Gabriele Tumminello

Scopus Publications

Coronary arterial age for mortality prediction and risk reclassification in SCORE COVID-19 registry: When vascular age runs faster or slower than chronological age
Alberto Cereda, Marco Toselli, Anna Palmisano, Marco Stracqualursi, Gabriele Tumminello, et al.
Age and Ageing, 2026
Background Coronary arterial age (CAA), derived from coronary artery calcium (CAC) percentiles from the Multi-Ethnic Study of Atherosclerosis (MESA), reflects vascular biological ageing. Its prognostic role in acute settings such as COVID-19 remains unclear. Methods We analysed 1482 hospitalized patients from the multicentre SCORE-COVID registry undergoing chest CT. CAA was estimated from CAC percentiles; ΔAge was defined as CAA minus chronological age. A calcium-adjusted biological age (BioAge) was also assessed. The primary endpoint was 30-day all-cause mortality. Results Chronological age and CAA showed similar discrimination (AUC 0.76 vs 0.74; P = .466) and were independently associated with mortality and increased stepwise across ΔAge strata. CAA mainly improved specificity by down-classifying survivors. While no significant interaction was observed between CAA and the 4C score, ΔAge significantly re-stratified mortality risk among patients at high 4C risk. Conclusions CAA demonstrated prognostic performance comparable to chronological age for short-term mortality in COVID-19 and added clinically relevant information on vascular ageing. BioAge meaningfully refined risk stratification among patients at high clinical risk, supporting its use as an adjunctive biomarker whenever chest CT imaging is available.
From giant fistula to haemodynamic relief: successful percutaneous closure of a symptomatic circumflex coronary artery connection to venous coronary sinus
Gabriele Tumminello, Paolo Fabio D’Andria, Stefano Carugo, Lucia Barbieri
European Heart Journal Case Reports, 2026
Drug coated balloon angioplasty for de novo coronary lesions in large vessels: a systematic review and meta-analysis
Cecilia Gobbi, Francesco Giangiacomi, Ioannis Merinopoulos, Elisa Gherbesi, Andrea Faggiano, et al.
Scientific Reports, 2025
One-Year Results of the Magmaris BRS in Coronary Artery Disease Patients: The IT-MASTERS Registry
Stefano Galli, Domenico Tavella, Marco Sesana, Ferdinando Varbella, Dario Buccheri, et al.
American Journal of Cardiology, 2025
Short-Term Outcomes of Two Self-Expanding Transcatheter Valves in Sievers Type 1 Bicuspid Aortic Valve Stenosis: The “Proof-of-Concept” CLASS Effect Study
Andrea Buono, Paolo Alberto Del Sole, Andrea Zito, Barbara Bellini, Nicholas Montarello, et al.
Journal of Vascular Diseases, 2025
Background: Self-expanding transcatheter heart valves (SEVs) are often used to treat Sievers type 1 bicuspid aortic valve (BAV) stenosis. It remains unclear, however, if different SEVs yield similar outcomes in BAV stenosis, a class effect, or if the unique design features of different SEVs produce disparate clinical results. Objectives: This is a “proof-of-concept” study that compares procedural and clinical outcomes of Acurate neo2 and Evolut Pro/Pro+/Fx platforms in Sievers type 1 BAV stenosis. Methods: The CLASS effect is a retrospective, multicenter registry that enrolls patients with raphe-type 1 BAV stenosis undergoing TAVI at 29 international centers, who received Acurate neo2 and Evolut Pro/Pro+/Fx devices. An inverse probability of treatment weighting (IPTW) analysis was performed to adjust for baseline imbalances. Primary endpoints included VARC-3 technical success, 30-day device success, and early safety according to VARC-3. Results: Among 389 eligible patients, 155 and 234 patients were treated with Acurate neo2 and Evolut platforms, respectively. A higher rate of technical success was observed in the Evolut group (Acurate neo2 vs. Evolut: 93.4% vs. 97.1%, OR 0.41, 95% CI 0.19–0.83, and p = 0.017). At 30 days, device success was comparable (90.1% vs. 89.4%, OR 1.09, 95% CI 0.68–1.75, and p = 0.733), whereas Acurate neo2 was associated with a higher rate of early safety (84.1% vs. 70.4%, OR 2.22, 95% CI 1.56–3.17, and p < 0.001), which was mainly driven by a lower risk of new permanent pacemaker implantation (PPI) (6.3% vs. 19.5%, OR 0.28, 95% CI 0.16–0.46, and p < 0.001). Conclusions: Acurate neo2 and Evolut Pro/Pro+/Fx platforms provide similarly effective procedural and short-term outcomes in Sievers type 1 BAV stenosis. However, Evolut was associated with a higher technical success, while Acurate neo2 demonstrated a lower incidence of new PPI.
