Suleiman Ambali

Prof Ambali obtained the DVM, and M.Sc., and Ph.D. degrees in Veterinary Toxicology from the Ahmadu Bello University in 1992, 2004, and 2009, respectively. He is currently a Professor of Environmental Toxicology and the Deputy Vice-Chancellor, Management Services, and a member of the Governing Council of the University of Ilorin. He had served both Universities at the Departmental, Faculty, and University levels. He was the Head of the Department of Veterinary Physiology and Pharmacology, Sub-Dean, and Dean of the Faculty of Veterinary Medicine from 2012-2017. He was Chairman of the Technical Sub-committee of the Appointments and Promotions Committees from 2018-2020. He is a member and fellow of various academic, professional, and cultural organizations. With an h-index of 26 with over 130 articles in peer review journals and books, Prof. Ambali has attended many local and international conferences. He is married and blessed with children.

EDUCATION

Doctor of Veterinary Medicine - Ahmadu Bello University, Zaria, Nigeria
M.Sc. Veterinary Toxicology, Ahmadu Bello University, Zaria, Nigeria
Ph.D. Veterinary Toxicology, Ahmadu Bello University, Zaria, Nigeria

RESEARCH, TEACHING, or OTHER INTERESTS

Toxicology, Veterinary, Pharmacology, Toxicology and Pharmaceutics, Neuroscience

Scopus Publications

Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes
Aishat Omobolanle Olatunji, Root Oluwapelumi Alegbe, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Afisu Basiru, Jamila Abdulhamid Atata, Kolawole Yusuf Suleiman, and Charles Amoto Shuaibu
Elsevier BV



Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats
Aishat Omobolanle Olatunji, Joseph Olusegun Ayo, Mohammed Musa Suleiman, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Ibrahim Yusuf Lamidi, Basiru Afisu, and Olubukola Tolulope Adenubi
Springer Science and Business Media LLC



Developmental deficits in male rat pups caused by maternal and dietary administration of chlorpyriphos and cypermethrin: Melatonin’s mitigating effect
Muftau Shittu, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, Mohammed Umaru Kawu, Motunrayo Ganiyat Akande, and Zainab Abdulmalik
SAGE Publications
The ability of melatonin to reduce growth inadequacy induced by parental and nutritional combination administration to chlorpyriphos (Ch) and cypermethrin (Cy) was examined in male albino rats. Oral alimentation was given to gravid dams divided into six groups ( n = 10; age: 12 weeks) from the first day of pregnancy to the 21st postnatal day. Distilled water (DW), Soya oil (SYO), and melatonin (MeL) groups were exposed to 2 mL/kg, 2 mL/kg, and 0.5 mg/kg, respectively; the Ch+Cy group was co-exposed to Ch (1.9 mg/kg of LD50) and Cy (7.5 mg/kg of LD50); the MChCy group was preconditioned with MeL (0.5 mg/kg), followed by co-exposure to Ch and Cy; and the ChCyM group was exposed to Ch and Cy and post treated with MeL. Male offspring rats were tested for ontogeny criteria at various points after accouchement. MeL pre- and post-administration reduced the variation in litter size and weight, number of live/dead pups, anogenital distance , crown-rump length, the timing of eye and ear openings, and testicular descent caused by fetal and nutritional co-administration to Ch+Cy in offspring male albino rats. MeL demonstrated preventive promise as a result of its apparent antioxidative capability.


Vitamin C Protects Against Blood and Thyroid Toxicities Induced by the Chronic Use of Carbamazepine in Rats
Ganiu Jimoh Akorede, , Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Akeem Olayiwola Ahmed, Afisu Basiru, Mistura Oyebisi Azeez, Fatima Sanusi, Rafiu Adebisi Kadir,et al.
Negah Scientific Publisher
Background: Drugs are the mainstay of the clinical management of epilepsy. Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This drug has been reported to have toxic effects on the hematological system due to its induction of oxidative stress. This study aimed to investigate the protective effects of vitamin C against hematological and thyroid toxicities caused by the chronic use of carbamazepine in male Wistar rats. Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels. Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities. Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.


