Ehsan Mohammad Hosseini
@sums ac.ir
Neurosurgery
Shiraz university of medical sciences
RESEARCH INTERESTS
Neurovascular
Neurosurgery
Skullbase
Tumor
AVM
aneurysm
Scopus Publications
Scopus Publications
Ehsan Mohammad Hosseini, Nariman Sepehrvand, Mohammad Ghasemi-rad, Ravi Shastri, Mohammad Jamali, Abdolkarim Rahmanian, Adrina Habibzadeh, Reza Taheri, and Saber Zafarshamspour
Elsevier BV
Abdolkarim Rahmanian, Ahmad Salehi, Eskandar Kamali-Sarvestani, Iman Ahrari, Ehsan Mohamadhoseini, Mohammad Jamali, and Sulmaz Ghahramani
Georg Thieme Verlag KG
Abstract Background Intracranial aneurysms are more commonly associated with inflammation as a cause of their development, progression, and rupture. Macrophages and other cells can express the CD68 antigen. The aim of this study was to assess the CD68 antigen levels in cerebral aneurysm (CA) patients compared to a control group at a referral center in Iran. Methods A case-control investigation was undertaken on 88 individuals (44 of whom were cases and 44 were controls). Individuals with CA as the case group consisted of 28 ruptured and 16 unruptured subgroups. Clinical, radiographic, and CD68 levels were evaluated and registered. Results The average age of the participants was 49 years. Males comprised 43.2% of the patients, while 56.8% were females (p = 0.002). There was a statistically significant difference in the CD68 levels between the two groups. There was no significant difference (p = 0.42) between the ruptured and unruptured subgroups (23.66 and 20.47, respectively) in this comparison. No significant correlation was seen between the patients' CD68 and Glasgow Coma Scale (GCS) levels and their aneurysm diameter (p = 0.74 and 0.45, respectively). A link between CD68 levels and age was found, but it was not statistically significant (r = 0.44 and p = 0.002). Conclusions A possible involvement of CD68 as an inflammatory agent in the development of CAs but not in aneurysm rupture has been suggested. Inflammation and CD68 were positively associated with age. The CD68 antigen should be studied further in population-based cohort studies.
Abdolkarim Rahmanian, Nasser Gholijani, Mohammad Salehi, Arash Saffarian, Mohammad Jamali, Keyvan Eghbal, Ehsan Mohammad Hosseini, and Abbas Rakhsha
Turkish Neurosurgical Society
AIM
Determining the screening value of the serum levels of IL-1β in aneurysmal SAH and its association to the severity of initial bleeding.
MATERIAL AND METHODS
It was a case-control study which was conducted in Namazi Hospital affiliated to Shiraz University of Medical Sciences. The study population was included into the patients who referred to the abovementioned hospital in Shiraz with a diagnosis of subarachnoid hemorrhage which had a history of less than 48 hours of the onset of symptoms. The case group was the patients with cerebral aneurysms divided into two groups of raptured and un-raptured brain aneurysms. Our aim was to determine the relationship of IL-1β serum levels with the brain aneurysm. The number of samples in each group was 43 and in total 86 people. 48 hours before the onset of symptoms, and before the surgery, a blood sample was taken to measure the anti- IL-1β antibody in less than 3 hours, the serum was isolated and placed in a -80 °C freezer.
RESULTS
Fisher\\'s average grading was 0 in the patients with unruptured aneurysm, while the most of ruptured aneurysm was 3. MCA with 10 cases (23%) was the most site of aneurysms followed by A.COM with 9 cases (20%). There was significant correlation between ruptured aneurysm and the GCS scores (p = 0.01), and also with the fisher classification (P = 0.04). There was no significant difference among the serum levels of IL-1β in patients with ruptured and un-ruptured aneurysms. There was a significant difference among the serum levels of IL-1β in our patients with control group. (P = 0.04) Conclusion: The knowledge of the association between the inflammatory cascades and aneurysm formation may have significant clinical consequences and will be the goal of future treatments. Our outcome indicates a significant correlation between IL-1β levels and outcome following aneurysmal SAH, dependent of initial hemorrhage.
Ehsan Mohammad Hosseini, Alireza Rasekhi, Keyvan Eghbal, Abdolkarim Rahmanian, Arash Saffarrian, Abbas Rakhsha, Sulmaz Ghahramani, and Mohammad Jamali
Briefland
Introduction: Spinal dural arteriovenous fistulas (SDAVFs) are characterized by an abnormal connection between a spinal radicular artery and a perimedullary vein, mainly fed by a radicular artery at the nerve root sleeve. Case Presentation: Here, we describe the case of a 40-year-old woman, presenting with progressive weakness of the lower extremities and the sphincter. Thoracic magnetic resonance imaging (MRI) showed spinal cord edema and signal voids on the dorsal surface of the cord. Spinal angiography demonstrated a SDAVF with a nidus at the sacral level; the feeder of the arteriovenous fistula was a lateral sacral artery, as a branch of the internal iliac artery. The lateral sacral artery was subselectively catheterized, and SDAVF was embolized with 25% n-butyl cyanoacrylate (NBCA) glue (glue: lipiodol ratio, 1:3). Conclusion: After embolization, no definite residual connection was visualized between the arterial and venous systems.
A.R. Aminsharifi, T. Talaei, V. Kumar, B. Sabayan, S. Samani, and E. Mohamadhoseini
Elsevier BV