Fernanda Fonseca

@inrae.fr

Paris-Saclay Food and Bioproduct Engineering research unit (UMR 782 SayFood INRAE-AgroParisTech)
INRAE - French National Research Institute for Agriculture, Food and Environment



                 

https://researchid.co/ffonseca

Research Director (since January 2015) ), in Paris-Saclay Food and Bioproduct Engineering research unit (UMR 782 SayFood INRAE-AgroParisTech), Versailles-Grignon Centre, French National Research Institute for Agriculture, Food and Environment (INRAE), France.

Researcher Scientist (September 2001 – December 2014), in the Joint Research Unit for Food Process Engineering and Microbiology (UMR 782 GMPA INRA-AgroParisTech), Versailles-Grignon Centre, Institut National de la Recherche Agronomique (INRA), France.

EDUCATION

Habilitation à Diriger des Recherches (HDR). Université de Technologie de Compiègne, 2010. Title : « Stabilization of bio functionalities trough an approach combining the understanding of mechanisms and the product-process engineering”

Ph.D. Degree in Biotechnology and Process Engineering, Institut National Agronomique Paris-Grignon (AgroParisTech), 2001.
Ph.D. thesis title: "Influence of cryoprotection and freezing on the acidification activity of thermopile lactic acid bacteria: relationships between biological and thermodynamic

Master Degree in Biotechnology and Process Engineering, Institut National Agronomique Paris-Grignon (AgroParisTech), 1997.
M.Sc. thesis title: "Study of the freezing step on the activity of frozen lactic acid

Engineer in Chemical Engineering, Montevideo University (Uruguay), 1996.

RESEARCH INTERESTS

Main fields of expertise:
Biotechnology and process engineering: fermentation, formulation, and stabilization of bioproducts.
• Bioproducts: micro-organisms, proteins, food products.
• Stabilization processes: freezing and freeze-drying
• Biophysical characterization of bioproducts (thermal analysis, freeze-drying microscopy, Fourier Transformed InfraRed microspectroscopy)
Research approach:
Focusing on biophysical and chemical behaviours of bioproducts during stabilization processes and by relating them to biological and functional responses, to identify and quantify the mechanisms governing the degradation and preservation of bioproducts during the stabilization processes. The ambition is also to find general principles for simplifying and rationalizing the development of newly formulated products and the stabilization process optimization, with particular attention to limiting the environmental impact.

3896

Scholar Citations

35

Scholar h-index

54

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Stabilization of Lactiplantibacillus plantarum WCFS1 during freezing, freeze-drying, and storage using legume wastewater extracts
    GN Martins, MG Sanchez, AD Carboni, F Fonseca, S Campoy, ...
    3rd Food Chemistry Conference 2023

  • Resistencia de L. plantarum WCFS1 frente a distintos mtodos de secado: anlisis de componentes celulares asociados a su degradacin mediante microespectroscopa FTIR en suspensin
    M Gagneten, S Passot, C Schebor, F Fonseca
    XVIII Congreso argentino de ciencia y tecnologa de alimento 2023

  • Perchlorate salts lower the vitrification point of Bacillus Subtilis to temperatures lower than those expected beneath the Martian south pole
    S Gault, CS Cockell, F Fonseca, S Passot
    European Astrobiology Network Association 2023

  • Insights into the mechanisms of L. salivarius CECT5713 resistance to freeze-dried storage
    MG Sanchez, S Passot, S Ghorbal, S Campoy, M Olivares, F Fonseca
    Cryobiology 112, 104556 2023

  • Membrane lipid composition of Carnobacterium maltaromaticum CNCM I-3298, a highly cryoresistant lactic bacterium
    HP Ta, C Clarisse, E Maes, N Yamakawa, Y Guerardel, F Krzewinski, ...
    Chemistry and Physics of Lipids 255, 105326 2023

  • Environmental performances of the production of dried lactic acid bacteria concentrates protected by fructo-oligosaccharides ICEF14, June 20 th to 23 rd 2023, Nantes, France
    S Passot, M Gagneten, C Quentier, S Cenard, B Gauducheau-Chevalier, ...
    International Congress on Engineering and Food 2023

  • Scale up of layer-by-layer microencapsulation of probiotic bacteria Lactiplantibacillus plantarum WCFS1
    G Tavares, N Romano, S Passot, MG Sanchez, MA Golowczyc, S Campoy, ...
    International Congress on Engineering and Food 2023

