Eniola Risikat Kadir

@unilorin.edu.ng

Senior Assistant Professor, Faculty of Basic Medical Sciences
Senior Assistant Professor, Others
University of Ilorin

https://researchid.co/eniolakadir

RESEARCH, TEACHING, or OTHER INTERESTS

Developmental Biology, Endocrinology, Molecular Biology, Obstetrics and Gynecology

Scopus Publications

236

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

A training program improves poor first aid knowledge and skills among primary school teachers in Ibadan, Nigeria
Abdulmumin Ibrahim, Nadia Adjoa Sam-Agudu, Sadiya Musa Gwadabe, Risikat Eniola Kadir, Boniface Ayanbekongshie Ushie, Adesola Oluwafunmilola Olumide, and Oyeyemi Olufemi-Julius Omotade
Pan African Medical Journal

Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Parkinson’s disease model
Fatimo Ajoke Sulaimon, Ruqayyah Yetunde Ibiyeye, Aminu Imam, Aboyeji Lukuman Oyewole, Abubakar Lekan Imam, Monsur Shehu, Sikiru Abayomi Biliaminu, Risikat Eniola Kadir, Gabriel Olaiya Omotoso, and Moyosore Salihu Ajao
Korean Association of Anatomists
Parkinson’s disease (PD) affects about 8.5 million individuals worldwide. Oxidative and inflammatory cascades are implicated in the neurological sequels, that are mostly unresolved in PD treatments. However, proper nutrition offers one of the most effective and least costly ways to decrease the burden of many diseases and their associated risk factors. Moreover, prevention may be the best response to the progressive nature of PD, thus, the therapeutic novelty of honey and levodopa may be prospective. This study aimed to investigate the neuroprotective role of honey and levodopa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced oxidative stress. Fifty-four adult male Swiss mice were divided into control and PD model groups of 27 mice. Each third of the control mice either received phosphate buffered saline, honey, or levodopa for 21 days. However, each third of the PD models was either pretreated with honey and levodopa or not pretreated. Behavioral studies and euthanasia were conducted 2 and 8 days after MPTP administration respectively. The result showed that there were significantly (P<0.05) higher motor activities in the PD models pretreated with the honey as well as levodopa. furthermore, the pretreatments protected the midbrain against the chromatolysis and astrogliosis induced by MPTP. The expression of antioxidant markers (glutathione [GSH] and nuclear factor erythroid 2-related factor 2 [Nrf2]) was also significantly upregulated in the pretreated PD models. It is thus concluded that honey and levodopa comparably protected the substantia nigra pars compacta neurons against oxidative stress by modulating the Nrf2 signaling molecule thereby increasing GSH level to prevent MPTP-induced oxidative stress.

MORINGA OLEIFERA (MOF6) AND MUSA SAPIENTUM (MSF1) AMELIORATED 7,12-DIMETHYLBENZ[A]ANTHRACENE-INDUCED SKIN HISTO-PATHOLOGY, INFLAMMATION, HEPATIC OXIDATIVE STRESS AND MUTAGENESIS IN RATS

Morinda lucida and Annona muricata reduced hepatic lipid peroxidation and promoted melatonin/TNFα/p53-mediated apoptosis in sodium arsenite-induced toxicity in rats
Adelaja Akinlolu, Adeoye Oyewopo, Risikat Kadir, Mubarak Ameen, Victor Owoniyi, Fauzeeyah Adam, and Shukrat Okeleye
Loki & Dimas
Arsenic-induced carcinogenesis can result in cancers of the liver in exposed organisms. This study evaluated anticancer potentials of MLF1 and AMF1 extracted from Morinda lucida and Annona muicata leaves respectively in Sodium arsenite (SA)-induced toxicity in rats. Sixty adult female rats were randomly divided into 12 groups (n = 5). Group 1 was control. Group 2 received 5-weeks administrations of 10 mg/kg bodyweight of SA. Groups 3-6 received SA-dose for 2 weeks followed by 3-weeks posttreatments with MLF1-doses and AMF1-doses respectively. Groups 7-10 received only 5-weeks administrations of MLF1-doses and AMF1- doses respectively. Groups 11 and 12 received 5-weeks co-administrations of SA-dose with highdoses of MLF1 and AMF1 respectively. Drugs/ extracts were administered orally. Liver histopathology (Heamatoxylin and Eosin) and ELISA concentrations of sera Melatonin and TNF-alpha were evaluated. Malondialdehyde (thiobarbituricacid assay) and p53 (ELISA) levels were evaluated in liver homogenates. Data were statistically analysed. Results showed normal liver histology in Groups 1-12. Post-treatments of SA-induced toxicity with MLF1 and AMF1 resulted in significant (P≤0.05) and non-significant decreased levels (P≥0.05) of Malondialdehyde, TNF-alpha and p53, but significant (P≤0.05) and non-significant increased Melatonin levels (P≥0.05) in Groups 3-12 compared with Group 2. MLF1 and AMF1 possess anticancer, antioxidant, pro-Melatonin, anti-inflammatory and hepato-protective potentials.

