Viktoria

Scopus Publications

Stress-induced endocrine changes in adolescent girls with menstrual cycle disorders in under the influence of the war in Ukraine
V.O. Dynnik, O.Н. Verhoshanova, O.O. Dynnik, А.Ye. Druzhynina, H.O. Havenko, Yu.V. Volkova, S.V. Novokhatska
Reproductive Health of Woman, 2026
Hormonal functioning against the background of stress is almost the most discussed problem in Ukraine today. The menstrual cycle as a vital indicator of life activity reacts sharply to changes in the environment. Russian military aggression in Ukraine forced the majority of the population to experience the hardships of war. Research of hormonal support of menstrual cycle disorders in the emergency situations will expand the understanding of the interaction of the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes.The objective: to compare the hormonal determinants of stress-related menstrual disorders in adolescent girls in the pre-war period and against the background of war.Materials and methods. 331 adolescent girls with menstrual disorders (in 2018–2021 – 184 girls and in 2022–2024 – 147 girls) aged 11–17 years were examined. 149 girls were diagnosed with abnormal uterine bleeding (AUB) (84 girls before the war and 65 – after the war), and 182 patients with oligomenorrhea (OM) (100 adolescents before the war and 82 – after the war). All patients lived in the territory of the city of Kharkiv and the Kharkiv region, which are subject to constant military attacks during the war. The hormonal examination complex included determination of blood serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, testosterone, cortisol, estradiol (E2), dehydroepiandrosterone sulfate (DHEA-S), and their ratios were calculated (LH/FSH, cortisol/DHEA-S, prolactin/cortisol, testosterone/cortisol, testosterone/E2).Results. In adolescents with menstrual disorders of the AUB and OM type, who were in the epicenter of constant bombardment, hormonal determinants changed. The level of stress-dependent hormones probably increased. These are the DHEA-S and prolactin concentrations. Accordingly, the ratio prolactin/cortisol increased and ratio cortisol/DHEA-S decreased, which indicates an increased resistance to a stressful situation. Being in a zone of armed conflict leads to the classic relationship between cortisol and DHEA-S, their correlation appears. Sex hormones also participate in the reaction to a stressful situation, and in AUB – testosterone, and in OM – E2. In girls in a zone of constant air raids and bombardments, against the background of a strong positive relationship between cortisol and DHEA-S, a rather weak correlation between cortisol and testosterone is found, which may indicate a less sensitive relationship between stress and sex hormones.Conclusions. Menstrual disorders are accompanied by impaired regulation of the pituitary-adrenal and pituitary-gonadal axes. Being in a zone of armed conflict increases the tension of stress-dependent and sex hormones in this contingent of patients, which can provoke a complicated course of AUB and OM.
Neurotransmitters involvement in the formation of abnormal uterine bleeding against different body weight
V.O. Dynnik, O.O. Dynnik
Journal of V N Karazin Kharkiv National University Series Medicine, 2025
Background. The problem of hormonal relationships in endocrine-dependent gynecological pathology has not lost its relevance today, as it is a key link in deciphering the pathogenesis of these diseases. Purpose – of the study was to determine the role of catecholamines, serotonin and histamine in the formation of abnormal uterine bleeding at different body weights. Materials and Methods. 125 patients with abnormal uterine bleeding aged 11 to 17 years were under observation. Depending on body mass index, they were divided into three groups. First group consisted of 19 patients with a body weight deficit (body mass index = 16.48 ± 0.20), second group included 75 patients with physiological body mass index (19.58 ± 0.17), and three group – 31 girls with excess body weight (body mass index = 27.0 ± 0.74). The complex of laboratory examinations included the determination of the levels of adrenaline, noradrenaline in daily urine, serotonin, histamine, cortisol in blood serum. Results. Abnormal uterine bleeding occurs against the background of significant changes in the content of adrenaline, noradrenaline, serotonin, histamine which indicate the activation of the sympatho-adrenal system and the production of serotonin and histamine. An increase in the adrenaline/noradrenaline index indicates the predominance of the hormonal link in the activity of the sympatho-adrenal system of this contingent of patients. It has been proven that patients with abnormal uterine bleeding with different body weights have certain features in the content of neurotransmitters, which indicate that the monoaminergic control of the course of abnormal uterine bleeding is influenced by the body weight gained at the time of the appearance of uterine bleeding. A mathematical model has been created that confirms the existence of differences in the levels and interaction of neurotransmitters in abnormal uterine bleeding, which depend on the distribution of adolescent girls with abnormal uterine bleeding into groups depending on the body mass index at which abnormal uterine bleeding occurs. Conclusions. Abnormal uterine bleeding occurs against the background of dissociation of the activity of the sympatho-adrenal system, the content of serotonin, histamine. With physiological body weight and its deficiency, both stress-providing (daily urinary excretion of adrenaline, noradrenaline increases) and stress-limiting (the level of S in the blood increases). With excess body weight, the reaction of the sympatho-adrenal system is much lower, which may indicate reduced adaptive resources to a stressful situation – the occurrence of uterine bleeding.