  • Differential scanning calorimetry applied to the preservation of bacteria and mammalian cells
    F Fonseca, S Passot
    JCAT53-53mes Journes de Calorimtrie et d'Analyse Thermique 2023

  • Multiobjective optimization of frozen and freeze-dried Lactobacillus delbrueckii subsp. bulgaricus CFL1 production via the modification of fermentation conditions
    ML Tovilla Coutio, S Passot, IC Trelea, MH Ropers, Y Gohon, F Fonseca
    Journal of Applied Microbiology 134 (2), lxad003 2023

  • Biosys-LiDeOGraM: A visual analytics framework for interactive modelling of multiscale biosystems
    N Mejean Perrot, S Layec, A Tonda, N Boukhelifa, F Fonseca, E Lutton
    bioRxiv, 2023.06. 23.546209 2023

  • Effect of protective agents on the storage stability of freeze-dried Ligilactobacillus salivarius CECT5713
    M Guerrero Sanchez, S Passot, S Campoy, M Olivares, F Fonseca
    Applied Microbiology and Biotechnology 106 (21), 7235-7249 2022

  • Estudio de la estabilidad de L. bulgaricus protegido con fructooligosacridos durante el secado y el almacenamiento
    M Gagneten, C Schebor, S Cenard, A Gomez-Zavaglia, S Passot, ...
    VIII Congreso Internacional de Ciencia y Tecnologa de Alimentos (CICYTAC 2022) 2022

  • A critical transfer temperature from slow cooling to cryogenic storage for optimal recovery across a range of cryopreserved mammalian cells.
    J Meneghel, P Kilbride, F Fonseca, J Morris
    Annual Meeting of the Society for Cryobiology 2022

  • Perchlorate brines in the Martian deep subsurface and the low temperature limit for life
    S Gault, CS Cockell, F Fonseca, S Passot
    Astrobiology Science Conference 2022

  • Use of 3D mathematical modelling to understand the heat transfer mechanisms during freeze-drying using high-throughput vials
    JP Buceta, S Passot, B Scutell, E Bourls, F Fonseca, IC Trelea
    Applied Thermal Engineering 207, 118099 2022

  • Insights into lactic acid bacteria cryoresistance using FTIR microspectroscopy
    A Girardeau, S Passot, J Meneghel, S Cenard, P Lieben, IC Trelea, ...
    Analytical and Bioanalytical Chemistry 414 (3), 1425-1443 2022

  • Ligilactobacillus salivarius functionalities, applications, and manufacturing challenges
    M Guerrero Sanchez, S Passot, S Campoy, M Olivares, F Fonseca
    Applied Microbiology and Biotechnology, 1-24 2022

  • The transfer temperature from slow cooling to cryogenic storage is critical for optimal recovery of cryopreserved mammalian cells
    P Kilbride, J Meneghel, F Fonseca, J Morris
    PLoS One 16 (11), e0259571 2021

  • Modlisation thermodynamique de la croissance microbienne
    C Dussat, C Puentes, IC Trelea, F Fonseca, S Passot, T Bouchez
    Microbes 2021 16me congrs national de la SFM 2021

  • Dynamic Modeling of Carnobacterium maltaromaticum CNCM I-3298 Growth and Metabolite Production and Model-Based Process Optimization
    C Puentes, A Girardeau, S Passot, F Fonseca, IC Trelea
    Foods 10 (8), 1922 2021

MOST CITED SCHOLAR PUBLICATIONS

  • Changes in texture, cellular structure and cell wall composition in apple tissue as a result of freezing
    S Chassagne-Berces, C Poirier, MF Devaux, F Fonseca, M Lahaye, ...
    Food Research International 42 (7), 788-797 2009
    Citations: 226

  • Method of quantifying the loss of acidification activity of lactic acid starters during freezing and frozen storage
    F Fonseca, C Bal, G Corrieu
    Journal of Dairy Research 67 (1), 83-90 2000
    Citations: 214

  • Freezing injury: the special case of the sperm cell
    GJ Morris, E Acton, BJ Murray, F Fonseca
    Cryobiology 64 (2), 71-80 2012
    Citations: 210

  • Operating conditions that affect the resistance of lactic acid bacteria to freezing and frozen storage
    F Fonseca, C Bal, G Corrieu
    Cryobiology 43 (3), 189-198 2001
    Citations: 186

