Evandro Neves Silva

@unifenas.br

PhD student and Laboratory of Molecular and Cellular Biology
Professor Edson Antonio Velano University



              

https://researchid.co/evandroneves95

He has a Technical Course in Clinical Analysis (2015), with an emphasis on Biochemistry and Hematology from the Federal Institute of Education, Science and Technology of the South of Minas Gerais - IFSULDEMINAS/Muzambinho, Graduated in Biomedicine (2017) from the José do Rosário Vellano University - UNIFENAS/ Alfenas, with emphasis on Microbiology. Master's degree completed (2019) by the Graduate Program in Reproduction, Health and Animal Welfare, working in Microbiology and Immunology. He is currently a PhD candidate at the same program, with an emphasis on Immunology and Genetics (Molecular Biology). He is a permanent member of the Brazilian Society of Immunology (SBI), the Society for Leukocyte Biology (SLB) and the Nucleus of Studies in Assisted Human Reproduction (NERHA), collaborator in research projects at the Department of Microbiology and Immunology of the Federal University of Alfenas - UNIFAL and researcher/PhD student at the Laboratory of Molecular and Cellular Biology.

RESEARCH INTERESTS

- Gut microbiota
- Host-pathogen infection
- Immunotherapy
- Murine reproduction
- Molecular Biology of domestic animals

7

Scopus Publications

Scopus Publications

  • A network-based approach to understanding gene–biological processes affecting economically important traits of Nelore cattle
    Mariely Simone Lopes Corrêa, Evandro Neves Silva, Thaís Cristina Ferreira dos Santos, Larissa Fernanda Simielli Fonseca, Ana Fabrícia Braga Magalhães, Lucas Lima Verardo, Lucia Galvão de Albuquerque, and Danielly Beraldo dos Santos Silva
    Wiley
    AbstractThis study aimed to build gene–biological process networks with differentially expressed genes associated with economically important traits of Nelore cattle from 17 previous studies. The genes were clustered into three groups by evaluated traits: group 1, production traits; group 2, carcass traits; and group 3, meat quality traits. For each group, a gene–biological process network analysis was performed with the differentially expressed genes in common. For production traits, 37 genes were found in common, of which 13 genes were enriched for six Gene Ontology (GO) terms; these terms were not functionally grouped. However, the enriched GO terms were related to homeostasis, the development of muscles and the immune system. For carcass traits, four genes were found in common. Thus, it was not possible to functionally group these genes into a network. For meat quality traits, the analysis revealed 222 genes in common. CSRP3 was the only gene differentially expressed in all three groups. Non‐redundant biological terms for clusters of genes were functionally grouped networks, reflecting the cross‐talk between all biological processes and genes involved. Many biological processes and pathways related to muscles, the immune system and lipid metabolism were enriched, such as striated muscle cell development and triglyceride metabolic processes. This study provides insights into the genetic mechanisms of production, carcass and meat quality traits of Nelore cattle. This information is fundamental for a better understanding of the complex traits and could help in planning strategies for the production and selection systems of Nelore cattle.

  • Shared immunogenic epitopes between host entry and exit proteins from monkeypox and Alaskapox viruses
    Leonardo Pereira de Araújo, Evandro Neves Silva, Patrícia Paiva Corsetti, and Leonardo Augusto de Almeida
    Elsevier BV

  • Reactive oxygen species trigger inflammasome activation after intracellular microbial interaction
    Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natália Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patrícia Paiva Corsetti, and Leonardo Augusto de Almeida
    Elsevier BV

  • Cis-regulatory modules prediction in spliced genes associated with carcass and meat traits of Nelore cattle
    Thaís Cristina Ferreira Dos Santos, Evandro Neves Silva, Larissa Fernanda Simielli Fonseca, Lucia Galvão De Albuquerque, and Danielly Beraldo Dos Santos Silva
    Elsevier BV

  • Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus
    Josidel Conceição Oliver, Evandro Neves Silva, Letícia Martins Soares, Gislaine Cristina Scodeler, Ana de Souza Santos, Patrícia Paiva Corsetti, Carlos Roberto Prudêncio, and Leonardo Augusto de Almeida
    SAGE Publications
    According to the World Health Organization (WHO), in the second half of 2022, there are about 606 million confirmed cases of COVID-19 and almost 6,500,000 deaths around the world. A pandemic was declared by the WHO in March 2020 when the new coronavirus spread around the world. The short time between the first cases in Wuhan and the declaration of a pandemic initiated the search for ways to stop the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or to attempt to cure the disease COVID-19. More than ever, research groups are developing vaccines, drugs, and immunobiological compounds, and they are even trying to repurpose drugs in an increasing number of clinical trials. There are great expectations regarding the vaccine’s effectiveness for the prevention of COVID-19. However, producing sufficient doses of vaccines for the entire population and SARS-CoV-2 variants are challenges for pharmaceutical industries. On the contrary, efforts have been made to create different vaccines with different approaches so that they can be used by the entire population. Here, we summarize about 8162 clinical trials, showing a greater number of drug clinical trials in Europe and the United States and less clinical trials in low-income countries. Promising results about the use of new drugs and drug repositioning, monoclonal antibodies, convalescent plasma, and mesenchymal stem cells to control viral infection/replication or the hyper-inflammatory response to the new coronavirus bring hope to treat the disease.

