Sofia Oliveira-Martins
@ul.pt
Faculdade de Farmácia da Universidade de Lisboa
Faculdade de Farmácia da Universidade de Lisboa
EDUCATION
Pharmacy degrre (PhD)
Master in Public Health (MSc)
PhD in Pharmacoepidemiology
RESEARCH INTERESTS
public health, pharmacoepidemiology, pharmaceutical legislation, medicaiton use,
Scopus Publications
Scopus Publications
Margarida Perdigão, Anabela Afonso, Sofia de Oliveira-Martins, Manuel José Lopes, and Ana Margarida Advinha
Springer Science and Business Media LLC
AbstractPharmacovigilance stands out for its importance in obtaining existing knowledge about medicine and patient safety and should be recognized as a continuous line of study. It constitutes a highly relevant component in the activities of health professionals, with spontaneous notification of suspected adverse drug reactions being its main emphasis. The underreporting that persists can be overcome through continuous professional development programs, reinforcing theoretical and practical knowledge in the curricular plans of health courses. As a result, more educated professionals will also allow citizens to recognize the importance of pharmacovigilance. The main objective of this study was to describe and characterize the teaching-learning process of pharmacovigilance in Portugal, analyzing the knowledge, perceptions and attitudes of students and health professionals. In total, ninety-three curricular unit forms of the seventeen healthcare courses included were analyzed, among which only three referred to pharmacovigilance as mandatory and thirty-nine did not address any keywords. The questionnaire applied was answered by 650 participants, both students (62%) and professionals (38%). Approximately 84.4% of the students and 54.7% of the professionals affirmed that they had never spontaneously reported an adverse drug reaction. Only 24.6% of the students and 17.8% of professionals referred to the existence of specific course content dedicated to pharmacovigilance in their coursework. In view of these results, it is evident that there is a need for a wider reflection regarding the further training and constant update of practicing professionals as well as in diverse health institutions, investing in the creation of an academic curriculum that integrates pharmacovigilance in healthcare courses.
Ana Margarida Advinha, Rita de Oliveira Cachão, Ana Catarina Raposo, Miguel Domingos, Anabela Afonso, Ana Serralheiro, Manuel José Lopes, and Sofia de Oliveira-Martins
Springer Nature Switzerland
Edna Ribeiro Parracha, Ana Margarida Advinha, Manuel José Lopes, and Sofia Oliveira‐Martins
Wiley
Spontaneous notification systems are essential in a post‐marketing safety context. However, using this method, only about 6% of all adverse drug reactions are notified. To overcome this sub‐notification problem, new methods need to be developed to improve and facilitate reporting. In this sense, the use of digital media, mainly medical mobile apps, has been presented as a powerful tool, including in pharmacovigilance. We performed a scope review to identify the available apps used to report adverse drug reactions around the world to eventually identify which of them best fits the Portuguese pharmacovigilance system.
Ana Margarida Advinha, Carla Nunes, Carla Teixeira de Barros, Manuel José Lopes, and Sofia de Oliveira-Martins
Springer Science and Business Media LLC
AbstractDaily medication use can be affected by the gradual loss of functional ability. Thus, elderly patients are at risk for nonadherence due to functional decline, namely, decreases in cognitive skills and visual and manual dexterity. The main objective was to assess the ability of older people to self-manage their medication and to identify the main predictors for unintentional nonadherence. A cross-sectional study was conducted (2014–2017) in community centers and pharmacies. Functional assessment was performed with the Portuguese versions of the Drug Regimen Unassisted Grading Scale (DRUGS-PT) and the Self-Medication Assessment Tool (SMAT-PT). A purposive sample including 207 elderly patients was obtained. To identify the main predictors, binary logistic regression was performed. The average DRUGS-PT score was slightly lower than that in other studies. On the SMAT-PT, the greatest challenge for patients was identifying medications by reading labels/prescriptions. The main difficulties identified were medication memorization and correct schedule identification. The scores were higher with the real regimen than with the simulated regimen, underlining the difficulties for patients in receiving new information. Regarding the predictors of an older individual’s ability to self-manage medications, two explanatory models were obtained, with very high areas under the curve (> 90%). The main predictors identified were cognitive ability, level of schooling and daily medication consumption.
