Giordano Bruno Soares-Souza

@rededorsaoluiz.com.br

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Giordano Bruno Soares-Souza


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https://researchid.co/gbss_02
19

Scopus Publications

816

Scholar Citations

13

Scholar h-index

14

Scholar i10-index

Scopus Publications

  • Decoding pilocarpine biosynthesis and its roles in Pilocarpus microphyllus through a comparative transcriptomics approach
    Mariane Brom Sobreiro, Giordano Bruno Soares-Souza, Leandro Magalhães, Débora de Morais Cordeiro, Michele Molina, Santelmo Vasconcelos, Yan Nunes Dias, Renato R. Moreira-Oliveira, Markus Gastauer, Silvio Ramos, Guilherme Oliveira, Cecílio Frois Caldeira, Amanda F. Vidal
    BMC Plant Biology, 2025
    Pilocarpus microphyllus, widely known as jaborandi, faces a decline in its natural population due to unsustainable harvesting for pilocarpine extraction, an imidazole alkaloid with significant pharmacological properties. This study presents the first comparative transcriptomic analysis in jaborandi by investigating gene expression across four different tissues (leaflets, rachis, root, and stem) and exploring potential pathways and functions involved in pilocarpine biosynthesis. The comparisons involving the root had the highest number of DEGs, including root vs. leaflets, rachis vs. root, and stem vs. root. In contrast, no DEGs were identified in the comparison between stem and leaflets. We observed that the root exhibited the most diverse functional profile, including an abundance of TFs involved in alkaloid biosynthesis. Functional enrichment analysis of root-overexpressed genes revealed associations with cell transport, regulatory processes, and defense responses. In contrast, aerial tissues exhibited enrichment for photosynthesis and oxidative stress response pathways, with antioxidant enzymes highly expressed in the leaflets—the primary site of pilocarpine accumulation in its final form—suggesting a potential link between pilocarpine production and the plant’s antioxidative response. The presence of enzymes potentially involved in pilocarpine biosynthesis in both aerial and root tissues supports the idea that its biosynthesis is a multi-tissue process. This study provides important insights into the metabolic pathways for advancing conservation strategies and promoting sustainable management of this species.
  • Exploring Aerobic Energy Metabolism in Breast Cancer: A Mutational Profile of Glycolysis and Oxidative Phosphorylation
    Ricardo Cunha de Oliveira, Giovanna C. Cavalcante, Giordano B. Soares-Souza
    International Journal of Molecular Sciences, 2024
    Energy metabolism is a fundamental aspect of the aggressiveness and invasiveness of breast cancer (BC), the neoplasm that most affects women worldwide. Nonetheless, the impact of genetic somatic mutations on glycolysis and oxidative phosphorylation (OXPHOS) genes in BC remains unclear. To fill these gaps, the mutational profiles of 205 screened genes related to glycolysis and OXPHOS in 968 individuals with BC from The Cancer Genome Atlas (TCGA) project were performed. We carried out analyses to characterize the mutational profile of BC, assess the clonality of tumors, identify somatic mutation co-occurrence, and predict the pathogenicity of these alterations. In total, 408 mutations in 132 genes related to the glycolysis and OXPHOS pathways were detected. The PGK1, PC, PCK1, HK1, DONSON, GPD1, NDUFS1, and FOXRED1 genes are also associated with the tumorigenesis process in other types of cancer, as are the genes BRCA1, BRCA2, and HMCN1, which had been previously described as oncogenes in BC, with whom the target genes of this work were associated. Seven mutations were identified and highlighted due to the high pathogenicity, which are present in more than one of our results and are documented in the literature as being correlated with other diseases. These mutations are rs267606829 (FOXRED1), COSV53860306 (HK1), rs201634181 (NDUFS1), rs774052186 (DONSON), rs119103242 (PC), rs1436643226 (PC), and rs104894677 (ETFB). They could be further investigated as potential biomarkers for diagnosis, prognosis, and treatment of BC patients.
  • Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon
    Maria Clara Barros, Jorge Estefano Santana de Souza, Daniel Henrique F. Gomes, Catarina Torres Pinho, Caio S. Silva, Cíntia Braga-da-Silva, Giovanna C. Cavalcante, Leandro Magalhães, Jhully Azevedo-Pinheiro, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão, Patrícia Fagundes Costa, Cláudio Guedes Salgado, Thiago Xavier Carneiro, Rommel Rodrigues Burbano, José Ricardo dos Santos Vieira, Sidney Santos, Giordano Bruno Soares-Souza, Sandro José de Souza, Ândrea Ribeiro-dos-Santos
    Scientific Reports, 2024
    Despite all the efforts acquired in four years of the COVID-19 pandemic, the path to a full understanding of the biological mechanisms involved in this disease remains complex. This is partly due to a combination of factors, including the inherent characteristics of the infection, socio-environmental elements, and the variations observed within both the viral and the human genomes. Thus, this study aimed to investigate the correlation between genetic host factors and the severity of COVID-19. We conducted whole exome sequencing (WES) of 124 patients, categorized into severe and non-severe groups. From the whole exome sequencing (WES) association analysis, four variants (rs1770731 in CRYBG1, rs7221209 in DNAH17, rs3826295 in DGKE, and rs7913626 in CFAP46) were identified as potentially linked to a protective effect against the clinical severity of COVID-19, which may explain the less severe impact of COVID-19 on the Northern Region. Our findings underscore the importance of carrying out more genomic studies in populations living in the Amazon, one of the most diverse from the point of view of the presence of rare and specific alleles. To our knowledge, this is the first WES study of admixed individuals from the Brazilian Amazon to investigate genomic variants associated with the clinical severity of COVID-19.
  • Unveiling differential gene co-expression networks and its effects on levodopa-induced dyskinesia
    Tatiane Piedade de Souza, Gilderlanio Santana de Araújo, Leandro Magalhães, Giovanna C. Cavalcante, Arthur Ribeiro-dos-Santos, Camille Sena-dos-Santos, Caio Santos Silva, Gracivane Lopes Eufraseo, Alana de Freitas Escudeiro, Giordano Bruno Soares-Souza, Bruno Lopes Santos-Lobato, Ândrea Ribeiro-dos-Santos
    Iscience, 2024
    Levodopa-induced dyskinesia (LID) refers to involuntary motor movements of chronic use of levodopa in Parkinson's disease (PD) that negatively impact the overall well-being of people with this disease. The molecular mechanisms involved in LID were investigated through whole-blood transcriptomic analysis for differential gene expression and identification of new co-expression and differential co-expression networks. We found six differentially expressed genes in patients with LID, and 13 in patients without LID. We also identified 12 co-expressed genes exclusive to LID, and six exclusive hub genes involved in 23 gene-gene interactions in patients with LID. Convergently, we identified novel genes associated with PD and LID that play roles in mitochondrial dysfunction, dysregulation of lipid metabolism, and neuroinflammation. We observed significant changes in disease progression, consistent with previous findings of maladaptive plastic changes in the basal ganglia leading to the development of LID, including a chronic pro-inflammatory state in the brain.
  • Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans
    Katharine L Korunes, Giordano Bruno Soares-Souza, Katherine Bobrek, Hua Tang, Isabel Inês Araújo, Amy Goldberg, Sandra Beleza
    G3 Genes Genomes Genetics, 2022
    Genetic data can provide insights into population history, but first, we must understand the patterns that complex histories leave in genomes. Here, we consider the admixed human population of Cabo Verde to understand the patterns of genetic variation left by social and demographic processes. First settled in the late 1400s, Cabo Verdeans are admixed descendants of Portuguese colonizers and enslaved West African people. We consider Cabo Verde’s well-studied historical record alongside genome-wide SNP data from 563 individuals from 4 regions within the archipelago. We use genetic ancestry to test for patterns of nonrandom mating and sex-specific gene flow, and we examine the consequences of these processes for common demographic inference methods and genetic