  • Amoxicillin-induced gut dysbiosis influences estrous cycle in mice and cytokine expression in the ovary and the caecum
    Evandro Neves Silva, Thaís Viana Fialho Martins, Tatimara Maria Miyauchi‐Tavares, Bianca Aparecida Expedito Miranda, Gabriela de Assis Santos, Caio Pupin Rosa, Jeferson Antônio Santos, Rômulo Dias Novaes, Leonardo Augusto Almeida, and Patrícia Paiva Corsetti
    Wiley
    Gut dysbiosis is caused by several factors, including the use of antibiotics. Since intestinal dysbiosis is associated with a wide range of immunopathological and reproductive conditions, the main goal of this study was to evaluate amoxicillin‐induced gut dysbiosis and its influence on the oestrous cycle in mice.

  • Vancomycin-induced gut dysbiosis during Pseudomonas aeruginosa pulmonary infection in a mice model
    Caio Pupin Rosa, Jéssica Assis Pereira, Natália Cristina de Melo Santos, Gustavo Andrade Brancaglion, Evandro Neves Silva, Carlos Alberto Tagliati, Rômulo Dias Novaes, Patrícia Paiva Corsetti, and Leonardo Augusto de Almeida
    Oxford University Press (OUP)
    Abstract Pseudomonas aeruginosa is one of the most common opportunistic pathogens causing respiratory infections in hospitals. Vancomycin, the antimicrobial agent usually used to treat bacterial nosocomial infections, is associated with gut dysbiosis. As a lung-gut immunologic axis has been described, this study aimed to evaluate both the immunologic and histopathologic effects on the lungs and the large intestine resulting from vancomycin-induced gut dysbiosis in the P. aeruginosa pneumonia murine model. Metagenomic analysis demonstrated that vancomycin-induced gut dysbiosis resulted in higher Proteobacteria and lower Bacteroidetes populations in feces. Given that gut dysbiosis could augment the proinflammatory status of the intestines leading to a variety of acute inflammatory diseases, bone marrow-derived macrophages were stimulated with cecal content from dysbiotic mice showing a higher expression of proinflammatory cytokines and lower expression of IL-10. Dysbiotic mice showed higher levels of viable bacteria in the lungs and spleen when acutely infected with P. aeruginosa, with more lung and cecal damage and increased IL-10 expression in bronchoalveolar lavage. The susceptible and tissue damage phenotype was reversed when dysbiotic mice received fecal microbiota transplantation. In spite of higher recruitment of CD11b+ cells in the lungs, there was no higher CD80+ expression, DC+ cell amounts or proinflammatory cytokine expression. Taken together, our results indicate that the bacterial community found in vancomycin-induced dysbiosis dysregulates the gut inflammatory status, influencing the lung-gut immunologic axis to favor increased opportunistic infections, for example, by P. aeruginosa.

Publications

1. Cis-regulatory modules prediction in spliced genes associated with carcass and meat traits of Nelore cattle. Animal Gene, v. 27, p. 200142, 2023.
2. Esporotricose felina: Conduta clínica, diagnóstico e tratamento preconizado no município de Vitória - ES. RESEARCH, SOCIETY AND DEVELOPMENT, v. 11, p. e589111031028, 2022.
3. Different drug approaches to COVID-19 treatment worldwide: an update of new drugs and drugs repositioning to fight against the novel coronavirus. Therapeutic Advances in Vaccines and Immunotherapy, v. 10, p. 251513552211448, 2022.
4. Incidence of Staphylococcus aureus on equipment from a gym of physical activities in Alfenas - MG. RESEARCH, SOCIETY AND DEVELOPMENT, v. 10, p. e15101220056, 2021.
5. Vancomycin-induced gut dysbiosis during Pseudomonas aeruginosa pulmonary infection in a mice model. JOURNAL OF LEUKOCYTE BIOLOGY, v. 107, p. 95-104, 2020.
6. Caracterização bromatológica da sementes de Aleurites moluccana (L.) Willd.. REVISTA BRASILEIRA DE OBESIDADE, NUTRIÇÃO E EMAGRECIMENTO, v. 14, p. 29-36, 2020.
7. Amoxicillin-induced gut dysbiosis influences estrous cycle in mice and cytokine expression in the ovary and the caecum. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v. 84, p. e13247, 2020.
8. Avaliação dos parâmetros nutricionais de refeições transportadas em um restaurante comercial na cidade de Alfenas - MG. REVISTA BRASILEIRA DE OBESIDADE, NUTRIÇÃO E EMAGRECIMENTO, v. 13, p. 1168-1174, 2019.

GRANT DETAILS

1. Society Brazilian of Immunology (SBI).
2. Society for Leukocyte Biology (SLB).
3. Center for Assisted Human Reproduction (NERHA).

Industry, Institute, or Organisation Collaboration

1. Researcher/Master's student member. Laboratory of Immunology of Infectious and Chronic Diseases (LIDIC). José do Rosário Vellano University (UNIFENAS).
2. Member researcher/collaborator. Laboratory of Molecular Biology of Microorganisms (LaBioMol). Federal University of Alfenas (UNIFAL).
3. Researcher/doctoral member. Laboratory of Molecular and Cellular Biology (BioMol). José do Rosário Vellano University (UNIFENAS).
4. Member of the Center for Academic Studies in Human Reproduction. José do Rosário Vellano University (UNIFENAS).

INDUSTRY EXPERIENCE

1. Laboratory of Molecular and Cellular Biology (BioMol)/ UNIFENAS.
2. Laboratory of Molecular Biology of Microorganisms (LaBioMol)/ UNIFAL.

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

1. Integral member, treasurer, vice-president and president of Academic League. José do Rosário Vellano University (UNIFENAS), Biomedicine Course.