HORMONE IMBALANCE AS A MANIFESTATION OF STRESS IN THE FORMATION OF OLIGOMENORRHEA IN TEENAGE GIRLS
V. Dynnik, O. Dynnik, S. Novokhatska
Neonatology Surgery and Perinatal Medicine, 2025
Stress is currently the most significant factor contributing to reproductive function disorders and has become a major public health problem in the 21st century. Stress is implicated in the development of oligomenorrhea (OM), particularly in the context of the ongoing full-scale war in Ukraine.The aim of the study was to determine the characteristics of the content of steroid hormones, including stress-related hormones, in adolescent girls with OM.Materials and methods. A total of 193 girls aged 12–18 years with OM were observed and stratified into groups according to OM duration. Hormonal assessment included serum measurements of estradiol (E2), testosterone (T), cortisol (C), 17-hydroxyprogesterone (17-OH), dehydroepiandrosterone sulfate (DHEA-S), and sex steroid-binding globulin (SSBG). The ratios of C/DHEA-S and the free T index were also calculated.Written informed consent for all medical procedures was obtained from each participant or their parents/guardians. The study protocol was approved by the Bioethics and Deontology Committee of the State Institution “Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine” (protocol No. 7 dated 25.11.2024).Statistical analysis was performed using the computer program Statgraphics Plus. Results were analyzed by one-way analysis of variance. Differences were considered significant at ρ < 0.05. Data are presented as mean ± standard deviation (SD) and frequency counts. The significance of differences between groups was assessed using Fisher’s exact test, the Wilcoxon–Mann–Whitney test, and the χ² test.The study was conducted according to the research plan entitled “Study of the mechanisms of comorbid pathology formation in adolescent girls with menstrual disorders (primary oligomenorrhea and abnormal uterine bleeding)” (state registration number: 0121U114425).Results. At OM onset, nearly 20% of participants exhibited low E2 levels. With increased disease duration (years 2–3), the proportion of adolescents with low E2 decreased while those with elevated E2 increased. E2 is known to influence reproductive potential and correlate with mood alterations; a parallel trend was observed for C. Conversely, DHEA-S levels rose with prolonged OM duration. Early in OM progression, characteristic findings include low E2, C, and DHEA-S levels, accompanied by increased C/DHEA-S ratios, suggesting diminished adaptive capacity. With extended OM duration, the proportion of girls exhibiting elevated free T, 17-OH, DHEA-S, and T/E2 ratios increased, indicative of emerging polycystic ovary syndrome (PCOS). The percentage of adolescents with elevated C/DHEA-S ratios declined, whereas low ratios became more prevalent. Significant positive correlations were observed between C and T (r = 0.31; P < 0.001), DHEA-S and C (r = 0.46; P < 0.0001), and free T and DHEA-S (r = 0.44; P < 0.0005).Conclusions. The findings do not support an association between OM development and dysregulation of adrenal–gonadal interactions, which govern menstrual function regulation and are linked to stress responses and maladaptation.
