Eszter Lakatos

@chalmers.se

Assistant Professor, Department of Mathematical Sciences
Chalmers University of Technology

Eszter Lakatos


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https://researchid.co/elakatos
I am a computational biologist passionate about applying quantitative techniques to understand the biological principles governing disease in order to improve clinical decision making. I am particularly interested in uncovering how cancers evolve using next-generation sequencing datasets.

EDUCATION

2017 - Ph.D. in Theoretical Systems Biology - Imperial College London
Supervisor: Prof Michael P.H. Stumpf
2013 - M.Sc. of Infobionics Engineer - Pázmány Péter Catholic University
Grade: honours, Average: 5.0/5.0

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Cancer Research, Applied Mathematics
1528

Scholar Citations

15

Scholar h-index

20

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Bridging Mechanism and Data: Hybrid Modeling Approaches for Cancer and Aging Research
    L Eriksson, H Häggström, E Lakatos, A Polster, M Cvijovic
    Current Opinion in Systems Biology, 100573 , 2026
    2026
  • Sensitive detection of copy number alterations in low-pass liquid biopsy sequencing data
    L Eriksson, E Lakatos
    Briefings in Bioinformatics 27 (2), bbag111 , 2026
    2026
  • Timing and mechanisms of immune evasion in colorectal cancers
    E Lakatos
    NATURE GENETICS , 2025
    2025
  • Epigenetically driven and early immune evasion in colorectal cancer evolution
    E Lakatos, V Gunasri, L Zapata, J Househam, T Heide, N Trahearn, ...
    Nature Genetics, 1-11 , 2025
    2025
    Citations: 15
  • Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma
    M Barroux, J Househam, E Lakatos, T Ronel, AM Baker, H Salié, ...
    Nature Cancer 6 (5), 820-837 , 2025
    2025
    Citations: 13
  • Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
    H Hockings, E Lakatos, W Huang, M Mossner, MA Khan, N Bakali, ...
    Cancer Research , 2025
    2025
    Citations: 38
  • Abstract SY43-01: Translating adaptive therapy to ovarian cancer patients
    MA Khan, H Hockings, M Mossner, AM Baker, H Amy, RL Hollis, W Huang, ...
    Cancer Research 85 (8_Supplement_2), SY43-01-SY43-01 , 2025
    2025
  • Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project
    M Ní Leathlobhair, A Frangou, B Kinnersley, AJ Cornish, D Chubb, ...
    Nature Communications 15 (1), 9247 , 2024
    2024
    Citations: 17
  • The genomic landscape of 2,023 colorectal cancers
    AJ Cornish, AJ Gruber, B Kinnersley, D Chubb, A Frangou, G Caravagna, ...
    Nature 633 (8028), 127-136 , 2024
    2024
    Citations: 193
  • Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
    H Kayhanian, W Cross, SEM van der Horst, P Barmpoutis, E Lakatos, ...
    Nature Genetics 56 (7), 1420-1433 , 2024
    2024
    Citations: 27
  • Lower incidence of small intestinal adenocarcinomas may be due to constrained copy number karyotype and increased immune surveillance
    S Nowinski, V Balarajah, AM Baker, R Katainen, C Hughes, Q Guo, ...
    CANCER RESEARCH 84 (3) , 2024
    2024
  • Long deletion signatures in repetitive genomic regions track somatic evolution and enable sensitive detection of microsatellite instability
    Q Guo, J Househam, E Lakatos, S Nowinski, I Al Bakir, H Grant, ...
    bioRxiv, 2024.10. 03.616572 , 2024
    2024
    Citations: 4
  • Spatially resolving the dynamics of immunoediting in advanced colorectal cancer
    V Gunasri, N Trahearn, E Lakatos, J Househam, T Heide, GD Cresswell, ...
    JOURNAL OF PATHOLOGY 261, S29-S29 , 2023
    2023
  • O44 Co-evolution of mismatch repair loss and the immune response in Lynch Syndrome
    O Swinyard, AM Baker, K Monahan, M Jansen, C Gabbutt, C Kimberley, ...
    Gut 72 (Suppl 2), A25-A26 , 2023
    2023
    Citations: 1
  • 253e IMMUNE EDITING IN THE INVASIVE MARGIN AND NODE DEPOSITS OF COLORECTAL CANCER SELECTS FOR CELLULAR NEIGHBOURHOODS ENRICHED IN PDL1+ CANCER CELLS
    V Gunasri, E Lakatos, N Trahearn, L Cisneros, J Househam, T Heide, ...
    Gastroenterology 164 (6), S-1569 , 2023
    2023
  • Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
    L Zapata, G Caravagna, MJ Williams, E Lakatos, K AbdulJabbar, ...
    Nature Genetics 55 (3), 451-460 , 2023
    2023
    Citations: 83
  • Phenotypic plasticity and genetic control in colorectal cancer evolution
    J Househam, T Heide, GD Cresswell, I Spiteri, C Kimberley, L Zapata, ...
    Nature, 1-10 , 2022
    2022
    Citations: 195
  • The co-evolution of the genome and epigenome in colorectal cancer
    T Heide, J Househam, GD Cresswell, I Spiteri, C Lynn, M Mossner, ...
    Nature, 1-11 , 2022
    2022
    Citations: 133
  • The mutational signatures of formalin fixation on the human genome
    Q Guo, E Lakatos, IA Bakir, K Curtius, TA Graham, V Mustonen
    Nature communications 13 (1), 1-14 , 2022
    2022
    Citations: 132
  • Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
    C Gabbutt, RO Schenck, DJ Weisenberger, C Kimberley, A Berner, ...
    Nature biotechnology 40 (5), 720-730 , 2022
    2022
    Citations: 72

