Biomechanical Assessment of Femur Fracture Fixation Using Modified Locking Compression Plate Made of Biodegradable and Non-Biodegradable Materials Under Physiological Loading During Healing Phases Girish Chandra, Rajdeep Ghosh, Vivek Verma Journal of Biomedical Materials Research Part B Applied Biomaterials, 2026 Transverse femoral fractures heal through a complex secondary healing process, often stabilized using locking compression plates (LCPs) that maintain compression across an interfragmentary gap. Conventional LCPs made of non‐biodegradable Ti‐alloys provide adequate mechanical support but can induce stress‐shielding in newly formed callus and bone, necessitating revision surgeries. To address this, Mg‐based biodegradable LCPs have been actively investigated. However, their clinical translation and commercial adoption remain limited, primarily due to concerns regarding their lower mechanical strength and fixation stability compared to Ti‐alloys. Embossed structure‐based LCP (ELCP) was designed previously to enhance its mechanical performance. However, its biomechanical feasibility under physiological loading across different fracture healing phases has not yet been systematically evaluated. In the present study, fractured femur models for two fixation strategies, a conventional LCP (M2) and the ELCP (M3), were developed. These strategies were tested using three candidate biomaterials (one non‐biodegradable material, Ti‐alloy, and two biodegradable materials, Mg‐alloy and PLA/50% Mg composite). Three physiological loading conditions corresponding to the healing and early repair phases were applied. The results showed that although Ti‐alloy‐based conventional LCPs provided superior fixation strength, Mg‐alloy‐based ELCPs also performed substantially better than conventional LCPs, as reflected by high safety factors ranging from 1.81 to 3.42, unlike composite‐based plates. Moreover, Mg‐alloy‐based ELCPs exhibited higher interfragmentary strain (within or above the ideal strain range) in the callus compared to Ti‐alloy‐based LCPs, which might promote faster callus strengthening. Thus, Mg‐alloy‐based ELCPs could represent a viable alternative to conventional LCPs by offering adequate fixation strength while potentially reducing stress‐shielding.
Biomechanical evaluation of temporomandibular joint implants and periprosthetic bone under unilateral and bilateral clenching Rajdeep Ghosh, Girish Chandra, Vivek Verma, Kamalpreet Kaur, Ajoy Roychoudhury, et al. Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, 2025 To ensure the long-term success of temporomandibular joint (TMJ) implants, it is imperative to understand their biomechanical performances. This study aims to compare the biomechanical performance of two stock implants (narrow and standard) under unilateral and bilateral clenching during both osseointegrated and non-osseointegrated conditions. Finite element models of a human mandible were developed from QCT data, with the left TMJ being replaced by the implants. Six clenching tasks were simulated to evaluate stress and strain distributions in the mandible and implants. Ipsilateral clenching produced higher mandibular strains, while contralateral clenching generated larger implant stresses. Furthermore, intercuspal biting was found to have produced the highest strain (1750–1880 µε) and stress (∼17 MPa) in the mandible. Osseointegration reduced stresses (up to 0.14 MPa) and strains (up to 30 µε) in mandible as well as stresses in mandibular components (up to 48 MPa) and screws (up to 71 MPa). However, during non-osseointegrated conditions, stresses in cortical bone were higher for standard TMJ implant as compared to narrow implant. This suggests possible preference of narrow implant over standard ones.
Finite element method-based simulation on bone fracture fixation configuration factors for biodegradable embossed locking compression plate Girish Chandra, Ajay Pandey, Ashish Kumar Singh, Gourav Singh, Nilesh Tipan Computer Methods in Biomechanics and Biomedical Engineering, 2024 As an evolution, biodegradable implants need to maximize mechanical performance thereby may lead to confusion in selection of the biodegradable material and implant design to the fracture site. This requires selecting a unique fixation configuration to fit within the fractured bone, factors of which can be bone-plate clearance, interfragmentary gap, alteration in screw fixation position and variation in the number of screws whose configuration optimization can re-maximize the mechanical performance of the biodegradable implant. Therefore, these factors have been optimized based on the induced minimum stress using the finite element method-based simulation for which biodegradable embossed locking plates (BELCP) via screws made of Mg-alloy have been fitted over two fragments of femur body (as hollow cylindrical cortical bone). An average human weight of 62 kg is applied to one segment of the femur for all different configurations of each factor, where another segment is assumed to be fixed. By this simulation, the most optimal fixation configuration was found at a minimum induced stress value of 41.96 MPa which is approximately 85%, 18%, 6% and 48% respectively less than all maximum stress induced configurations in each of the factor. This optimized configuration was at the minimum clearance between bone and plate with a 3 mm interfragmentary gap using 8 screws where the locking screw begins to apply from the center of the BELCP. Overall, BELCP may be a better biodegradable implant plate for bone fracture fixation with these optimized fixation configurations as the improved mechanical performance after experimental validation.