Plasma cortisol and insulin levels as a biomarkers of stress in girls with oligomenorrhea in the frontline city Kharkiv, Ukraine
V.O. Dynnik, О.О. Dynnik, O Verhoshanova, S.V. Novokhatska
Endokrynologia, 2025
Резюме. Порушення менструальної функції залишаються актуальною проблемою сучасної медицини. Поряд із багатьма несприятливими факторами, що впливають на здоров’я дівчат, яких слід розглядати як майбутніх матерів, вплив травматичних подій займає одне з провідних місць. Стрес є комплексною адаптивною реакцією, що потребує додаткових енергозатрат. Під його впливом змінюється функціонування як гіпоталамо-гіпофізарноадреналової осі, так і секреція інсуліну. Метою нашого дослідження стало з’ясування особливостей реакції напруги в дівчат з олігоменореєю (ОМ) в прифронтовому місті. Матеріал і методи. Для оцінки адаптаційних можливостей було вивчено вміст у сироватці крові кортизолу (К) і інсуліну (Ін) та їх співвідношення в 116 хворих дівчат з олігоменореєю. Усі хворі були розподілені на групи в залежності від терміну існування ОМ. У першу групу увійшли 20 дівчинок, які звернулися по медичну допомогу в перший рік після менархе. До другої групи було включено 28 підлітків з існуванням захворювання до 2 років, третю групу становили 39 пацієнток, у яких ОМ спостерігалася до 3 років і в четверту групу було віднесено 39 хворих, у яких ОМ існувала понад 3 роки. Результати. Функція наднирників і підшлункової залози щодо синтезу К і Ін у половини дівчат з ОМ була збережена, про що свідчить співвідношення К/Ін, яке коливалось у межах нормативних значень. Зниження цього індексу відмічалося більш ніж у третини і від 3 до 10% дівчат мали підвищення індексу напруги. Встановлено, що при виникненні ОМ в перший рік існування менструацій не відмічається високих цифр індексу напруги (К/Ін), які свідчать про зниження резервів компенсаторних можливостей організму та порушення енергозабезпечення адаптаційних процесів. З подовженням терміну існування ОМ вже з’являються ознаки виснаження, тобто неадекватної реакції організму на хронізацію процесу. Висновки. У результаті проведеного дослідження і аналізу виявлених порушень встановлено, що в 39,7% хворих з ОМ мають місце розлади адаптації. Дані відхилення підкреслюють необхідність визначення адаптаційних ресурсів для вирішення питання щодо їх корекції з метою підвищення можливостей організму переносити стрес та посилення адаптаційних спроможностей.
The impact of the COVID-19 pandemic on the physical and mental health of children and adolescents
, H.M. Danylenko, N.V. Medvedovska, , V.O. Dynnik, and
Modern Pediatrics Ukraine, 2025
The aim of this study is to identify the most significant factors that influenced the quality of life of school-aged children with chronic non-communicable diseases during COVID-19. Materials and methods. There were 2.905 respondents in total: 2.135 children aged 10-18 years who studied in general secondary education institutions (health groups 1-3), 770 children and adolescents who sought help at the clinics (health groups 4-5). Results. The most significant issue for all children and adolescents in the context of the COVID-19 pandemic was the threat of illness of their relatives. The second most significant issue was that children could not attend school and had to start online learning. The most common place to find information about COVID-19 was on the Internet, less often from parents, and even less often from the media and friends. Most children and adolescents did not notice any changes in their health (84.3%). Of those who experienced changes, 22.5% reported feeling unwell, drowsiness, weakness, disability, fatigue, 21.2% reported physical inactivity, and 26.5% reported deteriorating vision. They also complained of headaches, migraines, weight gain, knee pain, high blood sugar, and other. As a manifestation of the impact on the emotional and psychological state, children reported mood swings, depressive thoughts, aggressiveness, irritability, agitation, and emotional instability (14.2%). Concerns about the COVID-19 pandemic were expressed primarily in anxiety and tension in 27.3% of respondents almost constantly and 24.8% - sometimes (“from time to time”); 25.5% admitted to a sense of uncertainty and instability; 19.4% were threatened with COVID-19. Conclusions. Children have gained some experience and have prioritized the realization of the value of life and health, not only their own but also their loved ones. The second and third places were shared by mastering online learning, the ability to manage their time wisely, and expanding knowledge of hygiene skills during the pandemic. About 12% of children and adolescents have reconsidered their attitude to communication and having friends, connections with society, and have acquired new hobbies. No conflict of interests was declared by the authors.