MOST CITED SCHOLAR PUBLICATIONS

  • Phenotypic plasticity and genetic control in colorectal cancer evolution
    J Househam, T Heide, GD Cresswell, I Spiteri, C Kimberley, L Zapata, ...
    Nature, 1-10 , 2022
    2022
    Citations: 195
  • The genomic landscape of 2,023 colorectal cancers
    AJ Cornish, AJ Gruber, B Kinnersley, D Chubb, A Frangou, G Caravagna, ...
    Nature 633 (8028), 127-136 , 2024
    2024
    Citations: 193
  • NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline
    RO Schenck, E Lakatos, C Gatenbee, TA Graham, ARA Anderson
    BMC bioinformatics 20 (1), 1-6 , 2019
    2019
    Citations: 146
  • Evolutionary dynamics of neoantigens in growing tumors
    E Lakatos, MJ Williams, RO Schenck, WCH Cross, J Househam, L Zapata, ...
    Nature genetics 52 (10), 1057-1066 , 2020
    2020
    Citations: 141
  • The co-evolution of the genome and epigenome in colorectal cancer
    T Heide, J Househam, GD Cresswell, I Spiteri, C Lynn, M Mossner, ...
    Nature, 1-11 , 2022
    2022
    Citations: 133
  • The mutational signatures of formalin fixation on the human genome
    Q Guo, E Lakatos, IA Bakir, K Curtius, TA Graham, V Mustonen
    Nature communications 13 (1), 1-14 , 2022
    2022
    Citations: 132
  • Multivariate moment closure techniques for stochastic kinetic models
    E Lakatos, A Ale, PDW Kirk, MPH Stumpf
    The Journal of chemical physics 143 (9), 094107 , 2015
    2015
    Citations: 107
  • Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
    L Zapata, G Caravagna, MJ Williams, E Lakatos, K AbdulJabbar, ...
    Nature Genetics 55 (3), 451-460 , 2023
    2023
    Citations: 83
  • Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues
    C Gabbutt, RO Schenck, DJ Weisenberger, C Kimberley, A Berner, ...
    Nature biotechnology 40 (5), 720-730 , 2022
    2022
    Citations: 72
  • Transition state characteristics during cell differentiation
    RD Brackston, E Lakatos, MPH Stumpf
    PLoS computational biology 14 (9), e1006405 , 2018
    2018
    Citations: 71
  • Immunosuppressive niche engineering at the onset of human colorectal cancer
    CD Gatenbee, AM Baker, RO Schenck, M Strobl, J West, MP Neves, ...
    Nature Communications 13 (1), 1798 , 2022
    2022
    Citations: 59
  • Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control
    H Hockings, E Lakatos, W Huang, M Mossner, MA Khan, N Bakali, ...
    Cancer Research , 2025
    2025
    Citations: 38
  • Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer
    H Kayhanian, W Cross, SEM van der Horst, P Barmpoutis, E Lakatos, ...
    Nature Genetics 56 (7), 1420-1433 , 2024
    2024
    Citations: 27
  • MEANS: python package for Moment Expansion Approximation, iNference and Simulation
    S Fan, Q Geissmann, E Lakatos, S Lukauskas, A Ale, AC Babtie, ...
    Bioinformatics 32 (18), 2863-2865 , 2016
    2016
    Citations: 19
  • Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project
    M Ní Leathlobhair, A Frangou, B Kinnersley, AJ Cornish, D Chubb, ...
    Nature Communications 15 (1), 9247 , 2024
    2024
    Citations: 17
  • Epigenetically driven and early immune evasion in colorectal cancer evolution
    E Lakatos, V Gunasri, L Zapata, J Househam, T Heide, N Trahearn, ...
    Nature Genetics, 1-11 , 2025
    2025
    Citations: 15
  • LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations
    E Lakatos, H Hockings, M Mossner, W Huang, M Lockley, TA Graham
    Iscience 24 (8) , 2021
    2021
    Citations: 14
  • Evolutionary and immune microenvironment dynamics during neoadjuvant treatment of esophageal adenocarcinoma
    M Barroux, J Househam, E Lakatos, T Ronel, AM Baker, H Salié, ...
    Nature Cancer 6 (5), 820-837 , 2025
    2025
    Citations: 13
  • Topology of interaction between titin and myosin thick filaments
    M Kellermayer, D Sziklai, Z Papp, B Decker, E Lakatos, Z Mártonfalvi
    Journal of structural biology 203 (1), 46-53 , 2018
    2018
    Citations: 11
  • Control mechanisms for stochastic biochemical systems via computation of reachable sets
    E Lakatos, MPH Stumpf
    Royal Society Open Science 4 (8) , 2017
    2017
    Citations: 11