Gow-Chin Yen
@nchu.edu.tw
Professor, Department of Food Science and Biotechnology
National Chung Hsing University
100
Scopus Publications
Scopus Publications
- Modifying pea protein by cold plasma for the development of functional vegan cheese
Bing-Fan Chuang, Sheng-Yi Chen, Jer-An Lin, and Gow-Chin Yen
Elsevier BV - Characterization of a novel type 4 resistant starch from tapioca and its obesity-preventive effects through gut microbiota modulation in high-fat diet-treated mice
Chia-Chien Liao, Sheng-Yi Chen, Ying-Ying Chen, Chien-Chih Huang, Ruei-Yuan Pan, and Gow-Chin Yen
Elsevier BV - Protective role of Hsian-tsao ethanol extract against body fat, serum lipid profiles, and hepatic lipid profiles in high-fat diet-fed rats
Ching-Chang Cho, Gow-Chin Yen, Hsin-Yi Lee, Chun-Tse Tsai, Wei-Tang Chang, and Chin-Lin Hsu
The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)
This study investigated the preventive effects of a 40% ethanol extract of Hsian-tsao (40EEHT) on obesity in high-fat diet (HFD)-induced obese rats. Male Wistar rats were administered 0, 100, 200, or 500 mg/kg of 40EEHT, resulting in reduced body weight, total body fat, and hepatic tissue weight after 8 weeks. 40EEHT also decreased adipocyte size, improved lipid profiles, alleviated oxidative stress, and enhanced hepatic antioxidant enzyme activities. Additionally, it regulated fatty acid metabolism by reducing lipogenesis and increasing lipolysis and β-oxidation, suggesting its potential as an anti-obesity dietary supplement. - Effect of multi-processing technologies on the quality of sweet potato starch and associated starch pearl products
Min-Yu Lan, Jer-An Lin, Sheng-Yi Chen, and Gow-Chin Yen
Elsevier BV - Gastroprotective effects of Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 against ethanol-induced gastric ulcers via regulation of the immune response and gut microbiota in mice
Yun-En Huang, Sheng-Yi Chen, Tsung-Ju Li, You-Shan Tsai, Chin-Chu Chen, and Gow-Chin Yen
Royal Society of Chemistry (RSC)
Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 exert gastroprotective effects against ethanol-induced gastric ulcers through multiple mechanisms. - Recent advances in the potential of Phyllanthus emblica L. and its related foods for combating metabolic diseases through methylglyoxal trapping
Sheng-Yi Chen, I-Chen Chiang, Ying-Ying Chen, Yi-Hsien Hsu, and Gow-Chin Yen
Elsevier BV - Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl<inf>3</inf>-treated rats
Yu-Chen Liu, Sheng-Yi Chen, Ying-Ying Chen, Hsin-Yu Chang, I-Chen Chiang, and Gow-Chin Yen
Elsevier BV - Phyllanthus emblica Fruit Improves Obesity by Reducing Appetite and Enhancing Mucosal Homeostasis via the Gut Microbiota-Brain-Liver Axis in HFD-Induced Leptin-Resistant Rats
Hsin-Yu Chang, Sheng-Yi Chen, Jer-An Lin, Ying-Yin Chen, Ying-Ying Chen, Yu-Chen Liu, and Gow-Chin Yen
American Chemical Society (ACS)
The impact of leptin resistance on intestinal mucosal barrier integrity, appetite regulation, and hepatic lipid metabolism through the microbiota–gut–brain–liver axis has yet to be determined. Water extract of Phyllanthus emblica L. fruit (WEPE) and its bioactive compound gallic acid (GA) effectively alleviated methylglyoxal (MG)-triggered leptin resistance in vitro. Therefore, this study investigated how WEPE and GA intervention relieve leptin resistance-associated dysfunction in the intestinal mucosa, appetite, and lipid accumulation through the microbiota–gut–brain–liver axis in high-fat diet (HFD)-fed rats. The results showed that WEPE and GA significantly reduced tissues (jejunum, brain, and liver) MG-evoked leptin resistance, malondialdehyde (MDA), proinflammatory cytokines, SOCS3, orexigenic neuropeptides, and lipid accumulation through increasing leptin receptor, tight junction proteins, antimicrobial peptides, anorexigenic neuropeptides, excretion of fecal triglyceride (TG), and short-chain fatty acids (SCFAs) via a positive correlation with the Allobaculum and Bifidobacterium microbiota. These novel findings suggest that WEPE holds the potential as a functional food ingredient for alleviating obesity and its complications. - High glucose reduces Nrf2-dependent cRAGE release and enhances infl ammasomedependent IL-1β production in monocytes: the modulatory effects of EGCG
Chi-Hao Wu, Yin-Hsuan Chang, Chin-Lin Hsu, Sheng-Yi Chen, and Gow-Chin Yen
Tsinghua University Press - Pterostilbene and 6-shogaol exhibit inhibitory effects on sunitinib resistance and motility by suppressing the RLIP76-initiated Ras/ERK and Akt/mTOR pathways in renal cancer cells
I-Chen Chiang, Sheng-Yi Chen, Yi-Hao Hsu, Fereidoon Shahidi, and Gow-Chin Yen
