Dr. Hanan Y. Aati

Scopus Publications

Non-targeted metabolomic insights into Euphorbia heterophylla L.: sustainable textile dye synthesis and evaluation of abscess-healing efficacy in an earthworm model
Mostafa A. Asmaey, Hanan Y. Aati, Fatma El-Zahraa A. Abd El-Aziz, Dennis Abatis, Mohamed O. Saleh
Results in Chemistry, 2026
AM1-Stabilized PEG-Modified Nanoemulsions for Interfacial Engineering and Biomolecule Conjugation
Sarah Almaghrabi, Dina Salman, Abdulaziz Alhussan, Hanan Y. Aati, Farid Ahmed, et al.
Langmuir, 2026
Functional food potential of Suaeda fruticosa (L.) Forssk: A medicinal halophyte with protective effects against neuropathic pain and diabetes
Duraiz Ahmed Khan, Afia Shahid, Kashif ur Rehman Khan, Chitchamai Ovatlarnporn, Huma Rao, et al.
Journal of Agriculture and Food Research, 2026
Development of an Artemisia absinthium Essential Oil Nanoemulsion and Evaluation of Its Safety, Stability, Antimicrobial and Antioxidant Properties
Nojod H. Hasaballah, Shareefa Abdullah AlGhamdi, Adeel G. Chaudhary, Hanan Aati, Jawzaa Almutairi, et al.
Colloids and Interfaces, 2026
Antimicrobial resistance is driving the urgent need for novel antimicrobials. Nanoemulsions (NEs) offer alternatives to traditional antimicrobials by improving the physiochemical and biological properties of bioactive compounds. Artemisia absinthium essential oil (Art-EO) has antimicrobial and antioxidant properties, although its medical applications are limited by hydrophobicity and potential cytotoxicity. To improve these properties, this study investigated an NE loaded with Art-EO (Art-EO NE) extracted via hydrodistillation from A. absinthium grown in Saudi Arabia. Extracted with 0.92% (v/w) yield from the aerial parts of A. absinthium, Art-EO was analysed by gas chromatography–mass spectrometry, revealing 29 compounds. The Art-EO NE, prepared using ultrasonication, showed a droplet size of 116 ± 0.2 nm, polydispersity index of 0.14 ± 0.0, and zeta potential of −23.9 ± 1.0 mV determined by dynamic and electrophoretic light scattering. The NE remained physically stable for two months and exhibited antimicrobial activity for one week. Compared to the Art-EO aqueous extract (minimum inhibitory concentration (MIC): 20% v/v Art-EO), the Art-EO NE enhanced antibacterial activity against Staphylococcus aureus by 32-fold (MIC: 0.625% v/v Art-EO). The NE also exhibited potent antioxidant activity and produced an acceptable in vivo safety profile. These findings present Art-EO NEs as effective antimicrobial and antioxidant agents.
Bottle Gourd (Lagenaria siceraria): Novel Insights Into the Biochemical Propensities of the Unexplored Cultivar
Scientifica, 2026
Unrevealing the Wound Healing Involvement of TGF-β/VEGF Signaling of Tamarix Honey-Derived Chlorogenic Acid in 1H NMR Metabolomics, In Vivo, and In Silico Studies
Hanan Aati, Sultan Y. Aati, Mohammad A. Khanfar, Hebatallah S. Bahr, Asmaa T. Ali, et al.
Chemistry and Biodiversity, 2025
Tamarix sp., often known as tamarisk, is a wide genus of flowering plants that reduce inflammation and cure wounds. In addition, using honey for wound therapy and care dates back thousands of years. Herein, we aimed to assess the wound healing potential of Saudi Tamarix honey (STH) metabolites in vivo, and support our hypothesis through in silico studies. Using an excision wound model, the possibility of Tamarix honey for in vivo wound healing was investigated via examining its effects on molecular targets involved in wound healing, including TGF‐β, VEGF, matrix metalloproteinase‐1 (MMP‐1), TNF‐α, and IL‐1β. In addition, physicochemical properties were examined, and 1H NMR based metabolomics technique was employed to identify STH chemical metabolites. Results revealed that Tamarix honey had a substantial impact on wound closure rate, increased levels of TGF‐β and VEGF, and markedly decreased the gene expression of MMP‐1, TNF‐α, and IL‐1β compared to the group treated with topical MEBO ointment. Biochemical and histological studies corroborated the phenotypic results. Furthermore, the effect of Tamarix honey on the redox state of wounds was investigated. On the other hand, the physical and chemical properties of STH demonstrated that it possesses moisture content 14.60%, glucose 33.7%, fructose 37.9%, sucrose 5.0%, pH 5.0, hydroxymethylfurfural (HMF) 15.40 mg/kg, and diastase enzyme 17.6 Goth scale Min, all of which that attest to its superior quality and compliance with both national and international requirements. 1H NMR based metabolomics analysis revealed thirteen metabolites, mainly flavonoids. All Tamarix honey‐derived flavonoids demonstrated high target probability against two wound healing‐related targets, namely, glycogen synthase kinase‐3β (GSK‐3β) and NADPH oxidase 4 (NOX4). Alternatively, Tamarix honey‐derived chlorogenic acid showed a high probability of targeting MMP‐2, which was verified by molecular docking and molecular dynamics simulation (MDS). Our study highlights the potential of Tamarix honey in wound repair by revealing the most likely signaling pathway utilizing in silico and gene expression analysis.