  • Resistance to freezing and frozen storage of Streptococcus thermophilus is related to membrane fatty acid composition
    C Bal, F Fonseca, G Corrieu
    Journal of Dairy Science 84 (11), 2347-2356 2001
    Citations: 181

  • A low temperature limit for life on Earth
    A Clarke, GJ Morris, F Fonseca, BJ Murray, E Acton, HC Price
    PLoS One 8 (6), e66207 2013
    Citations: 149

  • Effect of Sucrose and Maltodextrin on the Physical Properties and Survival of Air‐Dried Lactobacillus bulgaricus: An in Situ Fourier Transform Infrared Spectroscopy
    H Oldenhof, WF Wolkers, F Fonseca, S Passot, M Marin
    Biotechnology progress 21 (3), 885-892 2005
    Citations: 146

  • The high viscosity encountered during freezing in glycerol solutions: effects on cryopreservation
    GJ Morris, M Goodrich, E Acton, F Fonseca
    Cryobiology 52 (3), 323-334 2006
    Citations: 136

  • Rapidly cooled horse spermatozoa: loss of viability is due to osmotic imbalance during thawing, not intracellular ice formation
    GJ Morris, K Faszer, JE Green, D Draper, BWW Grout, F Fonseca
    Theriogenology 68 (5), 804-812 2007
    Citations: 131

  • Freezing protocol effect on quality properties of fruit tissue according to the fruit, the variety and the stage of maturity
    S Chassagne-Berces, F Fonseca, M Citeau, M Marin
    LWT-Food Science and Technology 43 (9), 1441-1449 2010
    Citations: 117

  • Collapse Temperature of Freeze‐Dried Lactobacillus bulgaricusSuspensions and Protective Media
    F Fonseca, S Passot, O Cunin, M Marin
    Biotechnology progress 20 (1), 229-238 2004
    Citations: 116

  • Cyclopropanation of unsaturated fatty acids and membrane rigidification improve the freeze-drying resistance of Lactococcus lactis subsp. lactis TOMSC161
    H Velly, M Bouix, S Passot, C Pnicaud, H Beinsteiner, S Ghorbal, ...
    Applied microbiology and biotechnology 99, 907-918 2015
    Citations: 104

  • Freeze-drying of lactic acid bacteria
    F Fonseca, S Cenard, S Passot
    Cryopreservation and freeze-drying protocols, 477-488 2015
    Citations: 102

  • Stabilization of Frozen Lactobacillus delbrueckii subsp. bulgaricus in Glycerol Suspensions: Freezing Kinetics and Storage Temperature Effects
    F Fonseca, M Marin, GJ Morris
    Applied and Environmental Microbiology 72 (10), 6474-6482 2006
    Citations: 101

  • The impact of varying cooling and thawing rates on the quality of cryopreserved human peripheral blood T cells
    J Baboo, P Kilbride, M Delahaye, S Milne, F Fonseca, M Blanco, ...
    Scientific reports 9 (1), 3417 2019
    Citations: 97

  • Effect of controlled ice nucleation on primary drying stage and protein recovery in vials cooled in a modified freeze-dryer
    S Passot, IC Trla, M Marin, M Galan, GJ Morris, F Fonseca
    2009
    Citations: 92

  • Critical water activity and amorphous state for optimal preservation of lyophilised lactic acid bacteria
    S Passot, S Cenard, I Douania, IC Trelea, F Fonseca
    Food Chemistry 132 (4), 1699-1705 2012
    Citations: 88

  • Physical characterisation of formulations for the development of two stable freeze-dried proteins during both dried and liquid storage
    S Passot, F Fonseca, M Alarcon-Lorca, D Rolland, M Marin
    European Journal of Pharmaceutics and Biopharmaceutics 60 (3), 335-348 2005
    Citations: 79

  • Effect of product temperature during primary drying on the long-term stability of lyophilized proteins
    S Passot, F Fonseca, N Barbouche, M Marin, M Alarcon-Lorca, D Rolland, ...
    Pharmaceutical development and technology 12 (6), 543-553 2007
    Citations: 78

  • Factors influencing the membrane fluidity and the impact on production of lactic acid bacteria starters
    F Fonseca, C Pnicaud, EE Tymczyszyn, A Gmez-Zavaglia, S Passot
    Applied microbiology and biotechnology 103, 6867-6883 2019
    Citations: 73