Evelyn Garcia-Moreira

@tecnologicoargos.edu.ec

Research Directorate
Instituto Superior Tecnológico ARGOS

Evelyn Garcia-Moreira


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https://researchid.co/evegarcia

RESEARCH, TEACHING, or OTHER INTERESTS

Economics and Econometrics, Education, Business, Management and Accounting
2

Scopus Publications

41

Scholar Citations

4

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data
    Gabriel Morey-León, Paulina M. Mejía-Ponce, Juan Carlos Fernández-Cadena, Evelyn García-Moreira, Derly Andrade-Molina, Cuauhtémoc Licona-Cassani, Pablo Fresia, Luisa Berná
    Scientific Reports, 2025
    Tuberculosis is a global public health concern, and understanding Mycobacterium tuberculosis transmission routes and genetic diversity of M. tuberculosis is crucial for outbreak control. This study aimed to explore the genomic epidemiology and genetic diversity of M. tuberculosis in Ecuador by analyzing 88 local isolates and 415 public genomes from 19 countries within the Euro-American lineage (L4). Our results revealed significant genomic diversity among the isolates, particularly in the genes related to protein processing, carbohydrate metabolism, lipid metabolism, and xenobiotic biodegradation and metabolism. The population structure analysis showed that sub-lineages 4.3.2/3 (35.4%), 4.1.2.1 (22.7%), 4.4.1 (12.7%), and 4.1.1. (10.7%) were the most prevalent. Phylogenetic and transmission network analyses suggest that these isolates circulating within Ecuador share genetic ties with isolates from other continents, implying historical and ongoing intercontinental transmission events. Our findings underscore the importance of integrating genomic data into public health strategies for tuberculosis control and suggest that enhanced genomic surveillance is essential for understanding and mitigating the global spread of M. tuberculosis. This study provides a comprehensive genomic framework for future epidemiological investigations and control measures targeting M. tuberculosis L4 in Ecuador.
  • A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools
    Gabriel Morey-León, Paulina M. Mejía-Ponce, Juan Carlos Granda Pardo, Karen Muñoz-Mawyin, Juan Carlos Fernández-Cadena, Evelyn García-Moreira, Derly Andrade-Molina, Cuauhtémoc Licona-Cassani, Luisa Berná
    Plos One, 2023
    Introduction Tuberculosis (TB) is among the deadliest diseases worldwide, and its impact is mainly due to the continuous emergence of resistant isolates during treatment due to the laborious process of resistance diagnosis, nonadherence to treatment and circulation of previously resistant isolates of Mycobacterium tuberculosis. In this study, we evaluated the performance and functionalities of web-based tools, including Mykrobe, TB-profiler, PhyResSE, KvarQ, and SAM-TB, for detecting resistance in 88 Ecuadorian isolates of Mycobacterium tuberculosis drug susceptibility tested previously. Statistical analysis was used to determine the correlation between genomic and phenotypic analysis. Our results showed that with the exception of KvarQ, all tools had the highest correlation with the conventional drug susceptibility test (DST) for global resistance detection (98% agreement and 0.941 Cohen’s kappa), while SAM-TB, PhyResSE, TB-profiler and Mykrobe had better correlations with DST for first-line drug analysis individually. We also identified that in our study, only 50% of mutations characterized by the web-based tools in the rpoB, katG, embB, pncA, gyrA and rrs regions were canonical and included in the World Health Organization (WHO) catalogue. Our findings suggest that SAM-TB, PhyResSE, TB-profiler and Mykrobe were efficient in determining canonical resistance-related mutations, but more analysis is needed to improve second-line detection. Improving surveillance programs using whole-genome sequencing tools for first-line drugs, MDR-TB and XDR-TB is essential to understand the molecular epidemiology of TB in Ecuador. Importance Tuberculosis, an infectious disease caused by Mycobacterium tuberculosis, most commonly affects the lungs and is often spread through the air when infected people cough, sneeze, or spit. However, despite the existence of effective drug treatment, patient adherence, long duration of treatment, and late diagnosis have reduced the effectiveness of therapy and increased drug resistance. The increase in resistant cases, added to the impact of the COVID-19 pandemic, has highlighted the importance of implementing efficient and timely diagnostic methodologies worldwide. The significance of our research is in evaluating and identifying a more efficient and user-friendly web-based tool to characterize resistance in Mycobacterium tuberculosis by whole-genome sequencing, which will allow more routine application to improve TB strain surveillance programs locally.