The relationships of the pituitary-gonadal regulation link of the menstrual cycle and hormones of energy metabolism in adolescents with abnormal uterine bleeding at different times of menstrual disorders debut
V.O. Dynnik, O.O. Dynnik, N.V. Bagatska
Reproductive Health of Woman, 2025
The objective: to study the relationship between gonadotropic, steroid, metabolic hormones and sex steroid-binding globulin (SSBG) at different times of the debut of abnormal uterine bleeding (AUB) in adolescents relative to menarche based on the development of a mathematical model.Materials and methods. 200 adolescent girls with AUB were examined. They were divided into groups depending on the time of onset of uterine bleeding relative to menarche. The blood serum concentration of gonadotropic, steroid hormones, insulin, leptin, and SSBG was determined. The comparison group consisted of 45 girls of the same age with a normal menstrual cycle. The variance and regression analyses of the obtained data were performed using the application program package Statgraphics Plus for Windows 5.0 and SPSS-17.Results. The formation of uterine bleeding in adolescent girls occurs on the background of increased levels of luteinizing hormone, estradiol, and testosterone, and the highest rates are observed in patients with AUB that occurred after previous disorders of the oligomenorrhea type.The sensitivity of the reproductive axis to energy-regulating hormones, which depends on the time of disease debut, has been proven. There is a relationship between gonadotropic hormones, energy metabolism hormones, steroid hormones.Menstrual dysfunction with menarche or in the first year of the menstrual cycle formation, regardless of the type of disorder (AUB or oligomenorrhea), is accompanied by identical changes in hormonal and metabolic status and is formed on the background of immaturity of the pituitary-gonadal system components. AUB which occurs after 2 or more years of normal menstrual function, is formed on the background of a more mature relationship between estradiol and follicle-stimulating hormone, and insulin, interacting with luteinizing hormone, modulates mainly the production of testosterone, which contributes to the prolongation of the period of anovulatory cycles, which in the future can contribute to the formation of polycystic ovary syndrome.Conclusions. The variability of gonadotropic hormone production in AUB during puberty is determined with a high degree of significance (p < 0.001) by leptin, insulin, SSBG and steroid hormones. This indicates the sensitivity of the reproductive axis to available energy and demonstrates that the level of energy hormones affects not only the production of gonadotropins, but is also associated with ovarian function. Moreover, the features of the associative relationships of pituitary hormones depend on the time of the debut of menstrual disorders.
The impact of the war in Ukraine on the physical and sexual development of girls with menstrual disorders
V.O. Dynnik, O.O. Dynnik, O.G. Verhoshanova, A.Ye. Druzhynina, H.O. Havenko, S.V. Novokhatska
Child S Health, 2025
Background. Puberty and the formation of menstrual function are significant stressors for a girl. Traumatic war experience can deepen maladaptive reactions of the body and lead to more serious consequences of menstrual disorders. The purpose of the study was to investigate the features of changes in physical and sexual maturation in girls with menstrual disorders under the influence of a long stay in a front-line city. Materials and methods. One hundred and fifty-three adolescent girls aged 11–18 years were examined, including 69 patients with abnormal uterine bleeding (AUB) and 84 with oligomenorrhea (OM), who resided in a front-line city. The comparison group was girls with similar menstrual disorders who were treated at the pediatric gynecology department of the State Institution “Institute for Children and Adolescents Health Care” in 2019–2021. Clinical anthropometry was performed to assess physical development, and body mass index was calculated. The main indicators of sexual maturation were the degree of development of secondary sex characteristics (breast development, pubic and axillary hair), and the time of onset of the first menstruation. Results. Slightly more than half of the girls with OM (51.9 %) and a third with AUB (37.1 %) had growth within the normative values before the start of the full-scale war. During the war, a tendency to decrease these indicators was noted. Among the deviations both before and during the war, precocious puberty and tall stature prevailed. Stay in the combat zone leads to a decrease in the proportion of adolescents with physiological body mass index. The number of girls with excess body weight and obesity is significantly increasing (in AUB, from 16.7 % before the war to 32.4 % during the war, P < 0.001; in OM, from 12.3 % before the war to 33.3 % during the war, P < 0.0001). A significant increase in precocious puberty among 11–13-year-old girls has been recorded (in AUB, from 75 % before the war to 83.9 % during the war, P < 0.05; in OM, from 38.5 % before the war to 92.3 % during the war, P < 0.000001). The age of menarche has probably decreased due to early menarche (in AUB, the percentage of girls with early menarche in relation to the total number of those surveyed increased from 18.2 % before the war to 31.9 % during the war, P < 0.01; in OM, from 8.5 % before the war to 14.3 % during the war, P < 0.02). Conclusions. The physical and sexual development of girls with menstrual disorders are among the most important indicators of the impact of stress on the body, which can be used as the main, most evident and reliable criteria for the adverse course of menstrual disorders against the background of war.
