Elena Curto Sanchez
@santpau.cat
Scopus Publications
- What Patients With Asthma Share When No One Listens: Multimethod Observational Study of Patient Narratives on Reddit
Elena Curto-Sánchez, Gabriela Salazar-Palacios, Ana Martín-Varillas, Estela Cristina Prieto-Maíllo, Jacinto Ramos-González, et al.
Journal of Medical Internet Research, 2026
Background The use of social media platforms, such as Reddit, to seek and share information about disease management and treatment strategies is increasingly common. In the context of asthma—a chronic condition characterized by limiting symptoms and exacerbations that require active patient engagement and adherence to treatment—there is a lack of research describing the content of Reddit posts and the specific topics of interest to patients. Objective This study aimed to describe the topics discussed by users on the Reddit asthma forum and identify the sentiments and polarity of the language used in the posts. Methods A retrospective observational study of public posts on the asthma subreddit forum (r/Asthma) over a 1-year period (October 2023-October 2024). All posts and related threads were included, subdivided into hot, news, and top, and those voted “up” or “down,” those that received “awards,” categorized as “golds.” The messages were reviewed manually and excluded if they were not related to asthma. A mixed methods analysis was conducted, comprising (1) analysis using text lemmatization, (2) structural topic modeling to identify topics based on word frequency, and (3) sentiment and polarity analysis. This approach aimed to identify the most frequently used topics on Reddit, detect positive and negative sentiments based on the words used, and acceptance or rejection (polarity) based on the language used in the asthma subreddit. Statistical analyses were performed using R software (version 4.1.3; R Foundation for Statistical Computing), with a significance threshold set at P<.05. Results After removing duplicates, 7806 posts were identified. The suitability of the chosen analysis model was confirmed, as it presented the best balance between exclusivity and semantic coherence. Clusters of 25 topics were identified and distributed according to their weight. The topics with the highest weight were Topic 7 (Symptoms and severity of asthma attacks) and Topic 18 (Causes of asthma). No significant differences were found in the evolution of emerging topics throughout the year except in Topic 20 (Seeking advice from people with asthma; P=.04), Topic 21 (Medical tests that should be reviewed periodically; P=.04), and Topic 22 (Times of year when attacks occur; P=.03). The proportion of feelings and emotions showed a stable trend throughout the year. Discrepancies in feelings and emotions were identified depending on the dictionaries used. Thus, a higher probability of positive feelings was confirmed in the AFINN lexicon. Meanwhile, negative feelings were significant in the Stanford Natural Language Processing, Bing, and National Research Council Canada lexicons. Conclusions These results can serve as a guide to identify hidden patient needs and help professionals develop specific interventions on topics relevant to patients. - Identification of Dual Super-Response in Patients With Asthma and CRSwNP Treated With Mepolizumab
Miguel Estravís, David Carreiras-Quintas, Juan Triviño, Jacqueline Pérez-Pazos, María Gil-Melcón, et al.
Journal of Investigational Allergology and Clinical Immunology, 2026
Background: Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are both type 2 (T2) inflammatory diseases that frequently co-occur and are interconnected through shared immunological pathways. The anti–IL-5 monoclonal antibody mepolizumab has shown efficacy in reducing eosinophilic inflammation and improving clinical outcomes. However, the molecular mechanisms underlying response to treatment, particularly at the transcriptomic level, remain underexplored. We aimed to investigate peripheral blood transcriptomic changes and identify potential biomarkers associated with dual super-response to mepolizumab in patients with severe asthma and CRSwNP. Methods: The study population comprised 29 participants (19 patients with severe asthma and CRSwNP and 10 healthy controls). Whole blood RNA sequencing was performed before and after treatment with mepolizumab in 6 patients, followed by validation of candidate genes using qPCR. Clinical responses were assessed using the FEOS score (FEV1, exacerbations, oral corticosteroids, symptoms) and lung function measurements, and the 22-item Sino-Nasal Outcome Test (SNOT-22) score. Results: Mepolizumab significantly improved clinical parameters, including exacerbation rates, asthma control, and the SNOT-22 score. Transcriptomic analysis identified 156 differentially expressed genes after treatment with mepolizumab, significantly enriching immune and inflammatory pathways. Twelve candidate genes were studied. Three of these genes (PNPLA1, C3AR1, and RGS1) were validated as potential predictors of super-response to treatment of asthma and CRSwNP. Baseline expression levels of RGS1 were associated with dual super-response in asthma and CRSwNP. Conclusion: This study provides new insights into transcriptomic changes following mepolizumab treatment and highlights RGS1 as a potential biomarker for predicting dual super-response in asthma and CRSwNP. Our findings contribute to precision medicine approaches and support the identification of optimal candidates for anti–IL-5 therapy. - FEV1Q as a Predictive Metric for Asthma Outcomes
Diana Betancor, Jose Maria Olaguibel, Victoria del Pozo, Maria Jose Alvarez Puebla, Ebymar Arismendi, et al.