Meta-Analytic Review of Coronary Angiography in Peri-Procedural Myocardial Injury and Infarction After Cardiac Surgery
Alberto Francesco Cereda, Marco Toselli, Paolo Cimaglia, Antonio Gabriele Franchina, Lorenzo Tua, et al.
Journal of Clinical Medicine, 2025
Introduction: Peri-procedural myocardial infarction (PMI) after cardiac surgery is a significant yet often under-recognised complication, sometimes necessitating urgent coronary angiography (PMI-rCA). This meta-analysis evaluates its prevalence, angiographic findings, management strategies, and associated mortality. Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines. Data from nine studies comprising 104,445 post-cardiac surgery patients were analysed. Among them, those undergoing PMI-rCA were categorised by treatment strategy: conservative management, percutaneous coronary intervention (PCI), or reperform surgery. A network meta-analysis compared mortality risks across these groups, with findings visualised using forest plots, network diagrams, and SUCRA rankings. Results: PMI-rCA was performed in 1205 patients (2%). Of these, 34.3% had no significant angiographic abnormalities, 53.7% exhibited graft failure, and 10.4% had native vessel ischemia. Management strategies included conservative treatment (55.5%), PCI (23.5%), and reperforming surgery (21%). Network meta-analysis indicated that conservative management was associated with the lowest mortality risk, followed by PCI, while reperforming surgery had the highest risk. Discussion: These findings highlight the complexity of PMI diagnosis and treatment. The high proportion of patients without significant angiographic abnormalities raises concerns about potential overuse of invasive procedures. Meanwhile, PCI appears to be a more favourable interventional strategy than reperforming surgery in terms of mortality outcomes. Conclusions: PMI requiring coronary angiography is uncommon but clinically significant, with a 16% mortality rate. A tailored, risk-based approach is essential to optimise management, balancing conservative therapy, PCI, and reperforming surgery based on individual patient profiles.
Efficacy and Safety of Sirolimus-Coated Balloon Angioplasty in De Novo Lesions in Large Coronary Vessels: A Propensity Score-Matched Study
Cecilia Gobbi, Francesco Giangiacomi, Guido Pasero, Andrea Faggiano, Lucia Barbieri, et al.
Catheterization and Cardiovascular Interventions, 2025
BackgroundEvidence regarding drug‐coated balloon (DCB)‐only angioplasty in de novo lesions of large vessels is still limited and mainly focused on paclitaxel‐coated balloon. We aimed to analyze the safety and efficacy of sirolimus‐coated balloon (SCB)‐only angioplasty in de novo lesions in large vessels compared to drug‐eluting stent (DES).MethodsIn this retrospective, dual‐center, case‐control study, we enrolled all consecutive patients treated between January 2022 and January 2024 with SCB‐only angioplasty in de novo lesion in large vessel (> 2.75 mm) compared to a propensity‐score matched contemporary population treated with DES. The primary endpoint was the rate of target lesion revascularization (TLR), while secondary endpoints were cardiac death (CD), target vessel revascularization (TVR), myocardial infarction (MI), and target lesion failure (TLF), defined as a composite of them.ResultsThe mean age was 70.1 ± 9.8 years in the SCB group (n = 92) and 67.9 ± 9.6 years in the DES group (n = 92) (p = 0.76). The median follow‐up was 19.5 ± 12 months in the SCB group and 20.1 ± 13.1 months in the DES group (p = 0.47). TLR occurred in 6.7% of patients in the SCB group and 5.6% in the DES group (p = 0.75). The incidence of MI, TVR, and TLF were similar between the two groups (4.3% vs 3.3%, p = 0.7, 2.2% vs 3.4%, p = 0.65% and 9.8% vs 8.7%, p = 0.79). CD occurred in 4.3% in the SCB group, compared to 3.3% in the DES group (p = 0.70).ConclusionOur study suggests that SCB angioplasty is both safe and effective in the treatment of de novo lesions of large vessels compared with DES.