Artur Mendes Moura, Sofia Oliveira Martins, and João Filipe Raposo
Springer Science and Business Media LLC
Abstract Background Studies of drug utilization in patients with diabetes, a chronic disease that can be treated with a wide range of available medicines, have attracted substantial social and clinical interest. Objective To characterize antidiabetic medicine consumption between 2005 and 2017, to evaluate the trends of these medicines in mainland Portugal, and to compare district consumption. An additional objective was to perform a statistical analysis on drug consumption in different regions of Portugal. Methods A descriptive, longitudinal observational study; the setting was mainland Portugal ( excluding Azores and Madeira). Each medicine has a respective defined daily dose (DDD). The sum of the DDD, provides the annual consumption in terms of the DDD for each district each year. When calculating the annual average for the resident district population and the number of days in a year, the denominator is expressed as 1000 inhabitants per day (TID). Main outcome measure: The DDD/TID for mainland Portugal (for all districts) between 2005 and 2017 for antidiabetic medicines. Information was obtained from the official database of prescription medicine invoices with reimbursement in mainland Portugal. Results In mainland Portugal, the antidiabetic medicine consumption was 49.3 DDD/TID in 2005 and 88.2 DDD/TID in 2017. The consumption of insulins and their analogs increased from 10.8% to 17.4% compared to the total consumption of antidiabetic medicines. In 2017, the level of biguanide consumption was 23.1 DDD/TID, that of sulphonylurea consumption was 15.8 DDD/TID, that of DPP-4 inhibitor consumption was 6.8 DDD/TID, and that of SGLT2 inhibitor consumption was 3.0 DDD/TID. The oral consumption of fixed-dose combinations reached 21.4 DDD/TID. After employing a geographical division between north and south and between coastal and inland regions, the consumption of several different drugs showed statistically significant differences. Conclusions When comparing 2017 with 2005, the panorama was quite different, with higher levels of consumption of antidiabetic medicines, insulins and their analogs, noninsulin medicines, long-acting and fast-acting insulins and their analogs, metformin, DPP-4 inhibitors and, mainly, metformin combined with a DPP-4 inhibitor. The SGLT2 inhibitors achieved a representative consumption. Different consumption patterns may be related to sociodemographic factors or to clinical practices.
Catarina Caçador, Edite Teixeira-Lemos, Sofia Oliveira Martins, and Fernando Ramos
MDPI AG
Adequate nutritional status is necessary for the proper management of polypharmacy, the prevention of cognitive decline, and the maintenance of functional capacity in activities of daily living. Although several studies validate this fact for the general elderly population, data on institutionalized seniors concerning this relation are scarce. A systematic review was performed according to the PRISMA guidelines, aiming to study the potential correlation between nutritional status and polypharmacy, cognitive decline, and functional performance in institutionalized elders. The search was limited to studies in English or Portuguese in the last decade. Inclusion criteria relied on the PICO method. Five studies explored the relationship of nutritional status with cognitive performance in the institutionalized elderly, and nine prospective observational studies reported significant positive associations between appropriate nutritional status and physical abilities. Nutritional status was primarily measured by MNA. Adequate nutritional status was described as an important parameter in preventing cognitive and functional decline in the institutionalized elderly. No studies were found describing the impact of nutritional status on the prevention of polypharmacy. Given the strong impact of malnutrition found in the studies in cognition and functional abilities in the institutionalized elderly, an evaluation of nutritional status of the elders is crucial to prevent health problems and allow early intervention programs in order to further prevent health decline.