Archivos De Bronconeumologia, 2025 - Stability of Asthma Phenotypes in the Spanish Cohort of the MEGA Project
MJ Rial, D Betancor, JA Cañas, JM Olaguibel, JM Rodrigo-Muñoz, et al.
Journal of Investigational Allergology and Clinical Immunology, 2025 - Parasympathetic nervous system: A key role in control and mood disorders in patients with asthma
Lorena Soto-Retes, Javier Milagro, Astrid Crespo-Lessmann, Elena Curto, Éder F. Mateus Medina, et al.
Annals of Allergy Asthma and Immunology, 2024 - The discrepancy in bronchodilator response between ATS/ERS 2021 and 1991 criteria
Diana Betancor, Blanca Barroso, Marcela Valverde-Monge, Alicia Gomez-Lopez, Joaquin Sastre, et al.
Respiratory Medicine, 2024 - Asthma
Celia Pinedo Sierra, Elena Curto Sánchez, Rocio Diaz Campos, Tamara Hermida Valverde, Silvia Sánchez-Cuellar, et al.
Open Respiratory Archives, 2024 - Clinical and functional characteristics, possible causes, and impact of chronic cough in patients with cerebellar ataxia, neuropathy, and bilateral vestibular areflexia syndrome (CANVAS)
Esther Palones, Elena Curto, Vicente Plaza, Lidia Gonzalez-Quereda, Alba Segarra-Casas, et al.
Journal of Neurology, 2024
Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is an hereditary autosomal recessive disease. Recent studies propose including chronic cough (CC) as a symptom of CANVAS. For 10 patients with CANVAS as genetically confirmed by biallelic expansion of the AAGG repeat motif (AAGGGexp) in intron 2 of replication factor C subunit 1 (RFC1), our aim was, as a multidisciplinary team, to describe clinical and functional characteristics and possible causes of CC following European Respiratory Society (ERS) recommendations, and to evaluate CC impact on quality of life (QoL) using self-administered questionnaires (Cough Severity Diary, Leicester Cough Questionnaire, Discrete Emotions Questionnaire, and EQ-5D-5L). In all 10 patients, the CC was a dry cough that developed several years prior to the neurological symptoms (mean 14.2 years); 7 patients had symptoms compatible with gastroesophageal reflux (GER), 5 with pathological GER diagnosed by 24-h esophageal pH testing, and 6 patients had impaired esophageal motility diagnosed by high-resolution esophageal manometry, most frequently ineffective peristalsis. Although further studies are required for confirmation, we conclude that CC may be a characteristic prodrome of CANVAS and may be related to GER and esophageal disorders. Furthermore, CC affects patients’ QoL, especially in the psychosocial sphere. - Erratum to “Iatrogenic Adrenal Insufficiency Following Post COVID-19 Organizing Pneumonia” [Archivos de Bronconeumologia 59 (2023) 63–65, (S0300289622004975), (10.1016/j.arbres.2022.07.011)]
Esther Palones, Elena Curto, Anna Pelegrí, Marina Arilla, Ingrid Solanes, et al.