patterns. Notably, multiple population genetic tools that assume random mating underestimate the timing of admixture, but incorporating nonrandom mating produces estimates more consistent with historical records. We consider how admixture interrupts common summaries of genomic variation such as runs of homozygosity. While summaries of runs of homozygosity may be difficult to interpret in admixed populations, differentiating runs of homozygosity by length class shows that runs of homozygosity reflect historical differences between the islands in their contributions from the source populations and postadmixture population dynamics. Finally, we find higher African ancestry on the X chromosome than on the autosomes, consistent with an excess of European males and African females contributing to the gene pool. Considering these genomic insights into population history in the context of Cabo Verde’s historical record, we can identify how assumptions in genetic models impact inference of population history more broadly.
  • Human-sars-cov-2 interactome and human genetic diversity: Tmprss2-rs2070788, associated with severe influenza, and its population genetics caveats in native americans
    Fernanda S.G. Kehdy, Murilo Pita-Oliveira, Mariana M. Scudeler, Sabrina Torres-Loureiro, Camila Zolini, Rennan Moreira, Lucas A. Michelin, Isabela Alvim, Carolina Silva-Carvalho, Vinicius C. Furlan, Marla M. Aquino, Meddly L. Santolalla, Victor Borda, Giordano B. Soares-Souza, Luis Jaramillo-Valverde, Andres Vasquez-Dominguez, Cesar Sanchez Neira, Renato S. Aguiar, Ricardo A. Verdugo, Timothy D. O`Connor, Heinner Guio, Eduardo Tarazona-Santos, Thiago P. Leal, Fernanda Rodrigues-Soares
    Genetics and Molecular Biology, 2021
    For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of genetic association studies in different human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in populations with Native American ancestry.
  • Origins, admixture dynamics, and homogenization of the african gene pool in the americas
    Mateus H Gouveia, Victor Borda, Thiago P Leal, Rennan G Moreira, Andrew W Bergen, Fernanda S G Kehdy, Isabela Alvim, Marla M Aquino, Gilderlanio S Araujo, Nathalia M Araujo, Vinicius Furlan, Raquel Liboredo, Moara Machado, Wagner C S Magalhaes, Lucas A Michelin, Maíra R Rodrigues, Fernanda Rodrigues-Soares, Hanaisa P Sant Anna, Meddly L Santolalla, Marília O Scliar, Giordano Soares-Souza, Roxana Zamudio, Camila Zolini, Maria Catira Bortolini, Michael Dean, Robert H Gilman, Heinner Guio, Jorge Rocha, Alexandre C Pereira, Mauricio L Barreto, Bernardo L Horta, Maria F Lima-Costa, Sam M Mbulaiteye, Stephen J Chanock, Sarah A Tishkoff, Meredith Yeager, Eduardo Tarazona-Santos
    Molecular Biology and Evolution, 2020
    The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to infer how different African groups contributed to North-, South-American, and Caribbean populations, in the context of geographic and geopolitical factors, and compared genetic data with demographic history records of the Transatlantic Slave Trade. We observed that West-Central Africa and Western Africa-associated ancestry clusters are more prevalent in northern latitudes of the Americas, whereas the South/East Africa-associated ancestry cluster is more prevalent in southern latitudes of the Americas. This pattern results from geographic and geopolitical factors leading to population differentiation. However, there is a substantial decrease in the between-population differentiation of the African gene pool within the Americas, when compared with the regions of origin from Africa, underscoring the importance of historical factors favoring admixture between individuals with different African origins in the New World. This between-population homogenization in the Americas is consistent with the excess of West-Central Africa ancestry (the most prevalent in the Americas) in the United States and Southeast-Brazil, with respect to historical-demography expectations. We also inferred that in most of the Americas, intercontinental admixture intensification occurred between 1750 and 1850, which correlates strongly with the peak of arrivals from Africa. This study contributes with a population genetics perspective to the ongoing social, cultural, and political debate regarding ancestry, admixture, and the mestizaje process in the Americas.