Elevated blood mercury and haematological response in free ranging chicken (Gallus Gallus domesticus) from gold mining areas in Zamfara State Nigeria
Zainab Abdulmalik, Muftau Shittu, Sani Adamu, Suleiman Folorunsho Ambali, and Bolaji Fatai Oyeyemi
Elsevier BV



Effect of daflon-500^®, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats
Aishat O. Olatunji, Joseph O. Ayo, Mohammed M. Suleiman, Suleiman F. Ambali, Muftau Shittu, Ganiu J. Akorede, Lukman O. Raji, Jamila A. Atata, Khalid T. Biobaku, and Mistura O. Azeez
Springer Science and Business Media LLC



Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats
Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Afisu Basiru, Akeem Olayiwola Ahmed, Mistura Olabisi Azeez, Isiaku Abdulmajeed, and Rafiu Adebisi Kadir
Elsevier BV



Melatonin mitigates thyroid dysfunction induced by gestational and lactational exposure to mixture of chlorpyriphos and cypermethrin in male Wistar rats
Muftau Shittu, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, Mohammed Umaru Kawu, and Aishat Omobolanle Olatunji
Springer Science and Business Media LLC



Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Mikail Garba Hudu, Mohammed M. Suleiman, Kolawole Yusuf Suleiman, Halimat Amin Abdulrahim, Lukman Oladimeji Raji, and Isiaku AbdulMajeed
Springer Science and Business Media LLC



Effect of melatonin on reproductive indices in untreated females following mating with F1 male Wistar rats exposed in utero and via lactation to mixture of chlorpyrifos and cypermethrin
Muftau Shittu, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, and Mohammed Umaru Kawu
Walter de Gruyter GmbH
Abstract The study investigated effect of melatonin (MEL) on reproductive indices in untreated females mated with F1 male rats exposed in utero and via lactation to mixture of chlorpyrifos (CPF) and cypermethrin (CYP), and in the resulting F2 male rats. Sixty pregnant dams obtained via overnight mating of 72 nulliparous females with sexually mature males in a 1:1 mating scheme were divided into 6 groups of 10 animals each. Groups I (DW), II (S/oil) and III (MEL) were given distilled water (2 ml/kg), Soya oil (2 ml/kg) and melatonin (0.5 mg/kg) only, respectively, while group IV (CC) was co-administered with CPF (1.9 mg/kg) and CYP (7.5 mg/kg). Group V (MCC) was pretreated with MEL (0.5 mg/kg) and then co-exposed to CPF (1.9 mg/kg) and CYP (7.5 mg/kg), 30 minutes later. Group VI (CCM) was co-exposed to CPF (1.9 mg/kg) and CYP (7.5 mg/kg) and then treated with MEL (0.5 mg/kg) 30 minutes later. The regimens were administered by gavage once daily from gestation day 1 to postnatal day (PND) 21. The dams were allowed to deliver normally and the males F1 generation obtained from them was allowed to mate nulliparous females at PND 80 overnight in a ratio of 1:1 and some reproductive indices were thereafter evaluated. The mated females were evaluated for mating index, fertility index, gestation index and gestational length, while the resulting F2 male rats were evaluated for live birth index, viability index and sex ratio. The results revealed decreased mean gestational length, viability index and sex ratio in the CC group (p<0.05) relative to that of the other groups. Although not significant (p>0.05), the mating, gestation (pregnancy), fertility and live birth indices in the CC group were relatively lower when compared to that of other treated groups. In conclusion, alterations of reproductive indices from mating of nulliparous females with F1 male rats exposed in utero and via lactation to mixture of CPF and CYP were mitigated by melatonin.


Surveillance for avian influenza virus in captive wild birds and indigenous chickens in Nigeria
O. B. Daodu, H. O. Jegede, J. O. Aiyedun, O. O. Oludairo, I. D. Olorunshola, O. C. Daodu, A. Ajadi, and S. F. Ambali
Springer Science and Business Media LLC



