DARSI ESWAR TONY
@chalapathipharmacy.in
Professor - Pharmacology
Chalapathi Institute of Pharmaceutical Sciences
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
K.N. Rajini Kanth, Ch. Jaswanth Kumar, D. Eswar Tony, Sk. Munwar, Rama Rao Nadendla, and Chandragiri Siva Sai
Asian Journal of Chemistry
Molecular docking studies was performed on 20 analogous novel quinazolin-4-one derivatives as cox-2 inhibitors using glide tool of maestro 11.4 application of Schrodinger software. Anti-inflammatory and analgesic activities were further evaluated for the compounds. Based on docking studies, the binding affinity of QZN-16 was found to be -10.32 kcal/mol. In order to understand the significance of R-substituents on the quinazoline-4-one nucleus, the findings of hydrogen bonding interactions between designated ligands with binding site region of 4cox were studied. The ligands which are having high docking score were subjected to pharmacological screening. The compound QZN-16 has shown analgesic and anti-inflammatory activity at a dose level of 50 and 100 mg/kg body weight, respectively when compared with standard drug indomethacin. The newly designed quinazoline-4-one derivatives may serve as lead molecules for further development.
M. Mounica, G. Tanuja Lakshmi, K. Manaswini, D. Eswar Tony, and A. Narendra Babu
A and V Publications
Ficus hispida (tropical fig tree) is a moderate sized tree which is commonly known as devil fig, traditionally used in the ailment of pain, inflammation, and neurological disorders. Psidium guajava (Guava/peru)is a wellknown tropical tree and also used as a folk herbal tea used to treat diabetes and leaves were used as astringent, anodyne, febrifuge, antispasmodic, tonic, in wounds, cholera, lactagouge, diarrhoea, vomiting and variety of diseases like diarrhoea, dysentery, hypertension, gastroenteritis, diabetes, cough, oral ulcers etc., The aim of the present study is set out to evaluate the anti-diabetic activity of ethanolic leaf extracts of ficus hispida and psidium guajava on streptozocin induced diabetized rats. The leaf extracts at a dose of 100mg/kg were screened for their blood glucose lowering effectamong streptozocin induced diabetized rats and the blood samples were collected through the tail vein from which blood glucose levels were determinedat 0h, 1h, 2h and 4hafter administration of test samples. Both the leaf extracts of Ficus hispida and Psidium guajava produced significant (p 0.01) decrease in the blood glucose levels. The ethanolic extract of leaves of Ficus hispida and Psidium guava produced synergistic effect when compared with standard by showing an effective response on diabetic rats. These plants supported the folk fore claim of anti-diabetic activity. Further investigations are needed for the proper identification and isolation of these bioactive compounds to produce safer drugs for treatment of harmful diseases.