Microstructure, Mechanical, in Vitro Biodegradation, and Antimicrobial Behavior of a Mg-Zn-Ca-Sr/ZrO2Composite Prepared Using Powder Metallurgy Girish Chandra, Ajay Pandey, Sarit Prabha, Khushhali M. Pandey ACS Applied Bio Materials, 2022 Biodegradable materials, especially Mg alloys, have an exceptional advantage over nonbiodegradable materials in orthopedic applications, such as avoiding second surgery for removal/replacement, stress shielding, but not enough mechanical strength, and so forth. By further improving the Mg alloy to get all the remaining required properties, it can be used for better biodegradable implants, which depend adequately on material optimization, processing, and so forth. A Mg-Zn-Ca-Sr/ZrO2 composite has been prepared using powder metallurgy by adding 0, 1, 2, and 3 wt % of ZrO2, which also contains Zn, Ca, and Sr as nutrient elements. Microstructure characterization, as well as mechanical and in vitro biodegradation, have been investigated by hardness, compression, and immersion tests. The highest compressive strength, contraction, and hardness of about 185.6 MPa, 9.5%, and 65.2 HRB are observed in the 2% ZrO2-containing composite, respectively, whereas a minimum biodegradation rate of 2.76 mm/year is observed on the same. The antibiotic sensitivity observations against Staphylococcus aureus suggest that the alloy C3 has superior biological activity against the pathogen which ranks this alloy on top in merit. Overall, Mg-Zn-Ca-Sr/ZrO2 exhibits impressive potential for use as a biodegradable and antibiotic material for orthopedic applications.
Effectiveness of non-uniform thickness on a locking compression plate used as a biodegradable bone implant plate Gourav Singh, Ajay Pandey, Girish Chandra Journal of Biomaterials Applications, 2022 Conventional locking compression plate (LCP) made of non-biodegradable materials are well-known bone implants for internal fracture fixation because of their proven experimental success. LCP, however, is mechanically underpowered when made up of biodegradable materials (even with Mg-alloy). The biodegradable implant plate should not only exhibit adequate mechanical performance during implantation but also perform well after fracture, at least until complete healing of the fractured bone. With the aim of achieving enhanced mechanical performance, the design of the LCP has been modified to the design of Biodegradable Locking Compression Plate (BLCP) by adding a suitable thickness in the middle (only 4.6% of the total volume of the LCP), which may help retain some additional strength during implantation and after degradation. Both BLCP and LCP have been comparatively analyzed via FEM with the aid of axial compression and four-point bending tests. BLCP has a better mechanical capability of withstanding loads in its degraded form than in its non-degradable form. Furthermore, BLCP is up to 15.83% mechanically better in the non-degraded form as compared to LCP, which again becomes up to 100% more mechanically adequate in the degraded forms of BLCP than in LCP. BLCP is found safe for degradation up to 2 mm or 6 months with an estimated degradation rate of 4 mm/year, which may allow it to support fractured bone for at least the standard healing time. BLCP can be considered as a superior biodegradable bone implant plate after experimental assurance with the physiological environment and may replace LCP.