Effect of zinc supplementation on chronic hepatorenal toxicity following oral exposure to glyphosate-based herbicide (Bushfire®) in rats
Emmanuel Vandi Tizhe, Najume Dogon-Giginya Ibrahim, Mohammed Yakasai Fatihu, Suleiman Folorunsho Ambali, Ikechukwu Onyebuchi Igbokwe, and Ussa Delia Tizhe
SAGE Publications
Objectives To assess the effects of zinc pretreatment on hepatorenal toxicity following chronic exposure to glyphosate-based herbicides in male rats. Methods Following zinc pretreatment (50 mg/kg and 100 mg/kg), 14.4 to 750 mg/kg of oral glyphosate (Bushfire® herbicide) was administered daily for 36 weeks. Thereafter, serum samples were obtained following jugular venipuncture. Liver and kidney samples were processed for histopathological examination. Results Serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activity as well as levels of bicarbonate, calcium, creatinine were significantly increased following chronic exposure to Bushfire®. Serum levels of sodium, potassium, chloride, total protein, albumin, globulin and urea were unchanged. Moderate to severe coagulative necrosis of hepatocytes as well as glomerular and renal tubular necrosis were observed in herbicide-treated rats. Zinc pretreatment reduced the elevation of serum enzymes associated with hepatobiliary lesions, abrogated hypercalcemia and metabolic alkalosis, and mitigated serum accumulation of creatinine following Bushfire® exposure, but was ineffective in completely preventing histological lesions. Conclusion Chronic Bushfire® exposure in rats caused hepatorenal toxicity. The effects of exposure on serum parameters were ameliorated by zinc pretreatment, but the histopathological changes associated with toxicity persisted in milder forms in zinc-pretreated animals.


Effect of zinc on erythrocyte osmotic fragility and hemogram following chronic exposure to glyphosate-based herbicide in Wistar rats
Emmanuel Vandi Tizhe, Najume Dogon-Giginya Ibrahim, Mohammed Yakasai Fatihu, Suleiman Folorunsho Ambali, Ikechukwu Onyebuchi Igbokwe, and Delia Ussa Tizhe
Springer Science and Business Media LLC



Body weight and hematological changes induced by chronic exposure to low levels of chlorpyrifos and deltamethrin combination in rats: the effect of alpha-lipoic acid
Chidiebere Uchendu, S. F. Ambali, J. O. Ayo, and K. A. N. Esievo
Springer Science and Business Media LLC



Pancreatic function and histoarchitecture in Wistar rats following chronic exposure to Bushfire®: the mitigating role of zinc
Emmanuel Tizhe, Najume Ibrahim, Mohammed Fatihu, Suleiman Ambali, Ikechukwu Igbokwe, and Ussa Tizhe
SAGE Publications
Objectives To assess the toxicopathologic effects of chronic exposure to the glyphosate-based herbicide Bushfire® on the pancreas of Wistar rats and the protective role of zinc. Methods We exposed the rats to daily doses of 14.4 to 750 mg/kg body weight of the glyphosate-based herbicide Bushfire® and to 50 or 100 mg/kg zinc, and measured blood glucose levels and serum insulin levels. Tissue samples were evaluated for histopathological alterations. Results Levels of both blood glucose and serum insulin increased in glyphosate-exposed rats, and moderate to severe degenerative changes were observed in both glandular pancreatic acinar cells and islets of Langerhans in all rats exposed to glyphosate. These effects were prevented by pretreatment with zinc. Conclusion Chronic exposure to glyphosate can alter pancreatic function and histoarchitecture, but zinc supplementation can mitigate these toxicopathologic effects.


Chronic co-exposure to chlorpyrifos and deltamethrin pesticides induces alterations in serum lipids and oxidative stress in Wistar rats: mitigating role of alpha-lipoic acid
Chidiebere Uchendu, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, and King Akpofure Nelson Esievo
Springer Science and Business Media LLC



Assessment of antioxidant and neuroprotective activities of methanol extract of Moringa oleifera Lam. leaves in subchronic chlorpyrifos-intoxicated rats
Enokela Shaibu Idoga, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, and Aliyu Mohammed
Springer Science and Business Media LLC



Dyslipdemia induced by chronic low dose co-exposure to lead, cadmium and manganese in rats: the role of oxidative stress
Olusola Olalekan Oladipo, Joseph Olusegun Ayo, Suleiman Folorunsho Ambali, Bisalla Mohammed, and Tanang Aluwong
Elsevier BV