Anticancer potentials of Morinda lucida and Annona muricata on Ki67 and Multidrug resistance1 genes expressions in Sodium arsenite-induced hepato-toxicity in rats
Adelaja A. Akinlolu, Temitope Omohimoria, Adeoye Oyewopo, Risikat E. Kadir, Mubarak O. Ameen, Olivia Ahialaka, and Simisola Ogunfowora
Acta Pharmaceutica Sciencia

Author’s reply
Risikat Eniola Kadir, Abdulmumin Ibrahim, Balkis Abimbola Ibrahim, Sadiya Musa Gwadabe, Rukayat Sulaiman-Jaji, Munirat Foyeke Adigun, and Adeoye Oyetunji Oyewopo
Knowledge E
This is a Reply Letter and does not have an abstract. Please download the PDF or view the article HTML.

Low dose bitter leaf improves sperm quality disrupted in immunosuppressed wistar rats: An experimental study
Risikat Eniola Kadir, Abdulmumin Ibrahim, Balkis Abimbola Ibrahim, Sadiya Musa Gwadabe, Rukayat Jaji-Sulaimon, Munirat Foyeke Adigun, and Adeoye Oyetunji Oyewopo
Knowledge E
Background: Synthetic prednisolone (PRED) is a widely used over-the-counter glucocorticoid. Glucocorticoids have inhibitory effects on the immune system and are often used as immunosuppressive agents. Suppressed immunity may impact fertility via the hypothalamic-pituitary-adrenal axis. Bitter leaf (BL) has been shown to improve sperm parameters, but its effects on immunosuppression-associated infertility have not yet been documented. Objective: To determine the fertility effects of bitter leaf on immunosuppressed Wistar rats. Materials and Methods: A total of 30 male adult Wistar rats were randomly assigned to 6 groups (n = 5/each). Group A served as a control and were given distilled water in addition to normal feeds, group B received 2 mg/kg PRED for 14 days and served as the standard immunosuppressed group, and groups C-F were immunosuppressed as in B but in addition received 50 mg/kg levamisole, low-dose (250 mg/kg) BL, highdose (375 mg/kg) BL, and low-dose BL + levamisole, respectively. The CD4 counts, hematological parameters, and sperm parameters were analyzed and compared. Results: There were significant decreases in sperm motility, progressive motility, morphology, and life/death ratio in the animals given PRED only compared to the controls (p = 0.002, 0.001, 0.001, and 0.01, respectively). These were significantly increased in the treated groups, and animals given levamisole and 250 mg/kg BL showed significantly increased sperm counts compared to the controls (p = 0.04 and p = 0.04, respectively). Conclusion: Low-dose BL (250 mg/kg) restored the sperm parameters altered by prednisolone administration. Key words: Bitter leaf, Immunosuppression, Infertility, Prednisolone, Rats.