Indications, Management, and Short- and Medium-Term Outcomes of Patients with Chronic Coronary Occlusion Treated with Percutaneous Revascularization—A Single-Center Study
Lucia Barbieri, Gabriele Tumminello, Lorenzo Mafrici, Guido Pasero, Luca Mircoli, et al.
Journal of Cardiovascular Development and Disease, 2025
The diagnosis of chronic total occlusion (CTO), characterized by the complete obstruction of a coronary artery for at least three months, remains challenging and can be entirely asymptomatic. Since the indications for performing a recanalization procedure for CTO do not originate from randomized controlled trials, this study aimed to assess the indications, management, and procedural outcomes of patients undergoing percutaneous revascularization (PCI) for a CTO, ensuring that the population was as uniform as possible regarding technologies and methodological approaches. Forty-one consecutive patients who underwent PCI for CTO recanalization were enrolled from January 2021 to 2024. Additional outcomes included mortality, major adverse cardiovascular events, and the presence of residual cardiac symptoms, with a median follow-up of 449 days and an interquartile range of 230–643 days. Our real-life study confirmed that PCI for CTO has a high success rate and a low incidence of major complications.
A Case of Infarct Myocardial Fissure
Alberto Cereda
Anatolian Journal of Cardiology, 2025
Secondary access and routine protection wire for transfemoral transcatheter aortic valve replacement: the SURF-TAVR registry
Ottavia Cozzi, Prem Ratan, Giulia Costa, Luca Branca, Mauro Boiago, et al.
Clinical Research in Cardiology, 2025
Microcatheter tip fracture and acute vessel occlusion rescued with subintimal tracking and re-entry: Move the tip
Francesco Giangiacomi, Luca Mircoli, Gabriele Tumminello, Stefano Carugo
Catheterization and Cardiovascular Interventions, 2024
PCSK9 and Coronary Artery Plaque—New Opportunity or Red Herring?
Lucia Barbieri, Gabriele Tumminello, Isabella Fichtner, Alberto Corsini, Raul D. Santos, et al.
Current Atherosclerosis Reports, 2024
Exercise response in post-acute coronary syndrome patients survived to COVID-19 infection
Giovanni Provenzale, Lucia Barbieri, Gabriele Tumminello, Stefano Carugo, Marco Guazzi
International Journal of Cardiology, 2024
Concordance between Coronary Artery Computed Tomography and Invasive Coronary Angiography in a Real-World Population with Suspected Chronic Coronary Syndrome
Lucia Barbieri, Gabriele Tumminello, Guido Pasero, Carlo Avallone, Andrea D’Errico, et al.
Diagnostics, 2024
Unraveling the Enigma of Moderate Aortic Stenosis: Challenges and Future Prospects
Gloria Santangelo, Gabriele Tumminello, Lucia Barbieri, Giulio Pio Federico Mallardi, Andrea Faggiano, et al.
Journal of Clinical Medicine, 2024
Gender differences in outcomes after left atrial appendage closure with Watchman FLX device: insights from the Italian-FLX registry
Michela Bonanni, Marco Frazzetto, Annalisa Nardone, Francesco Meucci, Carmine Musto, et al.
Frontiers in Cardiovascular Medicine, 2024
The “Woggle” Technique for Venous Access Site Management: An Old Technique for a New Need
Gabriele Tumminello, Lucia Barbieri, Carlo Avallone, Nello Bellissimo, Luca Mircoli, et al.
Journal of Clinical Medicine, 2023
Right Heart Catheterization: An Antecubital Vein Approach to Reduce Fluoroscopy Time, Radiation Dose, and Guidewires Need
Giuseppe Locatelli, Luca Donisi, Luca Mircoli, Federico Colombo, Lucia Barbieri, et al.