  • Decommissioning of subsea structures in Brazil: Impact of invasive species and genome sequence of the invasive azooxanthellate coral tubastraea sp.
    Proceedings of the Annual Offshore Technology Conference, 2020
  • Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging
    Mateus H. Gouveia, Cibele C. Cesar, Meddly L. Santolalla, Hanaisa P. Sant Anna, Marilia O. Scliar, Thiago P. Leal, Nathalia M. Araújo, Giordano B. Soares-Souza, Wagner C. S. Magalhães, Ignacio F. Mata, Cleusa P. Ferri, Erico Castro-Costa, Sam M. Mbulaiteye, Sarah A. Tishkoff, Daniel Shriner, Charles N. Rotimi, Eduardo Tarazona-Santos, Maria Fernanda Lima-Costa
    Scientific Reports, 2019
    Age-related cognitive decline (ACD) is the gradual process of decreasing of cognitive function over age. Most genetic risk factors for ACD have been identified in European populations and there are no reports in admixed Latin American individuals. We performed admixture mapping, genome-wide association analysis (GWAS), and fine-mapping to examine genetic factors associated with 15-year cognitive trajectory in 1,407 Brazilian older adults, comprising 14,956 Mini-Mental State Examination measures. Participants were enrolled as part of the Bambuí-Epigen Cohort Study of Aging. Our admixture mapping analysis identified a genomic region (3p24.2) in which increased Native American ancestry was significantly associated with faster ACD. Fine-mapping of this region identified a single nucleotide polymorphism (SNP) rs142380904 (β = −0.044, SE = 0.01, p = 7.5 × 10−5) associated with ACD. In addition, our GWAS identified 24 associated SNPs, most in genes previously reported to influence cognitive function. The top six associated SNPs accounted for 18.5% of the ACD variance in our data. Furthermore, our longitudinal study replicated previous GWAS hits for cognitive decline and Alzheimer’s disease. Our 15-year longitudinal study identified both ancestry-specific and cosmopolitan genetic variants associated with ACD in Brazilians, highlighting the need for more trans-ancestry genomic studies, especially in underrepresented ethnic groups.
  • EPIGEN-Brazil Initiative resources: A Latin American imputation panel and the Scientific Workflow
    Wagner C.S. Magalhães, Nathalia M. Araujo, Thiago P. Leal, Gilderlanio S. Araujo, Paula J.S. Viriato, Fernanda S. Kehdy, Gustavo N. Costa, Mauricio L. Barreto, Bernardo L. Horta, Maria Fernanda Lima-Costa, Alexandre C. Pereira, Eduardo Tarazona-Santos, Maíra R. Rodrigues, and
    Genome Research, 2018
    EPIGEN-Brazil is one of the largest Latin American initiatives at the interface of human genomics, public health, and computational biology. Here, we present two resources to address two challenges to the global dissemination of precision medicine and the development of the bioinformatics know-how to support it. To address the underrepresentation of non-European individuals in human genome diversity studies, we present the EPIGEN-5M+1KGP imputation panel—the fusion of the public 1000 Genomes Project (1KGP) Phase 3 imputation panel with haplotypes derived from the EPIGEN-5M data set (a product of the genotyping of 4.3 million SNPs in 265 admixed individuals from the EPIGEN-Brazil Initiative). When we imputed a target SNPs data set (6487 admixed individuals genotyped for 2.2 million SNPs from the EPIGEN-Brazil project) with the EPIGEN-5M+1KGP panel, we gained 140,452 more SNPs in total than when using the 1KGP Phase 3 panel alone and 788,873 additional high confidence SNPs (info score ≥ 0.8). Thus, the major effect of the inclusion of the EPIGEN-5M data set in this new imputation panel is not only to gain more SNPs but also to improve the quality of imputation. To address the lack of transparency and reproducibility of bioinformatics protocols, we present a conceptual Scientific Workflow in the form of a website that models the scientific process (by including publications, flowcharts, masterscripts, documents, and bioinformatics protocols), making it accessible and interactive. Its applicability is shown in the context of the development of our EPIGEN-5M+1KGP imputation panel. The Scientific Workflow also serves as a repository of bioinformatics resources.
  • Population genetics of immune-related multilocus copy number variation in Native Americans