Archivos De Bronconeumologia, 2024 - Global Lung Initiative as Diagnostic Criteria in Asthma-COPD Overlap Syndrome: Prevalence and Disease Characterization in a Real-Life Asthma Cohort
D Betancor, M Otal, JM Olaguibel, JM Rodrigo-Muñoz, MJ Alvarez Puebla, et al.
Journal of Investigational Allergology and Clinical Immunology, 2024 - Disposition of Work-Related Asthma in a Spanish Asthma Cohort: Comparison of Asthma Severity Between Employed and Retired Workers
Christian Romero-Mesones, Maria-Jesus Cruz, Isam Alobid, Blanca Barroso, Ebymar Arismendi, et al.
Journal of Allergy and Clinical Immunology in Practice, 2023 - The New ERS/ATS 2022 Bronchodilator Response Recommendation: Comparison With the Previous Version in an Asthma Cohort
Diana Betancor, Carlos Villalobos-Vilda, José María Olaguibel, José Manuel Rodrigo-Muñoz, María Jose Alvarez Puebla, et al.
Archivos De Bronconeumologia, 2023 - Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis
Marcos Matabuena, Francisco Javier Salgado, Juan José Nieto-Fontarigo, María J. Álvarez-Puebla, Ebymar Arismendi, et al.
Archivos De Bronconeumologia, 2023 - Clinical Impact of Electronic Monitoring Devices of Inhalers in Adults with Asthma or COPD: A Systematic Review and Meta-Analysis
Noe Garin, Borja Zarate-Tamames, Laura Gras-Martin, Raimon Milà, Astrid Crespo-Lessmann, et al.
Pharmaceuticals, 2023 - Corrigendum to: Characteristics of Induced-Sputum Inflammatory Phenotypes in Adults with Asthma: Predictors of Bronchial Eosinophilia (J Asthma Allergy. 2023, 16, 95–103.)
Astrid Crespo-Lessmann, Elena Curto, Eder Freddy Mateus Medina, Esther Palones, Alicia Belda Soler, et al.
Journal of Asthma and Allergy, 2023 - Iatrogenic Adrenal Insufficiency Following Post COVID-19 Organizing Pneumonia
Esther Palones, Elena Curto, Anna Pelegrí, Marina Arilla, Ingrid Solanes, et al.
Archivos De Bronconeumologia, 2023 - Characteristics of Induced-Sputum Inflammatory Phenotypes in Adults with Asthma: Predictors of Bronchial Eosinophilia
Astrid Crespo-Lessmann, Elena Curto, Eder Freddy Mateus Medina, Esther Palones, Alicia Belda Soler, et al.
Journal of Asthma and Allergy, 2023 - Improvement in Olfaction in Patients With CRSwNP and Severe Asthma Taking Anti-IgE and Anti–IL-5 Biologics: A Real-Life Study
B Barroso, M Valverde-Monge, I Alobid, JM Olaguibel, MJ Rial, et al.
Journal of Investigational Allergology and Clinical Immunology, 2023 - Reply to “Olfactory Function and Biologic Treatments: A Comment on Available Real-life Studies”
B Barroso, M Valverde-Monge, I Alobid, JM Olaguibel, MJ Rial, et al.
Journal of Investigational Allergology and Clinical Immunology, 2023 - Exacerbations Among Patients With Asthma Are Largely Dependent on the Presence of Multimorbidity
J Domínguez-Ortega, JA Luna-Porta, JM Olaguibel, P Barranco, E Arismendi, et al.
Journal of Investigational Allergology and Clinical Immunology, 2023 - Lung Function Abnormalities and Their Correlation With Clinical Characteristics and Inflammatory Markers in Adult Asthma
C Betancor, JM Olaguibel, JM Rodrigo-Muñoz, MJ Alvarez Puebla, E Arismendi, et al.
Journal of Investigational Allergology and Clinical Immunology, 2023 - Identification of Two Eosinophil Subsets in Induced Sputum from Patients with Allergic Asthma According to CD15 and CD66b Expression
Elena Curto, Éder F. Mateus-Medina, Astrid Crespo-Lessmann, Rubén Osuna-Gómez, Cristina Ujaldón-Miró, et al.