The protective role of alpha-lipoic acid on long-term exposure of rats to the combination of chlorpyrifos and deltamethrin pesticides
Chidiebere Uchendu, Suleiman F Ambali, Joseph O Ayo, and King AN Esievo
SAGE Publications
The study was aimed at evaluating the protective role of α-lipoic acid (ALA) on long-term exposure of rats to the combination of chlorpyrifos (CPF) and deltamethrin (DLT). Forty-two (42) male Wistar rats were divided into 6 exposure groups with 7 animals in each group: (I) soya oil (2 ml kg−1), (II) ALA (60 mg kg−1), (III) DLT (6.25 mg kg−1), (IV) CPF (4.75 mg kg−1), (V) (CPF + DLT) DLT (6.25 mg kg−1) and CPF (4.75 mg kg−1; 1/20th of the previously determined median lethal dose) and (VI) (ALA + CPF + DLT) pretreated with ALA (60 mg kg−1) and then co-exposed to CPF and DLT, 45 min later. The regimens were administered by gavage once daily for a period of 16 weeks. Sera obtained from blood collected at the end of the experimental period were used for the evaluation of serum glucose, total protein, albumin, urea, creatinine and the activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase and acetylcholinesterase. The liver homogenate was used to assay for the activities of superoxide dismutase and glutathione peroxidase and the concentrations of malondialdehyde, cytokine and tumour necrotic factor α. The result showed that the combination of CPF and DLT resulted in marked alterations of these biochemical parameters in most cases compared to either of the pesticides singly, supplementation with ALA ameliorated these alterations.


Evaluation of hepatorenal impairments in Wistar rats coexposed to low-dose lead, cadmium and manganese: insights into oxidative stress mechanism
Olusola Olalekan Oladipo, Joseph Olusegun. Ayo, Suleiman Folorunsho Ambali, and Bisalla Mohammed
Informa UK Limited
Abstract The study aims to evaluate effects of chronic low-dose coexposure to lead (Pb), cadmium (Cd) and manganese (Mn) on hepatorenal toxicity and oxidative stress. Young male Wistar rats were treated with Pb acetate (1.4 mg/kg BW), Cd chloride (0.01 mg/kg BW), Mn chloride (0.14 mg/kg BW) and their combination (Pb + Cd + Mn) by oral gavage, for 15 weeks. Liver enzymes, albumin (Alb), globulin (Glb), total protein, creatinine, urea and electrolyte concentrations were measured in the serum. Hepatic and renal malondialdehyde (MDA), glutathione peroxidase-1 (GPx1) and metallothionein-1 (MT1) concentrations were measured by enzyme immunoassay technique. Chronic exposure to the metals significantly (p < .05) increased serum Glb concentration and decreased Alb/Glb ratio, compared to the controls. Serum creatinine concentration significantly (p < .05) decreased in the Pb, Cd and Pb + Cd + Mn groups, but elevated in the Mn group. Hepatic MDAs rose significantly (p < .05) in the Pb group, while hepatic GPx1 activities increased significantly (p < .05) in the Cd, Mn and Pb + Cd + Mn groups. Hepatic and renal MT1 concentration decreased (p < .05) in the Mn group only. Biochemical alterations were confirmed by light microscopy of the liver and kidneys, which showed degenerative changes. It is concluded that prolonged coexposure to environmentally relevant levels of Pb, Cd and Mn impairs liver and kidney functions via the induction of oxidative stress, and it underlines the importance of studying toxicants in combination.


