Gaurav Gautam

@iimtu.edu.in

Assistant Professor at Department of Pharmacognosy and Phytochemistry
IIMT college of medical science, Pharmacy, O Pocket, Ganga Nagar, Meerut, Uttar Pradesh 250001

https://researchid.co/gautamgaurav

RESEARCH INTERESTS

Phytochemistry, chromatography, phytopharmacology, bioautography, pharmacokinetics and metabolomics of medicinal plants.

Scopus Publications

630

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Anti-Epileptic Indian Medicinal Plants: A Comprehensive Review on their Ethnopharmacological Perspectives of Recent Advancement
Pooja Sinoriya and Gaurav .
Visagaa Publishing House
The study explores the potential of Indian medicinal plants as botanical treasures for managing epilepsy. Epilepsy, a neurological disorder characterized by recurrent seizures, poses a significant global health challenge. Traditional medicinal practices in India have a rich history of incorporating various plant-based remedies for neurological ailments, including epilepsy. The data was collected from various scientific databases like Google Scholar, Science Direct, Elsevier, Springer and Pubmed. The collected data includes the following details - Plant part used, dose and type of extract, reference and inducing drug used and the mechanism of actions. The article thoroughly examines the phytochemical constituents found in Indian medicinal plants, elucidating their neuroprotective and anticonvulsant properties and their scrutinized bioactive compounds and therapeutic potential. The review integrates findings from preclinical and clinical studies, shedding light on the mechanisms of action and safety profiles of these plant-derived compounds. The conclusion of the manuscript emphasizes the promising role of Indian medicinal plants in epilepsy management. The identified botanical treasures offer a holistic and potentially sustainable approach to complement existing antiepileptic medications. The reviewed evidence underscores the need for further research, clinical trials, and integration of traditional knowledge into mainstream healthcare for the development of effective and accessible treatments for epilepsy. By recognizing the botanical wealth embedded in Indian traditional medicine, this review advocates for a paradigm shift toward harnessing nature's gifts in the pursuit of enhanced epilepsy care.

Multi-targeted therapeutic exploration of Tamarix gallica flowers for anti-ulcer activity and associated complications
Aakash Kumar Jaiswal, Yasheshwar, Sapna Salar, Shamim, Dinesh Kumar Yadav, Mansi Aggarwal, Shalini Sharma, Rustam Ekbbal, and Gaurav
Elsevier BV

Ameliorative effect of traditional polyherbal formulation on TNF-α, IL-1β and Caspase-3 expression in kidneys of wistar rats against sodium fluoride induced oxidative stress
Mohammad Umar Khan, Parakh Basist, Gaurav, Sultan Zahiruddin, Naveen Reddy Penumallu, and Sayeed Ahmad
Elsevier BV

System Pharmacological Approach to Investigate and Validate Multitargeted and Therapeutic Effect of Furocoumarins of Apium graveolens L. for Treatment of Kidney Disease
Yasheshwar, Gaurav, Rustam Ekkbal, Prem Gupta, and Rajendra Gyawali
Hindawi Limited
Background. System pharmacological approaches play important roles in drug discovery and development and in biomolecular exploration to investigate the multitarget therapeutic effects of phytochemicals for the treatment of acute and chronic ailments. Objectives. The aim of the study was to apply a system pharmacological approach to investigate the multitarget therapeutic effects of furocoumarins of Apium graveolens L. for the treatment of kidney disease. Methods. Several furocoumarins of Apium graveolens were screened from online databases. Network biology and poly-pharmacology analyses were performed to investigate the multitarget therapeutic effect of furocoumarins. The potential metabolites that showed significant interactions with various genes were selected for in silico docking analysis with CASP-3 and SOD proteins. In silico ADME analysis was also performed to investigate the pharmacokinetic behavior of targeted furocoumarins. Results. Out of thirteen furocoumarins selected for analysis, six showed partial or significant interaction with SOD and CASP-3 proteins. These metabolites may alleviate kidney dysfunction by reducing oxidative and inflammatory stress, regulating apoptosis, slowing down the progression of diabetic nephropathy, and reducing hypertension and glomerular vascular rigidity. In silico docking analysis revealed bergapten as a potential therapeutic agent for kidney disease treatment. In silico docking analysis showed anglicine, imperatorin, and sphondin exhibited strong interaction with CASP-3 and SOD with binding energy −6.5, −7.2, −6.5 and −6.8, −6.2 −5.7 kcal/mol, respectively. These components exhibited greater conventional hydrogen bonding with CASP-3 and SOD than other furocoumarins. Furthermore, in silico ADME analysis of metabolites showed that all furocoumarins have a highly lipophilic nature, good skin permeability, and GI absorption, as well as good blood-brain permeability (BBB). Conclusion. Furocoumarins reduce kidney dysfunction and associated pathophysiological complications via the reduction of glomerular vascular rigidity, diabetic nephropathy, and oxidative and inflammatory stress. However, further biomolecular and clinical examinations are necessary to validate and enhance the credibility of present findings.

