Graduated in Chemistry (1990) from the Federal University of Ceará, where he completed a master's degree (1995) and doctorate (2003), in the area of Natural
Products Chemistry. He completed a post-doctoral internship in 2010 in the toxicological Biochemistry Program at the Federal University of Santa Maria - UFSM/RS. He is an Associate Professor at the Regional University of Cariri (URCA), Brazil. He is coordinator of the Natural Products Research Laboratory -
LPPN/URCA. He works as a journal reviewer, Ad hoc consultant for CNPq and member of the editorial board of several national/international scientific
journals funded by CNPq, FUNCAP and FINEP.
EDUCATION
PhD Organic Chemistry - Universidade Federal do Ceará
Post Doctoral (Postgraduate Program in Toxicological Biochemistry) - Universidade Federal de Santa Maria
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Ecology, Evolution, Behavior and Systematics, Analytical Chemistry, Drug Discovery
Antibacterial Activity of a Mouthwash Containing Plectranthus amboinicus (Lour.) Spreng Extract and Lippia sidoides Cham. Essential Oil Wilma Francisca da Silva, Carla de Fatima Alves Nonato, Débora Odília Duarte Leite, Fabiola Fernandes Galvão Rodrigues, Fazia Fernandes Galvão Rodrigues, Ana Cecília Calixto Donelardy, José Galberto Martins da Costa Chemistry and Biodiversity, 2026 This study investigated the development of a mouthwash formulated with Plectranthus amboinicus leaf extract (PaEE) and Lippia sidoides leaf essential oil (LsOE), exploring their antibacterial potential. Antimicrobial activity was evaluated in vitro using the broth microdilution method to determine the minimum inhibitory concentration (MIC) against Streptococcus mutans and Staphylococcus aureus. Chemical analysis of LsOE by GC/MS identified active compounds such as thymol and carvacrol, while PaEE demonstrated the presence of flavonoids, anthocyanins, mucilages, tannins, and phenolic compounds. Both extracts exhibited antibacterial activity, with LsOE and the natural mouthwash showing intermediate efficacy (MIC 128 µg/mL), while PaEE alone was less effective (MIC 512 µg/mL). The formulated mouthwash (F1) significantly reduced bacterial growth, and the combined use of LsOE and PaEE indicated a synergistic effect. These findings support the potential of plant‐based formulations for dental biofilm control and encourage further research to expand their applicability in public oral health.
Dominance of Ricinus communis in the Semi-Arid Region Mediated by Allelopathy Bruno M. Alcântara, Felipe R. Santos, José Anderson S. Silva, José W. Almeida‐Bezerra, José Galberto M. Costa, Delmira C. Silva, Cláudia M. Furlan, Maria Arlene P. Silva Weed Research, 2026 The introduction of invasive alien species can adversely affect the functioning of natural ecosystems. Ricinus communis L., widely present in the Brazilian semi‐arid region, establishes itself in areas with native species, such as Handroanthus impetiginosus (Mart. ex DC.) Mattos, because it does not go dormant and disperses balocorically, which can affect the latter's plant succession. This study aimed to evaluate whether the leaf biomass of R. communis exerts a negative allelopathic effect associated with its introduction into natural ecosystems. Leaves of R. communis , collected at the end of senescence, were mixed in alternating layers with Caatinga soil and allowed to decompose for 90 days at different concentrations by total soil mass (w/w). The chemical constituents of the decomposed R. communis material were identified using GC–MS. The GC–MS chromatographic analysis revealed the presence of 10 compounds, grouped into five main classes: monoglycerides, alkanes, fatty acids, terpenes and monosaccharides. Key compounds identified include Phytol (C 20 H 40 O) and palmitic acid (C 16 H 32 O 2 ). The byproducts of R. communis leaf decomposition had negative effects on seedling germination. At the two highest leaf litter concentrations, a 90% reduction in the seed germination rate was observed. For the post‐germination period, results showed a correlation between the residence time of allelochemicals in the substrate and the concentration of leaf biomass, with negative effects being most prominent at the highest concentration of R. communis leaves. Regarding the morpho‐anatomical analysis, significant variations in the tissue thickness of the radicle and hypocotyl were observed, in addition to pronounced qualitative changes. The results of this study confirm R. communis exhibits negative allelopathic potential against H. impetiginosus . This may lead to the reduction or elimination of the latter species in the medium to long term, directly impacting plant succession within the natural ecosystem.
Piper tuberculatum Jacq. essential oil and its impact on the control of Candida spp. and Pichia kudriavzevii: increased efficacy of fluconazole and inhibition of virulence Maria Flaviana Bezerra Morais-Braga, Victor Juno Alencar Fonseca, Joara Nalyda Pereira Carneiro, Antonia Thassya Lucas dos Santos, Maria Audilene de Freitas, Andressa Guilhermino dos Santos, Francildo dos Santos Silva, Elita de Sousa Santos, Débora Lima Sales, José Galberto Martins da Costa, Lariza Leisla Leandro Nascimento, Natália Kelly Gomes de Carvalho, Maria Inácio da Silva, Geane Gabriele de Oliveira Souza, Juliana Moura Mendes Arrua, Lucas Yure Santos da Silva, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade-Pinheiro Journal of Ethnopharmacology, 2026
Chemical and Biological Properties of Hymenaea courbaril L.: A Review Cicera Alane Coelho Gonçalves, Geane Gabriele de Oliveira Souza, Ana Maria Fernandes Duarte, Joice Barbosa do Nascimento, Fázia Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues Chemistry and Biodiversity, 2026 Hymenaea courbaril L., commonly known as jatobá, is a plant traditionally used by native populations for medicinal purposes, in addition to providing edible fruits and durable wood for construction. In Brazilian traditional medicine, products from this species are employed to treat wounds, inflammations, bacterial infections, rheumatism, anemia, respiratory and gastric disorders, bronchitis, and prostate conditions. This review aimed to summarize the phytochemical composition and biological activities of H. courbaril L., establishing a foundation for future studies. The species is rich in bioactive compounds, including flavonoids, terpenes, phenols, and coumarins present in its leaves, fruits, bark, and resin. Scientifically validated bioactivities include antibacterial, antifungal, antiviral, anti‐inflammatory, antioxidant, muscle‐relaxant, and antiproliferative effects. Low acute toxicity has been demonstrated in in vivo assays. Despite these promising results, gaps remain regarding its chemical characterization, medicinal, and nutraceutical potential. This review highlights the need for further research to validate traditional uses, ensure safe applications, and explore new therapeutic prospects.
Allelopathy as a Strategy for Biological Invasion: Calotropis procera and Its Impact on Plant Succession Bruno Melo de Alcântara, Paulo Henrique Calixto Santana, Felipe Rufino dos Santos, José Weverton Almeida‐Bezerra, José Galberto Martins da Costa, Delmira da Costa Silva, Cláudia Maria Furlan, Maria Arlene Pessoa da Silva Chemistry and Biodiversity, 2026 This article reports on the allelopathic potential of Calotropis procera (Aiton) W.T. Aiton foliage on Handroanthus impetiginosus (Mart. ex DC.) Mattos. Predominant species in semiarid environments, especially in the Caatinga of the Northeast, where it acts as an invasive species. The leaves of C. procera were mixed with soil from the Caatinga and left to decompose for 90 days. The control group consisted only of soil from the Caatinga, Northeast, Brazil. The germination test was conducted in quadruplicate (30 seeds/treatment). For growth, 30 replicates per treatment were used, each with one seedling of the recipient species. The identification of the chemical constituents of C. procera was assessed by GC–MS. The data was submitted to the one‐way ANOVA test. Residues from the decomposition of C. procera litter negatively affected seedling germination, with a reduction of up to 80% in the treatments evaluated. The phytochemical analysis showed the presence of 18 compounds, grouped into six main classes. Among the main compounds identified were: α‐amyrin (C 30 H 50 O) with 2.69% and O‐acetyl‐β‐amyrin (C 32 H 52 O 2 ) with 6.19% concentration. Significant variation was observed in the thickness of the tissues and regions of the radicle, hypocotyl and leaves of H. impetiginosus . C. procera litter has a negative allelopathic potential on the recipient species, which could lead to their reduction in the natural environment.