Co-treatment of chlorpyrifos and lead induce serum lipid disorders in rats: Alleviation by taurine
Motunrayo G Akande, Yusuf O Aliu, Suleiman F Ambali, and Joseph O Ayo
SAGE Publications
The aim of this study was to investigate the effects of taurine (TA) on serum lipid profiles following chronic coadministration of chlorpyrifos (CP) and lead acetate (Pb) in male Wistar rats. Fifty rats randomly distributed into five groups served as subjects. Distilled water (DW) was given to DW group, while soya oil (SO; 1 mL kg−1) was given to SO group. The TA group was treated with TA (50 mg kg−1). The CP + Pb group was administered sequentially with CP (4.25 mg kg−1; 1/20th median lethal dose (LD50)) and Pb at 233.25 mg kg−1(1/20th LD50), while the TA + CP + Pb group received TA (50 mg kg−1), CP (4.25 mg kg−1), and Pb (233.25 mg kg−1) sequentially. The treatments were administered once daily by oral gavage for 16 weeks. The rats were euthanised, and the blood samples were collected at the termination of the study. Sera obtained from the blood samples were analyzed for total cholesterol, high-density lipoprotein cholesterol, triglycerides, and malondialdehyde, and also the activities of serum antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase were analyzed. The low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and atherogenic index were calculated. The results showed that CP and Pb induced alterations in the serum lipid profiles and evoked oxidative stress. TA alleviated the disruptions in the serum lipid profiles of the rats partially by mitigating oxidative stress. It was concluded that TA may be used for prophylaxis against serum lipid disorders in animals that were constantly co-exposed to CP and Pb in the environment.


Hemato-Biochemical responses to packing in donkeys administered ascorbic acid during the harmattan season
Folashade OLAIFA, Joseph Olusegun AYO, Suleiman Folorunsho AMBALI, and Peter Ibrahim REKWOT
Japanese Society of Veterinary Science
Experiments were performed to investigate the effect of ascorbic acid (AA) in reducing hemato-biochemical changes in pack donkeys during the cold-dry (harmattan) season. Six experimental donkeys administered orally AA (200 mg/kg) and six control donkeys not administered ascorbic acid were subjected to packing. Blood samples were collected from all donkeys for hematological and biochemical analyses. In the control donkeys, packed cell volume (PCV), erythrocyte count and hemoglobin concentration (Hb) decreased significantly (P<0.05) at the end of packing. In the experimental donkeys, there was no significant difference between the pre- and post-packing values of PCV, erythrocyte count and Hb. In the control donkeys, the neutrophil and neutrophil:lymphocyte ratio increased significantly (P<0.05) post packing, but in the experimental donkeys, the pre- and post-packing values were not significantly different. The eosinophil count increased significantly (P<0.05) in experimental and control donkeys post packing. In conclusion, packing exerted significant adverse effects on the hematological parameters ameliorated by AA administration. AA may modulate neutrophilia and induce a considerable alteration of erythroid markers in donkeys subjected to packing during the harmattan season.


Liver histopathological changes in Clarias gariepinus exposed to ethanol extract of Adenium obesum stem bark
S. Abalaka, M. Fatihu, N. Ibrahim, and S. Ambali
The Brazilian Society of Anatomy (SBA)
Abstract Introduction: Histopathological effects of ethanol extract of Adenium obesum stem bark on the liver of Clariasgariepinus was investigated over a 96-h exposure period as an effective organic piscicide. Materials and Methods: An acute static toxicity bioassay was performed after a preliminary concentration range finding test was conducted. Results: Exposed fish showed adaptation behavioural changes with those of respiratory distress and abnormal nervous signs of toxicity, which was concentration-dependent. Mortality was recorded in some of the exposed fish while a median lethal concentration of 7.15 mgL-1 was established for the extract in the exposed fish. Non-significant (p&gt;0.05) changes were recorded in serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities of the exposed ish. Moderate liver damage was observed in the exposed fish based on the degree of tissue change (DTC) grading where significant (p&lt;0.05) differences were observed between the DTC of the exposed groups and the control. Conclusion: Ethanol extract of A. obesum stem bark was toxic to the exposed fish with evidence of hepatotoxicity and therefore, can be used to eradicate the hardy C.gariepinus from aquatic environments.