Regulation of Interleukin 2, Proto-Oncogene c-Fos and Poly (ADP-Ribose) Glycohydrolase Genomic Expression by Rosmarinic Acid in Attenuation of Diabetes and Associated Complications

Multi-Mechanistic and Therapeutic Exploration of Nephroprotective Effect of Traditional Ayurvedic Polyherbal Formulation Using In Silico, In Vitro and In Vivo Approaches
Gaurav, Ikshit Sharma, Mohammad Umar Khan, Sultan Zahiruddin, Parakh Basist, and Sayeed Ahmad
MDPI AG
Based on traditional therapeutic claims, NEERI KFT (a traditional Ayurvedic polyherbal preparation) has been innovatively developed in recent time on the decades of experience for treating kidney dysfunction. Due to the lack of scientific evidence, the present investigations are needed to support the rationale use of NEERI KFT. Considering the facts, the study investigated the nephroprotective effect of NEERI KFT against kidney dysfunction using in silico, in vitro and in vivo approaches. In this study, phytochemical and network pharmacology studies were performed for the developed formulation to evaluate the molecular mechanism of NEERI KFT in the amelioration of kidney disease. In vitro nephroprotective and antioxidant effect of NEERI KFT was determined on HEK 293 cells against cisplatin-induced cytotoxicity and oxidative stress. In vivo nephroprotective effect of NEERI KFT was determined against cisplatin-induced nephrotoxicity in Wistar rats, via assessing biochemical markers, antioxidant enzymes and inflammatory cytokines such as TNF-α, IL-1β, CASP-3, etc. The results showed that the compounds such as gallic acid, caffeic acid and ferulic acid are the major constituents of NEERI KFT, while network pharmacology analysis indicated a strong interaction between polyphenols and several genes (CASPs, ILs, AGTR1, AKT, ACE2, SOD1, etc.) involved in the pathophysiology of kidney disease. In vivo studies showed a significant (p < 0.05) ameliorative effect on biochemical markers and antioxidant enzymes (SOD, CAT, GSH, etc.), and regulates inflammatory cytokine (TNF-α, IL-1β, CASP-3) expression in kidney tissue. Hence, it can be concluded that NEERI KFT subsequently alleviates renal dysfunction mediated by cisplatin via attenuating oxidative and inflammatory stress, thus preserving the normalcy of kidney function.

Nephroprotective potential of Boerhaavia diffusa and Tinospora cordifolia herbal combination against diclofenac induced nephrotoxicity
Gaurav, Mohammad Umar Khan, Parakh Basist, Sultan Zahiruddin, Mohammad Ibrahim, Rabea Parveen, Anuja Krishnan, and Sayeed Ahmad
Elsevier BV

