Dissociation of plasma oxyntomodulin levels from anthropometric measures and metabolic markers in women with polycystic ovary syndrome Rachel C. Damasceno, Flávia R. Oliveira, Ana Lúcia Cândido, Karina B. Gomes, Mariana F. Bizzi, Ana Luiza Lunardi Rocha Archives of Endocrinology and Metabolism, 2025 INTRODUCTION: Oxyntomodulin (OXM) is a polypeptide hormone of the incretin family, which binds to the glucagon-like peptide 1 receptor, contributing to a reduction in caloric intake, an increase in energy expenditure, and weight loss in obese individuals. Polycystic ovary syndrome (PCOS) is a multifactorial condition characterized by reproductive and metabolic dysfunctions, with a high prevalence among overweight and obese women. This study aimed to investigate the correlation between clinical, anthropometric, endocrine, and metabolic variables and plasma OXM levels in women diagnosed with PCOS. SUBJECTS AND METHODS: This cross-sectional study included 20 women recently diagnosed with PCOS. Participants underwent screening that assessed body measurements, as well as serum/plasma lipids, fasting glucose, fasting insulin, irisin, and total testosterone levels. Plasma OXM concentrations were measured in duplicate using a commercial ELISA kit. RESULTS: OXM levels were positively correlated with age (r = 0.493, p = 0.027); however, they showed no significant correlation with body mass index, waist circumference, lipid accumulation product index, visceral adiposity index, or hormones such as insulin, irisin, and testosterone. Furthermore, plasma OXM levels remained unchanged in a subgroup of patients treated with metformin for 60 days. CONCLUSION: These findings suggest that plasma OXM levels may not reflect body composition or insulin resistance in women with PCOS.
Phase angle and body composition in long-term type 1 diabetes in adults: a comparative study in a Brazilian public reference outpatient clinic Natália Fenner-Pena, Virgínia Capistrano Fajardo, Lívia Froes, Paulo Augusto Miranda Carvalho, Fábio Vasconcellos Comim, Viviane Sahade, Márcio Weissheimer Lauria, Henrique Oswaldo da Gama Torres Diabetology and Metabolic Syndrome, 2024 Introduction Type 1 Diabetes Mellitus (DM1) affects a small percentage of the population. Nevertheless, its prevalence is currently growing with alarming data on uncontrolled cases. The importance of body composition and Phase Angle (PA), assessed by Bioelectrical Impedance (BIA), in long- term DM1 patients lies in the fact that alterations in cellular integrity and body compartments may affect risk profiles and metabolic control. The objective of this study was to compare PA and body composition parameters between adults with DM1 and healthy controls. Methods A comparative study was carried out in a public university outpatient clinic including a cohort of adult patients of both sexes diagnosed with DM1 and healthy controls matched by age and sex in a 2:1 ratio. Anthropometric measurements included weight, height and BMI. Using the raw BIA data of Resistance and Reactance, fat-free mass (FFM), fat mass (FM), fat-free mass index (FFMI), fat mass index (FMI), PA and standardized PA (SPA) were calculated. Means or medians were compared between the groups. Regression models were used to identify distinguishing characteristics of the groups and associations within the DM1 group (i.e. glycated hemoglobin (HbA1c), disease duration, presence of microvascular complications, capillary blood glucose, BMI and FMI). Results 88 patients with DM1and 46 healthy controls were evaluated. PA (6.05 vs. 6.85, p = 0.000) and SPA (-1.47 vs. -0,37, p = 0.000) were lower in patients with DM1 compared to healthy controls. People with DM1 displayed higher adiposity (%FM = 29.6 vs. 27.6, p = 0.016; FMI = 7.00 vs. 6.33, p = 0.016) and lower %FFM compared to healthy controls. Most of the differences were maintained after sex stratification; however, men with DM1 showed a lower FFMI than male controls (18.2 vs. 20.16, p = 0.029). Conclusion Patients with DM1 present lower PA than healthy controls, which may be related to worse cell membrane integrity. Significant body composition differences between the groups and between sexes were identified, with data showing greater adiposity in women with DM1 and men displaying lower muscle mass. These findings suggest the importance of including PA and body composition evaluations in the follow-up of patients with DM1. The ultimate goal is to obtain a better metabolic control and, consequently, a better prognosis.
