Dr T K S FAYAZ

Scopus Publications

Sustainable solvent-engineered carbon dots derived from Amaranthus campestris for photocatalytic antiretroviral drug degradation and luminophores in security inks for anti-counterfeit applications
T.K.S. Fayaz, Ashega Sherly Robinson, Priti Gupta, Pavithra Suresh, Komal Murugan, Arunkumar Thirugnanasambandam
Diamond and Related Materials, 2025
New Multicomponent Solid Forms of the Antitumor Drug Ripretinib: The Role of Conformations in Dictating Dissolution and Photostability
Muthukumari Muthaiyan, Fayaz T. K. S, Gowtham Kenguva, Aditya Kumar Prajapati, Rambabu Dandela, Vladimir V. Chernyshev, Palash Sanphui
Crystal Growth and Design, 2024
Ripretinib (RIP), a medication to treat gastrointestinal stromal tumors, possesses very poor aqueous solubility and bioavailability and is prone to degrade under sunlight. In order to overcome the bottlenecks of the drug, salt screening was performed that resulted in hydrochloride, acetate, 2,6-dihydroxybenzoate, and ferulate salts, along with a solvate with formic acid and an unexpected methanol solvate. The new multicomponent solids were characterized by PXRD, DSC, TGA, FT-IR, and SC-XRD. In all these RIP multicomponent solids, the N–H···O hydrogen-bonded centrosymmetric dimer involving urea NH groups and the carbonyl group of the naphthyridine ring is consistent as the reported polymorphs and solvates. In RIP salts, a proton is transferred from the acid to the N-methyl pyridine fraction of the RIP. Even though formic acid is a stronger acid than acetic acid, RIP-formic acid (1:2) is crystallized as a cocrystal (solvate), whereas the RIP acetate acetic acid salt hydrate (1:1:2:1) is crystallized as a mixed ionized state. RIP-2,6-dihydroxybenzoate is crystallized as a solvate (or hydrate), whereas RIP-ferulate forms an anhydrous phase. Solubility experiments in 75% EtOH-water medium indicated that the HCl salt improved up to 4-fold solubility, whereas the RIP-2,6-dihydroxybenzoate and ferulate salts exhibited comparable solubility as the native drug. Similarly, RIP-HCl salt offered 1.5-fold improved chemical stability during photolysis compared to the native drug. The improved solubility and chemical stability of the RIP multicomponent solids are partially correlated to the extended conformation of the native drug and their melting points.
Propylene carbonate as an ecofriendly solvent: Stability studies of Ripretinib in RPHPLC and sustainable evaluation using advanced tools
T.K.S. Fayaz, Hemanth Kumar Chanduluru, Reem H. Obaydo, Palash Sanphui
Sustainable Chemistry and Pharmacy, 2024
Functional mimic for catechol oxidase and phenoxazinone synthase: Structural, spectral, electrochemical and catalytic properties of mononuclear copper(II) complex
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T.K.S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Inorganica Chimica Acta, 2024
Structural analysis of anti-retroviral drug raltegravir and its potential impurity C: investigation of solubility and stability
T. K. S. Fayaz, Hemanth Kumar Chanduluru, Puja Lal, Animesh Ghosh, Vladimir Chernyshev, Palash Sanphui
Crystengcomm, 2023
An anhydrous form of raltegravir and two crystalline phases of its impurity C were obtained during solid form screening and their crystal structures are reported with variable conformations.
Polymorph Screening of the Antitumor Drug Ripretinib─Selective Preference of Dimer Synthons
T. K. S. Fayaz, Parag Roy, Animesh Ghosh, Shubham Som, Deepak Chopra, Palash Sanphui
Crystal Growth and Design, 2023
Ripretinib is commercialized as a medication to treat patients suffering from advanced gastrointestinal stromal tumor. The USFDA-approved drug (2020) is highly water-insoluble and belongs to the biopharmaceutics classification system (BCS) class II category. Solid form screening was performed to initiate its structural landscape and establish thermodynamic relationship between the crystalline forms. This resulted in two anhydrous polymorphs (Forms 1 and 2), one hydrate, and a series of solvates with acetone, ethanol, isoamyl alcohol–water, dimethyl sulfoxide (DMSO), N,N-dimethylformamide (DMF), and tetrahydrofuran (THF)–water that were characterized by powder X-ray diffraction (XRD), vibrational spectroscopy (FT-IR), thermal analysis (DSC/TGA), and finally single-crystal XRD. Both Form 1 (Z′ = 2) and Form 2 (Z′ = 1) constitute an N–H···O (mono/bifurcated) hydrogen-bonded centrosymmetric dimer. They are designated as packing polymorphs. Note that there is also a minor conformational difference observed in the N-methyl fraction of the polymorphs. Interestingly, all the crystalline solid forms of the drug maintain a robust N–H···O H-bonded dimer in the polymorphs as well as solvates that was supported by a similar CO vibration. Comparatively, the acetone, ethanol, isoamyl alcohol–water, and THF–water solvates transformed to Form 1 following desolvation. Form 1 is supposed to be the thermodynamically most stable form based on its higher crystal density, melting point/enthalpy of fusion, and lower solubility compared to Form 2. Among the Forms 1 and 2 and hydrate, the hydrate was more soluble in pure ethanol than the anhydrous forms and their solubility order is hydrate > Form 2 > Form 1.
3, 3′-[succinylbis(diazaneyl)]bis(N,N,N-trimethylpropan-1-ammonium) perchlorate: Synthesis, characterization, computational studies and in vitro anticancer activity against the human colon carcinoma cell line (HT-29)
Sahin Reja, Kaushik Sarkar, Deboshmita Mukherjee, T.K.S. Fayaz, Pranesh Kumar, Purak Das, Palash Sanphui, Rajesh Kumar Das
Journal of Molecular Structure, 2023
Multicomponent solid forms of antibiotic cephalexin towards improved chemical stability
T. K. S. Fayaz, Vasanthi Palanisamy, Palash Sanphui, Vladimir Chernyshev
Crystengcomm, 2023
Chemical stability of antibiotic cephalexin was improved by 2-fold in acidic medium using crystal engineering approach.
In vitro cytotoxicity activity of copper complexes of imine and amine ligands: A combined experimental and computational study
Deboshmita Mukherjee, Sahin Reja, Kaushik Sarkar, T.K.S. Fayaz, Pranesh Kumar, Ambica Kejriwal, Purak Das, Palash Sanphui, Rajesh Kumar Das
Inorganic Chemistry Communications, 2022
Enhanced catalytic activity of new di-site onium salt in the kinetics of a-Tolunitrile monoalkylation
P.A. Vivekanand, T.K. Fayaz, S. Harikumar, P. Kamaraj, V. Thiruvengadam, V. Shanmugam
Materials Today Proceedings, 2019