    Luciana W. Zuccherato, Silvana Schneider, Eduardo Tarazona-Santos, Robert J. Hardwick, Douglas E. Berg, Helen Bogle, Mateus H. Gouveia, Lee R. Machado, Moara Machado, Fernanda Rodrigues-Soares, Giordano B. Soares-Souza, Diego L. Togni, Roxana Zamudio, Robert H. Gilman, Denise Duarte, Edward J. Hollox, Maíra R. Rodrigues
    Journal of the Royal Society Interface, 2017
  • Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
    Fernanda S. G. Kehdy, Mateus H. Gouveia, Moara Machado, Wagner C. S. Magalhães, Andrea R. Horimoto, Bernardo L. Horta, Rennan G. Moreira, Thiago P. Leal, Marilia O. Scliar, Giordano B. Soares-Souza, Fernanda Rodrigues-Soares, Gilderlanio S. Araújo, Roxana Zamudio, Hanaisa P. Sant Anna, Hadassa C. Santos, Nubia E. Duarte, Rosemeire L. Fiaccone, Camila A. Figueiredo, Thiago M. Silva, Gustavo N. O. Costa, Sandra Beleza, Douglas E. Berg, Lilia Cabrera, Guilherme Debortoli, Denise Duarte, Silvia Ghirotto, Robert H. Gilman, Vanessa F. Gonçalves, Andrea R. Marrero, Yara C. Muniz, Hansi Weissensteiner, Meredith Yeager, Laura C. Rodrigues, Mauricio L. Barreto, M. Fernanda Lima-Costa, Alexandre C. Pereira, Maíra R. Rodrigues, Eduardo Tarazona-Santos, , Neuza Alcantara-Neves, Nathalia M. Araújo, Márcio L.B. Carvalho, Jackson Santos Conceição, Josélia O.A. Firmo, Denise P. Gigante, Lindolfo Meira, Thais Muniz-Queiroz, Guilherme C. Oliveira, Isabel O. Oliveira, Sérgio V. Peixoto, Fernando A. Proietti, Domingos C. Rodrigues, Meddly L. Santolalla, Agostino Strina, Camila Zolini
    Proceedings of the National Academy of Sciences of the United States of America, 2015
  • Bayesian inferences suggest that Amazon Yunga Natives diverged from Andeans less than 5000 ybp: Implications for South American prehistory
    Marilia O Scliar, Mateus H Gouveia, Andrea Benazzo, Silvia Ghirotto, Nelson JR Fagundes, Thiago P Leal, Wagner CS Magalhães, Latife Pereira, Maira R Rodrigues, Giordano B Soares-Souza, Lilia Cabrera, Douglas E Berg, Robert H Gilman, Giorgio Bertorelle, Eduardo Tarazona-Santos
    BMC Evolutionary Biology, 2014
  • Socioeconomic and nutritional factors account for the association of gastric cancer with amerindian ancestry in a latin american admixed population
    Latife Pereira, Roxana Zamudio, Giordano Soares-Souza, Phabiola Herrera, Lilia Cabrera, Catherine C. Hooper, Jaime Cok, Juan M. Combe, Gloria Vargas, William A. Prado, Silvana Schneider, Fernanda Kehdy, Maira R. Rodrigues, Stephen J. Chanock, Douglas E. Berg, Robert H. Gilman, Eduardo Tarazona-Santos
    Plos One, 2012
  • DIVERGENOME: A bioinformatics platform to assist population genetics and genetic epidemiology studies
    Wagner C. S. Magalhães, Maíra R. Rodrigues, Donnys Silva, Giordano Soares‐Souza, Márcia L. Iannini, Gustavo C. Cerqueira, Alessandra C. Faria‐Campos, Eduardo Tarazona‐Santos
    Genetic Epidemiology, 2012
  • The population genetics of quechuas, the largest native south american group: Autosomal sequences, SNPs, and microsatellites evidence high level of diversity
    Marilia O. Scliar, Giordano B. Soares‐Souza, Juliana Chevitarese, Livia Lemos, Wagner C.S. Magalhães, Nelson J. Fagundes, Sandro L. Bonatto, Meredith Yeager, Stephen J. Chanock, Eduardo Tarazona‐Santos
    American Journal of Physical Anthropology, 2012
  • Extensive admixture in Brazilian sickle cell patients: Implications for the mapping of genetic modifiers
    Maria Clara F. da Silva, Luciana W. Zuccherato, Flavia C. Lucena, Giordano B. Soares-Souza, Zilma M. Vieira, Sérgio D.J. Pena, Marina L. Martins, Eduardo Tarazona-Santos
    Blood, 2011
  • Development of two multiplex mini-sequencing panels of ancestry informative snps for studies in latin americans: An application to populations of the state of minas gerais (brazil)
    M.C.F. Silva, L.W. Zuccherato, G.B. Soares-Souza, Z.M. Vieira, L. Cabrera, P. Herrera, J. Balqui, C. Romero, H. Jahuira, R.H. Gilman, M.L. Martins, E. Tarazona-Santos
    Genetics and Molecular Research, 2010
  • Characterization of a candidate locus for malaria susceptibility in human populations: A (TA)n microsatellite in the promoter region of the CYBB gene, the gp91phox subunit of the NADPH oxidase
    G. B. Soares‐Souza, E. Tarazona‐Santos, S. J. Chanock
    International Journal of Immunogenetics, 2008