Metabolite Profiling and Nephroprotective Potential of the Zea mays L. Silk Extract against Diclofenac-Induced Nephrotoxicity in Wistar Rats
Parakh Basist, Mohammad Umar Khan, Bisma Jan, Gaurav, Mohammad Ahmed Khan, Rabea Parveen, and Sayeed Ahmad
American Chemical Society (ACS)
The lack of sufficient scientific evidence prompted the analytical investigation of nephroprotective potential of the silk extract of Zea mays L., which is traditionally and ethnomedicinally used for various disorders including kidney dysfunction. The present study was conducted to investigate the phytochemical analysis and demonstrate the nephroprotective potential of the methanolic silk extract of Z. mays L. using a rodent model. High-performance thin-layer chromatography (HPTLC) analysis was carried out to standardize the methanolic silk extract of Z. mays (ZME) using naringenin as a marker. The metabolite profiling of the ZME was carried out using ultrahigh-performance liquid chromatography mass spectrometry (UPLC-MS) on a monolithic capillary silica-based C18 column to identify bioactive compounds and for confirmation of the identified markers. Furthermore, for acute toxicity study, a single dose (2000 mg/kg bw) of the ZME was administered orally to Wistar rats. Also, nephrotoxicity was induced in Wistar rats by injecting diclofenac (DC) (50 mg/kg, bw, i.p.) at a single dose. The efficacy of the ZME as a nephroprotective agent was then evaluated at doses of 100, 200, and 400 mg/kg/day, bw, p.o. Furthermore, the kidney, liver, antioxidant, inflammatory, and apoptotic biochemical markers and histopathological and immunohistochemical alterations (caspase-3 and reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4 (NOX-4)) were evaluated. Phytochemical analysis by HPTLC and UPLC-MS revealed the presence of naringenin, vanillic acid, ferulic acid, gallic acid (GA), ellagic acid, quercetin, and morin, along with other bioactive constituents exhibiting multiple pharmacological properties. The acute toxicity study of the ZME showed no mortality or any clinical signs of toxicity through all the 14 days of the toxicity study at a dose of 2000 mg/kg. Also, administration of DC caused a significant elevation (P < 0.001) in kidney biochemical parameters and also caused oxidative, inflammatory, and apoptotic stress. Furthermore, DC also caused histopathological and immunohistochemical changes. Pretreatment with the ZME attenuated the elevated biochemical markers significantly at medium and high doses along with improvement in histopathological and immunohistochemical damages and showing comparable results to those of α-ketoanalogue. The present study verifies the traditional claims of Z. mays silk alleviating various kidney and related disorders by concluding the nephroprotective potential of the ZME. The nephroprotective activity of the ZME is attributed to the phytoconstituents present, acting as potent restoring antioxidants and preventing inflammatory and apoptotic cellular damages in rats. Thus, it holds promising potential in the management of nephrotoxicity.

Nephroprotective potential of Sharbat-e-Bazoori Motadil (sugar-free) in HEK-293 cells and Wistar rats against cisplatin induced nephrotoxicity
Mohammad Umar Khan, Gaurav, Sultan Zahiruddin, Parakh Basist, Anuja Krishnan, Rabea Parveen, and Sayeed Ahmad
Elsevier BV

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research
Sayeed Ahmad, Sultan Zahiruddin, Bushra Parveen, Parakh Basist, Abida Parveen, Gaurav, Rabea Parveen, and Minhaj Ahmad
Frontiers Media SA
The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory distress syndrome (ARDS) caused by systemic inflammatory reactions due to the excessive release of pro-inflammatory cytokines and chemokines by the immune effector cells. In India too, it is spreading very rapidly, although the case fatality rate is below 1.50% (https://www.statista.com), which is markedly less than in other countries, despite the dense population and minimal health infrastructure in rural areas. This may be due to the routine use of many immunomodulator medicinal plants and traditional AYUSH formulations by the Indian people. This communication reviews the AYUSH recommended formulations and their ingredients, routinely used medicinal plants and formulations by Indian population as well as other promising Indian medicinal plants, which can be tested against COVID-19. Special emphasis is placed on Indian medicinal plants reported for antiviral, immunomodulatory and anti-allergic/anti-inflammatory activities and they are categorized for prioritization in research on the basis of earlier reports. The traditional AYUSH medicines currently under clinical trials against COVID-19 are also discussed as well as furtherance of pre-clinical and clinical testing of the potential traditional medicines against COVID-19 and SARS-CoV-2. The results of the clinical studies on AYUSH drugs will guide the policymakers from the AYUSH systems of medicines to maneuver their policies for public health, provide information to the global scientific community and could form a platform for collaborative studies at national and global levels. It is thereby suggested that promising AYUSH formulations and Indian medicinal plants must be investigated on a priority basis to solve the current crisis.

TLC-MS bioautography-based identification of free-radical scavenging, α‑amylase, and α‑glucosidase inhibitor compounds of antidiabetic tablet BGR-34
Gaurav, Sultan Zahiruddin, Bushra Parveen, Mohammad Ibrahim, Ikshit Sharma, Sanchit Sharma, Anil Kumar Sharma, Rabea Parveen, and Sayeed Ahmad
American Chemical Society (ACS)
BGR-34 is a polyherbal formulation frequently used to combat diabetes around the globe especially in Asian countries. It provides an attractive treatment option to prediabetics, diabetics, and in metabolic disorders by controlling the altered blood glucose level. The lack of phytopharmacological studies on BGR-34 prompted as to reveal the compounds responsible for the antidiabetic and free-radical scavenging activity of BGR-34. An attempt was made to assess in vitro α-amylase and α-glucosidase enzyme inhibition of BGR-34 along with its free-radical scavenging potential via DPPH scavenging activity. Further, HPTLC profiling and quantitative analysis of berberine and palmatine in BGR-34 were carried out. Thereafter, the TLC-bioautographic-MS analysis was performed to identify the compounds responsible for antidiabetic and antioxidant activities in BGR-34. The results had shown a significant and dose-dependent inhibition potential of BGR-34 against in vitro α-amylase and α-glucosidase enzymatic reactions along with significant inhibition in DPPH free-radical scavenging activity. The HPTLC profiling and quantitative validation studies showed the presence of berberine and palmatine 44.926 ± 0.2907 and 10.507 ± 0.154 μg/g, respectively. The TLC-MS bioautography revealed a total of four DPPH-active, two α-amylase-active, and nine α-glucosidase-active compounds in BGR-34. It was observed from the study that BGR-34 possesses verities of bioactive compounds, which are reasonable not only for its antidiabetic effect but also for its antioxidant activity.