RECENT SCHOLAR PUBLICATIONS

Sustainable solvent-engineered carbon dots derived from Amaranthus campestris for photocatalytic antiretroviral drug degradation and luminophores in security inks for anti …
TKS Fayaz, AS Robinson, P Gupta, P Suresh, K Murugan, ...
Diamond and Related Materials, 112860 , 2025
2025
Citations: 1
New Multicomponent Solid Forms of the Antitumor Drug Ripretinib: The Role of Conformations in Dictating Dissolution and Photostability
M Muthaiyan, FT K. S, G Kenguva, AK Prajapati, R Dandela, ...
Crystal Growth & Design 24 (18), 7617-7631 , 2024
2024
Citations: 1
Propylene carbonate as an ecofriendly solvent: Stability studies of Ripretinib in RPHPLC and sustainable evaluation using advanced tools
TKS Fayaz, HK Chanduluru, RH Obaydo, P Sanphui
Sustainable chemistry and pharmacy 37, 101355 , 2024
2024
Citations: 52
Functional mimic for catechol oxidase and phenoxazinone synthase: structural, spectral, electrochemical and catalytic properties of mononuclear copper (II) complex
S Reja, D Sarkar, K Sarkar, D Mukherjee, TKS Fayaz, P Sanphui, RK Das
Inorganica Chimica Acta 560, 121809 , 2024
2024
Citations: 23
Structural analysis of anti-retroviral drug raltegravir and its potential impurity C: investigation of solubility and stability
TKS Fayaz, HK Chanduluru, P Lal, A Ghosh, V Chernyshev, P Sanphui
CrystEngComm 26 (4), 517-531 , 2024
2024
Citations: 3
Polymorph Screening of the Antitumor Drug Ripretinib─ Selective Preference of Dimer Synthons
TKS Fayaz, P Roy, A Ghosh, S Som, D Chopra, P Sanphui
Crystal Growth & Design 23 (4), 2470-2484 , 2023
2023
Citations: 9
3, 3′-[succinylbis (diazaneyl)] bis (N, N, N-trimethylpropan-1-ammonium) perchlorate: Synthesis, characterization, computational studies and in vitro anticancer activity …
S Reja, K Sarkar, D Mukherjee, TKS Fayaz, P Kumar, P Das, P Sanphui, ...
Journal of Molecular Structure 1273, 134377 , 2023
2023
Citations: 2
Propylene carbonate as an eco-friendly solvent: Stability studies of Ripretinib in RP-HPLC and sustainable evaluation using advanced tools, Sustain. Chem. Pharm. 37 (2024) 101355
TKS Fayaz, HK Chanduluru, RH Obaydo, P Sanphui
2023
Citations: 6
Multicomponent solid forms of antibiotic cephalexin towards improved chemical stability
TKS Fayaz, V Palanisamy, P Sanphui, V Chernyshev
CrystEngComm 25 (8), 1252-1262 , 2023
2023
Citations: 12
In vitro cytotoxicity activity of copper complexes of imine and amine ligands: A combined experimental and computational study
D Mukherjee, S Reja, K Sarkar, TKS Fayaz, P Kumar, A Kejriwal, P Das, ...
Inorganic Chemistry Communications 146, 110190 , 2022
2022
Citations: 11
Enhanced catalytic activity of new di-site onium salt in the kinetics of α-Tolunitrile monoalkylation
PA Vivekanand, TK Fayaz, S Harikumar, P Kamaraj, V Thiruvengadam, ...
Materials Today: Proceedings 36, 848-852 , 2021
2021
Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

