Farah A. Al-Marzook
@alzahraa.edu.iq
al-zahraa
Scopus Publications
- Microwave-Assisted Green Synthesis and Characterization of Silver Nanoparticles Using Neem Extract and Evaluation of Biomedical Properties
Mustafa Mudhafar, Khayr Zaid, Farah A. Al-Marzook, H. A. Alsailawi, Ismail Zainol, et al.
International Journal of Nanoscience, 2025
This study aimed to synthesize, physicochemical characterize, and evaluate the biomedical properties of silver nanoparticles (AgNPs). The methodology section included using two green methods to synthesize silver nanoparticles and comparing them to be chosen appropriately by future researchers. Two samples were obtained: one from green microwave-assisted (MSGS) called AgNPs-1 and the second sample prepared by rapid synthesis method called AgNPs-2; these samples were characterized for their physicochemical using X-ray Powder Diffraction (XRD), Dynamic Light Scattering (DLS), Fourier-transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDX). Moreover, the biomedical properties were evaluated by determining the antibacterial and cytotoxicity studies. The results observed two peaks in the UV–Vis spectroscopy were indicated at 446[Formula: see text]nm and 454[Formula: see text]nm for AgNPs-2 and AgNPs-1, respectively, which first revealed the different particle sizes and conformed in the XRD. DLS showed that the particle sizes of AgNPs-2 were 84.30[Formula: see text]nm and 121[Formula: see text]nm, respectively, while AgNPs-1 were 120.20[Formula: see text]nm and 437[Formula: see text]nm, respectively. The morphology of the synthesized samples was investigated using scanning electron microscopy (SEM) and showed different shapes, which were spherical and spherical-rod for AgNPs-2 and AgNPs-1, respectively. The presence of the silver element was indicated at 3[Formula: see text]KeV in EDX for both samples. The antibacterial test showed a significant ability to inhibit the growth of the four evaluated bacteria, and AgNPs-2 showed more effect than AgNPs-1 because of the size of the particles. The cytotoxicity study showed no toxic effect, and the average cell availability of HeLa cells was 91%. The current research demonstrated that new products from natural materials have good antibacterial properties that can be used as antibiotics with nontoxic effects in the biomedical field. - Evaluation of Intraepithelial Lymphocytes Using Duodenal Biopsy in Patients with Celiac Disease
Advanced Journal of Chemistry Section A, 2025 - NK cells direct the perspective approaches to cancer immunotherapy
Abduladheem Turki Jalil, Mohanad Ali Abdulhadi, Farah A. Al-Marzook, Manar Mohammed Hizam, Sada Jasim Abdulameer, et al.
Medical Oncology, 2023 - MicroRNA-32 Suppression: Its Effects on Prostate Cancer Cells' Capability to Proliferate and Migrate
Farah A. Al-Marzook, Duha Maithem Hassan, Maha Waleed Alghazal, Rana Abd Alameer Kadheem, Abduladheem Turki Jalil, et al.
Drug Research, 2023
Introduction This paper sought to scrutinize the role of microRNA-32 (miR-32) on the growth and migration as well as on the expression of metastatic genes in PC3 cells of prostate cancer in vitro. Methods Subsequent transfection of cells with miR-32 mimics, miR-32 inhibitor, negative control (NC), cell proliferation using MTT, and apoptosis by ELISA were performed. Furthermore, qRT-PCR was directed to measure the expression levels of matrix metalloproteinase 2 (MMP2) and vascular endothelial growth factors (VEGF) as metastatic and angiogenesis genes in the progression of PC3. Results miR-32 was overexpressed in PC3 cells compared to normal cells (P<0.001). Down-regulation of miR-32 obstructs in vitro proliferation and migration while intensifying the apoptosis rate in PC3 cells. Also, we found that miR-32 negatively modulates the expression of VEGF and MMP2 in PC3 cells. Conclusion These results indicate that the suppression of miR-32 might offer an auxiliary treatment procedure for addressing the invasion, progression, and metastasis in PCa patients by improving cell apoptosis. - Studying Ga and Ge-doped AlP nanotube as a drug carrier for ciclopirox anticancer drug using DFT
Farah A. Al-Marzook, Ehab Salam Hussein, Mustafa M. Kadhim, Ahmed Mahdi Rheima, Mohammed F. Al-Marjani, et al.
Computational and Theoretical Chemistry, 2023 - Morphology analysis and microbial diversity in novel anaerobic baffled reactor treating recycled paper mill wastewater
Archives of Environmental Protection, 2021 - Association of 5 - HTTLPR (S allele) polymorphisms with depression, schizophrenia and anxiety
International Journal of Pharmaceutical Research, 2020 - Genetic polymorphisms of Catalase enzyme with hypertension patients in Babylon governorate
Medico Legal Update, 2020 - Catalase gene polymorphism in patient with diabetes disease type 1 in karbala city
Medico Legal Update, 2020 - Antibacterial activity of copper oxide nanoparticles against methicillin resistant Staphylococcus aureus (Mrsa)
Haider Qassim Raheem, Linda H Al-Ghazali, Farah A. Al-Marzook
International Journal of Pharmaceutical Quality Assurance, 2019
One hundred wound swab samples were collected from wound patients who visited in the Teaching Hospital wound unit in Hillah, Babylon province, Iraq. S. aureus was identified morphologically and biochemically. Total of 30 (30%) from total samples exhibited positive culture for S. aureus. Out of 30 S. aureus, 8 (26.6%) isolates were MRSA, Antibiotic susceptibility was tested for 8 antibiotics for MRSA that appeared sensitive toward Tetracycline, Rifampin and Ciprofloxacin (62.5%) but (37.5%) were resistant. For PenicillinG and Cefoxitin, all isolates were resistant (100%). For Clindamycin, (25%) of isolates were resistant but (75%) were sensitive. About (62.5%) were resistant to Erythromycin but (37.5%) were sensitive. Isolates showed resistance to Gentamycin in 50% and 50% sensitive. Anti-bacterial activity of copper oxide nanoparticles (CuO NPs) against S. aureus displays excessive widespread spectrum antibacterial action against established bacteria with increase zone of inhibition diameter that is proportional with the increase in nanoparticle concentration. The (MIC of CuO NPs ranged from 75-150μg/ml and the MBC ranged from 150-300μg/ml. CuO NPs is recommended as an efficient anti-MRSA alternative. - Cytotoxic activity of alkaloid extracts of different plants against breast cancer cell line
Farah A Al-marzook, Rabab Omran
Asian Journal of Pharmaceutical and Clinical Research, 2017 - Cytotoxic activity of alkaloids extracted from three Iraqi plants against breast cancer cell line
Farah A Al-marzook, Rabab Omran
Asian Journal of Pharmaceutical and Clinical Research, 2017