RECENT SCHOLAR PUBLICATIONS

  • TRYPANOSOMA CRUZI: STANDARDIZATION AND VALIDATION OF MITOCHONDRIAL RT-MTQPCR DIAGNOSIS IN SAMPLES FROM THE AMAZON
    L Closset, MC da Costa Barros, CS Silva, LWMS Vinagre, JRG Duarte, ...
    The Brazilian Journal of Infectious Diseases 30, 105631 , 2026
    2026
  • Pipeasm: a tool for automated large chromosome-scale genome assembly and evaluation
    B Marques Silva, FJ Trindade, LE Costa Canesin, G Souza, A Aleixo, ...
    Bioinformatics Advances 6 (1), vbaf326 , 2026
    2026
    Citations: 3
  • Tubastraea coccinea (Cnidaria: Anthozoa) is the globally dispersed species of Sun Coral
    AF Portella, JGRN Ferreira, GB Soares-Souza, D Amaral, KV Macieira, ...
    bioRxiv, 2025.11. 26.690498 , 2025
    2025
  • Downregulation of the Ca 2+ sensor Synaptotagmin-1 ( SYT1 ) in Parkinson’s Disease: Insights from Gene Expression Profiling
    GC Cavalcante, GB Soares-Souza
    bioRxiv, 2025.09. 12.675906 , 2025
    2025
    Citations: 1
  • Decoding pilocarpine biosynthesis and its roles in Pilocarpus microphyllus through a comparative transcriptomics approach
    MB Sobreiro, GB Soares-Souza, L Magalhães, D de Morais Cordeiro, ...
    BMC Plant Biology 25 (1), 1024 , 2025
    2025
    Citations: 3
  • Exploring Aerobic Energy metabolism in breast Cancer: a Mutational Profile of Glycolysis and oxidative phosphorylation
    RC Oliveira, GC Cavalcante, GB Soares-Souza
    International Journal of Molecular Sciences 25 (23), 12585 , 2024
    2024
    Citations: 6
  • Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon
    MC Barros, JES de Souza, DHF Gomes, CT Pinho, CS Silva, ...
    Scientific Reports 14 (1), 27332 , 2024
    2024
  • Unveiling differential gene co-expression networks and its effects on levodopa-induced dyskinesia
    TP de Souza, GS de Araújo, L Magalhães, GC Cavalcante, ...
    Iscience 27 (9) , 2024
    2024
    Citations: 2
  • Explorando mecanismos genéticos e epigenéticos na hanseníase para a identificação de novos biomarcadores
    MÁC Durán, GBS Souza, L Magalhães, P Pinto, TP de Souza, A Gobbo, ...
    The Brazilian Journal of Infectious Diseases 27, 103627 , 2023
    2023
    Citations: 1
  • COMPREHENSIVE CIRCRNA ANALYSIS REVEALS MOLECULAR INTERACTIONS RELATED TO POOR OVERALL SURVIVAL IN MULTIPLE MYELOMA
    LRD Merces, L Magalhães, GBS Souza, A Berg, A Santos
    Hematology, Transfusion and Cell Therapy 45, S425-S426 , 2023
    2023
  • Transmission dynamics of SARS-CoV-2 variants in the Brazilian state of Pará
    CT Pinho, AF Vidal, TC Negri Rocha, RRM Oliveira, MC da Costa Barros, ...
    Frontiers in Public Health 11, 1186463 , 2023
    2023
    Citations: 8
  • Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans
    KL Korunes, GB Soares-Souza, K Bobrek, H Tang, II Araújo, A Goldberg, ...
    G3 12 (10), jkac183 , 2022
    2022
    Citations: 17
  • Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2 -rs2070788, associated with severe influenza, and its population genetics caveats in …
    FSG Kehdy, M Pita-Oliveira, MM Scudeler, S Torres-Loureiro, C Zolini, ...
    Genetics and molecular biology 44 (1 Suppl 1), e20200484 , 2021
    2021
    Citations: 13
  • The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture
    V Borda, I Alvim, M Mendes, C Silva-Carvalho, GB Soares-Souza, TP Leal, ...
    Proceedings of the National Academy of Sciences 117 (51), 32557-32565 , 2020
    2020
    Citations: 71
  • Origins, admixture dynamics, and homogenization of the African gene pool in the Americas
    MH Gouveia, V Borda, TP Leal, RG Moreira, AW Bergen, FSG Kehdy, ...
    Molecular Biology and Evolution 37 (6), 1647-1656 , 2020
    2020
    Citations: 87
  • Population structure of the invasive golden mussel ( Limnoperna fortunei ) on reservoirs from five Brazilian drainage basins
    JGRN Ferreira, GB Soares-Souza, JA Americo, A Dumaresq, MF Rebelo
    bioRxiv, 2020.05. 28.122069 , 2020
    2020
    Citations: 1
  • Decommissioning Of Subsea Structures In Brazil: Impact Of Invasive Species And Genome Sequence Of The Invasive Azooxanthellate Coral.
    JHG Batista, M Rebelo, G Soares-Souza
    Offshore Technology Conference, D031S030R001 , 2020
    2020
    Citations: 3
  • The genomes of invasive coral Tubastraea spp. (Dendrophylliidae) as tool for the development of biotechnological solutions
    GB Soares-Souza, D Amaral, D Batista, AQ Torres, AC Silva Serra, ...
    bioRxiv, 2020.04. 24.060574 , 2020
    2020
    Citations: 4
  • The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture
    V Borda, I Alvim, MM Aquino, C Silva, GB Soares-Souza, TP Leal, ...
    bioRxiv, 2020.01. 30.916270 , 2020
    2020
    Citations: 7
  • Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging
    MH Gouveia, CC Cesar, ML Santolalla, HPS Anna, MO Scliar, TP Leal, ...
    Scientific Reports 9 (1), 18085 , 2019
    2019
    Citations: 14