RECENT SCHOLAR PUBLICATIONS

  • First Aerobiological Survey of Pollen and Fungal Spores in Urban Guayaquil
    IC Ojeda, A Espinoza-Maticurena, E García-Moreira, O Calderón-Llosa, ...
    Journal of Allergy and Clinical Immunology 157 (2), AB125 , 2026
    2026.0
  • Perfil Emprendedor en Educación Superior, una perspectiva desde la educación técnica y tecnológica
    E García
    Espíritu Emprendedor TES 9 (1), 99-111 , 2025
    2025.0
    Citations: 1
  • First Aerobiological Documentation of Ragweed (Ambrosia spp.) Pollen in Ecuador: Implications for Public Health and Environmental Management
    IC Ojeda, A Ochoa-Brito, AE Maticurena, G Rodas-Valero, DH Molina, ...
    Journal of Allergy and Clinical Immunology 155 (2), AB283 , 2025
    2025.0
  • Climatic Influence on Pollen and Fungal Spore Variability: A Correlation Analysis
    IC Ojeda, P Mardones, G Ramon, OC LLosa, IT Moran, L Barrionuevo, ...
    Journal of Allergy and Clinical Immunology 155 (2), AB128 , 2025
    2025.0
  • Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data
    G Morey-León, PM Mejía-Ponce, JC Fernández-Cadena, ...
    Scientific Reports 15 (1), 3823 , 2025
    2025.0
    Citations: 4
  • A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools
    G Morey-León, PM Mejía-Ponce, JC Granda Pardo, K Muñoz-Mawyin, ...
    PLoS One 18 (12), e0294670 , 2023
    2023.0
    Citations: 11
  • LOCAL DEVELOPMENT AND SOCIO-ECONOMIC ENTREPRENEURSHIP THROUGH THE USE OF NEW INFORMATION AND COMMUNICATION TECHNOLOGIES AS A RELEVANT DIMENSION OF COMPETITIVENESS IN GUAYAQUIL …
    MM Claudett, J Bonilla-Freire, V Briones-Kusactay, G Poveda-Burgos, ...
    Russian Law Journal 11 (6S), 398-405 , 2023
    2023.0
  • La relación entre el uso de las NTIC en la competitividad en las micro y pequeñas empresas comerciales de Guayaquil
    MEJ Cercado, MMA Véliz, DM Naranjo, E García
    3 c TIC: cuadernos de desarrollo aplicados a las TIC 9 (2), 119-137 , 2020
    2020.0
    Citations: 10
  • Reformas universitarias en Ecuador: impacto en la investigación científica en la Universidad de Guayaquil
    Y Peñate Santana, K Hernández Ludeña, E García
    Conrado 15 (69), 71-78 , 2019
    2019.0
    Citations: 3
  • Factores que influyen en la deserción de los estudiantes en la Universidad de Guayaquil
    EVG Moreira, RC Rodríguez, SC Tumbaco, YP Santana, RL Fernández, ...
    Revista de la Facultad de Ciencias Médicas de la Universidad de Guayaquil , 2017
    2017.0
  • La creación de Organizaciones de Alto Desempeño (OAD) basadas en la gestión económica del conocimiento
    C Vélez, C Triviño, E García, J Jácome
    Alternativas 16 (2), 35-41 , 2015
    2015.0
    Citations: 1
  • La cadena de valor de la leche en funda plástica y su incidencia en la economía de la industria de lácteos del cantón El Empalme, provincia del Guayas
    M Acuña, G Evelyn.
    https://repositorio.ug.edu.ec/items/5449f568-3d41-4e74-ae53-38554add78b2/full , 2015
    2015.0
  • El cacao y su incidencia en la industria nacional de elaborados de cacao en el período 2008-2012
    C García, G Evelyn
    Universidad de Guayaquil , 2014
    2014.0
    Citations: 11
  • Posicionamiento de Marca Empresa Online. Caso Vintage Roos, Facultad de Ciencias Administrativas – Universidad de GuayaquilPo
    E García, V Coello
    Memorias CIDE , 0