Peculiarities of echography of pelvic organs disorders of menstrual function during puberty
V.O. Dynnik, O.O. Dynnik, N.V. Bagatska
Ukrainian Journal of Radiology and Oncology, 2024
Background. Pelvic ultrasonography is the method of choice for evaluating genitalia in children as an accurate, painless, non-invasive method that does not require sedation or ionizing radiation.Purpose – to determine the characteristics of ultrasound parameters of the pelvic organs, the level of steroid hormones and insulin in teenage girls with various disorders of the menstrual cycle (oligomenorrhea and abnormal uterine bleeding).Materials and methods. 393 girls with various disorders of the menstrual cycle were examined. 192 adolescents with abnormal uterine bleeding (AUB) and 201 patients with oligomenorrhea (OM). All patients underwent ultrasound examination of the pelvic organs. Serum levels of estradiol, testosterone, cortisol, DHEA-S and insulin were determined.Results. Peculiarities of echosonographic parameters of the uterus and ovaries in girls with various pathologies of the menstrual cycle-AUB and OM have been established. It was found that the increase in the size of the uterus and ovaries with age was characteristic of adolescents with OM, as it also happens during the physiological course of puberty. Such dynamics are not observed in patients with AUB. Phenomena of endometrial hyperplasia were 2.3 times more frequent in AUB (p ˂ 0.0001). Moreover, the thickness of the endometrium depended on the duration of bleeding, and decreased with prolonged uterine bleeding. In girls with OM, the thickness of the endometrium decreased with the increase in the period of existence of the violation of menstrual function. The location of ovarian cysts was observed in every 8–9 girls with disorders of menstrual function and did not differ significantly depending on the type of menstrual disorder. Multifollicular ovaries were detected twice as often. Morphometric and hormonal indicators had different effects on the parameters of the uterus and ovaries in girls with the opposite pathology of menstruation. The size of the uterus and ovaries during bleeding was influenced by BMI, cortisol, and testosterone, and in OM, primarily by age, estradiol, and insulin.Conclusions. The high diagnostic value and safety of ultrasound examinations make them the method of choice for pathology of the pelvic organs in teenage girls, which make it possible to reliably assess the anatomical features and hormonal status of children, to speed up the final diagnosis, which will contribute to the timely and differentiated appointment of treatment to girls with menstrual disorders.