Gills and skin histopathological evaluation in African sharptooth catfish, Clarias gariepinus exposed to ethanol extract of Adenium obesum stem bark
Samson Eneojo Abalaka, Muhammad Yakasai Fatihu, Najume Doguwar Giginya Ibrahim, and Suleiman Folorunsho Ambali
Elsevier BV



Haematotoxicity of ethanol extract of Adenium obesum (forssk) roem &amp; schult stem bark in Wistar rats
SE Abalaka, MY Fatihu, NDG Ibrahim, and SF Ambali
African Journals Online (AJOL)
Purpose : To investigate the acute toxicity of ethanol extract of Adenium obesum (Forssk.) Roem. & Schult stem bark in Wistar rats in relation to haematological parameters. Methods : This involved the administration of single dose of 300 mgkg -1 , 2000 mgkg -1 and 5000 mgkg -1  of the extract by oral gavage separately to three different groups of female rats (n = 3) one after another based on the absence of mortality and/or morbidity during a 14-day observation period. The control group was administered distilled water as placebo (1 mL per 100 g body weight). Results : The exposed rats did not show any obvious signs of toxicity, morbidity or mortality. Median lethal dose (LD50) of the extract was ≥ 5000 mgkg -1 or ∞ (unclassified) based on the fixed LD50 cut-off values. Final body weight of control rats (196.00 ± 3.06 g) was significantly (p  0.05). Packed cell volume, red blood cell count and haemoglobin concentrations in the rats (42.67 ± 1.33 %, 5.10 ± 0.20 x 10 12 L -1 and 130.70 ± 2.96 gL -1 , respectively did not change significantly (p > 0.05). However, the white blood cell count significantly increased from 7.50 ± 0.63 x 10 9 to 11.63 ± 0.50 x 10 9 L -1 while the lymphocyte count significantly increased from 5.81 ± 0.43 x 10 9 to 9.99 ± 0.42 x 10 9 L -1 (p < 0.05) at the highest extract dose (5000 mgkg -1 ) compared to their respective controls. Conclusion : Adenium obesum might not be haematotoxic and is considered a safe medicinal plant administered orally. Keywords : Adenium obesum , Haemoglobin, Blood count, Mortality, Morbidity, Haematotoxicity

RECENT SCHOLAR PUBLICATIONS

Co-administration of Hibiscus sabdariffa linn and Daflon-500 mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes
AO Olatunji, RO Alegbe, SF Ambali, M Shittu, GJ Akorede, A Aremu, ...
Phytomedicine Plus 5 (1), 100699 2025



Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male
AO Olatunji, JO Ayo, MM Suleiman, SF Ambali, M Shittu, GJ Akorede, ...
Naunyn-Schmiedeberg's Archives of Pharmacology 397 (11), 9181-9190 2024



Evaluating the Supplementary Effects of Vitamin C on Carbamazepine and Pentylenetetrazol-Induced Seizures and Preimplantation Loss in Pregnant Wistar Rats: Implications for
AG JIMOH, AS FOLORUNSHO, A OLATUNBOSUN, OA OMOBOLANLE, ...
Asia Pacific Journal of Medical Toxicology 13 (2) 2024



Developmental deficits in male rat pups caused by maternal and dietary administration of chlorpyriphos and cypermethrin: Melatonin’s mitigating effect
M Shittu, SF Ambali, JO Ayo, MU Kawu, MG Akande, Z Abdulmalik
Toxicology and Industrial Health 39 (7), 398-405 2023



Vitamin C protects against blood and thyroid toxicities induced by the chronic use of carbamazepine in rats
GJ Akorede, SF Ambali, AO Olatunji, A Aremu, AO Ahmed, A Basiru, ...
Iranian Journal of Toxicology 17 (2), 147-156 2023



Elevated blood mercury and haematological response in free ranging chicken (Gallus Gallus domesticus) from gold mining areas in Zamfara State Nigeria
Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi
Environmental Chemistry and Ecotoxicology 5, 39-44 2023



Assessment of blood mercury, immune response, heat shock and oxidative stress marker in free-ranging chicken (Gallus Gallus domesticus) from gold mining areas in Zamfara State
Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi
Journal of Hazardous Materials Advances 8, 100176 2022



Prolongation of survival duration by extract and fraction of Commiphora africana in mice injected with LD₉₉ of Naja nigricollis crude venom.
HI Isa, A Saleh, M Shittu, MM Suleiman, SF Ambali
Savannah Veterinary Journal 5 (2) 2022



Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats
GJ Akorede, SF Ambali, AO Olatunji, A Aremu, A Basiru, AO Ahmed, ...
Pharmacological Research-Modern Chinese Medicine 2, 100055 2022