International Journal of Environmental Research and Public Health, 2022 - How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?
Diana Betancor, José María Olaguibel, José Manuel Rodrigo‐Muñoz, Ebymar Arismendi, Pilar Barranco, et al.
Clinical and Translational Allergy, 2022 - Add-on inhaled budesonide in the treatment of hospitalised patients with COVID-19: a randomised clinical trial
Alvar Agustí, Gaston De Stefano, Alberto Levi, Xavier Muñoz, Christian Romero-Mesones, et al.
European Respiratory Journal, 2022 - Anxiety and body mass index affect asthma control: data from a prospective Spanish cohort
Leyre Baptista-Serna, José Manuel Rodrigo-Muñoz, Pablo Mínguez, Marcela Valverde-Monge, Ebymar Arismendi, et al.
Journal of Allergy and Clinical Immunology in Practice, 2022 - How to Approach Non Eosinophilic Asthma? Results of a Survey Conducted by the SEPAR Emerging Asthma Group
Elena Curto Sánchez, Íñigo Ojanguren Arranz, Marina Blanco-Aparicio, Astrid Crespo-Lessmann, Vicente Plaza Moral, et al.
Open Respiratory Archives, 2022 - Association of the CFTR gene with asthma and airway mucus hypersecretion
Astrid Crespo-Lessmann, Sara Bernal, Elisabeth del Río, Ester Rojas, Carlos Martínez-Rivera, et al.
Plos One, 2021 - Therapeutic Adherence of COPD Patients According to the Involvement Levels in Health Education in their Centers
Vicente Plaza, Carmen Fernández, Elena Curto, M. Bel, n Alonso-Ortiz, et al.
Archivos De Bronconeumologia, 2021 - Therapeutic adherence of COPD patients according to levels of involvement in health education in their sites
Vicente Plaza, Carmen Fernández, Elena Curto, M. Belén Alonso-Ortiz, Miren Itxaso Orue, et al.
Archivos De Bronconeumologia, 2021 - Reply to “Managing T2-high severe asthma in HIV-infected patients”
Elena Curto, Alfons Torrego, Noe Garin, Astrid Crespo-Lessmann, Vicente Plaza
Journal of Allergy and Clinical Immunology in Practice, 2021 - Assessing adherence by combining the test of adherence to inhalers with pharmacy refill records
V Plaza, J Giner, E Curto, MB Alonso-Ortiz, MI Orue, et al.
Journal of Investigational Allergology and Clinical Immunology, 2021 - Clinical characteristics in 545 patients with severe asthma on biological treatment during the COVID-19 outbreak
Manuel Jorge Rial, Marcela Valverde, Victoria del Pozo, Francisco Javier González-Barcala, Carlos Martínez-Rivera, et al.
Journal of Allergy and Clinical Immunology in Practice, 2021 - HIV-infected patient with severe asthma treated with mepolizumab: Case report
Elena Curto, Alfons Torrego, Noe Garin, Astrid Crespo-Lessmann, Vicente Plaza
Journal of Allergy and Clinical Immunology in Practice, 2020 - Determinants and Differences in Satisfaction with the Inhaler Among Patients with Asthma or COPD
Vicente Plaza, Jordi Giner, Elena Curto, M. Belén Alonso-Ortiz, Miren Itxaso Orue, et al.
Journal of Allergy and Clinical Immunology in Practice, 2020 - Total and specific immunoglobulin e in induced sputum in allergic and non-allergic asthma
Astrid Crespo-Lessmann, Elena Curto, Eder Mateus, Lorena Soto, Alba García-Moral, et al.
Plos One, 2020 - Pulmonary eosinophilia associated to treatment with natalizumab
MMarisol Dominguez-Alvarez, Elena Curto, Elvira Munteis-Olivas, Eva Balcells
Annals of Thoracic Medicine, 2016