A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients Fabiano Malard de Araujo, Fábio Vasconcellos Comim, Rodrigo N. Lamounier, Natália F. Pena, Virgínia C. Fajardo, Regina Bicalho G. de Faria, Yuri M. Silva, Márcio Weissheimer Lauria Diabetology and Metabolic Syndrome, 2024 The Steno Diabetes Center Copenhagen developed the Steno T1 Risk Engine (ST1RE) to predict cardiovascular events, encompassing fatal and nonfatal ischemic heart disease, ischemic stroke, heart failure, and peripheral arterial disease in type 1 diabetes mellitus(T1DM).The current study investigated the agreement between ST1RE and the Brazilian Society for Endocrinology and Metabology (SBEM) classification. Participants were included in the study if diagnosed with T1DM and had at least one outpatient visit in 2021. Patients with established cardiovascular disease and chronic kidney disease on dialysis were excluded. Clinical parameters were obtained from medical records, such as age, body mass index (BMI), blood pressure, physical activity, current smoking, microvascular target organ damage, levels of low-density lipoprotein cholesterol, creatinine, glycated hemoglobin (HbA1c), and albuminuria.Overall, 92 patients (38 males and 53 females) with an age median (P25; P75) of 33 years (25.5;42.5), BMI of 24.8 + 4.1 kg/m2, and duration of diabetes (mean ± SD) of 23.4 + 9.5 years were evaluated. There were no differences considering the gender for most analyzed variables, but a higher proportion of women exhibited microvascular complications such as microalbuminuria, macroalbuminuria, and retinopathy. Our results show a weak agreement in the 10-year cardiovascular risk estimation between SBEM and ST1RE classifications. According to SBEM criteria, 72.8% of patients were considered high-risk, while only 15.2% of patients received the same classification using ST1RE. The dissimilarities between these two classifications were also evident when age and gender factors were compared. While 60% of patients under 35 years were classified as high risk according to SBEM criteria, only 1.8% received this stratification risk in the ST1RE classification.The results indicate a low agreement between the 10-year cardiovascular event risk classification by SBEM and the classification by ST1RE for type 1 diabetes patients without established cardiovascular disease.
Contrasting Bone Profiles in PCOS Are Related to BMI: A Systematic Review and Meta-analysis Graziela Rissetti, Julia Mottecy Piovezan, Melissa Orlandin Premaor, Fabio Vasconcellos Comim Journal of Clinical Endocrinology and Metabolism, 2024 Context Controversial results have emerged regarding whether polycystic ovary syndrome (PCOS) is protective or increases the risk of bone frailty. Objective This study investigated whether the PCOS condition affects bone parameters of premenopausal women. This is an update for a previous meta-analysis published in 2019. Data Sources We searched MEDLINE and Embase. Study Selection Studies were considered eligible for the update if published in English between October 1, 2018, and December 31, 2023. The diagnosis of PCOS should be based on National Institutes of Health criteria, the Rotterdam Consensus, Androgen Excess & PCOS Society criteria, or International Classification of Diseases codes in women over 18 years old. Only records with the Newcastle-Ottawa Scale ≥ 6 were selected for data extraction. Data Extraction Data were extracted by 2 independent reviewers. Data Synthesis We identified 31 studies that met the inclusion criteria for qualitative analysis from 3322 studies in the whole period (1990-2023). Overall, cross-sectional studies included 1822 individuals with PCOS and 1374 controls, while cohort studies incorporated 30 305 women with PCOS and 10,1907 controls. Contrasting profiles emerged after stratification using a body mass index (BMI) cutoff of 27 kg/m2. Individuals with PCOS and a BMI <27 kg/m2 exhibited lower vertebral and nonvertebral bone density, reduced bone turnover marker (osteocalcin), and increased bone resorption marker (C-terminal type I collagen) levels. Conversely, individuals with PCOS and a BMI ≥27 kg/m2 exhibited increased vertebral and nonvertebral bone mineral density, with no significant changes in bone formation and resorption markers (except osteocalcin). Conclusion The findings of this study alert for a low bone mass, low bone formation, and increased bone resorption PCOS with a BMI <27 kg/m2.