Effect of daflon-500, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats
AO Olatunji, JO Ayo, MM Suleiman, SF Ambali, M Shittu, GJ Akorede, ...
Toxicological research, 1-9 2022



Melatonin Ameliorates Developmental Landmarks Induced by Gestational and Lactational Coexposure to Chlorpyriphos and Cypermethrin in F1 Male Rats
M Shittu, S Ambali, J Ayo, U Kawu, M Akande
2021



Melatonin mitigates thyroid dysfunction induced by gestational and lactational exposure to mixture of chlorpyriphos and cypermethrin in male Wistar rats
M Shittu, SF Ambali, JO Ayo, MU Kawu, AO Olatunji
Comparative Clinical Pathology 30 (3), 529-540 2021



Hibiscus sabdariffa Linn extract possesses potential to ameliorate chlorpyriphos-induced haemotoxicity in rats.
M Shittu, IT Oyedepo, IH Isa, SF Yahya, SF Ambali, LS Yaqub, AO Olatunji
2021



Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
GJ Akorede, SF Ambali, MG Hudu, MM Suleiman, KY Suleiman, ...
Comparative Clinical Pathology 29, 1179-1187 2020



Surveillance for avian influenza virus in captive wild birds and indigenous chickens in Nigeria
OB Daodu, HO Jegede, JO Aiyedun, OO Oludairo, ID Olorunshola, ...
Tropical Animal Health and Production 52, 2387-2393 2020



Effect of zinc supplementation on chronic hepatorenal toxicity following oral exposure to glyphosate-based herbicide (Bushfire) in rats
EV Tizhe, NDG Ibrahim, MY Fatihu, SF Ambali, IO Igbokwe, UD Tizhe
Journal of International Medical Research 48 (8), 0300060520925343 2020



Preventing pesticides from poisoning away our health and future: The oxidative approach
S AMBALI
University of Ilorin Library and Publication Committee 2020



Effect of melatonin on reproductive indices in untreated females following mating with F1 male Wistar rats exposed in utero and via lactation to mixture of chlorpyrifos and
M Shittu, SF Ambali, JO Ayo, MU Kawu
Interdisciplinary Toxicology 13 (3), 97-105 2020



Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats
GJ Akorede, SF Ambali, AO Olatunji, M Shittu, A Aremu, A Basiru, ...
Toxicology Reports 7, 269-276 2020



Sensorimotor changes following acute exposure to carbamazepine and phenytoin in male Wistar rats.
GJ Akorede, SF Ambali, KA Abidoye, AO Olatunji, A Aremu, A Basiru, ...
2020

MOST CITED SCHOLAR PUBLICATIONS

Evaluation of subchronic chlorpyrifos poisoning on hematological and serum biochemical changes in mice and protective effect of vitamin C
S Ambali, D Akanbi, N Igbokwe, M Shittu, M Kawu, J Ayo
The Journal of Toxicological Sciences 32 (2), 111-120 2007
Citations: 172



Ethnomedical importance of Citrus aurantifolia (christm) swingle
OS Enejoh, IO Ogunyemi, MS Bala, IS Oruene, MM Suleiman, SF Ambali
The Pharma Innovation 4 (8, Part A), 1 2015
Citations: 124



Chlorpyrifos-induced alteration of hematological parameters in Wistar rats: ameliorative effect of zinc.
SF Ambali, AT Abubakar, M Shittu, LS Yaqub, SB Anafi, A Abdullahi
2010
Citations: 102



The organophosphate, chlorpyrifos, oxidative stress and the role of some antioxidants: a review
C Uchendu, SF Ambali, JO Ayo
African Journal of Agricultural Research 2012
Citations: 92



Hemotoxicity induced by chronic chlorpyrifos exposure in Wistar rats: mitigating effect of vitamin C
SF Ambali, JO Ayo, KAN Esievo, SA Ojo
Veterinary medicine international 2011 (1), 945439 2011
Citations: 85



Chronic chlorpyrifos-induced oxidative changes in the testes and pituitary gland of wistar rats: Ameliorative effects of vitamin C
M Shittu, JO Ayo, SF Ambali, MY Fatihu, BI Onyeanusi, MU Kawu
Pesticide biochemistry and physiology 102 (1), 79-85 2012
Citations: 65