MOST CITED SCHOLAR PUBLICATIONS

  • Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations
    FSG Kehdy, MH Gouveia, M Machado, WCS Magalhães, AR Horimoto, ...
    Proceedings of the National Academy of Sciences 112 (28), 8696-8701 , 2015
    2015
    Citations: 339
  • Origins, admixture dynamics, and homogenization of the African gene pool in the Americas
    MH Gouveia, V Borda, TP Leal, RG Moreira, AW Bergen, FSG Kehdy, ...
    Molecular Biology and Evolution 37 (6), 1647-1656 , 2020
    2020
    Citations: 87
  • The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture
    V Borda, I Alvim, M Mendes, C Silva-Carvalho, GB Soares-Souza, TP Leal, ...
    Proceedings of the National Academy of Sciences 117 (51), 32557-32565 , 2020
    2020
    Citations: 71
  • Socioeconomic and nutritional factors account for the association of gastric cancer with Amerindian ancestry in a Latin American admixed population
    L Pereira, R Zamudio, G Soares-Souza, P Herrera, L Cabrera, CC Hooper, ...
    Public Library of Science 7 (8), e41200 , 2012
    2012
    Citations: 64
  • Bayesian inferences suggest that Amazon Yunga Natives diverged from Andeans less than 5000 ybp: implications for South American prehistory
    MO Scliar, MH Gouveia, A Benazzo, S Ghirotto, NJR Fagundes, TP Leal, ...
    BMC evolutionary biology 14 (1), 174 , 2014
    2014
    Citations: 29
  • EPIGEN-Brazil Initiative resources: a Latin American imputation panel and the Scientific Workflow
    WCS Magalhães, NM Araujo, TP Leal, GS Araujo, PJS Viriato, FS Kehdy, ...
    Genome research 28 (7), 1090 , 2018
    2018
    Citations: 28
  • Extensive admixture in Brazilian sickle cell patients: implications for the mapping of genetic modifiers
    MCF da Silva, LW Zuccherato, FC Lucena, GB Soares-Souza, ZM Vieira, ...
    Blood, The Journal of the American Society of Hematology 118 (16), 4493-4495 , 2011
    2011
    Citations: 23
  • Development of two multiplex mini-sequencing panels of ancestry informative SNPs for studies in Latin Americans: an application to populations of the State of Minas Gerais (Brazil)
    MC Silva, LW Zuccherato, GB Soares-Souza, ZM Vieira, L Cabrera, ...
    Genet Mol Res 9 (4), 2069-2085 , 2010
    2010
    Citations: 22
  • Admixture, genetics and complex diseases in Latin Americans and US Hispanics
    G Soares-Souza, V Borda, F Kehdy, E Tarazona-Santos
    Current Genetic Medicine Reports 6 (4), 208-223 , 2018
    2018
    Citations: 19
  • Sex-biased admixture and assortative mating shape genetic variation and influence demographic inference in admixed Cabo Verdeans
    KL Korunes, GB Soares-Souza, K Bobrek, H Tang, II Araújo, A Goldberg, ...