An Improved Approach for Semantic Segmentation of Fundus Lesions using R2U-Net Alejandro Pereira, Carlos Santos, Marilton Aguiar, Daniel Welfer, Marcelo Dias, Rafaela de Menezes, Paulo Roberto Ferreira, Fábio Rossi, Marcos d’Ornellas, Carlos Jesus Haygert, Juliano Kazienko, Fábio Comim, Aurélio Hoppe, Juliano Weber, Leandro Tavares, Leonardo Guths, Rodrigo Guerra Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS, 2024
Bone strength is reduced in a neonatal androgenized rat model Lady Katerine Serrano Mujica, Carolina dos Santos Amaral, Fernanda Soldatelli Valente, Ligia Gomes Miyazato, Soraia Macari, Tarcília Aparecida da Silva, Breno Rocha Barrioni, Bruna Leonel Carlos, Guilherme Jafroni Alves Silva, Antônio Carlos Shimano, Alfredo Quites Antoniazzi, Melissa Orlandin Premaor, Fabio Vasconcellos Comim Bone Reports, 2023
Trabecular Bone is Increased in a Rat Model of Polycystic Ovary Syndrome Lady Katerine Serrano Mujica, Werner Giehl Glanzner, Amanda Luiza Prante, Vitor Braga Rissi, Gabrielle Rebeca Everling Correa, Melissa Orlandin Premaor, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves, Fabio Vasconcellos Comim Experimental and Clinical Endocrinology and Diabetes, 2021
Prenatal androgenization of ewes as a model of hirsutism in polycystic ovary syndrome Joabel Tonellotto dos Santos, Jandui Escarião da Nóbrega, Lady Katerine Serrano Mujica, Carolina dos Santos Amaral, Fabrício Amadori Machado, Manuela W Manta, Tiele Medianeira Rizzetti, Renato Zanella, Rafael Fighera, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves, Fabio Vasconcellos Comim Endocrinology, 2018
PCOS and bone fractures Fabio V. Comim, Melissa O. Premaor Journal of Bone and Mineral Metabolism, 2018
Urinary inflammatory cytokines as indicators of kidney damage in type 2 diabetic patients Manuela Borges Sangoi, José Antonio M. de Carvalho, Etiane Tatsch, Bruna S. Hausen, Yãnaí S. Bollick, Sílvia W.K. Londero, Thiago Duarte, Rogério Scolari, Marta M.M.F. Duarte, Melissa O. Premaor, Fabio V. Comim, Maria B. Moretto, Rafael N. Moresco Clinica Chimica Acta, 2016
Obesity and fractures in postmenopausal women: A primary-care cross-sectional study at Santa Maria, Brazil Rafaela Martinez Copês, Fabio Vasconcellos Comim, Felipe Welter Langer, Antonio Aurelio da Silveira Codevilla, Giovani Ruviaro Sartori, Cristina de Oliveira, Aline Rubin Cocco, Adriana Maria de Almeida, Luciana Leiria de Almeida, Léo Canterle Dal Osto, Juliet Elizabeth Compston, Melissa Orlandin Premaor Journal of Clinical Densitometry, 2015
Obesity and fractures Melissa Orlandin Premaor, Fabio Vasconcellos Comim, Juliet E. Compston Arquivos Brasileiros De Endocrinologia E Metabologia, 2014