Prenatal exposure to gestational nicotine before neurulation is detrimental to neurodevelopment of wistar rats’ offspring
Gabriel Olaiya Omotoso, , Risikat Eniola Kadir, Fatima A. Sulaimon, Rukayat Jaji-Sulaimon, Ismail Temitayo Gbadamosi, , , , and
Penerbit Universiti Sains Malaysia
Background and aim This study aimed to determine the effect of gestational nicotine exposure before neurodevelopment on the morphology and histology of the prefrontal cortex (PFC) in rats. Methodology Adult female Wistar rats were time-mated and grouped into three categories: (a) control–given 0.1 mL of normal saline, (b) low-dose nicotine–given 6.88 mg/ kg/d/0.05 mL, and (c) high-dose nicotine–given 13.76 mg/kg/d/0.1 mL in two divided doses. Treatment was given intraperitoneally from gestational days 2 to 6. On postnatal day 15 (P15), the pups were separated from their mothers, anaesthetised and sacrificed, followed by intracardial perfusion with 4% paraformaldehyde. PFC was excised from the brain and processed for tissue histology, histochemistry, and morphology of brain cells. Results Gestational nicotine exposure during the first week of gestation in rats significantly reduced birth weights in nicotine-treated groups compared with control; it, however, accelerated body weights, altered neuronal morphology, and elevated astrocytic count significantly, while oligodendroglial count was slightly increased in the PFC of juvenile rats examined at P15. Conclusion These alterations revealed that gestational nicotine exposure before the commencement of the cellular processes involved in brain development negatively affects neurodevelopment, and this could result in neurological dysfunctions in later life.

Histoenzymic effects of cigarette smoke on the superior colliculus of rattus norvegicus
G. Omotoso, O. Akinola, E. A. Caxton-martins, R. Kadir and A. Akinyinka
Internet Scientific Publishers, LLC
The study was conducted using twenty adult Wistar rats that were randomly grouped into a treatment and a control group comprising both sexes. The control group was exposed to smoke from cotton wool, while the treatment group inhaled smoke from a completely burnt cigarette containing 0.735 g tobacco, once daily for 14 days. The rats were sacrificed by cervical dislocation and the superior colliculi (SC) excised, weighed, homogenized and assayed for the activities of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G6PDH), and alkaline phosphatase (ALP). SC tissues for histological studies were fixed in formol calcium and subsequently processed using Feulgen reaction for nucleic acids and Cresyl violet stain for Nissl bodies studies. There was an increase in the enzyme activities in the treated group, compared to the control; and this increase was more in the female rats although not statistically significant. The derangements observed in the enzyme studies led to various histoarchitectural changes in the SC of the rats exposed to tobacco smoke, and a gradual depletion of DNA positive cells and Nissl bodies in the neurons.

RECENT SCHOLAR PUBLICATIONS

Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1
FA Sulaimon, RY Ibiyeye, A Imam, AL Oyewole, AL Imam, M Shehu, ...
Anatomy & Cell Biology 57 (3), 431-445 2024

Cytoarchitectural differences in reproductive organs of some polycystic ovary-like induced animal models
ER Kadir, AD Yakub, LS Ojulari, AO Hussein, IA Lawal, R Jaji-Sulaimon, ...
Tissue and Cell 89, 102456 2024

Mammographic outcomes among women attending a large imaging facility in Ilorin, Nigeria: a retrospective chart review
A Ibrahim, AO Olagunju, MK Abdulkadir, K Mpolokeng, KO Mashood, ...
PAMJ Clinical Medicine 15 (7) 2024

Exposure to Bisphenol-A and Melatonin altered the Expression of Estrogen and Androgen Receptors in Neonatal Female rats
ER Kadir
2024

ANTI-TOXIC PRINCIPLES FROM MUSA SAPIENTUM AND MORINGA OLEIFERA AMELIORATED SKIN HISTO-PATHOLOGY, DECREASED LIPID PEROXIDATION AND PROMOTED MELATONIN/TNF-ALPHA/P53-MEDIATED
A Akinlolu, MO Ameen, AO Oyewopo, RE Kadir, P Nwogu, M Saad, ...
Malaysian Journal of Pharmaceutical Sciences 22 (1), 43-59 2024

MORINGA OLEIFERA (MOF6) AND MUSA SAPIENTUM (MSF1) AMELIORATED 7, 12-DIMETHYLBENZ [A] ANTHRACENE-INDUCED SKIN HISTO-PATHOLOGY, INFLAMMATION, HEPATIC OXIDATIVE STRESS AND
B FAGBOHUNKA, A AKINLOLU, M AMEEN, R KADIR, A OYEWOPO, ...
New Armenian Medical Journal 18 (1) 2024

Role of Pituitary Gland in Fertility Preservation
ER Kadir, AO Hussein, LS Ojulari, GO Omotoso
The Pituitary Gland-An Overview of Pathophysiology and Current Management 2023