Disorders of menstrual function during puberty and the risk of nonalcoholic fatty liver disease with comorbid diseases of the gastrointestinal tract
V. O. Dynnik, O. O. Dynnik, A. Ye. Druzhynina, S. V. Novokhatska
Modern Medical Technology, 2024
The aim of the study was to determine the relationship between disorders of menstrual function in adolescence and the risk of nonalcoholic fatty liver disease (NAFLD) with comorbid gastrointestinal pathology. Materials and methods. We examined 129 adolescent girls aged 12–17 years with menstrual disorders (61 with abnormal uterine bleeding (AUB) and 68 with oligomenorrhea (OM)) and measured anthropometrics, indices of lipid and carbohydrate metabolism and liver enzymes. Data are presented in the form of mean (M), standard deviation (SD) and median (Me), a factorial model was developed. Results. The study shows the peculiarities of the clinical course of menstrual function disorders in girls of puberty age. Patients with AUB were characterized by significantly lower average body mass indices, they were younger compared to patients with OM. The nature of metabolic changes that depended on the type of menstrual disorders in teenage girls was clarified. Adolescents with AUB had statistically significantly higher average levels of immunoreactive insulin, HOMA index, triglycerides, very low-density lipoprotein cholesterol, aspartate aminotransferase. This creates conditions for the formation of nonalcoholic fatty liver disease. A model was created regarding the participation of dyslipoproteinemia, changes in the carbohydrate spectrum and levels of liver enzymes in the formation of nonalcoholic fatty liver disease in girls with menstrual cycle disorders. Conclusions. Disorders of menstrual function are associated with an increased risk of NAFLD formation. Adolescent girls with menstrual disorders need metabolic screening. The atherogenic profile of lipoproteinemia, marked changes in the carbohydrate spectrum and increased serum levels of liver enzymes in girls with menstrual cycle disorders are the basis for the formation of nonalcoholic fatty liver disease.
FEATURES OF STEROID HORMONE LEVELS IN GIRLS WITH MENSTRUAL CYCLE DISORDERS AND MENTAL HEALTH DISORDERS
V.O. Dynnik, О.О. Dynnik, O.H. Verhoshanova, Tetiana Matkovska, O. N. Sheludko, et al.
Reproductive Endocrinology, 2024
Objectives of the study: to investigate the peculiarities of the steroid hormone status in girls with menstrual function disorders, depending on comorbid psychopathology.Materials and methods. A total of 174 girls with menstrual function disorders (78 with abnormal uterine bleedings (AUB) and 96 with oligomenorrhea (OM)) were examined. The diagnosis of psychopathology was determined based on the clinical presentation at the time of examination. The comparison group consisted of 35 girls with a normal menstrual cycle.The laboratory examination included the assessment of estradiol, testosterone, cortisol (C), and dehydroepiandrosterone sulfate (DHEA-S) levels. The C/DHEA-S ratio was calculated using the unprocessed raw values. Results. Menstrual function disorders are often associated with hypoestrogenemia, a prevalent phenomenon. It was observed in almost a third of patients with AUB, whereas in girls with OM this number was significantly higher. Significant reduced values are found in girls with accompanying depressive states, especially in cases of AUB and OM. In instances of AUB and OM, the number of individuals with elevated levels of testosterone increased by 1.97–2.2 times in the presence of psychopathology. DHEA-S in patients with AUB was reduced in more than half of the girls, while in patients with OM it varies evenly in both directions, regardless of the presence or absence of psychopathology. A C level were more often reduced than increased, and achieves statistical significance when OM combined with neurotic disorders and AUB combined with depressive states. The C/DHEA-S ratio, as a stress indicator, was statistically significantly elevated in patients with AUB. This may suggest more pronounced manifestations of stress in patients with AUB than in girls with OM and a higher adaptability of the girls’ bodies with OM.Conclusions. Thus, the understanding of the role of reproductive steroids in the development of menstrual function disorders during adolescence has been deepened. Distinctive features of their interrelations in the presence of psychopathology have been identified. The impact of cortisol and DHEA-S, as well as C/DHEA-S ratio, on mental well-being in endocrine-related gynecological disorders in girls has been established