MOST CITED SCHOLAR PUBLICATIONS

  • A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools
    G Morey-León, PM Mejía-Ponce, JC Granda Pardo, K Muñoz-Mawyin, ...
    PLoS One 18 (12), e0294670 , 2023
    2023.0
    Citations: 11
  • El cacao y su incidencia en la industria nacional de elaborados de cacao en el período 2008-2012
    C García, G Evelyn
    Universidad de Guayaquil , 2014
    2014.0
    Citations: 11
  • La relación entre el uso de las NTIC en la competitividad en las micro y pequeñas empresas comerciales de Guayaquil
    MEJ Cercado, MMA Véliz, DM Naranjo, E García
    3 c TIC: cuadernos de desarrollo aplicados a las TIC 9 (2), 119-137 , 2020
    2020.0
    Citations: 10
  • Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data
    G Morey-León, PM Mejía-Ponce, JC Fernández-Cadena, ...
    Scientific Reports 15 (1), 3823 , 2025
    2025.0
    Citations: 4
  • Reformas universitarias en Ecuador: impacto en la investigación científica en la Universidad de Guayaquil
    Y Peñate Santana, K Hernández Ludeña, E García
    Conrado 15 (69), 71-78 , 2019
    2019.0
    Citations: 3
  • Perfil Emprendedor en Educación Superior, una perspectiva desde la educación técnica y tecnológica
    E García
    Espíritu Emprendedor TES 9 (1), 99-111 , 2025
    2025.0
    Citations: 1
  • La creación de Organizaciones de Alto Desempeño (OAD) basadas en la gestión económica del conocimiento
    C Vélez, C Triviño, E García, J Jácome
    Alternativas 16 (2), 35-41 , 2015
    2015.0
    Citations: 1
  • First Aerobiological Survey of Pollen and Fungal Spores in Urban Guayaquil
    IC Ojeda, A Espinoza-Maticurena, E García-Moreira, O Calderón-Llosa, ...
    Journal of Allergy and Clinical Immunology 157 (2), AB125 , 2026
    2026.0
  • First Aerobiological Documentation of Ragweed (Ambrosia spp.) Pollen in Ecuador: Implications for Public Health and Environmental Management
    IC Ojeda, A Ochoa-Brito, AE Maticurena, G Rodas-Valero, DH Molina, ...
    Journal of Allergy and Clinical Immunology 155 (2), AB283 , 2025
    2025.0
  • Climatic Influence on Pollen and Fungal Spore Variability: A Correlation Analysis
    IC Ojeda, P Mardones, G Ramon, OC LLosa, IT Moran, L Barrionuevo, ...
    Journal of Allergy and Clinical Immunology 155 (2), AB128 , 2025
    2025.0
  • LOCAL DEVELOPMENT AND SOCIO-ECONOMIC ENTREPRENEURSHIP THROUGH THE USE OF NEW INFORMATION AND COMMUNICATION TECHNOLOGIES AS A RELEVANT DIMENSION OF COMPETITIVENESS IN GUAYAQUIL …
    MM Claudett, J Bonilla-Freire, V Briones-Kusactay, G Poveda-Burgos, ...
    Russian Law Journal 11 (6S), 398-405 , 2023
    2023.0
  • Factores que influyen en la deserción de los estudiantes en la Universidad de Guayaquil
    EVG Moreira, RC Rodríguez, SC Tumbaco, YP Santana, RL Fernández, ...
    Revista de la Facultad de Ciencias Médicas de la Universidad de Guayaquil , 2017
    2017.0
  • La cadena de valor de la leche en funda plástica y su incidencia en la economía de la industria de lácteos del cantón El Empalme, provincia del Guayas
    M Acuña, G Evelyn.
    https://repositorio.ug.edu.ec/items/5449f568-3d41-4e74-ae53-38554add78b2/full , 2015
    2015.0
  • Posicionamiento de Marca Empresa Online. Caso Vintage Roos, Facultad de Ciencias Administrativas – Universidad de GuayaquilPo
    E García, V Coello
    Memorias CIDE , 0