COMPARATIVE ANALYSIS OF HANDGRIP STRENGTH AND URINE C-PEPTIDE CREATININE RATIO AS BIOMARKERS FOR GLUCOSE REGULATION IN YOUNG ADULT FEMALES IN THE UNIVERSITY OF ILORIN: A CROSS
LS Ojulari, SE Sulaiman, TO Ayinde, RE Kadir, HO Jimoh-Abdulghaffaar, ...
Society for Experimental Biology of Nigeria 2023

Comparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats
KE Risikat, OL Sheriff, LI Adetayo, SG Lukman, H Abdulmalik, H Ayodele, ...
Anatomy Journal of Africa 11 (1), 2062-2074 2022

Morinda lucida and Annona muricata reduced hepatic lipid peroxidation and promoted melatonin/TNFα/p53-mediated apoptosis in sodium arsenite-induced toxicity in rats
A Akinlolu, A Oyewopo, R Kadir, M Ameen, V Owoniyi, F Adam, S Okeleye
Eur. J. Anat 26, 6 2022

Anti-Toxic Principles from Morinda lucida And Annona muricata Down-Regulated Ki67 and Multi-Drug Resistance1 Genes In Lead-Induced Hepato-Toxicity In Rats
AA Akinlolu, T Omohimoria, A Oyewopo, RE Kadir, MO Ameen
Malaysian Journal of Pharmaceutical Sciences 20 (2), 135-146 2022

Memory, neurogenic protein and oxidative deficits of frontal cortex following chlorpyrifos/dichlorvos exposure in rats
RE Kadir, TA Gegele, IO Kola-Taiwo, AL Ayewole, A Ibrahim, A Imam, ...
Research Journal of Health Sciences 10 (2), 101-111 2022

RESEARCH JOURNAL OF HEALTH SCIENCES
A JA, O Faokunla, SO Alabi, AKM OA, TO Saka, OA Abayomi, ...
2022

Anti-toxic principles from Moringa oleifera and Musa sapientium down-regulated Ki67 and Multidrug resistance1 proteins in Cadmium Chloride-induced hepato-toxicity and
A Akinlolu, R Kadir, A Oyewopo, M Ameen, E Okorie, J Jolaiya, S Olawale, ...
International Journal of Pharmacy Research & Technology (IJPRT) 12 (1), 67-74 2022

Author's Reply to" Low-dose bitter leaf improves sperm quality disrupted in immunosuppressed Wistar rats: An experimental study"
RE Kadir, A Ibrahim, BA Ibrahim, SM Gwadabe, R Sulaiman-Jaji, ...
International Journal of Reproductive BioMedicine (IJRM), 577-577 2021

Altered testicular histomorphometric and antioxidant levels following In vivo bisphenol-a administration
E Risikat Kadir, L Sheriff Ojulari, T Abdullah Gegele, I Adetayo Lawal, ...
Iranian journal of toxicology 15 (3), 165-174 2021

Anticancer effects of Morinda lucida and Annona muricata on immunomodulations of Melatonin, tumor necrosis factor-alpha and p53 concentrations in lead acetate-induced toxicity
AA Akinlolu, MO Ameen, AO Oyewopo, RE Kadir, O Ahialaka, S Tijani, ...
International Journal of Health Sciences 15 (4), 20 2021

Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamo-pituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats
ER Kadir, A Imam, OJ Olajide, MS Ajao
Anatomy & cell biology 54 (2), 212-224 2021

Moringa oleifera and Musa sapientum ameliorated 7, 12-Dimethylbenz [a] anthracene-induced upregulations of Ki67 and multidrug resistance 1 genes in rats
AA Akinlolu, AO Oyewopo, RE Kadir, A Lawal, J Ademiloye, A Jubril, ...
International journal of health sciences 15 (3), 26 2021

Bisphenol-a and melatonin exposure altered histomorphological and reproductive genetic biomarkers of hypothalamo-pituitary-ovarian axis in Wistar rats
ER KADIR
University of Ilorin 2021

MOST CITED SCHOLAR PUBLICATIONS

Midline diastema amongst south-western Nigerians
G Omotoso, E Kadir
The Internet Journal of Dental Science 8 (2), 1-5 2009
Citations: 39

