Emmanuel Saviour Saheed
@kwasu.edu.ng
Research Assistant, Department of Biochemistry
Kwara State University
Emmanuel is a dedicated Biochemist and Molecular Biologist with a passion for discovery and cross-cultural engagement, excelling in dynamic, multidisciplinary team environment
I am curious to understand the roles of proteins in pathophysiology. My previous research have given me the basic information that targeted protein (membrane receptors, enzymes, ion channels and transporter proteins) are innovative methods of drug discovery.
During my undergraduate years I conducted a research titled Effect of phenolic and alkaloid extract of Senna occidentalis leaf on the oxidative status of the heart in high fat-diet streptozotocin-induced type 2 diabetic Wistar rats. This experience made me understand that biomarkers, protein folding and interactions play significant roles in mechanisms leading to healthy and diseased states.
I want to conduct a translational research where I can use my findings to pave way for innovate therapies to bring hope to countless lives suffering from cancer
EDUCATION
BSc. Biochemistry, Kwara State University, Malete, Nigeria.
Associate Degree in Science, Ahmadu Bello University, Zaria, Nigeria.
RESEARCH, TEACHING, or OTHER INTERESTS
Cancer Research, Biochemistry, Genetics and Molecular Biology, Cell Biology, Structural Biology
FUTURE PROJECTS
Cancer Biology, Molecular Biology, Structural Biology, and Computational Biology
Cancer is a disease caused by uncontrollable division of abnormal cells within the body leading to the damage of body tissue. The fusion of the divided abnormal cells leads to the formation of tumor. Overtime the tumor grows bigger at the site of formation and moves to other parts of the body, this process is known as metastasis. Cancer is a complex and life-threatening disease which has killed and keeps killing millions of people around the world. Bioactive compounds are chemical substances derived from plants and certain food. Previous research has made it known that specific bioactive compounds posses anticancer properties. Considering all aforementioned facts, I am fascinated to conduct an interdisciplinary research to understand the cellular and molecular pathways that occurs from the onset of cancer to metastasis. I am also interested to discover novel and effective anticancer bioactive compounds.
Applications Invited
Fully Funded Biomedical Sciences (Cancer Biology) PhD Program
Scopus Publications
Scopus Publications
Mutiat A. Abdulkareem, Bunmi A. Owolabi, Emmanuel S. Saheed, Remilekun F. Aromolaran, Rukayat M. Bashiru, Toheeb A. Jumah, Doris U. Chijioke, Onyinyechi J. Amaechi, Fehintoluwa C. Adeleke, Omiyale O. Charles,et al.
Springer Science and Business Media LLC
AbstractThis review article gives an insight into the genetic factors and the role of pancreatic amylase in type 2 diabetes (T2D). Diabetes is a non-communicable, multifactorial, heritable, complex, and irreversible disease of public health burden with a global prevalence rate of 6.28%, about 6% in sub-Saharan Africa, and 1.7% in Nigeria. T2D is recognized as the ninth leading cause of mortality worldwide. This disease is yet to be diagnosed in a significant number of people who live with it in underdeveloped and developing countries like Nigeria due to the lack of free or subsidized access to health care, especially medical checkups, inadequate health facilities, government policies, and negligence. Consequently, undiagnosed cases of T2D have contributed to the prevalence of this disease and its comorbidities -hypertension and chronic kidney disease. Obesity, age, race and ethnicity, inactivity, family history, underlying illness, and unhealthy diets are prominent undisputable predisposing factors of T2D. Pancreatic amylase is a type of amylase produced in the pancreas, known to hydrolyze starch and prone to mutations, but most of the genetic components, causative polymorphisms, and affected genes are yet unknown. Even as insulin secretion is found to be influenced by the loci, the causation of T2D cannot be inferred. Pancreatic amylase was observed to be the most relevant digestive enzyme, whose role is to bind to glycoprotein N-glycan to activate starch digestion. In a malfunctioning pancreas, little or no insulin is generated to keep the blood glucose at an appropriate level, thereby resulting in T2D.
RECENT SCHOLAR PUBLICATIONS
INDUSTRY EXPERIENCE
Rajab limited pharmaceutical Industry, Ilorin, Kwara State
Internship (Quality Control Officer)
1. I performed laboratory analyses of raw materials for drug production as well as intermediate and finished products.
2. I engaged in lab rotation in different units of the organization and documented all records of analytical results.
3. I carried out water analyses on the water to be used for drug production and monitored the industrial effluent treatment at regular intervals.
SOCIAL, ECONOMIC, or ACADEMIC BENEFITS
1. Ambassador of the Nigerian Society of Biochemistry Students (NSBS), Kwara State University (2018-2019).
2. Best Graduating Student Centre for Entrepreneurship
Enterprise Creation and Skills Acquisition Programme, Kwara State University (2018-2019).
3. Outstanding performance in Social Entrepreneurship, Kwara State University (2018).