Analgesic and anti-inflammatory potential of Ficus Palmata Forssk.: an In-vitro and In-vivo approach
Jawaher Al-Qahtani, Zaryab Fatima, Hanan Y. Aati, Bilal Ahmad Ghalloo, Areej Al-Taweel, et al.
Scientific Reports, 2025
Unveiling the biochemical properties of Saudi mountain papaya (Vasconcellea pubescens): A wild nutritious food source with therapeutic relevance
Kashif ur Rehman Khan, Hanan Y. Aati, Mohsin Abbas Khan, Chitchamai Ovatlarnporn, Muhammad Adeel Arshad, et al.
Journal of Agriculture and Food Research, 2025
GC–MS Profiling and In Vitro and Silico Evaluation of Biological Propensities of Saudi Cultivar of Sugar Apple (Annona squamosa L.): A Preliminary Multidimensional Approach for the Development of Nutraceuticals
Hanan Y. Aati, Renad Al‐Arifi, Chitchamai Ovatlarnporn, Khloud AlYami, Abdul Rauf, et al.
Food Science and Nutrition, 2025
Annona squamosa L. , commonly known as sugar apple or custard apple, is a well‐known medicinal plant recently introduced for cultivation in Saudi Arabia. However, the pharmaceutical potential of the Saudi cultivar remains unexplored. This study aimed to evaluate the phytochemical composition and biological activities of the ethanolic extract of Saudi A. squamosa fruit (EASF) through comprehensive in vitro and in silico analyses. Phytochemical screening revealed a high content of phenolics, flavonoids, and tannins.GC‐MS analysis identified 34 bioactive compounds, including fatty acid esters and terpenoids. EASF exhibited strong anti‐oxidant activity, particularly in the ABTS assay, and demonstrated significant thrombolytic potential (90.21% ± 0.90%) along with moderate hemolytic activity (14.1% ± 1.01%). Notably, the extract showed effective antibacterial activity against Staphylococcus epidermidis with an inhibition zone of 11 mm at 150 mg/mL. Enzyme inhibition assays revealed potent activity against urease (95.65%), tyrosinase (85.50%), and α‐amylase (47.88%). In silico molecular docking supported these findings, with selected phytoconstituents showing strong binding affinities toward the target enzymes. ADMET profiling further confirmed their drug‐like properties. These results suggest that the Saudi cultivar of A. squamosa possesses significant therapeutic potential and may serve as a promising candidate for developing nutraceuticals and pharmaceutical agents.
Resveratrol from grape pomace: Mitigation of lead-induced oxidative stress-related renal toxicity: In silico and In vivo studies
Mohamed Seif, Hanan Y. Aati, Bin Wei, Mohamed A. Tantawy, Mohamed Sayed, et al.
Journal of Agriculture and Food Research, 2025
Exploring the Phytochemical Profile and Therapeutic Potential of Saudi Native Santolina chamaecyparissus L. Essential Oil
Hanan Y. Aati, Wedad Sarawi, Hala Attia, Rehab Ghazwani, Lama Aldmaine
Pharmaceutics, 2025
Kojic acid: A River Nile-derived fungal secondary metabolite with preservative potential against Listeria monocytogenes in milk
Hanan Y. Aati, Momen M. Lotfy, Areej Al-tweel, Basmah Al-enezi, Karim Abdelkader, et al.
Microbial Pathogenesis, 2025
Antimicrobial and Anti-Biofilm Activities of Medicinal Plant-Derived Honey Against ESKAPE Pathogens: Insights into β-Lactamase Inhibition via Metabolomics and Molecular Modeling Studies
Hanan Aati, Nadia M. Lithy, Sultan Y. Aati, Mohammad A. Khanfar, Hossam M. Hassan, et al.