Effects of aqueous extract of Allium sativum (garlic) on semen parameters in Wistar rats
G Omotoso, A Oyewopo, R Kadir, S Olawuyi, A Jimoh
Internet J Urol 7 (2), 1-5 2010
Citations: 30

A new model for alloxan-induced diabetes mellitus in rats
OL Sheriff, O Olayemi, AO Taofeeq, KE Riskat, DE Ojochebo, ...
Journal of Bangladesh Society of Physiologist 14 (2), 56-62 2019
Citations: 18

Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
GO Omotoso, RE Kadir, SF Lewu, IT Gbadamosi, AA Akinlolu, ...
Research journal of health sciences 6 (1), 13-25 2018
Citations: 17

Effects of monosodium glutamate on semen quality and the cytoarchitecture of the testis of adult Wistar rats
RE Kadir, GO Omotoso, TJ Balogun, AO Oyewopo
International Journal of Biochemical and Health Sciences 7 (1) 2011
Citations: 15

Lipid profile and liver histochemistry in animal models exposed to cigarette smoke
GO Omotoso, BU Enaibe, OB Akinola, RE Kadir, AA Akinlolu, ...
Journal of Basic & Applied Sciences 8 (1), 12-17 2012
Citations: 13

Testiculo-protective effect of stem bark extract of Enantia chlorantha on lead induced toxicity in adult Wistar rat (Rattus norvergicus)
AO Oyewopo, LC Saalu, BJ Dare, CI Oyewopo, AA Jimoh, OE Yama, ...
Reproductive Sys Sexual Disord 1 (107), 2 2012
Citations: 12

Exposure to cigarette smoke altered the cytoarchitecture and anti-oxidant activity of the frontal cortex in Wistar rats
GO Omotoso, RE Kadir, JT Alabi, AS Alabi, AO Oyabambi
International Journal of Biological and Chemical Sciences 7 (4), 1595-1601 2013
Citations: 11

Prenatal exposure to gestational nicotine before neurulation is detrimental to neurodevelopment of Wistar rats’ offspring
GO Omotoso, RE Kadir, FA Sulaimon, R Jaji-Sulaimon, IT Gbadamosi
The Malaysian Journal of Medical Sciences: MJMS 25 (5), 35 2018
Citations: 9

Cephalometric study of mouth morphology among major Nigerian tribes
AA Akinlolu, RE Akinola, B.Oluwole, Nurudeen R.L., Kadir, A M. S
Anatomy Journal of Africa 4 (1), 496 - 504 2015
Citations: 7

Testicular Morphology and Seminal fluid parameters of adult Wistar rats following honey administration
RE Kadir, LS Ojulari, A Ibrahim, E Oluwole J., R Jaji-Sulaimon, ...
Tropical Journal of Pharmaceutical Research 17 (7), 1331 - 1335 2018
Citations: 4

Haematological effects of aqueous extract of Vernonia amygdalina and a known immunostimulant in Wistar rats
RE Kadir, A Ibrahim, IM Bamtefa, BA Ibrahim, MK Ogunfemi, SM Gwadabe, ...
Tropical J. Health Sci 25 (1), 02-09 2018
Citations: 3

Histological alteration of the cerebellum of adult male wistar rat treated with the grape fruit extract (Citrus paradisi)
BJ Dare, AO Oyewopo, LC Saalu, RE Kadir, AAA Osinubi, OE Yama
Anatomy and Physiology 2, 107 2012
Citations: 3

Histoenzymic effects of cigarette smoke on the superior colliculus of rattus norvegicus
GO Omotoso, OB Akinola, EA Caxton-Martins, RE Kadir, A Akinyinka
The Internet Journal of Toxicology 8 (1), 32 2010
Citations: 3

Low dose bitter leaf improves sperm quality disrupted in immunosuppressed Wistar rats: An experimental study
RE Kadir, A Ibrahim, BA Ibrahim, SM Gwadabe, R Jaji-Sulaimon, ...
International Journal of Reproductive BioMedicine 18 (3), 215 2020
Citations: 2

Central cholinergic markers and spartial memory performance in rats following administration of Rauwolfia vomitoria and chlorphromazine
MS Ajao, A Imam, MY Adana, AS Alabi, A Olawepo, AA Okesina, RE Kadri, ...
Library and Publications Committee University of Ilorin, Ilorin, Nigeria 2015
Citations: 2