Elsevier BV - Phyllanthus emblica L. polysaccharides ameliorate colitis via microbiota modulation and dual inhibition of the RAGE/NF-κB and MAPKs signaling pathways in rats
Ying-Ying Chen, Sheng-Yi Chen, Hsin-Yu Chang, Yu-Chen Liu, Bing-Fan Chuang, and Gow-Chin Yen
Elsevier BV - Effect of Indian gooseberry extract on improving methylglyoxal-associated leptin resistance in peripheral tissues of high-fat diet-fed rats
Sheng-Yi Chen, Yue-Ning Huang, Jer-An Lin, and Gow-Chin Yen
The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)
Increased leptin resistance and methylglyoxal (MG) levels are observed in obese patients. However, whether MG deposits contribute to leptin resistance, oxidative stress, and inflammation in peripheral tissues remains unclear. In addition, the edible fruit of Indian gooseberry (Phyllanthus emblica L.) contains abundant bioactive components such as vitamin C, β-glucogallin (β-glu), gallic acid (GA), and ellagic acid (EA). Water extract of Indian gooseberry fruit (WEIG) and GA has been shown to improve cognitive decline by suppressing brain MG-induced insulin resistance in rats administered a high-fat diet (HFD). Accordingly, this study investigated the functions of WEIG and GA in inhibiting MG-induced leptin resistance, oxidative stress, and inflammation in the peripheral tissues of HFD-fed rats. The results showed that MG, advanced glycation end products (AGEs), and leptin resistance accumulation in the liver, kidney, and perinephric fat were effectively restored by elevated glyoxalase-1 (Glo-1) activity after WEIG and GA administration comparable to that of alagebrium chloride (positive control) treatment in HFD-fed rats. Furthermore, WEIG and GA supplementation increased adiponectin and antioxidant enzymes (glutathione peroxidase, superoxide dismutase, catalase) and decreased inflammatory cytokines (IL-6, IL-1β, TNF-α) in the peripheral tissues of HFD-fed rats. In conclusion, these findings demonstrated that MG may trigger leptin resistance, oxidative stress, and inflammation in peripheral tissues, which could be abolished by WEIG and GA treatment. These results show the potential of P. emblica for functional food development and improving obesity-associated metabolic disorders. - Protective effects of camellia oil and gac oil against corticosterone-induced neurotoxicity in Neuro-2a cells
Jo-Han Chiu, Sheng-Yi Chen, I-Chen Chiang, and Gow-Chin Yen
Elsevier BV - Gac (Momordica cochinchinensis Spreng.) oil supplementation mitigates cognitive decline in AlCl3-induced rats through the regulation of Alzheimer's disease markers and autophagy via gut-brain communication
Yen-Hsien Wu, Sheng-Yi Chen, Jhih-Yi Yang, Ying-Ying Chen, and Gow-Chin Yen
Elsevier BV - Optimized enzymatic synthesis of (epi)gallocatechin (EGC) monolaurate and the antioxidant evaluation of its ester analogs
Han Peng, Gow-Chin Yen, and Fereidoon Shahidi
Elsevier BV - Phyllanthus emblica L. extract alleviates leptin resistance and lipid accumulation by inhibiting methylglyoxal production
Yue-Ning Huang, Sheng-Yi Chen, Jer-An Lin, I-Chen Chiang, and Gow-Chin Yen
Elsevier BV - Preventive Effect of Indian Gooseberry (Phyllanthus emblica L.) Fruit Extract on Cognitive Decline in High-Fat Diet (HFD)-Fed Rats
Ying‐Yin Chen, Sheng‐Yi Chen, Jer‐An Lin, and Gow‐Chin Yen
Wiley
SCOPE Methylglyoxal (MG)-derived advanced glycation end products (AGEs) directly bind to the receptor for advanced glycation end products (RAGE), subsequently exacerbating obesity and obesity-induced cognitive decline. Indian gooseberry (Phyllanthus emblica L.) fruit has antiobesity properties. However, the underlying mechanism by which Indian gooseberry fruit prevents obesity-induced cognitive decline remains unclear. METHODS AND RESULTS This study aimed to investigate the preventive effect of a water extract of Indian gooseberry fruit (WEIG) and its bioactive compound gallic acid (GA) on the obesity-induced cognitive decline through MG suppression and gut microbiota modulation in high-fat diet (HFD)-fed rats. Trapping MG, WEIG, and GA significantly ameliorated fat accumulation in adipose tissue and learning and memory deficits. Mechanistically, WEIG and GA administration effectively reduced brain MG and AGE levels and subsequently reduced insulin resistance, inflammatory cytokines, MDA production, and Alzheimer's disease-related proteins, but increased both antioxidant enzyme activities and anti-inflammatory cytokine with inhibiting RAGE, MAPK, and NF-κB levels in HFD-fed rats. Additionally, WEIG and GA supplementation increased the relative abundances of Bacteroidetes, Gammaproteobacteria, and Parasutterella, which negatively correlate with MG, inflammatory cytokine, and Alzheimer's disease-related protein expressions. CONCLUSION This novel finding provides a possible mechanism by which WEIG prevents obesity-induced cognitive decline through the gut-brain axis. This article is protected by copyright. All rights reserved. - Ameliorative effect of buckwheat polysaccharides on colitis via regulation of the gut microbiota
