid-Based Drug Delivery Systems, 299-385 , 2023 2023.0 Citations: 5
Unlocking the potential of RNA nanoparticles: a breakthrough approach to overcoming challenges in colon cancer treatment D Karati, S Mukherjee, B Basu, KK Garala, A Dutta, BG Prajapati, ... Current Pharmaceutical Biotechnology 26 (7), 992-1013 , 2025 2025.0 Citations: 3
Parthenium-Turmeric ointment: A novel approach for excision wound healing on rabbits A Dutta, D Ash, A Roy, P Khamkat, A Ghosh Research Journal of Pharmacy and Technology 15 (1), 293-300 , 2022 2022.0 Citations: 3
Lipid nanoparticulate drug delivery system for the treatment of hepatic fibrosis S Mukherjee, A Dutta, D Ash Arch Hepat Res 7 (1), 001-003 , 2021 2021.0 Citations: 3
Smart multifunctional nanoparticles in Cancer Theranostics: Progress and Prospect D Karati, S Mukherjee, A Dutta, D Ash, SC Ganguly, A Acharya, B Basu Pharmaceutical Nanotechnology 13 (4), 726-738 , 2025 2025.0 Citations: 2
In-Vitro Antimicrobial Activity of Perthenium hysteroporus Comparison with Ofloxacin A Dutta International Journal of Pharmaceutical Sciences Review and Research , 0 Citations: 2
Biosurfactant: Green additives for the next generation pharmaceutical formulations P Kar, S Sen, D Sinha, D Karati, N Pahari, A Sengupta, BK Sarkar, A Dutta, ... International Journal of Polymeric Materials and Polymeric Biomaterials 75 … , 2026 2026.0 Citations: 1
Colorectal Cancer Disease and Advanced Drug Delivery Strategies: Micro and nanoemulsions in colorectal cancer B Basu, K Garala, A Dutta, R Joshi, BG Prajapati, S Mukherjee, D Karati, ... Elsevier , 2024 2024.0 Citations: 1
Evaluation of the Antifertility Activity of Methanolic Extract of Melia azedarach & Their GC-MS Study DR Kar, A Dutta, S Chandra, PP Das, DK Paul International Journal of Pharmaceutical and Phytopharmacological Research … , 2023 2023.0 Citations: 1
A Critical Review of Phytochemical, Pharmacological and Ethnomedicinal Properties of Eryngium foetidum L. A Dutta, R Majunder, S Banerjee, U Chakraborty, S Bose, P Chakraborty Current Functional Foods 1 (2), E120523216836 , 2023 2023.0 Citations: 1