    G3 12 (10), jkac183 , 2022
    2022
    Citations: 17
  • The population genetics of quechuas, the largest native south american group: Autosomal sequences, SNPs, and microsatellites evidence high level of diversity
    MO Scliar, GB Soares‐Souza, J Chevitarese, L Lemos, WCS Magalhães, ...
    American journal of physical anthropology 147 (3), 443-451 , 2012
    2012
    Citations: 17
  • Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging
    MH Gouveia, CC Cesar, ML Santolalla, HPS Anna, MO Scliar, TP Leal, ...
    Scientific Reports 9 (1), 18085 , 2019
    2019
    Citations: 14
  • Population genetics of immune-related multilocus copy number variation in Native Americans
    LW Zuccherato, S Schneider, E Tarazona-Santos, RJ Hardwick, DE Berg, ...
    Journal of The Royal Society Interface 14 (128) , 2017
    2017
    Citations: 14
  • Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2 -rs2070788, associated with severe influenza, and its population genetics caveats in …
    FSG Kehdy, M Pita-Oliveira, MM Scudeler, S Torres-Loureiro, C Zolini, ...
    Genetics and molecular biology 44 (1 Suppl 1), e20200484 , 2021
    2021
    Citations: 13
  • Transmission dynamics of SARS-CoV-2 variants in the Brazilian state of Pará
    CT Pinho, AF Vidal, TC Negri Rocha, RRM Oliveira, MC da Costa Barros, ...
    Frontiers in Public Health 11, 1186463 , 2023
    2023
    Citations: 8
  • DIVERGENOME: a bioinformatics platform to assist population genetics and genetic epidemiology studies
    WCS Magalhães, MR Rodrigues, D Silva, G Soares‐Souza, ML Iannini, ...
    Genetic epidemiology 36 (4), 360-367 , 2012
    2012
    Citations: 8
  • The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture
    V Borda, I Alvim, MM Aquino, C Silva, GB Soares-Souza, TP Leal, ...
    bioRxiv, 2020.01. 30.916270 , 2020
    2020
    Citations: 7
  • Gonad transcriptome of golden mussel Limnoperna fortunei reveals potential sex differentiation genes
    LF Afonso, JA Americo, GB Soares-Souza, ALQ Torres, IJR Wajsenzon, ...
    biorxiv, 818757 , 2019
    2019
    Citations: 7
  • Exploring Aerobic Energy metabolism in breast Cancer: a Mutational Profile of Glycolysis and oxidative phosphorylation
    RC Oliveira, GC Cavalcante, GB Soares-Souza
    International Journal of Molecular Sciences 25 (23), 12585 , 2024
    2024
    Citations: 6
  • The genomes of invasive coral Tubastraea spp. (Dendrophylliidae) as tool for the development of biotechnological solutions
    GB Soares-Souza, D Amaral, D Batista, AQ Torres, AC Silva Serra, ...
    bioRxiv, 2020.04. 24.060574 , 2020
    2020
    Citations: 4