Journal of Clinical Medicine, 2023
Outcome and Morphofunctional Changes on Cardiac Magnetic Resonance in Patients with Acute Myocarditis Following mRNA COVID-19 Vaccination
Enrico Ammirati, Laura Lupi, Matteo Palazzini, Michele Ciabatti, Valentina A. Rossi, et al.
Circulation Heart Failure, 2023
Systematic Review and Meta-Analysis of Oral Anticoagulant Therapy in Atrial Fibrillation Cancer Patients
Alberto Cereda, Stefano Lucreziotti, Antonio Gabriele Franchina, Alessandra Laricchia, Valentina De Regibus, et al.
Cancers, 2023
New Onset Atrial Fibrillation in STEMI Patients: Main Prognostic Factors and Clinical Outcome
Beatrice Dal Zotto, Lucia Barbieri, Gabriele Tumminello, Massimo Saviano, Domitilla Gentile, et al.
Diagnostics, 2023
Nurse-led distal radial access: efficacy, learning curve, and perspectives of an increasingly popular access Does learning by doing apply to both the doctor and the nurse?
Alberto CEREDA, Luca ALLIEVI, Lorenzo BUSETTI, Rita KOLECI, Vincenzo DE NORA, et al.
Minerva Cardiology and Angiology, 2023
Age-Related Mortality in STEMI Patients: Insight from One Year of HUB Centre Experience during the Pandemic
Gabriele Tumminello, Andrea D’Errico, Alessio Maruccio, Domitilla Gentile, Lucia Barbieri, et al.
Journal of Cardiovascular Development and Disease, 2022
Systematic review and meta-analysis on coronary calcifications in COVID-19
A. Cereda, L. Allievi, A. Palmisano, G. Tumminello, L. Barbieri, et al.
Emergency Radiology, 2022
Influence of Different COVID-19 Pandemic Phases on STEMI: Experience From an Italian Hub Centre
Gabriele Tumminello, Lucia Barbieri, Filippo Toriello, Stefano Lucreziotti, Matteo Carlà, et al.
Cardiovascular Revascularization Medicine, 2022
Coronary calcium score as a predictor of outcomes in the hypertensive Covid-19 population: results from the Italian (S) Core-Covid-19 Registry
Alberto Cereda, Marco Toselli, Anna Palmisano, Davide Vignale, Arif Khokhar, et al.
Hypertension Research, 2022
Author`s Reply
Anatolian Journal of Cardiology, 2021
Safety and efficacy of rotational atherectomy in heavily calcified lesions involving coronary aneurysms
Lucia Barbieri, Gabriele Tumminello, Stefano Lucreziotti, Francesco Rametta, Stefano Carugo
Future Cardiology, 2021
Meta-analysis of placebo-controlled trials of levosimendan in acute myocardial infarction
Gabriele Tumminello, Alberto Cereda, Lucia Barbieri, Giuseppe Biondi-Zoccai, Stefano Lucreziotti, et al.
Journal of Cardiovascular Development and Disease, 2021
The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification
Alberto Cereda, Marco Toselli, Anna Palmisano, Davide Vignale, Riccardo Leone, et al.
Geroscience, 2021
Acute myocarditis after the second dose of SARS-CoV-2 vaccine: Serendipity or atypical causal relationship?
Alberto Cereda, Cristina Conca, Lucia Barbieri, Giulia Ferrante, Gabriele Tumminello, et al.
Anatolian Journal of Cardiology, 2021
Mortality in STEMI Patients During the COVID Era: Has the Pandemic Changed Our Clinical Practice?
Lucia Barbieri, Gabriele Tumminello, Stefano Lucreziotti, Domitilla Gentile, Marco Centola, et al.
Cardiovascular Revascularization Medicine, 2021
Erectile dysfunction treatment with sirolimus-eluting balloons due to bilateral internal pudendal arterial stenosis
Vascular Disease Management, 2021
Impact of RAAS Inhibitors on Clinical Outcome and Mortality in Patients With STEMI During the COVID-19 Era: A Multicenter Observational Study
Lucia Barbieri, Daniela Trabattoni, Giulio G. Stefanini, Enrico Vizzardi, Gabriele Tumminello, et al.