Extreme order statistics based inference for Weibull distribution under Ranked Set Sampling with application to time-to-event data T Yadav, G Chandra, P Singh Life Cycle Reliability and Safety Engineering, 1-18 , 2025 2025
Contouring of an indistinct sex ratio and COVID-19 threat to the sustainability of Myrica esculenta in the Northwestern Himalayas S Panwar, G Chandra, HS Ginwal, S Pandey, RK Meena, MS Bhandari Vegetos 38 (5), 2035-2044 , 2025 2025
An in-silico approach to establish evolutionary relationship among the cold-regulated genes ( COR s) for understanding cold stress response in Eucalyptus A Malakar, S Barthwal, G Chandra Discover Forests 1 (1), 31 , 2025 2025
Estimation of Location and Scale Parameters of Lognormal Distribution Using Median with Extreme Ranked Set Sampling: N. Tiwari et al. N Tiwari, G Chandra, S Bhari, J Banerjie Sankhya B 87 (1), 76-102 , 2025 2025 Citations: 1
Ecosystem productivity and carbon dynamics in Keibul Lamjao National Park, Manipur, India: a gray relational analysis perspective KB Meetei, M Tsopoe, G Chandra, D Mukhopadhyay, K Giri Environmental Monitoring and Assessment 197 (2), 140 , 2025 2025 Citations: 7
VOLUME ESTIMATION MODELS FOR QUERCUS SERRATA AND PINUS KESIYA USING NON-DESTRUCTIVE TECHNIQUES. A CASE STUDY FROM NORTHEAST INDIA K Giri, G Chandra, RSC Jayaraj, G Mishra, EN Chanu WOOD RESEARCH 70 (3), 515-526 , 2025 2025
Ranked Set Sampling Model for Response Estimation of Developmental Programs with Exponential Impacts N Tiwari, G Chandra, S Bhari 2025
Impact of Shifting Cultivation on Phyto-diversity (Vegetation) under Different Land use Systems in Serchhip District, Mizoram, India. R Lalnungrenga, G Chandra, M Sankar, E Lalruatsangi, K Premkumar Ecology, Environment & Conservation (0971765X) 30 , 2024 2024 Citations: 1
Adaptive cluster sampling based on balanced sampling plan excluding contiguous units N Tiwari, J Banerjie, G Chandra, S Bhari Communications in Statistics-Theory and Methods 53 (15), 5364-5377 , 2024 2024 Citations: 2
Weighted ranked set sampling for skewed distributions DS Bhoj, G Chandra Mathematics 12 (13), 2023 , 2024 2024 Citations: 4
Can Forest Fire Cognizance Garner Community Support for Fire Prevention? Evidence from the Sal Forest of Northern India N Krishnambika, G Chandra, M Thiyaharajan, BM Dimri Human Ecology 52 (3), 579-589 , 2024 2024 Citations: 1
Ratio Type Estimator for Balanced Sampling Plan excluding Adjacent Units N Tiwari, J Banerjie, G Chandra, S Bhari International Journal of Statistical Sciences 24 (1), 103-114 , 2024 2024
Population and Production of Seed of Buchanania lanzan Spreng in Dhenkanal Forest Division of Odisha, India G Chandra, BP Tampta, M Mohanti, A Pandey, R Latpate The Indian Forester 149 (11) , 2024 2024
Tree genome databases: a new era in the development of cyber-infrastructures for forest trees A Malakar, G Chandra, S Barthwal Genomics data analysis for crop improvement, 285-308 , 2024 2024 Citations: 4
Genomics Data Analysis for Crop Improvement P Anjoy, K Kumar, G Chandra, K Gaikwad Springer Nature Singapore 1, 443 , 2023 2023 Citations: 6
Phenotypic, Geological, and Climatic Spatio-Temporal Analyses of an Exotic Grevillea robusta in the Northwestern Himalayas A Dabral, R Shankhwar, MAC Martins-Ferreira, S Pandey, R Kant, ... Sustainability 15 (16), 12292 , 2023 2023 Citations: 6
Favourable Allocation Models for Symmetric Distributions in Ranked Set Sampling N Tiwari, G Chandra, R Nautiyal JOURNAL OF THE INDIAN SOCIETY OF AGRICULTURAL STATISTICS 77 (1), 89-94 , 2023 2023 Citations: 1
Ranked set sampling with lowest order statistics for Pareto distribution DS Bhoj, G Chandra Communications in Statistics-Simulation and Computation 52 (6), 2327-2335 , 2023 2023 Citations: 8
Synthesis of pine needle cyanoethyl cellulose using Taguchi L25 orthogonal array T Ansari, G Chandra, PK Gupta, G Joshi, V Rana Industrial Crops and Products 191, 115973 , 2023 2023 Citations: 21
