Guittard Geoffrey

@inserm.fr

Cancer Research Center of Marseille: Marseille, FR
Inserm



        

https://researchid.co/geoffrey.guittard

EDUCATION

University of Mediterranean: Marseille, FR
2006-10-01 to 2010-02-17 | PhD (Immunology)

University of Mediterranean: Marseille, FR
2004 to 2005 | Master (Cellular Biology (Immunology))

University of Mediterranean: Marseille, FR
2002 to 2003 | Bachelor Degree

Publications

Karkeni E., Morin S.O., Bou Tayeh B., Goubard A., Josselin E., Castellano R., Fauriat C., Guittard G., Olive D., Nunès J.A. Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer. Front Immunol. 2019 Jun 6;10:1307. doi: 10.3389/. eCollection 2019.

Çuburu, N., Kim, R., Guittard, G.C., Thompson C.D., Day, P., Hamm, D.E., Pang, Y-Y.S., Graham, B.S., Lowy, D.R., Schiller, J.T. A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells. J. Immunol. 2019 Feb 15;202(4):1250-1264. doi: 10.4049/. Epub 2019 Jan 11.

Zidi B, Vincent-Fabert C, Pouyet L, Seillier M, Vandevelde A, N'guessan P, Poplineau M, Guittard G, Mancini SJC, Duprez E, Carrier A. TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling. Proc Natl Acad Sci U S A. 2018 Dec 17. pii: 201809980. doi: 10.1073/.

Guittard, G. ¶, Dios-Esponera, A., Palmer, D.C., Akpan, I., Barr, V.A., Manna, A., Restifo, N.P., Samelson, L.E. The Cish SH2 domain is essential for PLC-1 regulation in TCR stimulated CD8+ T cells. Sci Rep. 2018 Mar 28;8(1):5336. doi: 10.1038/s41598-018-23549-2.

Guittard, G., Pontarotti, P., Granjeaud, S., Rodrigues, M., Abi-Rached, L., Nunès, J.A. Evolutionary and expression analyses reveal a pattern of ancient duplications and functional specializations in the diversification of the Downstream of Kinase (DOK) genes. Dev Comp Immunol. 2018 Jul;84:193-198. doi: 10.1016/j.. Epub 2018 Feb 15.

Guittard, G., Gallardo, D.L., Li,W.,Melis,N., Lui, J.C., Kortum, Shakarishvilli, N.G., Huh, S., Baron, J., Weigert, R., Kramer, J.A., Samelson, L.E., Sommers, C.L. Unexpected cartilage phenotype in CD4-cre-conditional SOS-deficient mice. Front Immunol. 2017 Mar 23;8:343. doi: 10.3389/. eCollection 2017. (Article).

Eil, R., Vodnala, S.K., Clever, D., Klebanoff, C.A., Sukumar, M., Pan J.H., Palmer, D.C., Gros, A., Yamamoto, T.N., Patel, S.J., Guittard, G.C., Yu, Z., Carbonaro, V., Okkenhaug, K., Schrump, D.S., Linehan, W.M., Roychoudhuri, R., Restifo, N.P. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature. 2016 Sep 14;537(7621):539-543. doi: 10.1038/nature19364. Epub 2016 Sep 14.

Palmer, D.C.*, Guittard, G.C.*, Franco, Z., Crompton, J.G., Eil, R.L., Patel, S.J., Ji, Y., Van Panhuys, N., Klebanoff, C.A., Sukumar, M., Clever D., Chichura A., Roychoudhuri R., Varma R., Wang E., Gattinoni L., Marincola F.M., Balagopalan L., Samelson L.E., Restifo N.P. et al. (2015). Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance. J Exp Med 212, 2095-2113. doi: 10.1084/. Epub 2015 Nov 2.

Rodriguez-Pena, A.B., Gomez-Rodriguez, J., Kortum, R.L., Palmer, D.C., Yu, Z., Guittard, G.C., Wohlfert, E.A., Silver, P.B., Misplon, J.A., Sommers, C.L., Feigenbaum L., Epstein S.L., Caspi R.R., Belkaid Y., Restifo N.P., Samelson L.E., Balagopalan L. et al. (2015). Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules. Gene Ther 22, 781-792. doi: 10.1038/. Epub 2015 Jun 18.

Guittard, G., Kortum, R.L., Balagopalan, L., Cuburu, N., Nguyen, P., Sommers, C.L., and Samelson, L.E. (2015). Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration. Eur J Immunol 45, 2389-2395. doi: 10.1002/. Epub 2015 Jun 5.

Mkrtichyan, M., Najjar, Y.G., Raulfs, E.C., Liu, L., Langerman, S., Guittard, G., Ozbun, L., and Khleif, S.N. (2012). B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets. J Immunol 189, 2338-2347. doi: 10.4049/. Epub 2012 Jul 25.

Nunes, J.A., and Guittard, G. (2013). An Emerging Role for PI5P in T Cell Biology. Front Immunol 4, 80. doi: 10.3389/. eCollection 2013.

Guittard, G., Mortier, E., Tronchere, H., Firaguay, G., Gerard, A., Zimmermann, P., Payrastre, B., and Nunes, J.A. (2010). Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways. FEBS Lett 584, 2455-2460. doi: 10.1016/j.. Epub 2010 Apr 24.

Gerard, A., Ghiotto, M., Fos, C., Guittard, G., Compagno, D., Galy, A., Lemay, S., Olive, D., and Nunes, J.A. (2009). Dok-4 is a novel negative regulator of T cell activation. J Immunol 182, 7681-7689. doi: 10.4049/.

Guittard, G., Gerard, A., Dupuis-Coronas, S., Tronchere, H., Mortier, E., Favre, C., Olive, D., Zimmermann, P., Payrastre, B., and Nunes, J.A. (2009). Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. J Immunol 182, 3974-3978. doi: 10.4049/.