Gaurav Bhargava
@ptu.ac.in
Professor, Department of Chemical Sciences
IKG Punjab Technical University
RESEARCH INTERESTS
Organic Chemistry, Medicinal Chemistry, synthetic Chemistry, Green Chemistry, Material Chemistry
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Simranpreet K. Wahan, Gaurav Bhargava, Viney Chawla, and Pooja A. Chawla
Elsevier BV
Gobind Kumar, Gaurav Bhargava, Sanjay Kumar, Jaspreet Kaur Rajput, Baljinder Singh, Parvesh Singh, and Rupesh Kumar
Elsevier BV
Simranpreet K. Wahan, Gaurav Bhargava, and Pooja A. Chawla
Elsevier BV
Tnu Mahajan, Gaurav Bhargava, and Hitesh Sharma
Wiley
AbstractThe structural, electronic, and thermodynamical properties of Cn(N3)m (n = 1–7) (m = 4, 6) organic azides have been investigated using Density Functional Calculations. The ground state structures of organic azides were compared with CnHm (n = 1–7) (m = 4, 6) cumulenes which shows their higher relative stability. The stability and reactivity of organic azides were analyzed by calculating the HOMO‐LUMO gap, binding energies, and harmonic frequencies of the azides. The binding energy and formation energy of Cn(N3)m (n = 1–7) (m = 4, 6) organic azides suggest their energetic stability. The structural analysis of the azide group in Cn(N3)m (n = 1–7) (m = 4, 6) organic azide shows a tendency to stabilize at a maximum separation between functional azide groups. Ionization potential, electron affinities, and global hardness have been computed for Cn(N3)m (n = 1–7) (m = 4, 6) organic azides and the odd–even alternation rule was observed. The molecular dynamic simulation performed at 300 K for 1 fs confirms organic azide's structural stability at room temperature, except for C4(N3)4, and the members of their family can be synthesized.
Gobind Kumar, Pule Seboletswe, Neha Manhas, Parvesh Singh, Gaurav Bhargava, Jaspreet Kaur Rajput, and Rupesh Kumar
Wiley
AbstractA safer, greener, and more effective reaction methodology for the synthesis of dihydroquinazolinones (DHQs) has been developed. The deep eutectic solvent (DES) ZnCl2/urea employed in this study efficiently accelerated the cyclization of 2‐aminobenzamide with different aldehydes (aromatic and heteroaromatic) to afford the target scaffolds without the generation of any oxidized product. This method has exhibited remarkable advantages such as quick reaction time, mild reaction conditions, high yield (82%–98%), operational simplicity, and selectivity. The approach was observed to be tolerant to electron‐donating and electron‐withdrawing functional groups. Green metric parameters (AEf, OE, AE, RME, CE, etc.) determined further aided this greener chemical approach.
Maninderjeet K. Mann, Simranpreet K. Wahan, Gaurav Bhargava, and Nitin Tandon
Georg Thieme Verlag KG
AbstractButadienyl ketene is a useful intermediate because of its role as a 2p-component in cycloaddition reactions with a variety of substrates such as simple or conjugated imines and dienes. This review article summarizes recent reports on the generation of butadienyl ketene in situ and their cycloaddition reactions to afford heterocyclic systems. The chemistry of butadienyl ketene is explored with a focus on its [2+2] and [4+2] cycloaddition reactions with a variety of imines and azadiene derivatives such as 1,3-diazabuta-1,3-dienes, for the synthesis of four- and six-membered heterocycles, respectively.
Priyanka Sharma, Dinesh Mahajan, Vipan Kumar, Rupesh Kumar, and Gaurav Bhargava
Informa UK Limited
Simranpreet K. Wahan, Gaurav Bhargava, and Pooja A. Chawla
De Gruyter
Rayees Ahmad Naikoo, Rupesh Kumar, Rashmi Sharma, Dinesh Mahajan, and Gaurav Bhargava
Royal Society of Chemistry (RSC)
This work describes the highly regio-selective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-aminopyrimidinones with good to excellent yields under ambient conditions.
Simranpreet K Wahan, Pooja A Chawla, Parvesh Singh, Rupesh Kumar, and Gaurav Bhargava
Georg Thieme Verlag KG
A highly eco-friendly greener approach based on the mechanochemical method using mortar and pestle is explored for the preparation of a variety of functionalized 4-thiazolidinones. The developed methodology does not require the use of harmful or expensive reagents and organic solvents and requires very less reaction time with easy isolation. The explored greener approach for the synthesis of 4-thiazolidinones is an important in terms of their usefulness for their valuable pharmacological properties.
Pooja A. Chawla, Simranpreet K. Wahan, and Gaurav Bhargava
Georg Thieme Verlag KG
Simranpreet K. Wahan, Gaurav Bhargava, and Pooja A. Chawla
De Gruyter
Rayees Ahmad Naikoo, Rashmi Sharma, Rupesh Kumar, and Gaurav Bhargava
Wiley
Priyanka Sharma, Rashmi Sharma, Vipan Kumar, Parvesh Singh, and Gaurav Bhargava
Bentham Science Publishers Ltd.