Sara Faustino, Sofia Oliveira-Martins, and Ana Margarida Advinha
Springer International Publishing
Artur Mendes Moura, Marília Antunes, Sofia Oliveira Martins, and João Filipe Raposo
Public Library of Science (PLoS)
Aim To develop a statistical model to identify determinants of glycemic control. Materials and methods A database was extracted from patients’ records with at least one glycated hemoglobin (HbA1c) analysis and with antidiabetic therapy established and stabilized. A logistic regression model was designed to identify the statistical significance of factors associated with glycemic control. Results Higher probability of success (HbA1c ≤8% [64 mmol/mol]) was found for those who were older in age, those who were men, and those with higher education levels. Increased values for the following variables were associated with the poorest glycemic control: number of years of T2DM since diagnosis, number of antidiabetic medicines, body mass index, low-density lipoprotein cholesterol, triglycerides, systolic blood pressure and number of diabetes consultations in the last twelve months. The following pharmacotherapeutic treatments were associated with glycemic control (in decreasing order of the results): oral antidiabetic drugs; oral antidiabetic drugs and insulin; insulin. Patients using metformin and a dipeptidyl peptidase-4 inhibitors have a higher probability of success than do patients using metformin and a sulfonylurea, and patients using insulin and metformin have a higher probability of success than do patients using insulin alone. Conclusions Sociodemographic, clinical and therapeutic parameters can strongly affect glycemic control. Studies based on real-life patient data provide important information on the development of more effective glycemic control.
Mara Pereira Guerreiro, Madalena Plácido, Carla Teixeira Barros, Anabela Coelho, Anabela Graça, Maria João Gaspar, and Sofia de Oliveira Martins
BMJ
Objectives To determine the face and content validity of items for measuring safe medication practices in Portuguese hospitals. Methods 128 items were drafted from content analysis of existing questionnaires and the literature, employing preferred terms of the WHO International Classification for Patient Safety (Portuguese version). A two-round e-Delphi was convened, using a purposive multidisciplinary panel. Hospital-based experts were asked to rate the relevance of items on a 7-point Likert scale and to comment on their clarity and completeness. Results The response rate was similar in both rounds (70.3% and 73.4%, respectively). In the first round 91/128 (71.1%) items reached the predefined level of positive consensus. In the second round 23 additional items reached positive consensus, as well as seven items newly derived by the panel. Conclusions Most items have face and content validity, indicating relevance and clarity, and can be included in a future questionnaire for measuring safe medication practices in Portuguese hospitals.
Ana Margarida Advinha, Manuel José Lopes, and Sofia de Oliveira-Martins
Springer Science and Business Media LLC
A.M. Advinha, A. Henriques, M.P. Guerreiro, C. Nunes, M.J. Lopes, and S. de Oliveira-Martins
Elsevier BV
Carla Torre, José Guerreiro, Sofia de Oliveira Martins, João Filipe Raposo, Ana Paula Martins, and Hubert Leufkens
Elsevier BV
Ana Margarida Advinha, Sofia de Oliveira-Martins, Vanessa Mateus, Sara Grou Pajote, and Manuel José Lopes
Springer Science and Business Media LLC
Paula Araujo Opromolla and Ruy Laurenti
FapUNIFESP (SciELO)
Para controle da hanseníase, doença infectocontagiosa conhecida desde os tempos bíblicos, são mostradas as intrincadas convergências de histórias nacionais, de políticas médicas, governamentais e internacionais. O estudo descreve a história e as ações de controle da hanseníase, a partir do começo do século XIX, no estado de São Paulo, e sua conexão com o desenvolvimento da saúde pública, utilizando análises bibliográficas e documentais.
Sofia de Oliveira Martins, Polybio Serra e Silva, Ana Luisa Papoila, Margarida Caramona, Jan W. Foppe van Mil, and José Cabrita
Springer Science and Business Media LLC
Sofia Oliveira Martins, Maria Augusta Soares, J. W. Foppe van Mil, and José Cabrita
Springer Science and Business Media LLC