Processes, 2025
Gold nanoparticles synthesized from soil-derived Streptomyces sp. ASM19: Characterization, antimicrobial, anticancer potency targeted G2/M phase cell-cycle arrest, and in silico studies
Sultan Aati, Hanan Y. Aati, Ahmed A. Hamed, Sherine El-Shamy, Shahad H. Aati, et al.
Rsc Advances, 2025
Green synthesis of silver nanoparticles using Saudi Xanthium strumarium extract: anticancer potential against breast and lung cancer cells
Hanan Aati, Jawaher Al-Qahtani, Areej Al-Taweel, Nida N. Farshori, Raha Orfali, et al.
Frontiers in Pharmacology, 2025
Exploring the antidiabetic potential of Octhochloa compressa: a comprehensive study on chemical profiling, in vitro, in vivo and in silico pharmacological properties
Jawaria Aslam, Mirza Imran Shahzad, Hanan Y. Aati, Kashif-ur-Rehman Khan, Maria Aslam, et al.
Frontiers in Pharmacology, 2025
Bioactivity Profiling of Chemically Characterized Extract of Saudi Jackfruit (Artocarpus heterophyllus) Using In Vitro and In Silico Approaches
Hanan Y. Aati, Renad Al-Arifi, Chitchamai Ovatlarnporn, Abdul Rauf, Abdul Basit, et al.
Scientifica, 2025
GC-MS analysis, comprehensive biological profiling, molecular docking and ADMET studies of Ficus vasta Forssk. n-hexane extract
Hanan Y. Aati, Abdul Rauf, Jawahir Al-Qatani, Bilal Ahmad Ghalloo, Areej Al-Tweel, et al.
Future Science Oa, 2025
Tamarix honey phenolics attenuate cisplatin-induced kidney toxicity by inhibition of inflammation mediated IL-6/STAT3/TNF-α and oxidative stress-dependent Nrf2/caspase-3 apoptotic signaling pathways
Hanan Aati, Sultan Y. Aati, Hebatallah S. Bahr, Asmaa Ramadan Abdel-Sattar, Marwa Ahmed Embaby, et al.
Frontiers in Pharmacology, 2025
Phytochemical Characterization Utilizing HS-SPME/GC-MS: Exploration of the Antioxidant and Enzyme Inhibition Properties of Essential Oil from Saudi Artemisia absinthium L.
Hanan Y. Aati, Hala A. Attia, Arwa S. Alanazi, Luluh K. AL tamran, Juergen K. Wanner
Pharmaceuticals, 2024
Intratracheal Administration of Itraconazole-Loaded Hyaluronated Glycerosomes as a Promising Nanoplatform for the Treatment of Lung Cancer: Formulation, Physiochemical, and In Vivo Distribution
Sultan Aati, Hanan O. Farouk, Marwa H. Elkarmalawy, Hanan Y. Aati, Nahla Sameh Tolba, et al.
Pharmaceutics, 2024
Exploring the therapeutic potential of Saudi Kleinia anteuphorbium (L.) DC. Essential oil: Insights into antioxidant, analgesic, and hepatorenal protective effects
Hanan Y. Aati, Mohamed Seif, Mahmoud Emam, Jawaher Al-Qahtani, Hala Attia, et al.
Heliyon, 2024
Anti-Alzheimer’s Potency of Rich Phenylethanoid Glycosides Extract from Marrubium vulgare L.: In Vitro and In Silico Studies
Mahmoud Emam, Samah A. El-Newary, Hanan Y. Aati, Bin Wei, Mohamed Seif, et al.
Pharmaceuticals, 2024
Larvicidal potency of four Egyptian herbs on Culex pipiens larvae: Phytochemical composition and molecular networking for most potent extracts
Mostafa A. Asmaey, Hanan Y. Aati, Mahmoud Emam, Nikolas Tsafantakis, Nikolas Fokialakis, et al.
Arabian Journal of Chemistry, 2024
New Glycotoxin Inhibitor from Sesuvium sesuvioides Mitigates Symptoms of Insulin Resistance and Diabetes by Suppressing AGE-RAGE Axis in Skeletal Muscle
Safina Ghaffar, Rizwana Sanaullah Waraich, Raha Orfali, Areej Al-Taweel, Hanan Y. Aati, et al.
Molecules, 2024

Dr. Hanan Y. Aati

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