Ashwagandha in brain disorders: A review of recent developments
Sultan Zahiruddin, Parakh Basist, Abida Parveen, Rabea Parveen, Washim Khan, Gaurav, and Sayeed Ahmad
Elsevier BV

Optimization and evaluation of topical gel containing solid lipid nanoparticles loaded with luliconazole and its anti-fungal activity
SynthesisHub Advance Scientific Research

RECENT SCHOLAR PUBLICATIONS

HPTLC stability indicating analytical method of Andrographolide and 5-fluorouracil with network pharmacology analysis against cancer
Z Malik, R Parveen, S Zahiruddin, G Gautam, SA Husain, S Ahmad
Combinatorial Chemistry & High Throughput Screening 27 (6), 894-909 2024

Quality Control and Multi-targeted Therapeutic Approach of Nyctanthes arbor-tristris for Management of Hepatic Disease and Associated Complications
S Salar, P Sharma, Gaurav
Pharmacognosy Magazine 20 (1), 57-71 2024

Indian Medicinal Plants for the Management of Endometriosis: A Comprehensive Review on their phytopharmacology
R Ekbbal, AK Jaiswal, M Aggarwal, M Singh, S Ali, SA Ali, G Gautam
Natural Resources for Human Health 2024

Quality standards and pharmacological interventions of natural oils: Current scenario and future perspectives
S Ali, R Ekbbal, S Salar, Yasheshwar, SA Ali, AK Jaiswal, M Singh, ...
ACS omega 8 (43), 39945-39963 2023

Ameliorative effect of traditional polyherbal formulation on TNF-α, IL-1β and Caspase-3 expression in kidneys of wistar rats against sodium fluoride induced oxidative stress
MU Khan, P Basist, Gaurav, S Zahiruddin, NR Penumallu, S Ahmad
Journal of Ethnopharmacology, 116900 2023

A Review on Quality Control Aspects of Indian Medicinal Plants.
S Kumar, AK Jaiswal, M Aggarwal, R Ekbbal
Pharmacognosy Reviews 17 (34) 2023

TLC-bioautography-MS-based identification of antioxidant, α-amylase and α-glucosidase inhibitory compounds in a polyherbal formulation “Sugreen-120”
Gaurav, N Anwar, S Zahiruddin, S Ahmad
Pharmacognosy Magazine 19 (2), 254-268 2023

A comprehensive study to explore tyrosinase inhibitory medicinal plants and respective phytochemicals for hyperpigmentation; molecular approach and future perspectives
A Insaf, R Parveen, G Gautam, M Samal, S Zahiruddin, S Ahmad
Current Pharmaceutical Biotechnology 24 (6), 780-813 2023

LC-MS-based Metabolomics of Medicinal Plants
R Parveen, S Ahmad
Omics Studies of Medicinal Plants, 157-180 2023

Multi-mechanistic and therapeutic exploration of nephroprotective effect of traditional ayurvedic polyherbal formulation using in silico, in vitro and in vivo approaches
Gaurav, I Sharma, MU Khan, S Zahiruddin, P Basist, S Ahmad
Biomedicines 11 (1), 168 2023

Advancement of Network Pharmacology in Multi-targeted Therapeutic Evaluation of Medicinal Plants
G Gautam
J CAM Res Progress 2 (1), 113 2023

Regulation of interleukin 2, proto-oncogene c-fos and poly (ADP-Ribose) glycohydrolase genomic expression by rosmarinic acid in attenuation of diabetes and associated complications
R Ekbbal, MS Akhtar, WM Al-Shaqha, S Kumar, AK Jaiswal
J. Biol. Regul. Homeost. Agents 37 (6), 3321-3331 2023

Metabolite profiling and nephroprotective potential of Glycyrrhiza glabra L. roots against cisplatin-induced nephrotoxicity in vitro and in vivo
P Basist, S Zahiruddin, MU Khan, G Gautam, B Jan, MA Khan, R Parveen, ...
Iranian journal of basic medical sciences 25 (11), 1286 2022