Frontiers in Cardiovascular Medicine, 2021
IntravaScular Lithotripsy for the Management of UndILatable Coronary StEnt: The SMILE Registry
Alfonso Ielasi, Elisabetta Moscarella, Luca Testa, Gaetano Gioffrè, Gaetano Morabito, et al.
Cardiovascular Revascularization Medicine, 2020
Impact of COVID-19 on STEMI: Second youth for fibrinolysis or time to centralized approach?
Gabriele Tumminello, Lucia Barbieri, Stefano Lucreziotti, Domitilla Gentile, Barbara Conconi, et al.
Ijc Heart and Vasculature, 2020
Bail-out unexpanded stent implantation in acute left main dissection treated with intra coronary lithotripsy: A case report
Gabriele Tumminello, Chiara Cavallino, Andrea Demarchi, Francesco Rametta
European Heart Journal Case Reports, 2019
One-year clinical performance of ABSORB bioresorbable vascular scaffold in patients presenting with acute coronary syndromes: Results from the RAI registry
Elisabetta Moscarella, Alfonso Ielasi, Attilio Varricchio, Bernardo Cortese, Bruno Loi, et al.
Catheterization and Cardiovascular Interventions, 2019
“Full-plastic jacket” with everolimus-eluting Absorb bioresorbable vascular scaffolds: Clinical outcomes in the multicenter prospective RAI registry (ClinicalTrials.gov Identifier: NCT02298413)
Giuseppe Tarantini, Giulia Masiero, Luca Nai Fovino, Marco Mojoli, Attilio Varricchio, et al.
International Journal of Cardiology, 2018
One-year clinical outcomes after unrestricted implantation of the Absorb bioresorbable scaffold (RAI registry)
Alfonso Ielasi, Bernardo Cortese, Elisabetta Moscarella, Bruno Loi, Giuseppe Tarantini, et al.
Eurointervention, 2018
Clinical findings after bioresorbable vascular scaffold implantation in an unrestricted cohort of patients with ST-segment elevation myocardial infarction (from the RAI registry)
Elisabetta Moscarella, Alfonso Ielasi, Attilio Varricchio, Maria Carmen De Angelis, Bruno Loi, et al.
International Journal of Cardiology, 2018
Clinical outcomes of overlapping versus non-overlapping everolimus-eluting absorb bioresorbable vascular scaffolds: An analysis from the multicentre prospective RAI registry (ClinicalTrials.gov identifier: NCT02298413)
Giuseppe Tarantini, Marco Mojoli, Giulia Masiero, Bernardo Cortese, Bruno Loi, et al.
Catheterization and Cardiovascular Interventions, 2018
Thirty-Day Outcomes After Unrestricted Implantation of Bioresorbable Vascular Scaffold (from the Prospective RAI Registry)
Bernardo Cortese, Alfonso Ielasi, Elisabetta Moscarella, Bruno Loi, Giuseppe Tarantini, et al.
American Journal of Cardiology, 2017
Registro Absorb Italiano (BVS-RAI): An investigators-owned and -directed, open, prospective registry of consecutive patients treated with the Absorb™ BVS: Study design
Bernardo Cortese, Alfonso Ielasi, Attilio Varricchio, Giuseppe Tarantini, Luigi LaVecchia, et al.
Cardiovascular Revascularization Medicine, 2015
Eroded versus ruptured plaques at the culprit site of STEMI: In vivo pathophysiological features and response to primary PCI
Francesco Saia, Kenichi Komukai, Davide Capodanno, Vasile Sirbu, Giuseppe Musumeci, et al.
Jacc Cardiovascular Imaging, 2015
Mechanisms of atherothrombosis and vascular response to primary percutaneous coronary intervention in women versus men with acute myocardial infarction: Results of the OCTAVIA study
Giulio Guagliumi, Davide Capodanno, Francesco Saia, Giuseppe Musumeci, Giuseppe Tarantini, et al.
Jacc Cardiovascular Interventions, 2014
Circulating CD4+CD25hiCD127lo regulatory T-cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis
Enrico Ammirati, Domenico Cianflone, Michela Banfi, Viviana Vecchio, Alessio Palini, et al.