THE STATE OF GONADOTROPIC AND PROLACTIN-SYNTHESIZING FUNCTION OF THE PITUITARY GLAND IN ADOLESCENT GIRLS WITH OLIGOMENORRHEA DEPENDING ON THE DISEASE DURATION
V.O. Dynnik, S.V. Novokhatska, O.H. Verhoshanova, O.O. Dynnik, А.Y. Druzhynina, H.O. Havenko
Reproductive Endocrinology, 2024
Assessment of adaptative and compensatory capabilities of girls with disorders of menstrual function
V.O. Dynnik, , О.О. Dynnik, O.G. Verchoshanova, H.О. Havenko, , , and
Modern Pediatrics Ukraine, 2023
Сharacter of mental disorders and their hormonal accompaniment in adolescent girls with disorders of menstrual function
V.O. Dynnik, , О.О. Dynnik, H.О. Havenko, O.G. Verchoshanova, Yu.V. Volkova, , , , and
Modern Pediatrics Ukraine, 2023
Hormonal profiles and adjustment disorders in adolescent girls with menstrual abnormalities and comorbid pathology
V.O. Dynnik, О.О. Dynnik, H.О. Havenko, Yu.V. Volkova, O.G. Verchoshanova
Child S Health, 2023
Risk factors for the development of complicated oligomenorrhea in adolescent girls
V.O. Dynnik, , O.O. Dynnik, S.V. Novokhatska, A.E. Druzhinina, , , and
Ukrainian Journal of Perinatology and Pediatrics, 2022
ROLE OF VITAMIN D IN THE FORMATION OF ABNORMAL UTERINE BLEEDING IN THE PUBERTATE PERIOD
V.O. Dynnik, O.O. Dynnik, A.E. Druzhinina
Medicni Perspektivi, 2022
RELATIONSHIP BETWEEN BLOOD LIPIDS AND VITAMIN D STATUS IN ADOLESCENT GIRLS WITH OLIGOMENORRHEA
Вікторія Диннік, Олександра Диннік, Альона Дружиніна
Problemi Endokrinnoi Patologii, 2022
Comorbid pathology issues in pediatric gynecology
V.O. Dynnik, , N.V. Bagatska, O.O. Dynnik, O.G. Verchoshanova, H.O. Havenko, , , , and
Modern Pediatrics Ukraine, 2022
РREVENTION AND REHABILITATION OF HEALTH PROBLEMS OF SCHOOLCHILDREN FROM THE ZONE OF MILITARY CONFLICT IN UKRAINE
I.S. Lebets, V.O. Dynnik, T.M. Matkovskaya, N.V. Medvedovska, D.A. Kashkalda
Medicni Perspektivi, 2022
ABNORMAL UTERINE BLEEDING IN ADOLESCENT GIRLS: HEREDITARY AND ENVIRONMENTAL RISK FACTORSS
Georgian Medical News, 2021
VITAMIN D LEVEL AND HORMONAL STATUS ASSOCIATION IN ADOLESCENT GIRLS WITH OLIGOMENORRHEA
V.O. Dynnik, O.O. Dynnik, A.Y. Druzhynina
Reproductive Endocrinology, 2021
PHYSICAL DEVELOPMENT AS A KEY TO THE SUCCESS OF THE FORMATION OF REPRODUCTIVE POTENTIAL
Georgian Medical News, 2020
Echographic features of the pelvis organs in girls with abnormal uterine bleeding depending on the debut of the disease
V. A. Dynnik, A. A Dynnik
Ukrainian Journal of Radiology and Oncology, 2020
Diffusive non-toxic goiter and purbatic course in girls
С. І. Турчина, В. О. Динник
Reproductive Endocrinology, 2019
The relationship between the individual components of the reproductive system and energy metabolic hormones in abnormal uterine bleeding in adolescence
Dynnik V.A. Dynnik, Shcherbina N.A. Shcherbina, Dynnik A.A. Dynnik, , and
Akusherstvo I Ginekologiya Russian Federation, 2018

RECENT SCHOLAR PUBLICATIONS

Stress-induced endocrine changes in adolescent girls with menstrual cycle disorders in under the influence of the war in Ukraine
ВО Диннік, ОГ Верхошанова, ОО Диннік, АЄ Дружиніна, ГО Гавенко, ...
Репродуктивне здоров'я жінки, 38-44 , 2026
2026
Взаємозв’язок енергетичного балансу та продукції гонадотропінів у пацієнтів із аномальними матковими кровотечами
ВО Диннік, ОО Диннік
Український журнал дитячої ендокринології, 68-69 , 2026
2026
Neurotransmitters involvement in the formation of abnormal uterine bleeding against different body weight
ВО Диннік, ОО Диннік
Вісник Харківського національного університету імені ВН Каразіна. Серія … , 2025
2025
HORMONE IMBALANCE AS A MANIFESTATION OF STRESS IN THE FORMATION OF OLIGOMENORRHEA IN TEENAGE GIRLS
В Диннік, О Диннік, С Новохатська
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2025
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