GC–MS metabolomics and network pharmacology-based investigation of molecular mechanism of identified metabolites from Tinospora cordifolia (Willd.) miers for the treatment of
MU Gaurav: Khan, P Basist, S Zahiruddin, M Ibrahim, A Krishnan, ...
Pharmacognosy Magazine 18 (79), 548-558 2022

Vitamin D from vegetable VV sources: hope for the future
MU Khan, G Gautam, B Jan, S Zahiruddin, R Parveen, S Ahmad
Phytomedicine plus 2 (2), 100248 2022

Analysis of polyphenols in Aegle marmelos leaf and ameliorative efficacy against diabetic mice through restoration of antioxidant and anti‐inflammatory status
M Ibrahim, B Parveen, S Zahiruddin, G Gautam, R Parveen, MA Khan, ...
Journal of Food Biochemistry 46 (4), e13852 2022

Nephroprotective potential of Boerhaavia diffusa and Tinospora cordifolia herbal combination against diclofenac induced nephrotoxicity
G Gautam, MU Khan, P Basist, S Zahiruddin, M Ibrahim, R Parveen, ...
South African Journal of Botany 2022

Nephroprotective potential of sharbat-e-bazoori motadil (Sugar free) in HEK-293 cells and wistar rats against cisplatin induced nephrotoxicity
MU Khan, G Gautam, S Zahiruddin, P Basist, A Krishnan, R Parveen, ...
Journal of King Saud University-Science, 101839 2022

Network pharmacology-based validation of traditional therapeutic claim of momordica charantiain alleviating diabetic nephropathy
G Gautam
J. CAM Res. Prog 1, 102 2022

Vitamin D from natural sources: Hope for the future
MU Khan, G Gautam, B Jan, S Zahiruddin, R Parveen, S Ahmad
Phytomed. Plus 10 2022

MOST CITED SCHOLAR PUBLICATIONS

Indian medicinal plants and formulations and their potential against COVID-19–preclinical and clinical research
S Ahmad, S Zahiruddin, B Parveen, P Basist, G Gautam, A Parveen, ...
Frontiers in pharmacology 11, 2470 2021
Citations: 200

Ashwagandha in brain disorders: A review of recent developments
S Zahiruddin, P Basist, A Parveen, R Parveen, W Khan, G Gautam, ...
Journal of ethnopharmacology 257, 112876 2020
Citations: 121

TLC-MS Bioautography-Based Identification of Free-Radical Scavenging, α-Amylase, and α-Glucosidase Inhibitor Compounds of Antidiabetic Tablet BGR-34
G Gautam, S Zahiruddin, B Parveen, M Ibrahim, I Sharma, S Sharma, ...
ACS omega 5 (46), 29688-29697 2020
Citations: 50

Potential nephroprotective phytochemicals: Mechanism and future prospects
P Basist, B Parveen, S Zahiruddin, G Gautam, R Parveen, MA Khan, ...
Journal of Ethnopharmacology, 114743 2021
Citations: 38

A Systematic Review on nephron protective AYUSH drugs as constituents of NEERI-KFT (A traditional Indian polyherbal formulation) for the management of chronic kidney disease
G Gaurav, B Parveen, MU Khan, I Sharma, AK Sharma, R Parveen, ...
Saudi Journal of Biological Sciences 2021
Citations: 26

Thin layer chromatography-mass spectrometry bioautographic identification of free radical scavenging compounds and metabolomic profile of Carica papaya linn. fruit and seeds
A Khan, S Zahiruddin, M Ibrahim, P Basist, Gaurav, R Parveen, S Umar, ...
Pharmacognosy Magazine 17 (5), 21 2021
Citations: 16

Vitamin D from vegetable VV sources: hope for the future
MU Khan, G Gautam, B Jan, S Zahiruddin, R Parveen, S Ahmad
Phytomedicine plus 2 (2), 100248 2022
Citations: 15

Network pharmacology-based validation of traditional therapeutic claim of momordica charantiain alleviating diabetic nephropathy
G Gautam
J. CAM Res. Prog 1, 102 2022
Citations: 11

Ameliorative effect of traditional polyherbal formulation on TNF-α, IL-1β and Caspase-3 expression in kidneys of wistar rats against sodium fluoride induced oxidative stress
MU Khan, P Basist, Gaurav, S Zahiruddin, NR Penumallu, S Ahmad
Journal of Ethnopharmacology, 116900 2023
Citations: 5