Jhih-Yi Yang, Sheng-Yi Chen, Yen-Hsien Wu, Yi-Lun Liao, and Gow-Chin Yen
Elsevier BV - Protective effect of rosmarinic acid-rich extract from Trichodesma khasianum Clarke against microbiota dysbiosis in high-fat diet-fed obese mice
Ke-Mei Lai, Sheng-Yi Chen, Guan-Yu Wang, Fereidoon Shahidi, and Gow-Chin Yen
Elsevier BV - How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy
Ya-Chu Tang, Yung-Jen Chuang, Hsin-Huei Chang, Shin-Hun Juang, Gow-Chin Yen, Jang-Yang Chang, and Ching-Chuan Kuo
The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA)
Induction of antioxidant proteins and phase 2 detoxifying enzymes that neutralize reactive electrophiles are important mechanisms for protection against carcinogenesis. Normal cells provide multifaceted pathways to tightly control NF-E2-related factor 2 (NRF2)-mediated gene expression in response to an assault by a range of endogenous and exogenous oncogenic molecules. Transient activation of NRF2 by its activators is able to induce ARE-mediated cytoprotective proteins which are essential for protection against various toxic and oxidative damages, and NRF2 activators thereby have ef fi cacy in cancer chemoprevention. Because NRF2 has a cytoprotective function, it can protect normal cells from carcinogens like an angel, but when the protective effect acts on cancer cells, it will give rise to invincible cancer cells and play a devilish role in tumor progression. Indeed, aberrant activation of NRF2 has been found in a variety of cancers that create a favorable environment for the proliferation and survival of cancer cells and leads to drug resistance, ultimately leading to the poor clinical prognosis of patients. Therefore, pharmacological inhibition of NRF2 signaling has emerged as a promising approach for cancer therapy. This review aims to compile the regulatory mechanisms of NRF2 and its double-edged role in cancer. In addition, we also summarize the research progress of NRF2 modulators, especially phytochemicals, in chemoprevention and cancer therapy. - Advanced Glycation End Products (AGEs)
Jer-An Lin and Gow-Chin Yen
Elsevier - Dashboard charting for online compliance monitoring of heavy metals in school-meal chicken and pork in Taiwan
Yo-Yu Lin, Gow-Chin Yen, and Hsin-Tang Lin
Elsevier BV - Rhinacanthus nasutus and okara polysaccharides attenuate colitis via inhibiting inflammation and modulating the gut microbiota
Sheng‐Yi Chen, Yu‐Chieh Shen, Jer‐An Lin, and Gow‐Chin Yen
Wiley
Plant polysaccharides have prebiotic properties for gut microbiota and immune modulation. This study aimed to investigate the prevention abilities of edible Rhinacanthus nasutus polysaccharide (RNP) and okara polysaccharide (OP) in Sprague-Dawley rats with acetic acid-induced colitis. The characterizations of RNP and OP were analyzed, including Fourier transform infrared, thermogravimetric analysis, differential scanning calorimetry, and monosaccharide composition. The prebiotic properties of RNP and OP were determined in vitro. In addition, the pathological features of colon length and inflammatory cytokine levels in acetic acid-induced colitis were improved by intragastric preadministration of RNP and OP for 3 weeks. There was no nephrotoxicity or hepatotoxicity in rats via histopathological assessment after RNP and OP intake. Moreover, the abundance of short-chain fatty acids-producing bacteria (Lachnospiraceae, Lactobacilli, and Prevotellaceae) were increased after RNP supplementation. In conclusion, intragastric gavage of RNP and OP significantly modulated the gut microbiota and immune response, consequently alleviating the symptoms of colitis. This novel finding provides an alternative strategy and potential application of these two polysaccharides for colitis prevention and treatment. - Anti-fatigue effects of enzyme-hydrolyzed okara in C2C12 myotubes and Sprague-Dawley rats
Yu-Jou Chien, Gow-Chin Yen, Shih-Chien Huang, Shiuan-Chih Chen, and Chin-Lin Hsu
Royal Society of Chemistry (RSC)
Okara protein hydrolysate (OPH) could exert anti-fatigue effects both in vivo and in vitro through an improvement in mitochondrial function. - Protective effect of fermented okara on the regulation of inflammation, the gut microbiota, and SCFAs production in rats with TNBS-induced colitis
Cheng-Jie Hong, Sheng-Yi Chen, Yi-Hao Hsu, and Gow-Chin Yen
Elsevier BV