Abstract: Functionalized 3-amino-2-azetidinones are important heterocyclic systems which can easily be transformed into functionally decorated heterocycles using β-lactam synthon protocol. The different synthetic methods have been explored for the transformation of functionalized 3-amino-2-azetidiones to various heterocyclic molecules, such as imidazolidin-2-ones, piperazines, hydantoins, 4-oxo-1H-pyrroles, 1,4-benzodiazepin-2-ones, amino pyrrolidine-2- carboxylates etc., and β-lactam- based conjugates having diverse biological activities, such as anti-malarial activity, anti-tuberculosis, anti-trichomonas activity etc. The present review article summarizes the various reports on the synthetic transformation of functionalized 3-amino-2- azetidinones for the synthesis of a variety of heterocyclic systems.
Simranpreet K. Wahan, Gaurav Bhargava, and Pooja A. Chawla
Bentham Science Publishers Ltd.
Abstract: Ultrasound is well explored in the preparation of several heterocycles as it is an eco-friendly, safer and cheaper technique compared to the previous conventional synthetic approach. Ultrasonication offers a great deal of interest for chemists as it not only lowers the reaction time but also markedly reduces the use of hazardous chemicals and enhances the purity of synthesized compounds. Since the application of ultrasound waves acts as a nonpolluting energy source, therefore, it is an area of great importance in the field of green and sustainable chemistry. Also, nitrogen and oxygen-based pharmaceuticals have been found to be a beneficial tool for modifying solubility, lipophilicity, polarity and other important pharmacokinetic parameters which aid in optimizing ADMET characteristics of drug candidates. Further, nitrogen and oxygen-containing compounds have been reported to exhibit antibacterial, antiviral, anti-inflammatory, anticancer, analgesic, antihyperglycemic action etc. Therefore, the review focues to coveron covering the latest applications of ultrasonication in the preparation of oxygen and nitrogen nitrogencontaining heterocycles holding immense importance in therapeutically active molecules, which will aid new researchers in their ongoingnd future research.
Simranpreet K. Wahan, Shelly Pathania, Pooja A. Chawla, and Gaurav Bhargava
Informa UK Limited
Maninderjeet Kaur Mann, Rashmi Sharma, Pooja Chawla, Rupesh Kumar, and Gaurav Bhargava
Informa UK Limited
Gobind Kumar, Parvesh Singh, Gaurav Bhargava, Baljinder Singh Gill, Jaspreet Kaur Rajput, and Rupesh Kumar
Informa UK Limited
Gobind Kumar, Gaurav Bhargava, and Rupesh Kumar
Informa UK Limited
Vipan Kumar and Gaurav Bhargava
Frontiers Media SA
COPYRIGHT © 2022 Kumar and Bhargava. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Editorial PUBLISHED 31 August 2022 DOI 10.3389/fcimb.2022.1002602
Priyanka Sharma, Maninderjeet Kaur Mann, and Gaurav Bhargava
Bentham Science Publishers Ltd.
Abstract: The manuscript describes a facile and an efficient methodology for the synthesis of 1, 3, 4 trisubstituted-β-lactams by base mediated oxa-Michael addition reactions of 3-hydroxy-2- azetidinones with acetylenic esters under different reaction conditions. These functionalized 1, 3, 4-trisubstituted-azetidin-2-ones are useful organic synthons for the synthesis of various heterocyclic compounds having diverse pharmacological applications.
GOBIND KUMAR, GAURAV BHARGAVA, YOGESH KUMAR, and RUPESH KUMAR
Springer Science and Business Media LLC
Rayees Ahmad Naikoo, Rupesh Kumar, Vipan Kumar, and Gaurav Bhargava
Bentham Science Publishers Ltd.
Abstract: Functionalized bicyclic pyrimidinones and their derivatives are significant heterocyclic scaffolds being their all-around prevalence in biologically potent compounds. In several attempts to explore the different synthetic methodologies for the construction of bicyclic condensed pyrimidinones, different researchers from all across the globe have reported numerous substantial methods. In the present review, considerable work has been critically compiled on the synthesis of substituted and functionalized bicyclic pyrimidinones from 2000 onwards.
Rayees Ahmad Naikoo, Parvesh Singh, Rupesh Kumar, and Gaurav Bhargava
Informa UK Limited
An eco-friendly, easily achievable and efficient strategy has been explored to synthesize functionalized bisthioglycolic acids using a variety of aldehydes and thioglycolic acid. The employed protocol is solvent free and provides the desirable products in excellent yields (90–99%) with atom economy. Besides, cost effectiveness, short reaction times and milder reaction conditions are among other captivating benefits of the reported methodology. GRAPHICAL ABSTRACT
Rayees Ahmad Naikoo, Rupesh Kumar, Vipan Kumar, and Gaurav Bhargava
Informa UK Limited
Abstract Functionalized tricyclicpyrimidinones, a class of condensed heterocyclic systems, are found in numerouspotentially active molecules having both innate as well as synthetic origin. Different researchers across the world have explored different synthetic methods for the construction of appropriately functionalized tricyclicpyrimidinones. The present review article recapitulates various reports pertaining to substituted and functionalized tricyclic pyrimidinones reported since 2000. Graphical Abstract