Citrus reticulata Blanco: A Review on Chemical Composition and Biological Activities José Walber Gonçalves Castro, Geane Gabriele de Oliveira Souza, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues Chemistry and Biodiversity, 2026 This review compiled data on the chemical composition and biological activities of Citrus reticulata (Rutaceae) from 49 articles published between 2014 and 2024 in the Science Direct, PubMed, and SciELO databases. The fruit peel stands out for its abundance of monoterpenes and sesquiterpenes, especially limonene (up to 85.7%), and methoxylated flavonoids such as nobiletin, tangeretin, and hesperidin, which are known for their antioxidant, anti‐inflammatory, and antimicrobial activities. The essential oil demonstrated larvicidal activity against Aedes aegypti and action against Leishmania amazonensis . It is concluded that the peel is rich in metabolites with high therapeutic and industrial potential, and further studies are recommended on mechanisms of action and applications in food, cosmetics, insecticides, and fertilizers.
Anxiolytic, Anticonvulsant Effects, and Cytotoxic Analysis of Methanolic Extracts from the Pulp and Seeds of Annona squamosa L. Debora Odília Duarte Leite, Cicera Janaine Camilo, Natália Kelly Gomes de Carvalho, Johnatan Wellisson da Silva Mendes, Alexandro Rodrigues Dantas, Gerson Javier Torres Salazar, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses da Silva, Helcio Silva dos Santos, José Galberto Martins da Costa Current Bioactive Compounds, 2026 Introduction: Generalized anxiety disorder is a neurological condition that can lead to cardiovascular disease and type II diabetes mellitus. Physical activity and the consumption of foods rich in antioxidant compounds are strategies that substantially improve anxiety. Purpose: This study aimed to assess the cytotoxic potential of methanolic extracts obtained from the pulp and seeds of Annona squamosa using different analytical approaches, in addition to investigating their anxiolytic and anticonvulsant effects in adult zebrafish. Methods: For toxicity in Artemia salina, eggs were incubated and, after hatching, the larvae were exposed to concentrations of extracts (0.06-5 μg/mL) for 24 hours. Toxicity in Drosophila melanogaster involved exposure to different concentrations of extracts (125-2000 μg/mL) with mortality readings every 3, 6, 12, 24, and 48 hours. Locomotor damage was assessed using the negative geotaxis test. In Danio rerio, anxiolytic activity was investigated through open field, light/dark, and PTZ-induced convulsion tests, where fish were exposed to oral extracts at different concentrations (40, 200, and 400 mg/kg). GABAergic neuromodulation was analyzed using benzodiazepine antagonists. Results: The extracts demonstrated high cytotoxicity against A. salina, with LD50 values of 2.24 μg/mL for the pulp extract and 1.64 μg/mL for the seed extract. In D. melanogaster, toxic effects were limited, with mild toxicity observed for the seed extract at high concentrations. In the zebrafish model, the seed extract showed toxicity at doses higher than 200 mg/kg, while the pulp extract was non-toxic. In terms of locomotor activity, both extracts affected the locomotor behavior of fish and D. melanogaster, with the seed exhibiting more pronounced effects. In the anxiolytic test, the extracts displayed effects similar to diazepam, modulating behavior via GABAergic neurotransmission. Finally, the seed extract demonstrated anticonvulsant activity in zebrafish, particularly in the acute and chronic stages of PTZ-induced seizures, indicating specific therapeutic potential. Discussion: The pulp and seed extracts have different toxicological profiles, with greater toxicity associated with the seed extract, especially at high concentrations. The changes in locomotor behavior and the anxiolytic effects observed in both models suggest that they act on neuromodulatory pathways, possibly mediated by the GABAergic system. The anticonvulsant activity of the seed extract in the acute and chronic stages of PTZ-induced seizures in zebrafish points to a potential therapeutic use in neurological disorders. Conclusion: The study revealed that the methanolic extract from the pulp of A. squamosa exhibited a safe anxiolytic effect, while the seed extract showed both anxiolytic and anticonvulsant effects, albeit with acute toxicity. New formulations are suggested to reduce the toxicity of the seeds and explore the plant’s therapeutic potential.
Phenolic Compound Profile, Antimicrobial Activity, and Adjuvant Potential of Ethanolic Extracts From Bioproducts of Melipona quinquefasciata (Lepeletier, 1836) Suieny Rodrigues Bezerra, Antonio Henrique Bezerra, Cristina Rodrigues dos Santos Barbosa, Debora Feitosa Muniz, Debora de Menezes Dantas, Josivânia Teixeira de Sousa, Nair Silva Macêdo, Zildene de Sousa Silveira, Andressa Guilhermino dos Santos, Maria Alicy Neres de Oliveira, Débora Odília Duarte Leite, Datiane de Morais Oliveira‐Tintino, Maria Flaviana Bezerra Morais‐Braga, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra da Cunha Chemistry and Biodiversity, 2025 Antimicrobial resistance is a global emergency driven by the selection of multiresistant strains. As a result, research has intensified on products with direct antimicrobial effects or as adjuvants to antibiotics and antifungals. Products from stingless bees of the Melipona genus have shown biological properties, such as antimicrobial activity. This study evaluated the ethanolic extracts of geopropolis (EEGMq), wax (EEWMq), and pollen (EEPMq) from Melipona quinquefasciata (“Uruçu‐do‐chão”) against multiresistant strains of Staphylococcus aureus 10, Escherichia coli 06, Pseudomonas aeruginosa 24, and Candida spp. The extracts were characterized by high‐performance liquid chromatography‐diode array detection, and antimicrobial activity was assessed through broth microdilution and plate subculture methods. Phenolic compounds identified in EEGMq included p‐coumaric acid, ferulic acid, naringenin, and apigenin. The extracts did not show significant direct antibacterial activity; however, there was potentiation of the antibiotic action when combined with Norfloxacin, Amikacin, and Penicillin against S. aureus and potentiation of Amikacin and Penicillin against P. aeruginosa. EEGMq also exhibited antifungal activity, significantly reducing Fluconazole activity against C. albicans and C. tropicalis. The results suggest that M. quinquefasciata extracts, especially geopropolis, hold promise for enhancing antibiotics and antifungals and contain bioactive molecules that modulate biological activity.
Anxiety behavior in adult Zebrafish modulated by the alkaloid fraction of Cissampelos sympodialis Eichl. roots Johnatan Wellisson da Silva Mendes, Joice Barbosa do Nascimento, José Jonas Ferreira Viturino, Lariza Leisla Leandro Nascimento, Débora Odília Duarte Leite, Natália Kelly Gomes de Carvalho, Hélcio Silva dos Santos, Emmanuel Silva Marinho, Márcia Machado Marinho, Jane Eire Silva Alencar de Menezes, José Galberto Martins da Costa Phytomedicine Plus, 2025
Study of the Antioxidant and Antibacterial Effects of Genipa americana L. Against Food Pathogens Lariza Leisla Leandro Nascimento, Geane Gabriele de Oliveira Souza, Ana Cecília Calixto Donelardy, Maria Inácio da Silva, Cícera Alane Coelho Gonçalves, Ana Maria Duarte Fernandes, José Walber Gonçalves Castro, Débora Odília Duarte Leite, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues Foods, 2025
Characterization and analysis of the bioactivity of the Piper rivinoides Kunth essential oil and its components myristicin and elemicin, against opportunistic fungal pathogens Victor Juno Alencar Fonseca, Sarah Castro dos Santos, Joara Nályda Pereira Carneiro, Antonia Thassya Lucas dos Santos, Maria Audilene de Freitas, Natália Kelly Gomes de Carvalho, Francildo dos Santos Silva, Andressa Guilhermino dos Santos, Aparecida Vitória Silva Menêses, Naiza Saraiva Farias, Rivânia Pereira dos Santos, Ricardo Andrade Rebelo, Martinho Rau, Luiz Everson da Silva, Wanderlei do Amaral, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Maria Flaviana Bezerra Morais-Braga Microbial Pathogenesis, 2025
Genipa americana L.: A Review on Traditional Uses, Phytochemistry and Biological Activities Lariza Leisla Leandro Nascimento, Geane Gabriele de Oliveira Souza, Johnatan Wellisson da Silva Mendes, Ana Cecília Calixto Donelardy, José Jonas Ferreira Viturino, Natália Kelly Gomes de Carvalho, Débora Odília Duarte Leite, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues Chemistry and Biodiversity, 2024
Anticonvulsant, Anticholinesterase and Cytoprotective Effects of the Aqueous Extract of Lippia sidoides Cham Cicera Janaine Camilo, Débora Odília Duarte Leite, Natália Kelly Gomes de Carvalho, José Walber Gonçalves Castro, Jane Eire Silva Alencar de Menezes, Helcio Silva dos Santos, Joanda Paolla Raimundo Silva, Daniela Ribeiro Alves, Selene Maia de Morais, Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa Plants, 2024
Cytotoxic and Anti-HSV-1 Effects of Caulerpin Derivatives Gisely Maria Freire Abílio, Cicera Janaine Camilo, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Lindomar José Pena, Abelardo Silva-Júnior, Yuri Mangueira do Nascimento, José Maria Barbosa-Filho, Bárbara Viviana de Oliveira Santos, Kristerson Reinaldo de Luna Freire Molecules, 2024
Comparative antimicrobial potential of Ocimum basilicum essential oil, estragole and estragole/β-cyclodextrin complex in an infection model on adult zebrafish Francisco Lucas A. Batista, Jacqueline Cosmo Andrade-Pinheiro, Antonia Thassya L. dos Santos, Jessyca Nayara M. Lima, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Ana Raquel Pereira da Silva, Natália Kelly Gomes de Carvalho, Anita Oliveira Brito Pereira B. Martins, Roger Henrique S. da Costa, Lindaiane Bezerra Rodrigues, Henrique Douglas M. Coutinho, José Galberto Martins da Costa, Francisco Ernani A. Magalhães, Irwin Rose Alencar de Menezes Carbohydrate Polymer Technologies and Applications, 2023
Chemical Composition and Biological Activities of the Cnidoscolus quercifolis: A Review Joice Barbosa do Nascimento, Maria Inácio da Silva, Johnatan Wellisson da Silva Mendes, Alexandro Rodrigues Dantas, Fabíola Fernandes Galvão Rodrigues, Domenico Montesano, Monica Gallo, Paolo Trucillo, Gokhan Zengin, José Galberto Martins da Costa Processes, 2023
Antibacterial Activity and Anxiolytic Effect in Adult Zebrafish of Genus Lippia L. Species Carla de Fatima Alves Nonato, Emerson Vinicius Silva de Melo, Cicera Janaine Camilo, Maria Kueirislene Amâncio Ferreira, Jane Eire Alencar de Meneses, Antonio Wlisses da Silva, Hélcio Silva dos Santos, Jaime Ribeiro-Filho, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Tomasz Baj, Radosław Kowalski, José Galberto Martins da Costa Plants, 2023
13C NMR spectroscopic data of aporphine alkaloids Johnatan Wellisson da Silva Mendes, Walmir Emanuel Miranda Cunha, Raimundo Braz Filho, Natália Kelly Gomes de Carvalho, José Galberto Martins da Costa Alkaloids Chemistry and Biology, 2023
Consensus of the medicinal use of Copaifera langsdorffii Desf. in different phytophysiognomies Revista Brasileira De Plantas Medicinais, 2023
LC-MS Analysis and Antifungal Activity of Turnera subulata Sm. Jacqueline Cosmo Andrade-Pinheiro, Celestina Elba Sobral de Souza, Daiany Alves Ribeiro, Andressa de Alencar Silva, Viviane Bezerra da Silva, Antonia Thassya Lucas dos Santos, Victor Juno Alencar Fonseca, Delmacia Gonçalves de Macêdo, Rafael Pereira da Cruz, José Weverton Almeida-Bezerra, Antonio Júdson Targino Machado, Thiago Sampaio de Freitas, Edy Sousa de Brito, Paulo Riceli Vasconcelos Ribeiro, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Rafał Rowiński, Radosław Kowalski, Maria Flaviana Bezerra Morais-Braga Plants, 2023
Analysis toxicity by different methods and anxiolytic effect of the aqueous extract Lippia sidoides Cham. Cicera J. Camilo, Débora O. D. Leite, Johnatan W. da S. Mendes, Alexandro R. Dantas, Natália K. G. de Carvalho, José W. G. Castro, Gerson J. T. Salazar, Maria Kueirislene Amâncio Ferreira, Jane Eire Alencar de Meneses, Antonio Wlisses da Silva, Helcio S. dos Santos, Josean F. Tavares, Joanda P. R. e Silva, Fabiola F. G. Rodrigues, Chunhoo Cheon, Bonglee Kim, José Galberto Martins da Costa Scientific Reports, 2022
Chemical Composition and Antimicrobial Potential of Essential Oil of Acritopappus confertus (Gardner) R.M.King & H.Rob. (Asteraceae) Rafael Pereira da Cruz, José Walber Gonçalves Castro, Débora Odília Duarte Leite, Natália Kelly Gomes de Carvalho, José Weverton Almeida-Bezerra, Raimundo Luiz Silva Pereira, Fázia Fernandes Galvão Rodrigues, José Jailson Lima Bezerra, Adrielle Rodrigues Costa, Edna Mori, Pablo Antonio Maia de Farias, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga, Marcello Iriti, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues Pharmaceuticals, 2022
Central depressant effects of Piper tuberculatum Jacq essential oil in mice Valterlúcio dos Santos Sales, Francisco Romero Cabral, Emmily Petícia do Nascimento Sales, Tatyelle Bezerra Carvalho, Maria Haiele Nogueira Costa, Victor Afonso Pereira de Oliveira, Cristina Kelly de Souza Rodrigues, Francisco Rodolpho Sobreira Dantas Nóbrega de Figueirêdo, Daniel Souza Bezerra, Gyllyandeson de Araújo Delmondes, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food Bioscience, 2022
The Genus Miconia Ruiz & Pav. (Melastomataceae): Ethnomedicinal Uses, Pharmacology, and Phytochemistry Viviane Bezerra da Silva, José Weverton Almeida-Bezerra, Adrielle Rodrigues Costa, Maria Flaviana Bezerra Morais-Braga, Maraiza Gregorio de Oliveira, Anderson Angel Vieira Pinheiro, Raimundo Samuel Leite Sampaio, José Walber Gonçalves Castro, Marcos Aurélio Figueiredo dos Santos, Valdilia Ribeiro de Alencar Ulisses, Maria Edilania da Silva Serafim Pereira, Dieferson Leandro de Souza, Bruno Melo de Alcântara, Maria Elizete Machado Generino, José Thyálisson da Costa Silva, Ademar Maia Filho, Sabrina Bezerra da Silva, Myunghan Moon, Bonglee Kim, José Galberto Martins da Costa Molecules, 2022
Ferulic acid derivatives inhibiting Staphylococcus aureus tetK and MsrA efflux pumps Patrícia Gonçalves Pinheiro, Gilvandete Maria Pinheiro Santiago, Francisco Erivaldo Freitas da Silva, Ana Carolina Justino de Araújo, Cícera Rejane Tavares de Oliveira, Priscilla Ramos Freitas, Janaína Esmeraldo Rocha, José Bezerra de Araújo Neto, Maria Milene Costa da Silva, Saulo Relison Tintino, Abolghasem Siyadatpanah, Roghayeh Norouzi, Saeid Dashti, Polrat Wilairatana, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa Biotechnology Reports, 2022
HPLC–DAD analysis and antimicrobial activities of Spondias mombin L. (Anacardiaceae) Maria Audilene de Freitas, Rafael Pereira da Cruz, Antonia Thassya Lucas dos Santos, José Weverton Almeida-Bezerra, Antonio Júdson Targino Machado, Joycy Francely Sampaio dos Santos, Janaina Esmeraldo Rocha, Aline Augusti Boligon, Camila Fonseca Bezerra, Thiago Sampaio de Freitas, Maria Karollyna do Nascimento Silva, Ana Cleide Alcântara Morais Mendonça, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra da Cunha, Jaime Ribeiro Filho, Maria Flaviana Bezerra Morais-Braga 3 Biotech, 2022
Inhibition of the MepA efflux pump by limonene demonstrated by in vitro and in silico methods Priscilla Ramos Freitas, Ana Carolina Justino de Araújo, Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Ray Silva de Almeida, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Janaína Esmeraldo Rocha, Francisco Nascimento Pereira-Junior, Saulo Relison Tintino, Henrique Douglas Melo Coutinho Folia Microbiologica, 2022
Anti-inflammatory effects of α-humulene and β-caryophyllene on pterygium fibroblasts Department of Ophthalmology, School of Medicine of Botucatu, São Paulo State University–UNESP, Botucatu, Sao Paulo 18618-000, Brazil, Magda Massae Hata Viveiros, José Galberto Martins da Costa, Department of Biological Chemistry, Regional University of Cariri, Crato, Ceará 66100-900, Brazil, Anselmo Gomes de Oliveira, Department of Pharmacology, School of Pharmaceutical Sciences, São Paulo State University–UNESP, Araraquara, Sao Paulo 01049-010, Brazil, Carolina Rubio, Biological Sciences, Institute of Biosciences of Botucatu, São Paulo State University–UNESP, Botucatu, Sao Paulo 01049-010, Brazil, Carlos Roberto Padovani, Department of Biostatistics, São Paulo State University–UNESP, Botucatu, Sao Paulo 01049-010, Brazil, Cláudia Aparecida Rainho, Department of Biostatistics, São Paulo State University–UNESP, Botucatu, Sao Paulo 01049-010, Brazil, Silvana Artioli Schellini, Department of Ophthalmology, School of Medicine of Botucatu, São Paulo State University–UNESP, Botucatu, Sao Paulo 18618-000, Brazil International Journal of Ophthalmology, 2022
Copaifera langsdorffii Desf.: A chemical and pharmacological review Maria de Oliveira Santos, Cicera Janaine Camilo, Julimery Gonçalves Ferreira Macedo, Maria Natália Soares de Lacerda, Cristiane Marinho Uchôa Lopes, Antonio Yony Felipe Rodrigues, José Galberto Martins da Costa, Marta Maria de Almeida Souza Biocatalysis and Agricultural Biotechnology, 2022
Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats Enaide Soares Santos, Geraldo Lucas Abrantes Coelho, Yan Kauê Saraiva Fontes Loula, Bárbara Lourenço Saraiva Landim, Cícera Norma Fernandes Lima, Sara Tavares de Sousa Machado, Maria Janice Pereira Lopes, Acléssia Damiana Soares Gomes, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Bonglee Kim, Cícero Francisco Bezerra Felipe, Samya de Araújo Neves, Marta Regina Kerntopf Evidence Based Complementary and Alternative Medicine, 2022
Traditional Uses, Phytochemistry, and Bioactivities of Mesosphaerum suaveolens (L.) Kuntze José Weverton Almeida-Bezerra, Felicidade Caroline Rodrigues, José Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro, Saulo Almeida de Menezes, Aline Belém Tavares, Adrielle Rodrigues Costa, Priscilla Augusta de Sousa Fernandes, Viviane Bezerra da Silva, José Galberto Martins da Costa, Rafael Pereira da Cruz, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho, Edward Teixeira de Albergaria, Marcos Vinicius Meiado, Abolghasem Siyadatpanah, Bonglee Kim, Antônio Fernando Morais de Oliveira Evidence Based Complementary and Alternative Medicine, 2022
Topical anti-inflammatory effect of hydroalcoholic extract of leaves of Licania rigida Benth. in mice Enaide Soares Santos, Cícera Datiane de Morais Oliveira-Tintino, Denise Bezerra Correia, Cícero Damon Carvalho de Alencar, Maria de Fátima Sousa, Cícera Norma Fernandes Lima, Sara Tavares de Sousa Machado, Acléssia Damiana Soares Gomes, Francisca Adilfa de Oliveira Garcia, Irwin Rose Alencar Menezes, Aline Augusti Boligon, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Phytomedicine Plus, 2021
Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice Maria Rayane Correia de Oliveira, Maria Gabriely de Lima Silva, Isabel Sousa Alcântara, Jaime Ribeiro Filho, Cícera Datiane de Morais Oliveira Tintino, Francisco Ernani Alves Magalhães, Anita Oliveira Brito Pereira Bezerr Martins, Renata Torres Pessoa, Antonia Eliene Duarte, José Galberto Martins da Costa, Sidney Gonçalo de Lima, Henrique Douglas Melo Coutinho, Raffaele Capasso, Irwin Rose Alencar de Menezes Environment Development and Sustainability, 2021
Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives Patrícia Gonçalves Pinheiro, Gilvandete Maria Pinheiro Santiago, Francisco Erivaldo Freitas da Silva, Ana Carolina Justino de Araújo, Cícera Rejane Tavares de Oliveira, Priscilla Ramos Freitas, Janaína Esmeraldo Rocha, José Bezerra de Araújo Neto, Maria Milene Costa da Silva, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa Asian Pacific Journal of Tropical Biomedicine, 2021
Phytochemical characterization and inhibition of Candida sp. by the essential oil of Baccharis trimera (Less.) DC Taís Gusmão da Silva, Josefa Carolaine Pereira da Silva, Joara Nályda Pereira Carneiro, Wanderlei do Amaral, Cícero Deschamps, Jenifer Priscila de Araújo, José Galberto Martins da Costa, Waltécio de Oliveira Almeida, Luiz Everson da Silva, Henrique Douglas Melo Coutinho, Jaime Ribeiro Filho, Maria Flaviana Bezerra Morais-Braga Archives of Microbiology, 2021
Chemical synthesis, molecular docking and MepA efflux pump inhibitory effect by 1,8-naphthyridines sulfonamides Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, Tereza Cristina Leal Balbino, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Alexandre Magno Rodrigues Teixeira, Humberto Medeiros Barreto, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Teresinha Gonçalves da Silva European Journal of Pharmaceutical Sciences, 2021
The 1,8-naphthyridines sulfonamides are NorA efflux pump inhibitors Cícera Datiane de Morais Oliveira-Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Alexandre Magno Rodrigues Teixeira, Jaime Ribeiro-Filho, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Teresinha Gonçalves da Silva Journal of Global Antimicrobial Resistance, 2021
UPLC-MS-ESI-QTOF analysis and Anti-Candida activity of fractions from Psidium guajava L. Camila Fonseca Bezerra, Janaína Esmeraldo Rocha, Maria Karollyna do Nascimento Silva, Thiago Sampaio de Freitas, Amanda Karine de Sousa, Joara Nályda Pereira Carneiro, Antônio Linkoln Alves Borges Leal, Antônia Thassya Lucas dos Santos, Rafael Pereira da Cruz, Allana Silva Rodrigues, Débora Lima Sales, Henrique Douglas Melo Coutinho, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Waltécio de Oliveira Almeida, Maria Flaviana Bezerra Morais-Braga South African Journal of Botany, 2020
Effect of vitamin K3 inhibiting the function of nora efflux pump and its gene expression on staphylococcus aureus Saulo R. Tintino, Veruska C. A. de Souza, Julia M. A. da Silva, Cícera Datiane de M. Oliveira-Tintino, Pedro S. Pereira, Tereza C. Leal-Balbino, Antonio Pereira-Neves, José P. Siqueira-Junior, José G. M. da Costa, Fabíola F. G. Rodrigues, Irwin R. A. Menezes, Gabriel C. A. da Hora, Maria C. P. Lima, Henrique D. M. Coutinho, Valdir Q. Balbino Membranes, 2020
The algal polysaccharide ulvan suppresses growth of hepatoma cells Chao Zhao, Guopeng Lin, Desheng Wu, Dan Liu, Lijun You, Petra Högger, Jesus Simal‐Gandara, Mingfu Wang, José Galberto Martins da Costa, Yoshinori Marunaka, Maria Daglia, Haroon Khan, Rosanna Filosa, Shaoyun Wang, Jianbo Xiao Food Frontiers, 2020
Anxiolytic and antidepressant-like effects of Annona coriacea (Mart.) and caffeic acid in mice Álefe Brito Monteiro, Cristina Kelly de Souza Rodrigues, Emmily Petícia do Nascimento, Valterlúcio dos Santos Sales, Gyllyandeson de Araújo Delmondes, Maria Haiele Nogueira da Costa, Victor Afonso Pereira de Oliveira, Luis Pereira de Morais, Aline Augusti Boligon, Roseli Barbosa, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food and Chemical Toxicology, 2020
Antibacterial potential of essential oil from syzygium aromaticum (L.) Merr. and L. M. Perry Antimicrobial Potential of Essential Oils, 2020
Seasonality influence on the chemical composition and antifungal activity of Psidium myrtoides O. Berg Delmacia Gonçalves de Macêdo, Marta Maria de Almeida Souza, Maria Flaviana B. Morais-Braga, Henrique Douglas M. Coutinho, Antonia Thassya L. dos Santos, Antonio Judson Targino Machado, Fábio Fernandes G. Rodrigues, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes South African Journal of Botany, 2020
Antinociceptive activity of the Psidium brownianum Mart ex DC. leaf essential oil in mice Renata de Souza Sampaio, Emmily Petícia do Nascimento, Irwin Rose Alencar de Menezes, Valterlúcio dos Santos Sales, Anita Oliveira Brito Pereira, Giovana Mendes de Lacerda, Enaide Soares Santos, Maria Janice Pereira Lopes, Luanna Gomes da Silva, Gyllyandeson de Araújo Delmondes, Nélio Barreto Vieira, Victor Mantoani Zaia, Daniel Souza Bezerra, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food and Chemical Toxicology, 2020
Antibiotic-Potentiating Activity of Phanostenine Isolated from Cissampelos sympodialis Eichler Walmir E. M. Cunha, Cicera J. Camilo, Carla de F. A. Nonato, Johnatan W. S. Mendes, Natália K. G. de Carvalho, Henrique D. M. Coutinho, Irwin R. A. Menezes, Telma L. G. de Lemos, Raimundo Braz‐Filho, Fabiola F. G. Rodrigues, Edinardo F. F. Matias, Gokhan Zengin, José G. M. Costa Chemistry and Biodiversity, 2019
UPLC-MS-ESI-QTOF analysis and antifungal activity of the spondias tuberosa arruda leaf and root hydroalcoholic extracts Antonia Thassya Lucas dos Santos, Joara Nályda Pereira Carneiro, Rafael Pereira da Cruz, Débora Lima Sales, Jacqueline Cosmo Andrade, Waltécio de Oliveira Almeida, José Galberto Martins da Costa, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Francisco Lucas Alves Batista, Francisco Ernani Alves Magalhães, Marcello Iriti, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho Antibiotics, 2019
Cytoprotective effect of Eugenia uniflora L. against the waste contaminant mercury chloride Francisco A.B. Cunha, Antonio I. Pinho, Joycy F.S. Santos, Celestina E. Sobral-Souza, Rosimeire S. Albuquerque, Edinardo F.F. Matias, Nadghia F. Leite, Saulo R. Tintino, José G.M. Costa, Aline A. Boligon, Emily P. Waczuk, João B.T. Rocha, Thais Posser, Henrique D.M. Coutinho, Lucindo J. Quintans-Júnior, Jeferson L. Franco Arabian Journal of Chemistry, 2019
Piper diospyrifolium Kunth.: Chemical analysis and antimicrobial (intrinsic and combined) activities Joara Nályda Pereira Carneiro, Rafael Pereira da Cruz, Josefa Carolaine Pereira da Silva, Janaína Esmeraldo Rocha, Thiago Sampaio de Freitas, Débora Lima Sales, Camila Fonseca Bezerra, Waltécio de Oliveira Almeida, José Galberto Martins da Costa, Luiz Everson da Silva, Wanderlei do Amaral, Ricardo Andrade Rebelo, Ieda Maria Begnini, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga Microbial Pathogenesis, 2019
Effects of the Hyptis martiusii Benth. leaf essential oil and 1,8-cineole (eucalyptol) on the central nervous system of mice Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo, Álefe Brito Monteiro, Irwin Rose Alencar de Menezes, Valterlúcio dos Santos Sales, Emmily Petícia do Nascimento, Cristina Kelly de Souza Rodrigues, Ana Jaqueline Bitu Primo, Luzia Paulo da Cruz, Érika do Nascimento Amaro, Gyllyandeson de Araújo Delmondes, Juliana Ponciano Leite de Oliveira Sobreira Nóbrega, Maria Janice Pereira Lopes, José Galberto Martins da Costa, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Food and Chemical Toxicology, 2019
Anti-inflammatory activity of herb products from Licania rigida Benth. Enaide Soares Santos, Cícera Datiane de Morais Oliveira, Irwin Rose Alencar Menezes, Emmily Petícia do Nascimento, Denise Bezerra Correia, Cícero Damon Carvalho de Alencar, Maria de Fátima Sousa, Cícera Norma Fernandes Lima, Álefe Brito Monteiro, Camila Pedroso Estevam de Souza, Gyllyandeson de Araújo Delmondes, Daniel Souza Bezerra, Francisca Adilfa de Oliveira Garcia, Aline Augusti Boligon, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf Complementary Therapies in Medicine, 2019
Antibacterial and antibiotic modifying activity evaluation of ruminants’ body fat used as zootherapeutics in ethnoveterinary practices in Northeast Brazil Diógenes de Queiroz Dias, Débora Lima Sales, Jacqueline Cosmo Andrade, Ana Raquel Pereira da Silva, Saulo Relison Tintino, Cícera Datiane de Morais Oliveira-Tintino, Gyllyandeson de Araújo Delmondes, Maysa de Oliveira Barbosa, Henrique Douglas Melo Coutinho, Felipe Silva Ferreira, Marcos Fábio Gadelha Rocha, Daniela Maria do Amaral Ferraz Navarro, Suyana Karolyne Lino da Rocha, José Galberto Martins da Costa, Romulo Romeu da Nóbrega Alves, Waltécio de Oliveira Almeida Journal of Ethnopharmacology, 2019
Chemical composition, antifungal activity and potential anti-virulence evaluation of the Eugenia uniflora essential oil against Candida spp. Joycy Francely Sampaio dos Santos, Janaína Esmeraldo Rocha, Camila Fonseca Bezerra, Maria Karollyna do Nascimento Silva, Yedda Maria Lobo Soares de Matos, Thiago Sampaio de Freitas, Antonia Thassya Lucas dos Santos, Rafael Pereira da Cruz, Antonio Júdson Targino Machado, Tigressa Helena Soares Rodrigues, Edy Sousa de Brito, Dédora Lima Sales, Waltécio de Oliveira Almeida, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga Food Chemistry, 2018
Phytochemical analysis and central effects of annona muricata linnaeus: Possible involvement of the gabaergic and monoaminergic systems Iranian Journal of Pharmaceutical Research, 2018
Phytochemical prospection and modulation of the antibiotic activity of Cyperus rotundus L. against multiresistant bacteria Revista Cubana De Plantas Medicinales, 2018
Toxicity against Drosophila melanogaster and antiedematogenic and antimicrobial activities of Alternanthera brasiliana (L.) Kuntze (Amaranthaceae) Henrique Douglas Melo Coutinho, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Raimundo Luiz Silva Pereira, Thiago Sampaio de Freitas, Maria Arlene Pessoa da Silva, Jeferson Luis Franco, Francisco Assis Bezerra da Cunha, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Aline Augusti Boligon, João Batista Teixeira da Rocha, Maria Ivaneide Rocha, Joycy Francely Sampaio dos Santos Environmental Science and Pollution Research, 2018
Anti-edematogenic and anti-inflammatory activity of the essential oil from Croton rhamnifolioides leaves and its major constituent 1,8-cineole (eucalyptol) Anita Oliveira Brito Pereira Bezerra Martins, Lindaiane Bezerra Rodrigues, Francisco Rafael Alves Santana Cesário, Maria Rayane Correia de Oliveira, Cicera Datiane Morais Tintino, Fyama Ferreira e Castro, Isabel Sousa Alcântara, Maria Neyze Martins Fernandes, Thaís Rodrigues de Albuquerque, Maria Sanadia Alexandre da Silva, Adriano Antunes de Sousa Araújo, Lucindo José Quintans Júniur, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Almir Gonçalves Wanderley Biomedicine and Pharmacotherapy, 2017
Antibacterial enhancement of antibiotic activity by Enterolobium contortisiliquum (Vell.) Morong Zildene de Sousa Silveira, Nair Silva Macêdo, Thiago Sampaio de Freitas, Ana Raquel Pereira da Silva, Joycy Francely Sampaio dos Santos, Maria Flaviana Bezerra Morais-Braga, José Galberto Martins da Costa, Raimundo Nonato Pereira Teixeira, Jean Paul Kamdem, Henrique Douglas Melo Coutinho, Francisco Assis Bezerra da Cunha Asian Pacific Journal of Tropical Biomedicine, 2017
Antibacterial, modulatory activity of antibiotics and toxicity from Rhinella jimi (Stevaux, 2002) (Anura: Bufonidae) glandular secretions Débora Lima Sales, Maria Flaviana Bezerra Morais-Braga, Antonia Thassya Lucas dos Santos, Antonio Judson Targino Machado, João Antonio de Araujo Filho, Diógenes de Queiroz Dias, Francisco Assis Bezerra da Cunha, Rogério de Aquino Saraiva, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, José Galberto Martins Costa, Felipe Silva Ferreira, Rômulo Romeu da Nóbrega Alves, Waltécio de Oliveira Almeida Biomedicine and Pharmacotherapy, 2017
Chemical compounds and antibacterial activity of Tephrosia toxicaria Pers Angela Martha Campos Arriaga, Francisca Renata Lopes Da Silva, Maria Valdeline Sousa Texeira, Italo Gomes Pereira, Marcos Reinaldo Da Silva, Jair Mafezoli, Gilvandete Maria Pereira Santiago, Jackson Nunes E Vasconcelos, Raimundo Braz-Filho, José Galberto Martins Da Costa, Edinardo F.F. Matias, Fabiola Fernandes Galvão Rodrigues Oriental Journal of Chemistry, 2017
In vitro modulation of the antibiotic activity of essential oil from fruits of piper tuberculatum jacq Revista Cubana De Plantas Medicinales, 2017
Cytotoxic and antioxidative potentials of ethanolic extract of Eugenia uniflora L. (Myrtaceae) leaves on human blood cells Francisco Assis Bezerra da Cunha, Emily Pansera Waczuk, Antonia Eliene Duarte, Luiz Marivando Barros, Olusola Olalekan Elekofehinti, Edinardo Fagner Ferreira Matias, José Galberto Martins da Costa, Adekunle Adeniran Sanmi, Aline Augusti Boligon, João Batista Teixeira da Rocha, Diogo Onofre Souza, Thaís Posser, Henrique Douglas Melo Coutinho, Jeferson Luis Franco, Jean Paul Kamdem Biomedicine and Pharmacotherapy, 2016
Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats Germana Freire Rocha Caldas, Mayara Marília Ferreira Limeira, Alice Valença Araújo, Giwellington Silva Albuquerque, Jacinto da Costa Silva-Neto, Teresinha Gonçalves da Silva, João Henrique Costa-Silva, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Almir Gonçalves Wanderley Food and Chemical Toxicology, 2016
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes Luciana G. da S. Souza, Macia C.S. Almeida, Telma L.G. Lemos, Paulo R.V. Ribeiro, Edy S. de Brito, Vera L.M. Silva, Artur M.S. Silva, Raimundo Braz-Filho, José G.M. Costa, Fábio F.G. Rodrigues, Francisco S. Barreto, Manoel O. de Moraes Bioorganic and Medicinal Chemistry Letters, 2016
Preliminary in vitro evaluation of Caryocar coriaceum Wittm. leaf and bark extracts as antioxidants International Journal of Applied Research in Natural Products, 2016
Additive effect of Lygodium venustum SW. in association with gentamicin Maria F. B. Morais-Braga, Teógenes M. Souza, Karla K. A. Santos, Gláucia M. M. Guedes, Jacqueline C. Andrade, Saulo R. Tintino, Celestina E. Sobral-Souza, José G. M. Costa, Antonio A. F. Saraiva, Henrique D. M. Coutinho Natural Product Research, 2016
Evaluation of antimicrobial and modulatory activity of the ethanol extract of libidibia ferrea (Mart. ex tul.) l.p. queiroz Revista Cubana De Plantas Medicinales, 2016
Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.-Hill Francisca Valéria Soares de Araújo Pinho, Litiele Cezar da Cruz, Nathane Rosa Rodrigues, Emily Pansera Waczuk, Celestina Elba Sobral Souza, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa, Margareth Linde Athayde, Aline Augusti Boligon, Jeferson Luis Franco, Thaís Posser, Irwin Rose Alencar de Menezes Oxidative Medicine and Cellular Longevity, 2016
Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice Elizângela Beneval Bento, Francisco Elizaudo de Brito Júnior, Dayanne Rakelly de Oliveira, Cícera Norma Fernandes, Gyllyandeson de Araújo Delmondes, Francisco Rafael Alves Santana Cesário, Cristina Kelly de Sousa Rodrigues, Valterlúcio dos Santos Sales, Francisco Rodolpho Sobreira Dantas Nóbrega de Figueiredo, Izabel Cristina Santiago Lemos, Álefe Brito Monteiro, Irwin Rose Alencar de Menezes, José Galberto Martins da Costa, Marta Regina Kerntopf Saudi Journal of Biological Sciences, 2016
The genus Cordia: Botanists, ethno, chemical and pharmacological aspects Edinardo Fagner Ferreira Matias, Erivania Ferreira Alves, Maria Karollyna do Nascimento Silva, Victoria Regina de Alencar Carvalho, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa Revista Brasileira De Farmacognosia, 2015
Gastroprotective mechanisms of the monoterpene 1,8-cineole (eucalyptol) Germana Freire Rocha Caldas, Alisson Rodrigo da Silva Oliveira, Alice Valença Araújo, Simone Sette Lopes Lafayette, Giwellington Silva Albuquerque, Jacinto da Costa Silva-Neto, João Henrique Costa-Silva, Fabiano Ferreira, José Galberto Martins da Costa, Almir Gonçalves Wanderley Plos One, 2015
Content, yield and quality of essential oil Vanillosmopsis arborea (Gardner) Baker (candeeiro) and its allelopathy Revista Cubana De Plantas Medicinales, 2015
Topical Anti-Inflammatory Activity of Oil from Tropidurus hispidus (Spix, 1825) Israel J. M. Santos, Gerlânia O. Leite, José Galberto M. Costa, Romulo R. N. Alves, Adriana R. Campos, Irwin R. A. Menezes, Francisco Ronaldo V. Freita, Maria Janeth H. Nunes, Waltécio O. Almeida Evidence Based Complementary and Alternative Medicine, 2015
Antimicrobial activity and phytochemical characterization of hydroalcoholic extracts of Passiflora cincinnata mast. (maracujá-do-mato) Revista Cubana De Plantas Medicinales, 2014
Study on the chemical composition and antibacterial activity of Bowdichia virgilioides kunth (Sucupira) - Fabaceae - Papilonoidae Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2014
Gastroprotective and ulcer healing effects of essential oil of Hyptis martiusiibenth. (Lamiaceae) Germana Freire Rocha Caldas, Alisson Rodrigo da Silva Oliveira, Alice Valença Araújo, Dafne Carolina Alves Quixabeira, Jacinto da Costa Silva-Neto, João Henrique Costa-Silva, Irwin Rose Alencar de Menezes, Fabiano Ferreira, Ana Cristina Lima Leite, José Galberto Martins da Costa, Almir Gonçalves Wanderley Plos One, 2014
Topical antinociceptive effect of Vanillosmopsis arborea baker on acute corneal pain in mice Laura Hévila Inocêncio Leite, Gerlânia de Oliveira Leite, Thales Silva Coutinho, Severino Denício Gonçalves de Sousa, Renata Souza Sampaio, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Adriana Rolim Campos Evidence Based Complementary and Alternative Medicine, 2014
Phytochemical study, antioxidant and antibacterial activities of Stemodia maritima Francisca R. L. da Silva, Francisco E. A. Rodrigues, Aldenia R. S. Gomes, Angela M. C. Arriaga, Jair Mafezoli, Telma L. G. Lemos, Macia C. S. de Almeida, Gilvandete M. P. Santiago, Raimundo Braz-Filho, José G. M. da Costa, Fabiola F. G. Rodrigues, Henrique D. M. Coutinho Quimica Nova, 2014
Phytochemical constituents and toxicity of duguetia furfuracea hydroalcoholic extract in drosophila melanogaster Francisca Valéria Soares de Araújo Pinho, Gustavo Felipe da Silva, Giulianna Echeverria Macedo, Katiane Raquel Muller, Illana Kemmerich Martins, Ana Paula Lausmann Ternes, José Galberto Martins da Costa, Margareth Linde Athayde, Aline Augusti Boligon, Jean Paul Kamdem, Jeferson Luis Franco, Irwin Rose Alencar de Menezes, Thaís Posser Evidence Based Complementary and Alternative Medicine, 2014
Repeated-doses toxicity study of the essential oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss mice Germana Freire Rocha Caldas, Alice Valença Araújo, Giwellington Silva Albuquerque, Jacinto da Costa Silva-Neto, João Henrique Costa-Silva, Irwin Rose Alencar de Menezes, Ana Cristina Lima Leite, José Galberto Martins da Costa, Almir Gonçalves Wanderley Evidence Based Complementary and Alternative Medicine, 2013
Trypanocide, cytotoxic, and anti-Candida activities of natural products: Hyptis martiusii Benth. Karla K.A. Santos, Edinardo F.F. Matias, Celestina E. Sobral-Souza, Saulo R. Tintino, Maria F.B. Morais-Braga, Gláucia M.M. Guedes, Miriam Rolón, Cathia Coronel, Jorge Alfonso, Celeste Vega, José G.M. Costa, Irwin R.A. Menezes, Henrique D.M. Coutinho European Journal of Integrative Medicine, 2013
Antiulcerogenic activity of the hydroalcoholic extract of leaves of croton campestris a. St.-Hill in rodents Francisco E. B. Júnior, Dayanne R. de Oliveira, Elizângela B. Bento, Laura H. I. Leite, Daniele O. Souza, Ana Luiza A. Siebra, Renata S. Sampaio, Anita O. P. B. Martins, Andreza G. B. Ramos, Saulo R. Tintino, Luiz J. Lacerda-Neto, Patricia R. L. Figueiredo, Larissa R. Oliveira, Cristina K. S. Rodrigues, Valterlúcio S. Sales, Francisco R. S. D. N. Figueiredo, Emmily P. Nascimento, Alefe B. Monteiro, Érika N. Amaro, José G. M. Costa, Henrique Douglas Melo Coutinho, Irwin R. A. de Menezes, Marta R. Kerntopf Evidence Based Complementary and Alternative Medicine, 2013
In vitro evaluation of antimicrobial activity and modulating the ethanol and hexane extracts of Costus arabicus bulb Bioscience Journal, 2013
Antileishmanial in vitro activity of Eugenia uniflora and Momordica charantia Revista De Ciencias Farmaceuticas Basica E Aplicada, 2013
Modulation of the antibiotic activity by extracts from amburana cearensis A. C. Smith and anadenanthera macrocarpa (Benth.) Brenan Fernando G. Figueredo, Emerson O. Ferreira, Bruno F. F. Lucena, Cícero M. G. Torres, Daniel L. Lucetti, Elaine C. P. Lucetti, João Marcos F. L. Silva, Francisco A. V. Santos, Cássio R. Medeiros, Gardênia M. M. Oliveira, Aracélio V. Colares, José G. M. Costa, Henrique D. M. Coutinho, Irwin R. A. Menezes, Júlio C. F. Silva, Marta R. Kerntopf, Patrícia R. L. Figueiredo, Edinardo F. F. Matias Biomed Research International, 2013
Antibacterial, antifungal and antimicrobial modulatory activities of fractions from Lygodium venustum SW Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2013
Biological Activities and Chemical Characterization of Cordia verbenacea DC. as Tool to Validate the Ethnobiological Usage Edinardo Fagner Ferreira Matias, Erivânia Ferreira Alves, Beatriz Sousa Santos, Celestina Elba Sobral de Souza, João Victor de Alencar Ferreira, Anne Karyzia Lima Santos de Lavor, Fernando Gomes Figueredo, Luciene Ferreira de Lima, Francisco Antônio Vieira dos Santos, Flórido Sampaio Neves Peixoto, Aracélio Viana Colares, Aline Augusti Boligon, Rogério de Aquino Saraiva, Margareth Linde Athayde, João Batista Teixeira da Rocha, Irwin Rose Alencar Menezes, Henrique Douglas Melo Coutinho, José Galberto Martins da Costa Evidence Based Complementary and Alternative Medicine, 2013
Evaluation of antibiotic & antibiotic modifying activity of pilocarpine & rutin Indian Journal of Medical Research, 2012
Trypanocide, cytotoxic, and antifungal activities of Momordica charantia Karla K.A. Santos, Edinardo F.F. Matias, Celestina E. Sobral-Souza, Saulo R. Tintino, Maria F.B. Morais-Braga, Glaucia M.M. Guedes, Francisco A.V. Santos, Ana Carla A. Sousa, Miriam Rolón, Celeste Vega, Antonieta Rojas de Arias, José G.M. Costa, Irwin R.A. Menezes, Henrique D.M. Coutinho Pharmaceutical Biology, 2012
Hellenistic Judaism and Judeo-Paganism in the land of Israel: The example of minim Henoch, 2012
Additive effects of Pityrogramma calomelanos L. (link.) combinated with aminoglycosides against Staphylococcus aureus International Journal of Phytomedicine, 2012
Chemical composition of essential oil of Lantana camara L. (Verbenaceae) and synergistic effect of the aminoglycosides gentamicin and amikacin Records of Natural Products, 2012
Pteridophytes: Ethnobotany and pharmacologic bioactivities Natural Products Structure Bioactivity and Applications, 2012
Evaluation of the anti-Trypanosoma and anti-Leishmania activity of Mentha arvensis and Turnera ulmifolia Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2012
Cytotoxic, trypanocidal, and antifungal activities of Eugenia jambolana L. Karla K.A. dos Santos, Edinardo F.F. Matias, Saulo R. Tintino, Celestina E.S. Souza, Maria F.B.M. Braga, Gláucia M.M. Guedes, Miriam Rolón, Celeste Vega, Antonieta Rojas de Arias, José G.M. Costa, Irwin A. Menezes, Henrique D.M. Coutinho Journal of Medicinal Food, 2012
Cytotoxic and tripanocide activities of pityrogramma calomelanos (L.) link Teogenes M. de Souza, Maria F. B. M. Braga, Rogério A. Saraiva, Pablo A. Nogara, Diones C. Bueno, Aline A. Boligon, Margareth L. A. Fone, João B. T. da Rocha, Miriam Rolon, Celeste Vega, Antonieta Rojas de Arias, Jose G. M. Costa, Irwin R. Alencar de Menezes, Henrique D. M. Coutinho, Antônio A. F. Saraiva American Fern Journal, 2012
Comparative evaluation of antibiotic and antibiotic modifying activity of quercetin and isoquercetin in vitro Current Topics in Nutraceutical Research, 2011
Antibacterial and modulatory effect of Stryphnodendron rotundifolium Dayanne R. Oliveira, Francisco E. Brito-Junior, Elizângela B. Bento, Edinardo F.F. Matias, Ana Carla A. Sousa, Jose G.M. Costa, Henrique D.M. Coutinho, Marta R. Kerntopf, Irwin R.A. Menezes Pharmaceutical Biology, 2011
Antiulcerogenic activity of the essential oil of Hyptis martiusii Benth. (Lamiaceae) Germana Freire Rocha Caldas, Iggor Macêdo do Amaral Costa, Juciene Bezerra Rodrigues da Silva, Rafaella Farias da Nóbrega, Fabíola Fernandes Galvão Rodrigues, José Galberto Martins da Costa, Almir Gonçalves Wanderley Journal of Ethnopharmacology, 2011
Chemical composition and aminoglycosides synergistic effect of Lantana montevidensis Briq. (Verbenaceae) essential oil Records of Natural Products, 2011
Phythochemical screening and antimicrobial activity of essential oil from Lippia gracillis Vanessa Bitu, Marco Antônio Botelho, José G. M. da Costa, Fabiola F. G. Rodrigues, Helenicy N. H. Veras, Karine T. Martins, Aarão Lyra, Giselle Gasparino Coluchi, Ronaldo Sousa Ruela, Dinalva Brito Queiroz, Jullyana de Souza Siqueira, Lucindo J. Quintans-Junior Revista Brasileira De Farmacognosia, 2011
Screening for in vitro phototoxic activity of methanol extracts of Croton campestris A., Ocimum gravissimum L. & Cordia verbenaceae DC Indian Journal of Medical Research, 2010
Effect of collection time on essential oil composition of Lantana camara Linn (Verbenaceae) growing in Brazil Northeastern Records of Natural Products, 2010
Healing potential of Pequi (Caryocar coriaceum Wittm.) fruit pulp oil Glauberto da Silva Quirino, Gerlânia de Oliveira Leite, Luciana Magalhães Rebelo, Adriana da Rocha Tomé, José Galberto Martins da Costa, André Herzog Cardoso, Adriana Rolim Campos Phytochemistry Letters, 2009
In vitro interference of Hyptis martiusii Benth. & chlorpromazine against an aminoglycoside - Resistant Escherichia coli Indian Journal of Medical Research, 2009
Potentiating effect of Mentha arvensis and chlorpromazine in the resistance to aminoglycosides of methicillin - Resistant Staphylococcus aureus In Vivo, 2009