Effect of Prana vidya practices on cognitive abilities of adolescents: A randomized control trial P Prabhu, P Gowda, G Chandra Journal of Applied Consciousness Studies 11 (1), 12-21 , 2023 2023 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Advanced sampling methods R Latpate, J Kshirsagar, VK Gupta, G Chandra Springer , 2021 2021 Citations: 99
Effect of boron and zinc fertilization on growth and yield of cowpea (Vigna unguiculata Walp.) in Inceptisols of Arunachal Pradesh P Debnath, SK Pattanaaik, D Sah, G Chandra, AK Pandey Journal of the Indian Society of Soil Science 66 (2), 229-234 , 2018 2018 Citations: 51
Simple random sampling R Latpate, J Kshirsagar, V Kumar Gupta, G Chandra Advanced sampling methods, 11-35 , 2021 2021 Citations: 39
Prediction Mapping Through Maxent Modeling Paves the Way for the Conservation of Rhododendron arboreum in Uttarakhand Himalayas MS Bhandari, RK Meena, R Shankhwar, C Shekhar, J Saxena, R Kant, ... Journal of the Indian Society of Remote Sensing 48 (3), 411-422 , 2020 2020 Citations: 39
Synthesis of pine needle cyanoethyl cellulose using Taguchi L25 orthogonal array T Ansari, G Chandra, PK Gupta, G Joshi, V Rana Industrial Crops and Products 191, 115973 , 2023 2023 Citations: 21
A grey relational model for soil erosion vulnerability assessment in subwatershed of lesser Himalayan region S Pandey, R Nautiyal, P Kumar, G Chandra, VP Panwar Catena 210, 105928 , 2022 2022 Citations: 21
Probability proportional to size sampling R Latpate, J Kshirsagar, V Kumar Gupta, G Chandra Advanced sampling methods, 85-98 , 2021 2021 Citations: 18
Stratified random sampling R Latpate, J Kshirsagar, V Kumar Gupta, G Chandra Advanced Sampling Methods, 37-53 , 2021 2021 Citations: 16
A comparative study on grey relational analysis and C5.0 classification algorithm on adventitious rhizogenesis of Eucalyptus R Saha, HS Ginwal, G Chandra, S Barthwal Trees 35 (1), 43-52 , 2021 2021 Citations: 15
Integrated assessment of adventitious rhizogenesis in Eucalyptus : root quality index and rooting dynamics R Saha, HS Ginwal, G Chandra, S Barthwal Journal of Forestry Research 31 (6), 2145-2161 , 2020 2020 Citations: 13
Evaluation of Chemical and Physical Properties of Commercial Sandalwood Essential Oils and their Comparison with Essential Oil Extracted from Santalum album L SS Bisht, G Chandra, M Ravindra, R Kumar Journal of Essential Oil Bearing Plants 23 (2), 345-355 , 2020 2020 Citations: 13
Simple unequal allocation procedure for ranked set sampling with skew distributions D Bhoj, G Chandra Journal of Modern Applied Statistical Methods 18 (2), 22 , 2020 2020 Citations: 13
A systematic procedure for unequal allocation for skewed distributions in ranked set sampling N Tiwari, G Chandra Journal of the Indian Society of Agricultural Statistics 65 (3), 331-338 , 2011 2011 Citations: 12
Chromatographic and spectrophotometric analysis of heartwood extracts of four Pterocarpus species SS Bisht, K Mishra, KK Pandey, G Chandra, MM Nayak, S Shashikala Wood Science and Technology 56 (2), 459-476 , 2022 2022 Citations: 11
Critical limit of available Boron for rice under red and laterite zone of West Bengal, India P Debnath, G Chandra, SK Ghosh SAARC journal of Agriculture 7 (1), 99-105 , 2009 2009 Citations: 11
Adaptive cluster sampling-based design for estimating COVID-19 cases with random samples G Chandra, N Tiwari, R Nautiyal Current Science 120 (7), 1202-1210 , 2021 2021 Citations: 10
Valuating intangible benefits from afforested areas: A case study in India A Jaina, G Chandrab, R Nautiyal Economía agraria y recursos naturales 17 (1), 89-100 , 2017 2017 Citations: 9
An Overview of small area estimation techniques H Chandra, G Chandra Statistics in Forestry: Methods and Applications, 45-54 , 2015 2015 Citations: 9
Ranked set sampling with lowest order statistics for Pareto distribution DS Bhoj, G Chandra Communications in Statistics-Simulation and Computation 52 (6), 2327-2335 , 2023 2023 Citations: 8
Root distribution, orientation and root length density modelling in Eucalyptus and evaluation of associated water use efficiency R Saha, HS Ginwal, G Chandra, S Barthwal New Forests 51 (6), 1023-1037 , 2020 2020 Citations: 8