Ameliorative effects of vitamin C on short-term sensorimotor and cognitive changes induced by acute chlorpyrifos exposure in Wistar rats
SF Ambali, SB Idris, C Onukak, M Shittu, JO Ayo
Toxicology and Industrial Health 26 (9), 547-558 2010
Citations: 63



Vitamin E protects Wistar rats from chlorpyrifos-induced increase in erythrocyte osmotic fragility
SF Ambali, JO Ayo, SA Ojo, KAN Esievo
Food and chemical toxicology 48 (12), 3477-3480 2010
Citations: 62



Ameliorative effect of vitamin C on chronic chlorpyrifos-induced erythrocyte osmotic fragility in Wistar rats
SF Ambali, JO Ayo, SA Ojo, KAN Esievo
Human & experimental toxicology 30 (1), 19-24 2011
Citations: 60



Ameliorative effect of vitamins C and E on neurotoxicological, hematological and biochemical changes induced by chronic chlorpyrifos in Wistar rats
SF Ambali
Unpublished PhD Dissertation. Zaria, Nigeria: Ahmadu Bello University 2009
Citations: 52



Influence of zinc supplementation on histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen during subchronic exposure of Wistar rats to glyphosate
EV Tizhe, NDG Ibrahim, MY Fatihu, II Onyebuchi, BDJ George, SF Ambali, ...
Comparative clinical pathology 23, 1535-1543 2014
Citations: 49



Cytotoxicity of chlopyrifos and cypermethrin: The ameliorative effects of antioxidants
SB Idris, SF Ambali, JO Ayo
African Journal of Biotechnology 11 (99), 16461-16467 2012
Citations: 49



Erythrocyte osmotic fragility and lipid peroxidation following chronic co-exposure of rats to chlorpyrifos and deltamethrin, and the beneficial effect of alpha-lipoic acid
C Uchendu, SF Ambali, JO Ayo, KAN Esievo, AJ Umosen
Toxicology reports 1, 373-378 2014
Citations: 44



Subchronic chlorpyrifos-induced clinical, hematological and biochemical changes in Swiss albino mice: protective effect of vitamin E
SF Ambali, DO Akanbi, OO Oladipo, LS Yaqub, MU Kawu
Int J Biol Med Res. 2 (2), 497-503 2011
Citations: 43



Evaluation of hepatorenal impairments in Wistar rats coexposed to low-dose lead, cadmium and manganese: insights into oxidative stress mechanism
OO Oladipo, JO Ayo, SF Ambali, B Mohammed
Toxicology mechanisms and methods 26 (9), 674-684 2016
Citations: 42



Chronic co-exposure to chlorpyrifos and deltamethrin pesticides induces alterations in serum lipids and oxidative stress in Wistar rats: mitigating role of alpha-lipoic acid
C Uchendu, SF Ambali, JO Ayo, KAN Esievo
Environmental Science and Pollution Research 25, 19605-19611 2018
Citations: 41



Chlorpyrifos-induced clinical, haematological and biochemical changes in Swiss albino mice: mitigating effect by co-administration of vitamins C and E
SF Ambali, DO Akanbi, M Shittu, A Giwa, OO Oladipo, JO Ayo
Life Science Journal 7 (3), 37-44 2010
Citations: 41



Taurine mitigates cognitive impairment induced by chronic co-exposure of male Wistar rats to chlorpyrifos and lead acetate
MG Akande, YO Aliu, SF Ambali, JO Ayo
Environmental toxicology and pharmacology 37 (1), 315-325 2014
Citations: 39



Alleviating effects of melatonin on oxidative changes in the testes and pituitary glands evoked by subacute chlorpyrifos administration in Wistar rats
AJ Umosen, SF Ambali, JO Ayo, B Mohammed, C Uchendu
Asian Pacific Journal of Tropical Biomedicine 2 (8), 645-650 2012
Citations: 39



The protective role of alpha-lipoic acid on long-term exposure of rats to the combination of chlorpyrifos and deltamethrin pesticides
C Uchendu, SF Ambali, JO Ayo, KAN Esievo
Toxicology and industrial health 33 (2), 159-170 2017
Citations: 38