Arteriosclerosis Thrombosis and Vascular Biology, 2010
Prognostic value of flow-mediated dilatation following myocardial infarction
Marco Guazzi, Giuseppe Reina, Paola Gripari, Gabriele Tumminello, Marco Vicenzi, et al.
International Journal of Cardiology, 2009
Determinants of an abnormal response to exercise in patients with asymptomatic valvular aortic stenosis
P LANCELLOTTI, D KARSERA, G TUMMINELLO, F LEBOIS, L PIERARD
European Journal of Echocardiography, 2008
Effects of surgery on ischaemic mitral regurgitation: A prospective multicentre registry (SIMRAM registry)
P LANCELLOTTI, E DONAL, B COSYNS, G VANCAMP, J MONIN, et al.
European Journal of Echocardiography, 2008
Atorvastatin therapy improves exercise oxygen uptake kinetics in post-myocardial infarction patients
M. Guazzi, G. Tumminello, G. Reina, M. Vicenzi, M. D. Guazzi
European Journal of Clinical Investigation, 2007
Exercise ventilation inefficiency in heart failure: Pathophysiological and clinical significance
G. Tumminello, M. Guazzi, P. Lancellotti, L. A. Pierard
European Heart Journal, 2007
Determinants of pulmonary artery hypertension at rest and during exercise in patients with heart failure
G. Tumminello, P. Lancellotti, M. Lempereur, V. D'Orio, L. A. Pierard
European Heart Journal, 2007
Alveolar-capillary membrane conductance is the best pulmonary function correlate of exercise ventilation efficiency in heart failure patients
Marco Guazzi, Giuseppe Reina, Gabriele Tumminello, Maurizio D. Guazzi
European Journal of Heart Failure, 2005
Effects of orthostatic stress on forearm endothelial function in normal subjects and in patients with hypertension, diabetes, or both diseases
M GUAZZI, L LENATTI, G TUMMINELLO, M GUAZZI
American Journal of Hypertension, 2005
Exercise ventilation inefficiency and cardiovascular mortality in heart failure: The critical independent prognostic value of the arterial CO 2 partial pressure
Marco Guazzi, Giuseppe Reina, Gabriele Tumminello, Maurizio D. Guazzi
European Heart Journal, 2005
The effects of phosphodiesterase-5 inhibition with sildenafil on pulmonary hemodynamics and diffusion capacity, exercise ventilatory efficiency, and oxygen uptake kinetics in chronic heart failure
Marco Guazzi, Gabriele Tumminello, Fabio Di Marco, Cesare Fiorentini, Maurizio D. Guazzi
Journal of the American College of Cardiology, 2004
Exercise hyperventilation, dyspnea sensation, and ergoreflex activation in lone atrial fibrillation
Marco Guazzi, Sebastiano Belletti, Gabriele Tumminello, Cesare Fiorentini, Maurizio D. Guazzi
American Journal of Physiology Heart and Circulatory Physiology, 2004
The behaviour of the flow-mediated brachial artery vasodilatation during orthostatic stress in normal man
M. Guazzi, L. Lenatti, G. Tumminello, S. Puppa, C. Fiorentini, et al.
Acta Physiologica Scandinavica, 2004
Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure
Marco Guazzi, Giuseppe Reina, Gabriele Tumminello, Maurizio D. Guazzi
Journal of Applied Physiology, 2004
Influences of sildenafil on lung function and hemodynamics in patients with chronic heart failure
M GUAZZI, G TUMMINELLO, F DIMARCO, M GUAZZI
Clinical Pharmacology and Therapeutics, 2004
Cardiovascular effects of insulin in patients with heart failure
Italian Heart Journal Supplementi, 2003
Insulin ameliorates exercise ventilatory efficiency and oxygen uptake in patients with heart failure-type 2 diabetes comorbidity
Marco Guazzi, Gabriele Tumminello, Marco Matturri, Maurizio D Guazzi
Journal of the American College of Cardiology, 2003
Aspirin - Angiotensin-converting enzyme inhibitor coadministration and mortality in patients with heart failure: A dose-related adverse effect of aspirin
Marco Guazzi, Roberto Brambilla, Giuseppe Rèina, Gabriele Tumminello, Maurizio D. Guazzi
Archives of Internal Medicine, 2003

Gabriele Tumminello

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