Propylene carbonate as an ecofriendly solvent: Stability studies of Ripretinib in RPHPLC and sustainable evaluation using advanced tools
TKS Fayaz, HK Chanduluru, RH Obaydo, P Sanphui
Sustainable chemistry and pharmacy 37, 101355 , 2024
2024
Citations: 52
Functional mimic for catechol oxidase and phenoxazinone synthase: structural, spectral, electrochemical and catalytic properties of mononuclear copper (II) complex
S Reja, D Sarkar, K Sarkar, D Mukherjee, TKS Fayaz, P Sanphui, RK Das
Inorganica Chimica Acta 560, 121809 , 2024
2024
Citations: 23
Multicomponent solid forms of antibiotic cephalexin towards improved chemical stability
TKS Fayaz, V Palanisamy, P Sanphui, V Chernyshev
CrystEngComm 25 (8), 1252-1262 , 2023
2023
Citations: 12
In vitro cytotoxicity activity of copper complexes of imine and amine ligands: A combined experimental and computational study
D Mukherjee, S Reja, K Sarkar, TKS Fayaz, P Kumar, A Kejriwal, P Das, ...
Inorganic Chemistry Communications 146, 110190 , 2022
2022
Citations: 11
Polymorph Screening of the Antitumor Drug Ripretinib─ Selective Preference of Dimer Synthons
TKS Fayaz, P Roy, A Ghosh, S Som, D Chopra, P Sanphui
Crystal Growth & Design 23 (4), 2470-2484 , 2023
2023
Citations: 9
Propylene carbonate as an eco-friendly solvent: Stability studies of Ripretinib in RP-HPLC and sustainable evaluation using advanced tools, Sustain. Chem. Pharm. 37 (2024) 101355
TKS Fayaz, HK Chanduluru, RH Obaydo, P Sanphui
2023
Citations: 6
Structural analysis of anti-retroviral drug raltegravir and its potential impurity C: investigation of solubility and stability
TKS Fayaz, HK Chanduluru, P Lal, A Ghosh, V Chernyshev, P Sanphui
CrystEngComm 26 (4), 517-531 , 2024
2024
Citations: 3
3, 3′-[succinylbis (diazaneyl)] bis (N, N, N-trimethylpropan-1-ammonium) perchlorate: Synthesis, characterization, computational studies and in vitro anticancer activity …
S Reja, K Sarkar, D Mukherjee, TKS Fayaz, P Kumar, P Das, P Sanphui, ...
Journal of Molecular Structure 1273, 134377 , 2023
2023
Citations: 2
Sustainable solvent-engineered carbon dots derived from Amaranthus campestris for photocatalytic antiretroviral drug degradation and luminophores in security inks for anti …
TKS Fayaz, AS Robinson, P Gupta, P Suresh, K Murugan, ...
Diamond and Related Materials, 112860 , 2025
2025
Citations: 1
New Multicomponent Solid Forms of the Antitumor Drug Ripretinib: The Role of Conformations in Dictating Dissolution and Photostability
M Muthaiyan, FT K. S, G Kenguva, AK Prajapati, R Dandela, ...
Crystal Growth & Design 24 (18), 7617-7631 , 2024
2024
Citations: 1
Enhanced catalytic activity of new di-site onium salt in the kinetics of α-Tolunitrile monoalkylation
PA Vivekanand, TK Fayaz, S Harikumar, P Kamaraj, V Thiruvengadam, ...
Materials Today: Proceedings 36, 848-852 , 2021
2021
Citations: 1

Dr T K S FAYAZ

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Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS