GIOVANE GALDINO

Scopus Publications

Nanostructured lipid carrier-mediated delivery of donepezil attenuates neuropathic pain via central cholinergic receptor modulation
Fernanda Santos Rocha, Rayner Ribeiro Cardoso, João Paulo Prado, Bruno Zavan, Ester Siqueira Caixeta, et al.
Journal of Pharmacy and Pharmacology, 2026
Objectives This study evaluated the analgesic efficacy of intranasally administered donepezil-loaded nanostructured lipid carriers (DPZ-NLCs) for neuropathic pain (NP), focusing on the involvement of cholinergic receptors. Methods Male C57BL/6 mice subjected to chronic sciatic nerve constriction were assessed for mechanical withdrawal threshold using the von Frey test. To identify receptor-specific mechanisms, selective antagonists of M2 muscarinic (M2 mAChRs) and α7 nicotinic (α7 nAChRs) receptors were administered before DPZ-NLCs. mRNA expression of these receptors, microglial markers, and cytokine levels were quantified in the spinal cord and thalamus by RT-PCR and ELISA. DPZ-NLCs effects on LPS-activated microglia were evaluated by flow cytometry. Key findings Pharmacological data revealed that M2 mAChRs and α7 nAChRs mediate the antinociceptive effects of DPZ-NLCs. Treatment increased α7 nAChR mRNA expression in the thalamus, and this effect was blocked by intra-thalamic α7 nAChR antagonism. DPZ-NLCs also reduced TNF-α levels in the thalamus and in LPS-stimulated microglial cultures, indicating inhibition of microglial activation. Conclusion Intranasal DPZ-NLCs show promise as a therapeutic strategy for NP, likely involving central M2 mAChR- and α7 nAChR-dependent mechanisms. Limitations include the use of male mice only and the absence of pharmacokinetic assessments.
Respiratory Muscle Strength in Hypertensive Adults: Age- and Sex-Specific Reference Values for a Brazilian Population
Simone de Faria Rossetto, Juscelio Pereira da Silva, Afonso Santos de Lima, Anderson Geremias Macedo, Dalton Muller Pessôa Filho, et al.
Medical Sciences, 2025
Background/Objectives: Hypertension is a major modifiable risk factor for cardiovascular disease and may negatively affect muscle strength through vascular and metabolic mechanisms. Nevertheless, reference values for respiratory muscle strength (RMS) in hypertensive adults remain unavailable. This study aimed to establish sex- and age-specific reference values for maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in Brazilian adults with hypertension and to investigate clinical factors associated with these measures. Methods: This cross-sectional study included 234 hypertensive adults (109 women and 125 men; 30–80 years) enrolled in a cardiovascular rehabilitation program. Anthropometric, hemodynamic, and clinical data were collected. RMS was assessed using standardized procedures for MIP and MEP with an analog manovacuometer (−300 to +300 cmH2O). Participants were stratified by age and sex. Statistical analyses included the Mann–Whitney U and Kruskal–Wallis tests and multivariate linear regression (p < 0.05). Results: Men exhibited significantly higher MIP and MEP values than women across most age groups. RMS declined progressively with age, with a more marked reduction after 60 years. MIP was identified as the primary predictor of MEP in both sexes, with higher coefficients of determination in men. The reference values obtained were largely comparable to those reported for healthy individuals. Conclusions: This study provides clinically relevant reference values for RMS Brazilian individuals with hypertension, offering useful parameters for respiratory assessment and individualized rehabilitation strategies.
Perceptual and Metabolic Responses During Resistance Training Sessions: Comparing Low-Load Plus Blood Flow Restriction with High-Load Plans
Anderson Geremias Macedo, Danilo Alexandre Massini, Tiago André Freire Almeida, Adriana Teresa Silva Santos, Giovane Galdino, et al.
Sports, 2025
This study analysed perceived exertion (RPE) and blood lactate ([La−]) responses to two resistance training protocols planned with high- (HLI) and low-load intensities combined with blood flow restriction (LLI+BFR). Fourteen trained adults (26.2 ± 2.6 years) performed the HLI and LLI+BFR protocols 48 h apart. The HLI was planned with 70% 1RM (one repetition to maximum), three sets, 12 repetitions, 60 seconds (s) of rest between sets and 120 s between exercises; LLI+BFR was performed at 30% 1RM, for three sets, 15 repetitions, and with 30 s of rest between sets and 180 s between exercises. Blood samples (for [La−] analysis) and RPE (Borg 0–10 scale) were collected in the first minute after each exercise. A two-way ANOVA compared RPE and [La−] responses between exercises in the same protocol, and between protocols comparing the same exercise. RPE increased from the first to the last half (involving upper-limbs and lower-limbs) of exercises in both protocols (p < 0.001). All exercises in HLI elicited higher RPE values than LLI+BFR (p < 0.001). Average RPE scores were higher in HLI than for LLI+BFR (8.1 ± 0.6 > 6.2 ± 1.1, p < 0.001). The [La−] also increased throughout the exercises, with a higher peak response in LLI+BFR than for HLI (9.8 ± 1.6 > 7.2 ± 1.3 mmol × L−1, p < 0.01). Perceptual and metabolic responses during HLI and LLI+BFR training were distinguishable, despite both protocols characterising a high-intensity stimulus.
Spinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice
Gabriela Xavier Santos, Tayllon dos Anjos-Garcia, Ana Carolina de Jesus Vieira, Giovane Galdino
Brain Sciences, 2025
Background: Chronic postoperative pain (CPOP) is among the main consequences of surgical procedures, directly affecting the quality of life. Although many strategies have been used to treat this symptom, they are often ineffective. Thus, studies investigating CPOP-associated mechanisms may help to develop more effective treatment strategies. Therefore, the present study investigated the spinal participation of the transient potential receptor vanilloid type 1 (TRPV1) and PI3K/AKT/mTOR pathway activation during CPOP. Methods: In this study C57BL/6 male mice were used, and CPOP was induced by muscle retraction and incision. The nociceptive threshold was measured by the von Frey filament test. For pharmacological evaluation, TRPV1 and PI3K/AKT/mTOR inhibitors were administered intrathecally. TRPV1 and PI3K/AKT/mTOR protein levels were evaluated by Western blotting. Results: The results showed that CPOP increased TRPV1 and mTOR protein levels, and pretreatment with the specific inhibitors alleviated CPOP. In addition, pretreatment with the TRPV1 antagonist SB-366791 attenuated mTOR protein levels. Conclusions: The results suggest that TRPV1 and the PI3K/AKT/mTOR pathway are involved in CPOP at the spinal level, and TRPV1 may activate mTOR during this process.
Endogenous Cholinergic System Involved in Peripheral Analgesic Control in Mice Is Activated by TNF-α, CXCL-1, and IL-1β
Amanda Cristina Reis Gonzaga, Jayane Laís Dias Quintão, Giovane Galdino, Thiago Roberto Lima Romero, Grazielle Caroline da Silva, et al.
Pharmacology, 2024
Introduction: Tissue injury results in the release of inflammatory mediators, including a cascade of algogenic substances, which contribute to the development of hyperalgesia. During this process, endogenous analgesic substances are peripherally released to counterbalance hyperalgesia. The present study aimed to investigate whether inflammatory mediators TNF-α, IL-1β, CXCL1, norepinephrine (NE), and prostaglandin E2 (PGE2) may be involved in the deflagration of peripheral endogenous modulation of inflammatory pain by activation of the cholinergic system. Methods: Male Swiss mice were subjected to paw withdrawal test. All the substances were injected via the intraplantar route. Results: The main findings of this study were as follows: (1) carrageenan (Cg), TNF-α, CXCL-1, IL1-β, NE, and PGE2 induced hyperalgesia; (2) the acetylcholinesterase enzyme inhibitor, neostigmine, reversed the hyperalgesia observed after Cg, TNF-α, CXCL-1, and IL1-β injection; (3) the non-selective muscarinic receptor antagonist, atropine, and the selective muscarinic type 1 receptor (m1AChr) antagonist, telenzepine, potentiated the hyperalgesia induced by Cg and CXCL-1; (4) mecamylamine, a non-selective nicotinic receptor antagonist, potentiated the hyperalgesia induced by Cg, TNF-α, CXCL-1, and IL1-β; (5) Cg, CXCL-1, and PGE2 increased the expression of the m1AChr and nicotinic receptor subunit α4protein. Conclusion: These results suggest that the cholinergic system may modulate the inflammatory pain induced by Cg, PGE2, TNF-α, CXCL-1, and IL1-β.
Effect of a cardiac telerehabilitation program during COVID-19 associated social isolation
João Paulo Prado, Giovane Galdino
Sports Medicine and Health Science, 2024
The Role of the Thalamus in Nociception: Important but Forgotten
Giovane Galdino, Flavio Protasio Veras, Tayllon dos Anjos-Garcia
Brain Sciences, 2024
Pain is a complex response to noxious stimuli. Upon detection of the nociceptive stimulus by first-order neurons or nociceptors, an action potential ascends to the spinal dorsal horn, a crucial site for synapsing with second-order neurons. These second-order neurons carry the nociceptive stimulus to supraspinal regions, notably the thalamus. Although extensive research has focused on spinal-level nociceptive mechanisms (e.g., neurotransmitters, receptors, and glial cells), the thalamus is still poorly elucidated. The role of the thalamus in relaying sensory and motor responses to the cortex is well known. However, a comprehensive understanding of the mechanisms in the synapse between the second-order and third-order neurons that transmit this impulse to the somatosensory cortex, where the response is processed and interpreted as pain, is still lacking. Thus, this review investigated the thalamus’s role in transmitting nociceptive impulses. Current evidence indicates the involvement of the neurotransmitters glutamate and serotonin, along with NMDA, P2X4, TLR4, FGR, and NLRP3 receptors, as well as signaling pathways including ERK, P38, NF-κB, cytokines, and glial cells at nociceptive synapses within the thalamus.
Effects of Resistance Exercise with and without Blood Flow Restriction on Acute Hemodynamic Responses: A Systematic Review and Meta-Analysis
Anderson Geremias Macedo, Danilo Alexandre Massini, Tiago André Freire Almeida, Luciana Maria dos Reis, Giovane Galdino, et al.
Life, 2024
Low-load intensity resistance exercise with blood flow restriction (BFR) is an alternative method for enhancing strength and muscle mass. However, acute cardiovascular responses to a complete training session remain uncertain compared to high-load intensity resistance exercise (HI). Therefore, the objective of this study to examine acute and post-exercise hemodynamic responses to low-load BFR and HI protocols. This systematic review and meta-analysis (RD42022308697) followed PRISMA guidelines to investigate whether the responses of heart rate (HR), blood systolic (SBP), blood diastolic pressure (DBP), and rate pressure product (RPP) immediately after and up to 60 min post-exercise from BFR were consistent with those reported after resistance exercises performed at HI in healthy individuals. Searches using PICO descriptors were conducted in databases from January 2011 to December 2023, and effect sizes were determined by Hedge’s g. The selected studies involved 160 participants in nine articles, for which the responses immediately after BFR and HI exercises showed no differences in HR (p = 0.23) or SBP (p = 0.57), but significantly higher DBP (p < 0.01) and lower RPP (p < 0.01) responses were found when comparing BFR to HI. Furthermore, the BFR and HI protocols showed no differences regarding SBP (p = 0.21) or DBP (p = 0.68) responses during a 15 to 60 min post-exercise period. Thus, these results indicated that hemodynamic responses are similar between BFR and HI, with a similar hypotensive effect up to 60 min following exercise.
Efficacy of Respiratory Muscle Training in the Immediate Postoperative Period of Cardiac Surgery: A Systematic Review and Meta-Analysis
Tarcísio Nema de Aquino, João Paulo Prado, Ernesto Crisafulli, Enrico Maria Clini, Giovane Galdino
Brazilian Journal of Cardiovascular Surgery, 2024
Introduction This study aimed to evaluate the efficacy of respiratory muscle training during the immediate postoperative period of cardiac surgery on respiratory muscle strength, pulmonary function, functional capacity, and length of hospital stay. Methods This is a systematic review and meta-analysis. A comprehensive search on PubMed®, Excerpta Medica Database (or Embase), Cumulative Index of Nursing and Allied Health Literature (or CINAHL), Latin American and Caribbean Health Sciences Literature (or LILACS), Scientific Electronic Library Online (or SciELO), Physiotherapy Evidence Database (or PEDro), and Cochrane Central Register of Controlled Trials databases was performed. A combination of free-text words and indexed terms referring to cardiac surgery, coronary artery bypass grafting, respiratory muscle training, and clinical trials was used. A total of 792 studies were identified; after careful selection, six studies were evaluated. Results The studies found significant improvement after inspiratory muscle training (IMT) (n = 165, 95% confidence interval [CI] 9.68, 21.99) and expiratory muscle training (EMT) (n = 135, 95% CI 8.59, 27.07) of maximal inspiratory pressure and maximal expiratory pressure, respectively. Also, IMT increased significantly (95% CI 19.59, 349.82, n = 85) the tidal volume. However, no differences were found in the peak expiratory flow, functional capacity, and length of hospital stay after EMT and IMT. Conclusion IMT and EMT demonstrated efficacy in improving respiratory muscle strength during the immediate postoperative period of cardiac surgery. There was no evidence indicating the efficacy of IMT for pulmonary function and length of hospital stay and the efficacy of EMT for functional capacity.
A pilot observational study to identify reference values for the 6-minute walk test in Brazilian people with hypertension
Afonso Lima, João Paulo Prado, Tarcísio Nema de Aquino, Juliana Bassalobre Carvalho Borges, Fernanda de Carvalho Vidigal, et al.
Fisioterapia Em Movimento, 2024
Introduction Systemic arterial hypertension (SAH) is responsible for 9.5 million deaths in the global popu-lation. Lifestyle factors, including physical inactivity, are important modifiable risk factors in the development of SAH. Thus, physical exercise has been shown to be effective to control SAH and before the prescription, the six-minute walk test (6-MWT) has been commonly used to assess the physical capacity. Objective To propose reference values for the 6-MWT test in Brazilian people with SAH. Methods A cross-sectional observational study was conducted with 302 hypertensive subjects (62.61 + 10.93 years) admitted to a cardiac rehabilitation program. Participants were divided into different age quartiles and submitted to 6-MWT. The walking distance data was compared between the quartiles and adjusted by mul-tiple linear regression analysis. Results The hypertensive subjects walked 388.07 + 115.03 m during the 6-MWT. No significant difference between the genders was found. However, when the age quartiles were compared, for the 46–59 age group, the women walked less than the men. Intra-group comparisons showed that the distance walked in the 6-MWT decreased with the increase in age, in both men and women. Conclusion The present study provides reference values for the 6-MWT, both for Brazilian men and women of different age groups. This data may be an important parameter for future clinical studies, prevention strategies, and clinical intervention.
Spinal HMGB1 participates in the early stages of paclitaxel-induced neuropathic pain via microglial TLR4 and RAGE activation
Thamyris Reis Moraes, Flavio Protasio Veras, Angel Roberto Barchuk, Ester Siqueira Caixeta Nogueira, Alexandre Kanashiro, et al.
Frontiers in Immunology, 2024
Investigation of the involvement of platelet-activating factor in the control of hypertension by aerobic training. A randomized controlled trial
João Paulo Prado, Ana Emilia Castro, Jonatan Carvalho, Daniele Pereira, Lúcia Helena Faccioli, et al.
Biology of Sport, 2024
Cannabidiol reduces lipopolysaccharide-induced nociception via endocannabinoid system activation
Rafaela Silva dos Santos, Flávio Protassio Veras, Gonçalves Pedro Netto, Carlos Arterio Sorgi, Lúcia Helena Faccioli, et al.
Basic and Clinical Pharmacology and Toxicology, 2023
Involvement of the Endocannabinoid System in the Control of Pain and Obesity by Exercise in Rodents: A Systematic Review
Livia Elisei, Thamyris Moraes, Iago Malta, Javier Rodríguez, Vincenzo Di Marzo, et al.
Cannabis and Cannabinoid Research, 2023
Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinalTLR4 via endocannabinoid system activation
Rafaela dos Santos, Flávio Veras, Gonçalves Netto, Lívia Elisei, Carlos Sorgi, et al.
Journal of Pharmacy and Pharmacology, 2023
IL-10/β-Endorphin-Mediated Neuroimmune Modulation on Microglia during Antinociception
Thiago Caetano Andrade Belo, Gabriela Xavier Santos, Bruno Eduardo Gabriel da Silva, Bruno Lopes Gonçalves Rocha, Dennis William Abdala, et al.
Brain Sciences, 2023
Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model
Ivana F. Rosa, Ana P. B. Peçanha, Tábata R. B. Carvalho, Leonardo S. Alexandre, Vinícius G. Ferreira, et al.
International Journal of Molecular Sciences, 2023
Synergistic effect of cannabidiol and transcutaneous electrical nerve stimulation on neuropathic and inflammatory pain in mice
Iago Malta, Gonçalves Netto, Rafaela dos Santos, Flávio Veras, Giovane Galdino
Neuroreport, 2023
Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice
Iago Malta, Thamyris Moraes, Lívia Elisei, Rômulo Novaes, Giovane Galdino
Lasers in Medical Science, 2022
Resistance Exercise and Whey Protein Supplementation Reduce Mechanical Allodynia and Spinal Microglia Activation After Acute Muscle Trauma in Rats
Gusthavo Rodrigues, Thamyris Moraes, Lívia Elisei, Iago Malta, Rafaela dos Santos, et al.
Frontiers in Pharmacology, 2021
Cytokines and chemokines systemic levels are related to dialysis adequacy and creatinine clearance in patients with end-stage renal disease undergoing hemodialysis
Robson E. Silva, Eliziária C. Santos, Patrícia B.I. Justino, Margarida P. Santos, Giovane Galdino, et al.
International Immunopharmacology, 2021
Preclinical evaluation of polymeric nanocomposite containing pregabalin for sustained release as potential therapy for neuropathic pain
Rafaela Figueiredo Rodrigues, Juliana Barbosa Nunes, Sandra Barbosa Neder Agostini, Paloma Freitas dos Santos, Juliana Cancino-Bernardi, et al.
Polymers, 2021
Toxicological insights of Spike fragments SARS-CoV-2 by exposure environment: A threat to aquatic health?
Ives Charlie-Silva, Amanda P.C. Araújo, Abraão T.B. Guimarães, Flávio P Veras, Helyson L.B. Braz, et al.
Journal of Hazardous Materials, 2021
Evaluation of respiratory and peripheral muscle training in individuals undergoing myocardial revascularization
Tarcísio Nema de Aquino, Simone de Faria Rosseto, Jaqueline Lúcio Vaz, Carolline de Faria Cordeiro Alves, Fernanda de Carvalho Vidigal, et al.
Journal of Cardiac Surgery, 2021
Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis
Sandra Barbosa Neder Agostini, Iago Henrique Silva Malta, Rafaela Figueiredo Rodrigues, Jennifer Tavares Jacon Freitas, Mônica Esselin de Sousa Lino, et al.
European Journal of Pharmaceutical Sciences, 2021
Investigation of the combination of pregabalin with duloxetine or amitriptyline on the pharmacokinetics and antiallodynic effect during neuropathic pain in rats
Pain Physician, 2021
TNF-α, CXCL-1 and IL-1 β as activators of the opioid system involved in peripheral analgesic control in mice
Jayane Laís Dias Quintão, Amanda Cristina Reis Gonzaga, Giovane Galdino, Thiago Roberto Lima Romero, JosianeFernandes Silva, et al.
European Journal of Pharmacology, 2021
Mucoadhesive nanostructured lipid carriers as a cannabidiol nasal delivery system for the treatment of neuropathic pain
Ananda Pulini Matarazzo, Lívia Maria Silvestre Elisei, Flávia Chiva Carvalho, Rudy Bonfílio, André Luís Morais Ruela, et al.
European Journal of Pharmaceutical Sciences, 2021
Effect of a virtual cardiac rehabilitation program on patients with hypertension: A randomized trial
Luana Aparecida Brandão Leandro, Gabriella Cruz Ramos de Araújo, João Paulo Prado, Tarcísio Nema de Aquino, Juscelio Pereira da Silva, et al.
Fisioterapia Em Movimento, 2021
Antinociception induced by artemisinin nanocapsule in a model of postoperative pain via spinal TLR4 inhibition
L. M. S. Elisei, T. R. Moraes, I. H. Malta, I. Charlie-Silva, I. M. O. Sousa, et al.
Inflammopharmacology, 2020
Involvement of the Hsp70/TLR4/IL-6 and TNF-α pathways in delayed-onset muscle soreness
Rafaela Silva dos Santos, Flávio Protasio Veras, David Wilson Ferreira, Morena Brazil Sant'Anna, Pablo Christiano Barboza Lollo, et al.
Journal of Neurochemistry, 2020
Investigation of the Involvement of the Endocannabinoid System in TENS-Induced Antinociception
Herick Ulisses de Oliveira, Rafaela Silva dos Santos, Iago Henrique Silva Malta, José Phellipe Pinho, Ana Flávia Santos Almeida, et al.
Journal of Pain, 2020
Participation of CXCL1 in the glial cells during neuropathic pain
Thamyris Reis Moraes, Livia Silvestre Elisei, Iago Henrique Malta, Giovane Galdino
European Journal of Pharmacology, 2020
Involvement of Spinal Cannabinoid CB2 Receptors in Exercise-Induced Antinociception
Rafaela Silva dos Santos, Carlos Arterio Sorgi, Ana Paula Ferranti Peti, Flávio Protasio Veras, Lúcia Helena Faccioli, et al.
Neuroscience, 2019
The role of oligodendrocytes in chronic pain: Cellular and molecular mechanisms
Journal of Physiology and Pharmacology, 2019
Endogenous systems involved in exercise-induced analgesia
Journal of Physiology and Pharmacology, 2018
St36 electroacupuncture activates nNOS, iNOS and ATP-sensitive potassium channels to promote orofacial antinociception in rats
Journal of Physiology and Pharmacology, 2017
Association between respiratory muscle strength and reduction of arterial blood pressure levels after aerobic training in hypertensive subjects
Giovane Galdino, Andreia Maria Silva, José Angelo Bogão, Marcos Paulo Braz de Oliveira, Hayslenne Andressa Gonçalves de Oliveira Araújo, et al.
Journal of Physical Therapy Science, 2016
The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats
Giovane S. Galdino, Carlos H. Xavier, Renato Almeida, Grazielle Silva, Marcos A. Fontes, et al.
International Journal of Neuroscience, 2015
Central release of nitric oxide mediates antinociception induced by aerobic exercise
G.S. Galdino, I.D. Duarte, A.C. Perez
Brazilian Journal of Medical and Biological Research, 2015
Ang-(1-7) activates the NO/cGMP and ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats
Aline Costa, Giovane Galdino, Thiago Romero, Grazielle Silva, Steyner Cortes, et al.
Nitric Oxide Biology and Chemistry, 2014
Effect of dietary caloric restriction on the nociceptive threshold of rats that underwent aerobic and resistance exercise training
Giovane S. Galdino, Igor D. Duarte, Andrea C. Perez
International Journal of Neuroscience, 2014
Opioid receptors are not involved in the increase of the nociceptive threshold induced by aerobic exercise
Neurosciences, 2014
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats
Giovane Galdino, Thiago R.L. Romero, José Felipe P. Silva, Daniele C. Aguiar, Ana Maria de Paula, et al.
Neuropharmacology, 2014
Acute resistance exercise induces antinociception by activation of the endocannabinoid system in rats
Giovane Galdino, Thiago Romero, José Felippe Pinho da Silva, Daniele Aguiar, Ana Maria de Paula, et al.
Anesthesia and Analgesia, 2014
Involvement of the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N-palmitoyl-ethanolamine in rats
Thiago R.L. Romero, Giovane S. Galdino, Grazielle C. Silva, Lívia C. Resende, Andréa C. Perez, et al.
Journal of Neuroscience Research, 2012
Ketamine activates the l-arginine/nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats
Thiago R. L. Romero, Giovane S. Galdino, Grazielle C. Silva, Lívia C. Resende, Andréa C. Perez, et al.
Anesthesia and Analgesia, 2011
Evaluation of exercise and potassium chloride supplementation on blood pressure and nociceptive threshold in hypertensive rats
Giovane S. Galdino, Airton M.C. Lopes, Valéria M. Franca, Igor D.G. Duarte, Andrea C. Perez
Applied Physiology Nutrition and Metabolism, 2010
Involvement of the nitric oxide/CGMP/KATP pathway in antinociception induced by exercise in rats
Giovane S. Galdino, Steyner F. Cortes, Igor D.G. Duarte, Andrea C. Perez
Life Sciences, 2010
Participation of endogenous opioids in the antinociception induced by resistance exercise in rats
G.S. Galdino, I.D.G. Duarte, A.C. Perez
Brazilian Journal of Medical and Biological Research, 2010
Antinociceptive effect from Davilla elliptica hydroalcoholic extract
A.O. Azevedo, J.J. Campos, G.S. Galdino, F.C. Braga, I.D.G. Duarte, et al.
Journal of Ethnopharmacology, 2007

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